Paul G Wyatt

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 22

Top Venues

Journal of medicinal chemistry

ChemMedChem

ACS infectious diseases

Science (New York, N.Y.)

University of Dundee

University of Birmingham (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Dundee Mar 16 2006

United Kingdom

Head of Drug Discovery Unit :: Drug Discovery Unit

Astex Pharmaceuticals European office Oct 01 2001 - Mar 15 2006

United Kingdom

Project Leader, Group Leader :: Medicinal Chemistry

Education History

University of Birmingham

United Kingdom

PHD :: Chemistry

University of Birmingham

United Kingdom

BSC :: Chemistry

Publications

Stuart Lang, Daniel A Fletcher, Alain-Pierre Petit, Nicola Luise, Paul K Fyfe, Fabio Zuccotto, David Porter, Anthony Hope, Fiona Bellany, Catrina Kerr, Claire J Mackenzie, Paul G Wyatt, David W Gray
Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV-CA Binding Fragments. ChemMedChem 19 (13) (2024)
Stuart Lang, Daniel A Fletcher, Alain-Pierre Petit, Nicola Luise, Paul K Fyfe, Fabio Zuccotto, David Porter, Anthony Hope, Fiona Bellany, Catrina Kerr, Claire J Mackenzie, Paul G Wyatt, David W Gray
Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV-CA Binding Fragments. ChemMedChem 19 (13) (2024)
Stuart Lang, Daniel A Fletcher, Alain-Pierre Petit, Nicola Luise, Paul K Fyfe, Fabio Zuccotto, David Porter, Anthony Hope, Fiona Bellany, Catrina Kerr, Claire J Mackenzie, Paul G Wyatt, David W Gray
Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV-CA Binding Fragments. ChemMedChem (2024)
Stuart Lang, Daniel A Fletcher, Alain-Pierre Petit, Nicola Luise, Paul K Fyfe, Fabio Zuccotto, David Porter, Anthony Hope, Fiona Bellany, Catrina Kerr, Claire J Mackenzie, Paul G Wyatt, David W Gray
Application of an NMR/Crystallography Fragment Screening Platform for the Assessment and Rapid Discovery of New HIV-CA Binding Fragments. ChemMedChem 19 (13) (2024)
Simon R Green, Caroline Wilson, Thomas C Eadsforth, Avinash S Punekar, Fabio K Tamaki, Gavin Wood, Nicola Caldwell, Barbara Forte, Neil R Norcross, Michael Kiczun, John M Post, Eva Maria Lopez-Román, Curtis A Engelhart, Iva Lukac, Fabio Zuccotto, Ola Epemolu, Helena I M Boshoff, Dirk Schnappinger, Chris Walpole, Ian H Gilbert, Kevin D Read, Paul G Wyatt, Beatriz Baragaña
Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity. Journal of medicinal chemistry (2023)
Lauren A Webster, Susan E Farrell, Ian H Gilbert, Paul G Wyatt, Kevin D Read
Correction to "Bespoke Drug Discovery Training for Low-Middle Income Countries". ACS medicinal chemistry letters 14 (11) (2023)
Candice Soares de Melo, Vinayak Singh, Alissa Myrick, Sandile B Simelane, Dale Taylor, Christel Brunschwig, Nina Lawrence, Dirk Schnappinger, Curtis A Engelhart, Anuradha Kumar, Tanya Parish, Qin Su, Timothy G Myers, Helena I M Boshoff, Clifton E Barry, Frederick A Sirgel, Paul D van Helden, Kirsteen I Buchanan, Tracy Bayliss, Simon R Green, Peter C Ray, Paul G Wyatt, Gregory S Basarab, Charles J Eyermann, Kelly Chibale, Sandeep R Ghorpade
Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies. Journal of medicinal chemistry 64 (1) (2021)
Sangmi Oh, M Daben J Libardo, Shaik Azeeza, Gary T Pauly, Jose Santinni O Roma, Andaleeb Sajid, Yoshitaka Tateishi, Caroline Duncombe, Michael Goodwin, Thomas R Ioerger, Paul G Wyatt, Peter C Ray, David W Gray, Helena I M Boshoff, Clifton Earl Barry
Structure-Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents. ACS infectious diseases 7 (2) (2021)
Caroline Wilson, Peter Ray, Fabio Zuccotto, Jorge Hernandez, Anup Aggarwal, Claire Mackenzie, Nicola Caldwell, Malcolm Taylor, Margaret Huggett, Michael Mathieson, Dinakaran Murugesan, Alasdair Smith, Susan Davis, Mattia Cocco, Maloy K Parai, Arjun Acharya, Fabio Tamaki, Paul Scullion, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Eva Maria Lopez-Román, Pedro Alfonso Torres-Gómez, Ana Maria Toledo, Laura Guijarro-Lopez, Isabel Camino, Curtis A Engelhart, Dirk Schnappinger, Lisa M Massoudi, Anne Lenaerts, Gregory T Robertson, Chris Walpole, David Matthews, David Floyd, James C Sacchettini, Kevin D Read, Lourdes Encinas, Robert H Bates, Simon R Green, Paul G Wyatt
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target. Journal of medicinal chemistry 65 (1) (2021)
Michael G Thomas, Stephen Brand, Manu De Rycker, Fabio Zuccotto, Iva Lukac, Peter G Dodd, Eun-Jung Ko, Sujatha Manthri, Kate McGonagle, Maria Osuna-Cabello, Jennifer Riley, Caterina Pont, Frederick Simeons, Laste Stojanovski, John Thomas, Stephen Thompson, Elisabet Viayna, Jose M Fiandor, J Julio Martin, Paul G Wyatt, Timothy J Miles, Kevin D Read, Maria Marco, Ian H Gilbert
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis. Journal of medicinal chemistry 64 (9) (2021)
Joanna C Evans, Dinakaran Murugesan, John M Post, Vitor Mendes, Zhe Wang, Navid Nahiyaan, Sasha L Lynch, Stephen Thompson, Simon R Green, Peter C Ray, Jeannine Hess, Christina Spry, Anthony G Coyne, Chris Abell, Helena I M Boshoff, Paul G Wyatt, Kyu Y Rhee, Tom L Blundell, Clifton E Barry, Valerie Mizrahi
Targeting Mycobacterium tuberculosis CoaBC through Chemical Inhibition of 4'-Phosphopantothenoyl-l-cysteine Synthetase (CoaB) Activity. ACS infectious diseases 7 (6) (2021)
Michael G Thomas, Manu De Rycker, Richard J Wall, Daniel Spinks, Ola Epemolu, Sujatha Manthri, Suzanne Norval, Maria Osuna-Cabello, Stephen Patterson, Jennifer Riley, Frederick R C Simeons, Laste Stojanovski, John Thomas, Stephen Thompson, Claire Naylor, Jose M Fiandor, Paul G Wyatt, Maria Marco, Susan Wyllie, Kevin D Read, Timothy J Miles, Ian H Gilbert
Identification and Optimization of a Series of 8-Hydroxy Naphthyridines with Potent In Vitro Antileishmanial Activity: Initial SAR and Assessment of In Vivo Activity. Journal of medicinal chemistry 63 (17) (2020)
Qinglan Wang, Helena I M Boshoff, Justin R Harrison, Peter C Ray, Simon R Green, Paul G Wyatt, Clifton Earl Barry
PE/PPE proteins mediate nutrient transport across the outer membrane of Mycobacterium tuberculosis. Science (New York, N.Y.) 367 (6482) (2020)
Manu De Rycker, David Horn, Bree Aldridge, Richard K Amewu, Clifton E Barry, Frederick S Buckner, Sarah Cook, Michael A J Ferguson, Nathalie Gobeau, Jennifer Herrmann, Paul Herrling, William Hope, Jennifer Keiser, Maria Jose Lafuente-Monasterio, Paul D Leeson, Didier Leroy, Ujjini H Manjunatha, James McCarthy, Timothy J Miles, Valerie Mizrahi, Olena Moshynets, Jacquin Niles, John P Overington, John Pottage, Srinivasa P S Rao, Kevin D Read, Isabela Ribeiro, Lynn L Silver, Jen Southern, Thomas Spangenberg, Shyam Sundar, Caitlin Taylor, Wes Van Voorhis, Nicholas J White, Susan Wyllie, Paul G Wyatt, Ian H Gilbert
Setting Our Sights on Infectious Diseases. ACS infectious diseases 6 (1) (2019)
Victoriano Corpas-Lopez, Sonia Moniz, Michael Thomas, Richard J Wall, Leah S Torrie, Dorothea Zander-Dinse, Michele Tinti, Stephen Brand, Laste Stojanovski, Sujatha Manthri, Irene Hallyburton, Fabio Zuccotto, Paul G Wyatt, Manu De Rycker, David Horn, Michael A J Ferguson, Joachim Clos, Kevin D Read, Alan H Fairlamb, Ian H Gilbert, Susan Wyllie
Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani. ACS infectious diseases 5 (1) (2018)
Laura A T Cleghorn, Peter C Ray, Joshua Odingo, Anuradha Kumar, Heather Wescott, Aaron Korkegian, Thierry Masquelin, Abraham Lopez Moure, Caroline Wilson, Susan Davis, Margaret Huggett, Penelope Turner, Alasdair Smith, Ola Epemolu, Fabio Zuccotto, Jennifer Riley, Paul Scullion, Yoko Shishikura, Liam Ferguson, Joaquin Rullas, Laura Guijarro, Kevin D Read, Simon R Green, Phil Hipskind, Tanya Parish, Paul G Wyatt
Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB. Journal of medicinal chemistry 61 (15) (2018)
Federica Prati, Fabio Zuccotto, Daniel Fletcher, Maire A Convery, Raquel Fernandez-Menendez, Robert Bates, Lourdes Encinas, Jingkun Zeng, Chun-Wa Chung, Paco De Dios Anton, Alfonso Mendoza-Losana, Claire Mackenzie, Simon R Green, Margaret Huggett, David Barros, Paul G Wyatt, Peter C Ray
Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA. ChemMedChem 13 (7) (2018)
Justin R Harrison, Stephen Brand, Victoria Smith, David A Robinson, Stephen Thompson, Alasdair Smith, Kenneth Davies, Ngai Yi Mok, Leah S Torrie, Iain Collie, Irene Hallyburton, Suzanne Norval, Frederick R C Simeons, Laste Stojanovski, Julie A Frearson, Ruth Brenk, Paul G Wyatt, Ian H Gilbert, Kevin D Read
A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors. Journal of medicinal chemistry 61 (18) (2018)
Michael G Thomas, Manu De Rycker, Myriam Ajakane, Sébastian Albrecht, Ana Isabel Álvarez-Pedraglio, Markus Boesche, Stephen Brand, Lorna Campbell, Juan Cantizani-Perez, Laura A T Cleghorn, Royston C B Copley, Sabrinia D Crouch, Alain Daugan, Gerard Drewes, Santiago Ferrer, Sonja Ghidelli-Disse, Silvia Gonzalez, Stephanie L Gresham, Alan P Hill, Sean J Hindley, Rhiannon M Lowe, Claire J MacKenzie, Lorna MacLean, Sujatha Manthri, Franck Martin, Juan Miguel-Siles, Van Loc Nguyen, Suzanne Norval, Maria Osuna-Cabello, Andrew Woodland, Stephen Patterson, Imanol Pena, Maria Teresa Quesada-Campos, Iain H Reid, Charlotte Revill, Jennifer Riley, Jose Ramon Ruiz-Gomez, Yoko Shishikura, Frederick R C Simeons, Alasdair Smith, Victoria C Smith, Daniel Spinks, Laste Stojanovski, John Thomas, Stephen Thompson, Tim Underwood, David W Gray, Jose M Fiandor, Ian H Gilbert, Paul G Wyatt, Kevin D Read, Timothy J Miles
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis. Journal of medicinal chemistry 62 (3) (2018)
Dinakaran Murugesan, Peter C Ray, Tracy Bayliss, Gareth A Prosser, Justin R Harrison, Kirsteen Green, Candice Soares de Melo, Tzu-Shean Feng, Leslie J Street, Kelly Chibale, Digby F Warner, Valerie Mizrahi, Ola Epemolu, Paul Scullion, Lucy Ellis, Jennifer Riley, Yoko Shishikura, Liam Ferguson, Maria Osuna-Cabello, Kevin D Read, Simon R Green, Dirk A Lamprecht, Peter M Finin, Adrie J C Steyn, Thomas R Ioerger, Jim Sacchettini, Kyu Y Rhee, Kriti Arora, Clifton Earl Barry, Paul G Wyatt, Helena I M Boshoff
2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization. ACS infectious diseases 4 (6) (2018)
Irene Hallyburton, Raffaella Grimaldi, Andrew Woodland, Beatriz Baragaña, Torsten Luksch, Daniel Spinks, Daniel James, Didier Leroy, David Waterson, Alan H Fairlamb, Paul G Wyatt, Ian H Gilbert, Julie A Frearson
Screening a protein kinase inhibitor library against Plasmodium falciparum. Malaria journal 16 (1) (2017)
Tracy Bayliss, David A Robinson, Victoria C Smith, Stephen Brand, Stuart P McElroy, Leah S Torrie, Chido Mpamhanga, Suzanne Norval, Laste Stojanovski, Ruth Brenk, Julie A Frearson, Kevin D Read, Ian H Gilbert, Paul G Wyatt
Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors. Journal of medicinal chemistry 60 (23) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Paul G Wyatt