Wen Chao Lu (Wenchao Lu)

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 19

Top Topics

Molecular Docking

High Throughput

Top Venues

Journal of medicinal chemistry

Nature chemical biology

RSC chemical biology

Cancer research

This page only lists publications with an associated author ORCID identifier.

Publications

Zhengnian Li, Wen Chao Lu, Tyler S Beyett, Scott B Ficarro, Jie Jiang, Jason Tse, Audrey Yong-Ju Kim, Jarrod A Marto, Jianwei Che, Pasi A Jänne, Michael J Eck, Tinghu Zhang, Nathanael S Gray
ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases. Journal of medicinal chemistry 67 (4) (2024)
Zhengnian Li, Wen Chao Lu, Tyler S Beyett, Scott B Ficarro, Jie Jiang, Jason Tse, Audrey Yong-Ju Kim, Jarrod A Marto, Jianwei Che, Pasi A Jänne, Michael J Eck, Tinghu Zhang, Nathanael S Gray
ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases. Journal of medicinal chemistry (2024)
Zhengnian Li, Wen Chao Lu, Tyler S Beyett, Scott B Ficarro, Jie Jiang, Jason Tse, Audrey Yong-Ju Kim, Jarrod A Marto, Jianwei Che, Pasi A Jänne, Michael J Eck, Tinghu Zhang, Nathanael S Gray
ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases. Journal of medicinal chemistry 67 (4) (2024)
Zhengnian Li, Wen Chao Lu, Tyler S Beyett, Scott B Ficarro, Jie Jiang, Jason Tse, Audrey Yong-Ju Kim, Jarrod A Marto, Jianwei Che, Pasi A Jänne, Michael J Eck, Tinghu Zhang, Nathanael S Gray
ZNL0325, a Pyrazolopyrimidine-Based Covalent Probe, Demonstrates an Alternative Binding Mode for Kinases. Journal of medicinal chemistry 67 (4) (2024)
Wen Chao Lu, Yao Liu, Yang Gao, Qixiang Geng, Deepak Gurbani, Lianbo Li, Scott B Ficarro, Cynthia J Meyer, Dhiraj Sinha, Inchul You, Jason Tse, Zhixiang He, Wenzhi Ji, Jianwei Che, Audrey Y Kim, Tengteng Yu, Kenneth Wen, Kenneth C Anderson, Jarrod A Marto, Kenneth D Westover, Tinghu Zhang, Nathanael S Gray
Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. Journal of medicinal chemistry (2023)
Wen Chao Lu, Yao Liu, Yang Gao, Qixiang Geng, Deepak Gurbani, Lianbo Li, Scott B Ficarro, Cynthia J Meyer, Dhiraj Sinha, Inchul You, Jason Tse, Zhixiang He, Wenzhi Ji, Jianwei Che, Audrey Y Kim, Tengteng Yu, Kenneth Wen, Kenneth C Anderson, Jarrod A Marto, Kenneth D Westover, Tinghu Zhang, Nathanael S Gray
Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. Journal of medicinal chemistry 66 (5) (2023)
Wen Chao Lu, Yao Liu, Yang Gao, Qixiang Geng, Deepak Gurbani, Lianbo Li, Scott B Ficarro, Cynthia J Meyer, Dhiraj Sinha, Inchul You, Jason Tse, Zhixiang He, Wenzhi Ji, Jianwei Che, Audrey Y Kim, Tengteng Yu, Kenneth Wen, Kenneth C Anderson, Jarrod A Marto, Kenneth D Westover, Tinghu Zhang, Nathanael S Gray
Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. Journal of medicinal chemistry 66 (5) (2023)
Wen Chao Lu, Yao Liu, Yang Gao, Qixiang Geng, Deepak Gurbani, Lianbo Li, Scott B Ficarro, Cynthia J Meyer, Dhiraj Sinha, Inchul You, Jason Tse, Zhixiang He, Wenzhi Ji, Jianwei Che, Audrey Y Kim, Tengteng Yu, Kenneth Wen, Kenneth C Anderson, Jarrod A Marto, Kenneth D Westover, Tinghu Zhang, Nathanael S Gray
Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. Journal of medicinal chemistry (2023)
Wen Chao Lu, Mengyang Fan, Wenzhi Ji, Jason Tse, Inchul You, Scott B Ficarro, Isidoro Tavares, Jianwei Che, Audrey Y Kim, Xijun Zhu, Andrew Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Stephen P Hinshaw, Behnam Nabet, Steven M Corsello, Nicholas Kwiatkowski, Jarrod A Marto, Tinghu Zhang, Nathanael S Gray
Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors. Journal of medicinal chemistry (2023)
Wen Chao Lu, Yao Liu, Yang Gao, Qixiang Geng, Deepak Gurbani, Lianbo Li, Scott B Ficarro, Cynthia J Meyer, Dhiraj Sinha, Inchul You, Jason Tse, Zhixiang He, Wenzhi Ji, Jianwei Che, Audrey Y Kim, Tengteng Yu, Kenneth Wen, Kenneth C Anderson, Jarrod A Marto, Kenneth D Westover, Tinghu Zhang, Nathanael S Gray
Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. Journal of medicinal chemistry 66 (5) (2023)
Suman Mukhopadhyay, Hsin-Yi Huang, Ziyan Lin, Michela Ranieri, Shuai Li, Soumyadip Sahu, Yingzhuo Liu, Yi Ban, Kayla Guidry, Hai Hu, Alfonso Lopez, Fiona Sherman, Yi Jer Tan, Yeuan Ting Lee, Amanda P Armstrong, Igor Dolgalev, Priyanka Sahu, Tinghu Zhang, Wen Chao Lu, Nathanael S Gray, James G Christensen, Tracy T Tang, Vamsidhar Velcheti, Alireza Khodadadi-Jamayran, Kwok-Kin Wong, Benjamin G Neel
Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy. Cancer research (2023)
Mengyang Fan, Wen Chao Lu, Jianwei Che, Nicholas P Kwiatkowski, Yang Gao, Hyuk-Soo Seo, Scott B Ficarro, Prafulla C Gokhale, Yao Liu, Ezekiel A Geffken, Jimit Lakhani, Kijun Song, Miljan Kuljanin, Wenzhi Ji, Jie Jiang, Zhixiang He, Jason Tse, Andrew S Boghossian, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Joseph D Mancias, Jarrod A Marto, Sirano Dhe-Paganon, Tinghu Zhang, Nathanael S Gray
Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling. eLife 11 (2022)
Tian Lu, Haibo Lu, Zhe Duan, Jun Wang, Jie Han, Senhao Xiao, HuanHuan Chen, Hao Jiang, Yu Chen, Feng Yang, Qi Li, Dongying Chen, Jin Lin, Bo Li, Hualiang Jiang, Kaixian Chen, Wen Chao Lu, Hua Lin, Cheng Luo
Discovery of High-Affinity Inhibitors of the BPTF Bromodomain. Journal of medicinal chemistry 64 (16) (2021)
Mingxing Teng, Wen Chao Lu, Katherine Aleisha Donovan, Jialin Sun, Noah M Krupnick, Radosław P Nowak, Yen-Der Li, Adam S Sperling, Tinghu Zhang, Benjamin L Ebert, Eric S Fischer, Nathanael S Gray
Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. Journal of medicinal chemistry 65 (1) (2021)
Wen Chao Lu, Milka Kostic, Tinghu Zhang, Jianwei Che, Matthew P Patricelli, Lyn H Jones, Edward T Chouchani, Nathanael S Gray
Fragment-based covalent ligand discovery. RSC chemical biology 2 (2) (2021)
Baishan Jiang, Yang Gao, Jianwei Che, Wen Chao Lu, Ines H Kaltheuner, Ruben Dries, Marian Kalocsay, Matthew J Berberich, Jie Jiang, Inchul You, Nicholas Kwiatkowski, Kristin M Riching, Danette L Daniels, Peter Karl Sorger, Matthias Geyer, Tinghu Zhang, Nathanael S Gray
Discovery and resistance mechanism of a selective CDK12 degrader. Nature chemical biology 17 (6) (2021)
Hongru Tao, Jun Wang, Wen Chao Lu, Rukang Zhang, Yiqian Xie, Yu-Chih Liu, Rongfeng Liu, Liyan Yue, Kaixian Chen, Hualiang Jiang, Yuanyuan Zhang, Xiaohui Xu, Cheng Luo
Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening. RSC advances 9 (9) (2019)
Hong Ding, Wen Chao Lu, Jun Chi Hu, Yu-Chih Liu, Chen Hua Zhang, Fu Lin Lian, Nai Xia Zhang, Fan Wang Meng, Cheng Luo, Kai Xian Chen
Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search. Molecules (Basel, Switzerland) 23 (3) (2018)
Fei Ye, Weiyao Zhang, Wen Chao Lu, Yiqian Xie, Hao Jiang, Jia Jin, Cheng Luo
Identification of Novel Inhibitors against Coactivator Associated Arginine Methyltransferase 1 Based on Virtual Screening and Biological Assays. BioMed research international 2016 (2016)