Katherine Aleisha Donovan (Katherine Donovan, Katherine A Donovan)

ResearcherID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 69

Top Venues

Nature

Nature chemistry

Nature chemical biology

Science (New York, N.Y.)

Dana Farber Cancer Institute

University of Canterbury (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Dana Farber Cancer Institute Apr 01 2020

United States

Senior Scientist :: Cancer Biology

Dana Farber Cancer Institute - Mar 31 2020

United States

Scientist :: Cancer Biology

Dana Farber Cancer Institute

United States

Proteomics Group Lead :: Center for Protein Degradation

Dana Farber Cancer Institute

United States

Postdoctoral Fellow :: Cancer Biology

Education History

University of Canterbury

New Zealand

PHD :: Biological Sciences

Publications

Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Justine C Rutter, Ryan J Lumpkin, Brittany Sandoval, Cyrus Y Jin, Anna M Schmoker, Scott B Ficarro, Hakyung Cheong, Rebecca J Metivier, Michelle Y Wang, Shawn Xu, Woong Sub Byun, Brian J Groendyke, Inchul You, Logan H Sigua, Isidoro Tavares, Charles Zou, Jonathan M Tsai, Paul M C Park, Hojong Yoon, Felix C Majewski, Haniya T Sperling, Jarrod A Marto, Jun Qi, Radosław P Nowak, Katherine Aleisha Donovan, Mikołaj Słabicki, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert
Template-assisted covalent modification underlies activity of covalent molecular glues. Nature chemical biology (2024)
Emily C Erickson, Inchul You, Grace E Perry, Aurélien J F Dugourd, Katherine Aleisha Donovan, Claire Crafter, Jeffrey W Johannes, Stuart Charles Williamson, Jennifer I Moss, Susana Ros, Robert E Ziegler, Simon T Barry, Eric S Fischer, Nathanael S Gray, Ralitsa R Madsen, Alex Toker
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Science signaling 17 (825) (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature 628 (8007) (2024)
Hlib Razumkov, Zixuan Jiang, Kheewoong Baek, Inchul You, Qixiang Geng, Katherine Aleisha Donovan, Michelle T Tang, Rebecca J Metivier, Nada Mageed, Pooreum Seo, Zhengnian Li, Woong Sub Byun, Stephen P Hinshaw, Roman C Sarott, Eric S Fischer, Nathanael S Gray
Discovery of CRBN-dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library. bioRxiv : the preprint server for biology (2024)
Han-Yuan Liu, Zhengnian Li, Theresia Reindl, Zhixiang He, Xueer Qiu, Ryan P Golden, Katherine Aleisha Donovan, Adam Bailey, Eric S Fischer, Tinghu Zhang, Nathanael S Gray, Priscilla L Yang
Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism. Nature communications 15 (1) (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Emily C Erickson, Inchul You, Grace E Perry, Aurélien J F Dugourd, Katherine Aleisha Donovan, Claire Crafter, Jeffrey W Johannes, Stuart Charles Williamson, Jennifer I Moss, Susana Ros, Robert E Ziegler, Simon T Barry, Eric S Fischer, Nathanael S Gray, Ralitsa R Madsen, Alex Toker
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Science signaling 17 (825) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature 628 (8007) (2024)
Hai-Tsang Huang, Ryan J Lumpkin, Ryan W Tsai, Shuyao Su, Xu Zhao, Yuan Xiong, James Chen, Nada Mageed, Katherine Aleisha Donovan, Eric S Fischer, William R Sellers
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates. Nature chemical biology (2024)
Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Justine C Rutter, Ryan J Lumpkin, Brittany Sandoval, Cyrus Y Jin, Anna M Schmoker, Scott B Ficarro, Hakyung Cheong, Rebecca J Metivier, Michelle Y Wang, Shawn Xu, Woong Sub Byun, Brian J Groendyke, Inchul You, Logan H Sigua, Isidoro Tavares, Charles Zou, Jonathan M Tsai, Paul M C Park, Hojong Yoon, Felix C Majewski, Haniya T Sperling, Jarrod A Marto, Jun Qi, Radosław P Nowak, Katherine Aleisha Donovan, Mikołaj Słabicki, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert
Template-assisted covalent modification underlies activity of covalent molecular glues. Nature chemical biology (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Emily C Erickson, Inchul You, Grace E Perry, Aurélien J F Dugourd, Katherine Aleisha Donovan, Claire Crafter, Jeffrey W Johannes, Stuart Charles Williamson, Jennifer I Moss, Susana Ros, Robert E Ziegler, Simon T Barry, Eric S Fischer, Nathanael S Gray, Ralitsa R Madsen, Alex Toker
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Science signaling 17 (825) (2024)
Han-Yuan Liu, Zhengnian Li, Theresia Reindl, Zhixiang He, Xueer Qiu, Ryan P Golden, Katherine Aleisha Donovan, Adam Bailey, Eric S Fischer, Tinghu Zhang, Nathanael S Gray, Priscilla L Yang
Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism. Nature communications 15 (1) (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature 628 (8007) (2024)
Emily C Erickson, Inchul You, Grace E Perry, Aurélien J F Dugourd, Katherine Aleisha Donovan, Claire Crafter, Jeffrey W Johannes, Stuart Charles Williamson, Jennifer I Moss, Susana Ros, Robert E Ziegler, Simon T Barry, Eric S Fischer, Nathanael S Gray, Ralitsa R Madsen, Alex Toker
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Science signaling 17 (825) (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature 628 (8007) (2024)
Hai-Tsang Huang, Ryan J Lumpkin, Ryan W Tsai, Shuyao Su, Xu Zhao, Yuan Xiong, James Chen, Nada Mageed, Katherine Aleisha Donovan, Eric S Fischer, William R Sellers
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates. Nature chemical biology 20 (9) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature 628 (8007) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature 628 (8007) (2024)
Hai-Tsang Huang, Ryan J Lumpkin, Ryan W Tsai, Shuyao Su, Xu Zhao, Yuan Xiong, James Chen, Nada Mageed, Katherine Aleisha Donovan, Eric S Fischer, William R Sellers
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates. Nature chemical biology 20 (9) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Author Correction: Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Han-Yuan Liu, Zhengnian Li, Theresia Reindl, Zhixiang He, Xueer Qiu, Ryan P Golden, Katherine Aleisha Donovan, Adam Bailey, Eric S Fischer, Tinghu Zhang, Nathanael S Gray, Priscilla L Yang
Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism. Nature communications 15 (1) (2024)
Zuzanna Kozicka, Dakota J Suchyta, Vivian Focht, Georg Kempf, Georg Petzold, Marius Jentzsch, Charles Zou, Cristina Di Genua, Katherine Aleisha Donovan, Seemon Coomar, Marko Cigler, Cristina Mayor-Ruiz, Jonathan L Schmid-Burgk, Daniel Häussinger, Georg E Winter, Eric S Fischer, Mikołaj Słabicki, Dennis Gillingham, Benjamin L Ebert, Nicolas H Thomä
Design principles for cyclin K molecular glue degraders. Nature chemical biology (2023)
Yuen Lam Dora Ng, Aleša Bricelj, Jacqueline A Jansen, Arunima Murgai, Kirsten Peter, Katherine Aleisha Donovan, Michael Gütschow, Jan Krönke, Christian Steinebach, Gobec Izidor Sosič
Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins. Journal of medicinal chemistry (2023)
Yang Gao, Baishan Jiang, Hellen Kim, Matthew J Berberich, Jianwei Che, Katherine Aleisha Donovan, John M Hatcher, Fidel Huerta, Nicholas P Kwiatkowski, Yingpeng Liu, Peter P Liuni, Rebecca J Metivier, Vineeth K Murali, Radosław P Nowak, Tinghu Zhang, Eric S Fischer, Nathanael S Gray, Lyn H Jones
Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions. Journal of medicinal chemistry (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Wallace Bourgeois, Jevon A Cutler, Brandon J Aubrey, Daniela V Wenge, Florian Perner, Cynthia Martucci, Jill A Henrich, Kelly S Klega, Radosław P Nowak, Katherine Aleisha Donovan, Meaghan Boileau, Yanhe Wen, Charles Hatton, Athina A Apazidis, Sarah Naomi Olsen, Nadia Kirmani, Yana Pikman, Jessica A Pollard, Jennifer A Perry, Adam S Sperling, Benjamin L Ebert, Gerard M McGeehan, Brian D Crompton, Eric S Fischer, Scott A Armstrong
Mezigdomide is effective alone and in combination with Menin inhibition in pre-clinical models of KMT2A-r and NPM1c AML. Blood (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Justin T Cruite, Radosław P Nowak, Katherine Aleisha Donovan, Scott B Ficarro, Huang Huang, Hu Liu, Yingpeng Liu, Jarrod A Marto, Rebecca J Metivier, Eric S Fischer, Lyn H Jones
Covalent Stapling of the Cereblon Sensor Loop Histidine Using Sulfur-Heterocycle Exchange. ACS medicinal chemistry letters 14 (11) (2023)
Roman C Sarott, Inchul You, Yen-Der Li, Sean T Toenjes, Katherine Aleisha Donovan, Pooreum Seo, Martha Ordonez, Woong Sub Byun, Muhammad Murtaza Hassan, Franziska Wachter, Edward T Chouchani, Mikołaj Słabicki, Eric S Fischer, Benjamin L Ebert, Stephen P Hinshaw, Nathanael S Gray
Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry. Journal of the American Chemical Society (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Gongwei Wu, Noriaki Yoshida, Jihe Liu, Xiaoyang Zhang, Yuan Xiong, Tayla B Heavican-Foral, Elisa Mandato, Huiyun Liu, Geoffrey M Nelson, Lu Yang, Renee Chen, Katherine Aleisha Donovan, Marcus Kenneth Jones, Mikhail Roshal, Yanming Zhang, Ran Xu, Ajit J Nirmal, Salvia Jain, Catharine Leahy, Kristen L Jones, Kristen E Stevenson, Natasha Galasso, Nivetha Ganesan, Tiffany Chang, Wen-Chao Wu, Abner Louissaint, Lydie Debaize, Hojong Yoon, Paola Dal Cin, Wing C Chan, Shannan Ho Sui, Samuel Y Ng, Andrew L Feldman, Steven M Horwitz, Karen Adelman, Eric S Fischer, Chun-Wei David Chen, David M Weinstock, Myles A Brown
TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence. Science translational medicine 15 (714) (2023)
Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Ryan Lumpkin, Brittany Sandoval, Cyrus Y Jin, Scott B Ficarro, Michelle Y Wang, Shawn Xu, Brian J Groendyke, Logan H Sigua, Isidoro Tavares, Charles Zou, Jonathan M Tsai, Paul M C Park, Hojong Yoon, Felix C Majewski, Jarrod A Marto, Jun Qi, Radosław P Nowak, Katherine Aleisha Donovan, Mikołaj Słabicki, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. bioRxiv : the preprint server for biology (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Longlong Wang, Adeline Unterreiner, Ronan Kapetanovic, Selma Aslani, Yuan Xiong, Katherine Aleisha Donovan, Christopher J Farady, Eric S Fischer, Frédéric Bornancin, Patrick Matthias
HDAC6/aggresome processing pathway importance for inflammasome formation is context dependent. bioRxiv : the preprint server for biology (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Ryan Lumpkin, Brittany Sandoval, Cyrus Y Jin, Scott B Ficarro, Michelle Y Wang, Shawn Xu, Brian J Groendyke, Logan H Sigua, Isidoro Tavares, Charles Zou, Jonathan M Tsai, Paul M C Park, Hojong Yoon, Felix C Majewski, Jarrod A Marto, Jun Qi, Radosław P Nowak, Katherine Aleisha Donovan, Mikołaj Słabicki, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. bioRxiv : the preprint server for biology (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Tiffany Tsang, Fidel Huerta, Yingpeng Liu, Jianwei Che, Rebecca J Metivier, Silas Ferrao, Katherine Aleisha Donovan, Lyn H Jones, Breanna L Zerfas, Radosław P Nowak
HiBiT-SpyTag: A Minimal Tag for Covalent Protein Capture and Degrader Development. ACS chemical biology (2023)
Wenchao Wu, Geoffrey M Nelson, Raphael Koch, Katherine Aleisha Donovan, Radosław P Nowak, Tayla B Heavican-Foral, Ajit J Nirmal, Huiyun Liu, Lei Yang, Jessica Duffy, Foster Powers, Kristen E Stevenson, Marcus Kenneth Jones, Samuel Y Ng, Gongwei Wu, Salvia Jain, Ran Xu, Sam Amaka, Christopher Trevisani, Nicholas L Donaldson, Patrick R Hagner, Laurence de Leval, Philippe Gaulard, Javeed Iqbal, Anjan Thakurta, Eric S Fischer, Karen Adelman, David M Weinstock
Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1. Blood 139 (13) (2022)
Alyssa L Verano, Inchul You, Katherine Aleisha Donovan, Nada Mageed, Hong Yue, Radosław P Nowak, Eric S Fischer, Eric S Wang, Nathanael S Gray
Redirecting the Neo-Substrate Specificity of Cereblon-Targeting PROTACs to Helios. ACS chemical biology 17 (9) (2022)
Hoi-Yee Chow, Sofiia Karchugina, Brian J Groendyke, Sean Toenjes, John Hatcher, Katherine Aleisha Donovan, Eric S Fischer, Gleb Abalakov, Bulat Faezov, Roland L Dunbrack, Nathanael S Gray, Jonathan Chernoff
Development and Utility of a PAK1-Selective Degrader. Journal of medicinal chemistry 65 (23) (2022)
Eric S Wang, Alyssa L Verano, Radosław P Nowak, J Christine Yuan, Katherine Aleisha Donovan, Nicholas A Eleuteri, Hong Yue, Kenneth H Ngo, Patrick H Lizotte, Prafulla C Gokhale, Nathanael S Gray, Eric S Fischer
Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nature chemical biology 17 (6) (2021)
Mingxing Teng, Jie Jiang, Scott B Ficarro, Hyuk-Soo Seo, Jae Hyun Bae, Katherine Aleisha Donovan, Eric S Fischer, Tinghu Zhang, Sirano Dhe-Paganon, Jarrod A Marto, Nathanael S Gray
Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development. ACS medicinal chemistry letters 12 (8) (2021)
Vidyasiri Vemulapalli, Katherine Aleisha Donovan, Tom C M Seegar, Julia M Rogers, Munhyung Bae, Ryan J Lumpkin, Ruili Cao, Matthew T Henke, Soumya S Ray, Eric S Fischer, Gregory D Cuny, Stephen C Blacklow
Targeted Degradation of the Oncogenic Phosphatase SHP2. Biochemistry 60 (34) (2021)
Radosław P Nowak, Yuan Xiong, Nadia Kirmani, Joann Kalabathula, Katherine Aleisha Donovan, Nicholas A Eleuteri, J Christine Yuan, Eric S Fischer
Structure-Guided Design of a "Bump-and-Hole" Bromodomain-Based Degradation Tag. Journal of medicinal chemistry 64 (15) (2021)
Mingxing Teng, Wen Chao Lu, Katherine Aleisha Donovan, Jialin Sun, Noah M Krupnick, Radosław P Nowak, Yen-Der Li, Adam S Sperling, Tinghu Zhang, Benjamin L Ebert, Eric S Fischer, Nathanael S Gray
Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. Journal of medicinal chemistry 65 (1) (2021)
Qing Li, Baishan Jiang, Jiaye Guo, Hong Shao, Isabella S Del Priore, Qing Chang, Rei Kudo, Zhiqiang Li, Pedram Razavi, Bo Liu, Andrew S Boghossian, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Katherine Aleisha Donovan, Marta Palafox, Jorge S Reis-Filho, Elisa de Stanchina, Eric S Fischer, Neal X Rosen, Violeta Serra, Andrew Koff, John D Chodera, Nathanael S Gray, Sarat Chandarlapaty
INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors. Cancer discovery (2021)
Vidyasagar Koduri, Leslie Duplaquet, Benjamin L Lampson, Adam C Wang, Amin H Sabet, Mette Ishoey, Joshiawa Paulk, Mingxing Teng, Isaac S Harris, Jennifer E Endress, Xiaoxi Liu, Ethan Dasilva, Joao A Paulo, Kimberly J Briggs, John G Doench, Christopher J Ott, Tinghu Zhang, Katherine Aleisha Donovan, Eric S Fischer, Steven P Gygi, Nathanael S Gray, James E Bradner, Jeffrey A Medin, Sara J Buhrlage, Matthew G Oser, William G Kaelin
Targeting oncoproteins with a positive selection assay for protein degraders. Science advances 7 (6) (2021)
Mikołaj Słabicki, Zuzanna Kozicka, Georg Petzold, Yen-Der Li, Manisha Manojkumar, Richard D Bunker, Katherine Aleisha Donovan, Quinlan L Sievers, Jonas Koeppel, Dakota Suchyta, Adam S Sperling, Emma C Fink, Jessica A Gasser, Li R Wang, Steven M Corsello, Rob S Sellar, Max Jan, Dennis Gillingham, Claudia Scholl, Stefan Fröhling, Todd R Golub, Eric S Fischer, Nicolas H Thomä, Benjamin L Ebert
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature 585 (7824) (2020)
Lucienne Nouchikian, Cristina Lento, Katherine Aleisha Donovan, Renwick Dobson, Derek J Wilson
Comparing the Conformational Stability of Pyruvate Kinase in the Gas Phase and in Solution. Journal of the American Society for Mass Spectrometry 31 (3) (2020)
Elena Sugrue, David Coombes, David Wood, Tong Zhu, Katherine Aleisha Donovan, Renwick C J Dobson
The lid domain is important, but not essential, for catalysis of Escherichia coli pyruvate kinase. European biophysics journal : EBJ 49 (8) (2020)
Chelsea E Powell, Guangyan Du, Jianwei Che, Zhixiang He, Katherine Aleisha Donovan, Hong Yue, Eric S Wang, Radosław P Nowak, Tinghu Zhang, Eric S Fischer, Nathanael S Gray
Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. ACS chemical biology 15 (10) (2020)
Mikołaj Słabicki, Hojong Yoon, Jonas Koeppel, Lena Nitsch, Shourya S Roy Burman, Cristina Di Genua, Katherine Aleisha Donovan, Adam S Sperling, Moritz Hunkeler, Jonathan M Tsai, Rohan Sharma, Andrew A Guirguis, Charles Zou, Priya Chudasama, Jessica A Gasser, Peter G Miller, Claudia Scholl, Stefan Fröhling, Radosław P Nowak, Eric S Fischer, Benjamin L Ebert
Small-molecule-induced polymerization triggers degradation of BCL6. Nature 588 (7836) (2020)
M Catarina Silva, Fleur M Ferguson, Quan Cai, Katherine Aleisha Donovan, Ghata A Nandi, Debasis Patnaik, Tinghu Zhang, Hai-Tsang Huang, Diane E Lucente, Bradford C Dickerson, Timothy J Mitchison, Eric S Fischer, Nathanael S Gray, Stephen J Haggarty
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. eLife 8 (2019)
Mélissanne de Wispelaere, Guangyan Du, Katherine Aleisha Donovan, Tinghu Zhang, Nicholas A Eleuteri, Jingting C Yuan, Joann Kalabathula, Radosław P Nowak, Eric S Fischer, Nathanael S Gray, Priscilla L Yang
Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations. Nature communications 10 (1) (2019)
Tyler B Faust, Hojong Yoon, Radosław P Nowak, Katherine Aleisha Donovan, Zhengnian Li, Quan Cai, Nicholas A Eleuteri, Tinghu Zhang, Nathanael S Gray, Eric S Fischer
Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nature chemical biology 16 (1) (2019)

Katherine Aleisha Donovan.css-eqlu8i{font-size:small;padding-left:4px;} (Katherine Donovan, Katherine A Donovan)

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Katherine Aleisha Donovan (Katherine Donovan, Katherine A Donovan)