Radosław P Nowak (Radoslaw P Nowak)

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 44

Top Venues

Nature

Journal of the American Chemical Society

Nature chemical biology

RSC medicinal chemistry

Dana Farber Cancer Institute

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Dana Farber Cancer Institute

United States

Research Fellow :: Cancer Biology

Publications

Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Justine C Rutter, Ryan J Lumpkin, Brittany Sandoval, Cyrus Y Jin, Anna M Schmoker, Scott B Ficarro, Hakyung Cheong, Rebecca J Metivier, Michelle Y Wang, Shawn Xu, Woong Sub Byun, Brian J Groendyke, Inchul You, Logan H Sigua, Isidoro Tavares, Charles Zou, Jonathan M Tsai, Paul M C Park, Hojong Yoon, Felix C Majewski, Haniya T Sperling, Jarrod A Marto, Jun Qi, Radosław P Nowak, Katherine Aleisha Donovan, Mikołaj Słabicki, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert
Template-assisted covalent modification underlies activity of covalent molecular glues. Nature chemical biology (2024)
Jonathan M Tsai, Radosław P Nowak, Benjamin L Ebert, Eric S Fischer
Targeted protein degradation: from mechanisms to clinic. Nature reviews. Molecular cell biology (2024)
Yingpeng Liu, Radosław P Nowak, Jianwei Che, Katherine A Donovan, Fidel Huerta, Hu Liu, Rebecca J Metivier, Eric S Fischer, Lyn H Jones
Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators. RSC medicinal chemistry 15 (2) (2024)
Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Justine C Rutter, Ryan J Lumpkin, Brittany Sandoval, Cyrus Y Jin, Anna M Schmoker, Scott B Ficarro, Hakyung Cheong, Rebecca J Metivier, Michelle Y Wang, Shawn Xu, Woong Sub Byun, Brian J Groendyke, Inchul You, Logan H Sigua, Isidoro Tavares, Charles Zou, Jonathan M Tsai, Paul M C Park, Hojong Yoon, Felix C Majewski, Haniya T Sperling, Jarrod A Marto, Jun Qi, Radosław P Nowak, Katherine Aleisha Donovan, Mikołaj Słabicki, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert
Template-assisted covalent modification underlies activity of covalent molecular glues. Nature chemical biology (2024)
Jonathan M Tsai, Radosław P Nowak, Benjamin L Ebert, Eric S Fischer
Targeted protein degradation: from mechanisms to clinic. Nature reviews. Molecular cell biology 25 (9) (2024)
Jonathan M Tsai, Radosław P Nowak, Benjamin L Ebert, Eric S Fischer
Targeted protein degradation: from mechanisms to clinic. Nature reviews. Molecular cell biology 25 (9) (2024)
Yingpeng Liu, Radosław P Nowak, Jianwei Che, Katherine A Donovan, Fidel Huerta, Hu Liu, Rebecca J Metivier, Eric S Fischer, Lyn H Jones
Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators. RSC medicinal chemistry 15 (2) (2024)
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P Nowak, Thibault Viennet, Esteban A Orellana, Shourya S Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S Fischer, Richard I Gregory
Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature 613 (7943) (2023)
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P Nowak, Thibault Viennet, Esteban A Orellana, Shourya S Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S Fischer, Richard I Gregory
Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature 613 (7943) (2023)
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society 145 (2) (2023)
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P Nowak, Thibault Viennet, Esteban A Orellana, Shourya S Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S Fischer, Richard I Gregory
Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature 613 (7943) (2023)
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P Nowak, Thibault Viennet, Esteban A Orellana, Shourya S Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S Fischer, Richard I Gregory
Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature (2023)
Yang Gao, Baishan Jiang, Hellen Kim, Matthew J Berberich, Jianwei Che, Katherine Aleisha Donovan, John M Hatcher, Fidel Huerta, Nicholas P Kwiatkowski, Yingpeng Liu, Peter P Liuni, Rebecca J Metivier, Vineeth K Murali, Radosław P Nowak, Tinghu Zhang, Eric S Fischer, Nathanael S Gray, Lyn H Jones
Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions. Journal of medicinal chemistry (2023)
Wallace Bourgeois, Jevon A Cutler, Brandon J Aubrey, Daniela V Wenge, Florian Perner, Cynthia Martucci, Jill A Henrich, Kelly S Klega, Radosław P Nowak, Katherine Aleisha Donovan, Meaghan Boileau, Yanhe Wen, Charles Hatton, Athina A Apazidis, Sarah Naomi Olsen, Nadia Kirmani, Yana Pikman, Jessica A Pollard, Jennifer A Perry, Adam S Sperling, Benjamin L Ebert, Gerard M McGeehan, Brian D Crompton, Eric S Fischer, Scott A Armstrong
Mezigdomide is effective alone and in combination with Menin inhibition in pre-clinical models of KMT2A-r and NPM1c AML. Blood (2023)
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society 145 (2) (2023)
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society 145 (2) (2023)
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P Nowak, Thibault Viennet, Esteban A Orellana, Shourya S Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S Fischer, Richard I Gregory
Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature 613 (7943) (2023)
Radosław P Nowak, Jianwei Che, Silas Ferrao, Nikki R Kong, Hu Liu, Breanna L Zerfas, Lyn H Jones
Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivatives. RSC medicinal chemistry 14 (3) (2023)
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P Nowak, Thibault Viennet, Esteban A Orellana, Shourya S Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S Fischer, Richard I Gregory
Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature 613 (7943) (2023)
Justin T Cruite, Radosław P Nowak, Katherine Aleisha Donovan, Scott B Ficarro, Huang Huang, Hu Liu, Yingpeng Liu, Jarrod A Marto, Rebecca J Metivier, Eric S Fischer, Lyn H Jones
Covalent Stapling of the Cereblon Sensor Loop Histidine Using Sulfur-Heterocycle Exchange. ACS medicinal chemistry letters 14 (11) (2023)
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society (2023)
Radosław P Nowak, Leah Ragosta, Fidel Huerta, Hu Liu, Scott B Ficarro, Justin T Cruite, Rebecca J Metivier, Katherine A Donovan, Jarrod A Marto, Eric S Fischer, Breanna L Zerfas, Lyn H Jones
Development of a covalent cereblon-based PROTAC employing a fluorosulfate warhead. RSC chemical biology 4 (11) (2023)
Radosław P Nowak, Jianwei Che, Silas Ferrao, Nikki R Kong, Hu Liu, Breanna L Zerfas, Lyn H Jones
Structural rationalization of GSPT1 and IKZF1 degradation by thalidomide molecular glue derivatives. RSC medicinal chemistry 14 (3) (2023)
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society 145 (2) (2023)
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society 145 (2) (2023)
Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Ryan Lumpkin, Brittany Sandoval, Cyrus Y Jin, Scott B Ficarro, Michelle Y Wang, Shawn Xu, Brian J Groendyke, Logan H Sigua, Isidoro Tavares, Charles Zou, Jonathan M Tsai, Paul M C Park, Hojong Yoon, Felix C Majewski, Jarrod A Marto, Jun Qi, Radosław P Nowak, Katherine Aleisha Donovan, Mikołaj Słabicki, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. bioRxiv : the preprint server for biology (2023)
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society 145 (2) (2023)
Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Ryan Lumpkin, Brittany Sandoval, Cyrus Y Jin, Scott B Ficarro, Michelle Y Wang, Shawn Xu, Brian J Groendyke, Logan H Sigua, Isidoro Tavares, Charles Zou, Jonathan M Tsai, Paul M C Park, Hojong Yoon, Felix C Majewski, Jarrod A Marto, Jun Qi, Radosław P Nowak, Katherine Aleisha Donovan, Mikołaj Słabicki, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. bioRxiv : the preprint server for biology (2023)
Tiffany Tsang, Fidel Huerta, Yingpeng Liu, Jianwei Che, Rebecca J Metivier, Silas Ferrao, Katherine Aleisha Donovan, Lyn H Jones, Breanna L Zerfas, Radosław P Nowak
HiBiT-SpyTag: A Minimal Tag for Covalent Protein Capture and Degrader Development. ACS chemical biology (2023)
Wenchao Wu, Geoffrey M Nelson, Raphael Koch, Katherine Aleisha Donovan, Radosław P Nowak, Tayla B Heavican-Foral, Ajit J Nirmal, Huiyun Liu, Lei Yang, Jessica Duffy, Foster Powers, Kristen E Stevenson, Marcus Kenneth Jones, Samuel Y Ng, Gongwei Wu, Salvia Jain, Ran Xu, Sam Amaka, Christopher Trevisani, Nicholas L Donaldson, Patrick R Hagner, Laurence de Leval, Philippe Gaulard, Javeed Iqbal, Anjan Thakurta, Eric S Fischer, Karen Adelman, David M Weinstock
Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1. Blood 139 (13) (2022)
Alyssa L Verano, Inchul You, Katherine Aleisha Donovan, Nada Mageed, Hong Yue, Radosław P Nowak, Eric S Fischer, Eric S Wang, Nathanael S Gray
Redirecting the Neo-Substrate Specificity of Cereblon-Targeting PROTACs to Helios. ACS chemical biology 17 (9) (2022)
Brandon J Aubrey, Jevon A Cutler, Wallace Bourgeois, Katherine A Donovan, Shengqing Gu, Charles Hatton, Sarah Perlee, Florian Perner, Homa Rahnamoun, Alexandra C P Theall, Jill A Henrich, Qian Zhu, Radosław P Nowak, Young Joon Kim, Salma Parvin, Anjali Cremer, Sarah Naomi Olsen, Nicholas A Eleuteri, Yana Pikman, Gerard M McGeehan, Kimberly Stegmaier, Anthony G Letai, Eric S Fischer, X Shirley Liu, Scott A Armstrong
IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia. Nature cancer 3 (5) (2022)
Justin T Cruite, Geoffrey P Dann, Jianwei Che, Katherine A Donovan, Silas Ferrao, Scott B Ficarro, Eric S Fischer, Nathanael S Gray, Fidel Huerta, Nikki R Kong, Hu Liu, Jarrod A Marto, Rebecca J Metivier, Radosław P Nowak, Breanna L Zerfas, Lyn H Jones
Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC chemical biology 3 (9) (2022)
Paulina Kaplonek, Chuangqi Wang, Yannic C Bartsch, Stephanie Fischinger, Matthew J Gorman, Kathryn A Bowman, Jaewon Kang, Diana Dayal, Patrick Martin, Radosław P Nowak, Alexandra-Chloé Villani, Ching-Lin Hsieh, Nicole C Charland, Anna L K Gonye, Irena Gushterova, Hargun K Khanna, Thomas J LaSalle, Kendall M Lavin-Parsons, Brendan M Lilley, Carl L Lodenstein, Kasidet Manakongtreecheep, Justin D Margolin, Brenna N McKaig, Maricarmen Rojas-Lopez, Brian C Russo, Nihaarika Sharma, Jessica Tantivit, Molly Fisher Thomas, Moshe Sade-Feldman, Jared Feldman, Boris Julg, Eric J Nilles, Elon R Musk, Anil S Menon, Eric S Fischer, Jason S Mclellan, Aaron G Schmidt, Marcia B Goldberg, Michael R Filbin, Nir Hacohen, Douglas A Lauffenburger, Galit Alter
Early cross-coronavirus reactive signatures of humoral immunity against COVID-19. Science immunology 6 (64) (2021)
Radosław P Nowak, Anthony Tumber, Eline Hendrix, Mohammad Salik Zeya Ansari, Manuela Sabatino, Lorenzo Antonini, Regina Andrijes, Eidarus Salah, Nicola Mautone, Francesca Romana Pellegrini, Klemensas Simelis, Akane Kawamura, Catrine Johansson, Daniela Passeri, Roberto Pellicciari, Alessia Ciogli, Donatella Del Bufalo, Rino Ragno, Mathew L Coleman, Daniela Trisciuoglio, Antonello Mai, Udo Oppermann, Christopher J Schofield, Dante Rotili
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53. Journal of medicinal chemistry 64 (23) (2021)
Mingxing Teng, Wen Chao Lu, Katherine Aleisha Donovan, Jialin Sun, Noah M Krupnick, Radosław P Nowak, Yen-Der Li, Adam S Sperling, Tinghu Zhang, Benjamin L Ebert, Eric S Fischer, Nathanael S Gray
Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. Journal of medicinal chemistry 65 (1) (2021)
Tao Wu, Hojong Yoon, Yuan Xiong, Sarah E Dixon-Clarke, Radosław P Nowak, Eric S Fischer
Targeted protein degradation as a powerful research tool in basic biology and drug target discovery. Nature structural & molecular biology 27 (7) (2020)
Ivana Gasic, Brian J Groendyke, Radosław P Nowak, J Christine Yuan, Joann Kalabathula, Eric S Fischer, Nathanael S Gray, Timothy J Mitchison
Tubulin Resists Degradation by Cereblon-Recruiting PROTACs. Cells 9 (5) (2020)
Hong Yue, Radosław P Nowak, Daan Overwijn, N Connor Payne, Stephanie Fischinger, Caroline Atyeo, Lindsey R Baden, Eric James Nilles, Elizabeth W Karlson, Xu G Yu, Jonathan Z Li, Galit Alter, Ralph Mazitschek, Eric S Fischer
Rapid 'mix and read' assay for scalable detection of SARS-CoV-2 antibodies in patient plasma. medRxiv : the preprint server for health sciences (2020)
Chelsea E Powell, Guangyan Du, Jianwei Che, Zhixiang He, Katherine Aleisha Donovan, Hong Yue, Eric S Wang, Radosław P Nowak, Tinghu Zhang, Eric S Fischer, Nathanael S Gray
Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. ACS chemical biology 15 (10) (2020)
Mikołaj Słabicki, Hojong Yoon, Jonas Koeppel, Lena Nitsch, Shourya S Roy Burman, Cristina Di Genua, Katherine Aleisha Donovan, Adam S Sperling, Moritz Hunkeler, Jonathan M Tsai, Rohan Sharma, Andrew A Guirguis, Charles Zou, Priya Chudasama, Jessica A Gasser, Peter G Miller, Claudia Scholl, Stefan Fröhling, Radosław P Nowak, Eric S Fischer, Benjamin L Ebert
Small-molecule-induced polymerization triggers degradation of BCL6. Nature 588 (7836) (2020)
Mélissanne de Wispelaere, Guangyan Du, Katherine Aleisha Donovan, Tinghu Zhang, Nicholas A Eleuteri, Jingting C Yuan, Joann Kalabathula, Radosław P Nowak, Eric S Fischer, Nathanael S Gray, Priscilla L Yang
Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations. Nature communications 10 (1) (2019)
Tyler B Faust, Hojong Yoon, Radosław P Nowak, Katherine Aleisha Donovan, Zhengnian Li, Quan Cai, Nicholas A Eleuteri, Tinghu Zhang, Nathanael S Gray, Eric S Fischer
Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nature chemical biology 16 (1) (2019)
Radosław P Nowak, Stephen L DeAngelo, Dennis Buckley, Zhixiang He, Katherine A Donovan, Jian An, Nozhat Safaee, Mark P Jedrychowski, Charles M Ponthier, Mette Ishoey, Tinghu Zhang, Joseph D Mancias, Nathanael S Gray, James E Bradner, Eric S Fischer
Plasticity in binding confers selectivity in ligand-induced protein degradation. Nature chemical biology 14 (7) (2018)

Radosław P Nowak.css-eqlu8i{font-size:small;padding-left:4px;} (Radoslaw P Nowak)

Publication Activity (10 Years)

Top Topics

Top Venues

Radosław P Nowak (Radoslaw P Nowak)