Eric S Fischer

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 91

Top Venues

Nature

Science (New York, N.Y.)

Nature chemical biology

Journal of the American Chemical Society

Harvard Medical School

University of Basel (BSC)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Harvard Medical School Oct 01 2015

United States

Associate Professor :: BCMP

Dana Farber Cancer Institute Oct 01 2015

United States

Associate Professor :: Cancer Biology

Friedrich Miescher Institute Feb 01 2013 - Jun 30 2015

Switzerland

Postdoc

Education History

University of Basel

Switzerland

BSC

Publications

Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Justine C Rutter, Ryan J Lumpkin, Brittany Sandoval, Cyrus Y Jin, Anna M Schmoker, Scott B Ficarro, Hakyung Cheong, Rebecca J Metivier, Michelle Y Wang, Shawn Xu, Woong Sub Byun, Brian J Groendyke, Inchul You, Logan H Sigua, Isidoro Tavares, Charles Zou, Jonathan M Tsai, Paul M C Park, Hojong Yoon, Felix C Majewski, Haniya T Sperling, Jarrod A Marto, Jun Qi, Radosław P Nowak, Katherine Aleisha Donovan, Mikołaj Słabicki, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert
Template-assisted covalent modification underlies activity of covalent molecular glues. Nature chemical biology (2024)
Emily C Erickson, Inchul You, Grace E Perry, Aurélien J F Dugourd, Katherine Aleisha Donovan, Claire Crafter, Jeffrey W Johannes, Stuart Charles Williamson, Jennifer I Moss, Susana Ros, Robert E Ziegler, Simon T Barry, Eric S Fischer, Nathanael S Gray, Ralitsa R Madsen, Alex Toker
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Science signaling 17 (825) (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Jonathan M Tsai, Radosław P Nowak, Benjamin L Ebert, Eric S Fischer
Targeted protein degradation: from mechanisms to clinic. Nature reviews. Molecular cell biology (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature 628 (8007) (2024)
Hlib Razumkov, Zixuan Jiang, Kheewoong Baek, Inchul You, Qixiang Geng, Katherine Aleisha Donovan, Michelle T Tang, Rebecca J Metivier, Nada Mageed, Pooreum Seo, Zhengnian Li, Woong Sub Byun, Stephen P Hinshaw, Roman C Sarott, Eric S Fischer, Nathanael S Gray
Discovery of CRBN-dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library. bioRxiv : the preprint server for biology (2024)
Han-Yuan Liu, Zhengnian Li, Theresia Reindl, Zhixiang He, Xueer Qiu, Ryan P Golden, Katherine Aleisha Donovan, Adam Bailey, Eric S Fischer, Tinghu Zhang, Nathanael S Gray, Priscilla L Yang
Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism. Nature communications 15 (1) (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Yingpeng Liu, Radosław P Nowak, Jianwei Che, Katherine A Donovan, Fidel Huerta, Hu Liu, Rebecca J Metivier, Eric S Fischer, Lyn H Jones
Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators. RSC medicinal chemistry 15 (2) (2024)
Emily C Erickson, Inchul You, Grace E Perry, Aurélien J F Dugourd, Katherine Aleisha Donovan, Claire Crafter, Jeffrey W Johannes, Stuart Charles Williamson, Jennifer I Moss, Susana Ros, Robert E Ziegler, Simon T Barry, Eric S Fischer, Nathanael S Gray, Ralitsa R Madsen, Alex Toker
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Science signaling 17 (825) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature 628 (8007) (2024)
Hai-Tsang Huang, Ryan J Lumpkin, Ryan W Tsai, Shuyao Su, Xu Zhao, Yuan Xiong, James Chen, Nada Mageed, Katherine Aleisha Donovan, Eric S Fischer, William R Sellers
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates. Nature chemical biology (2024)
Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Justine C Rutter, Ryan J Lumpkin, Brittany Sandoval, Cyrus Y Jin, Anna M Schmoker, Scott B Ficarro, Hakyung Cheong, Rebecca J Metivier, Michelle Y Wang, Shawn Xu, Woong Sub Byun, Brian J Groendyke, Inchul You, Logan H Sigua, Isidoro Tavares, Charles Zou, Jonathan M Tsai, Paul M C Park, Hojong Yoon, Felix C Majewski, Haniya T Sperling, Jarrod A Marto, Jun Qi, Radosław P Nowak, Katherine Aleisha Donovan, Mikołaj Słabicki, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert
Template-assisted covalent modification underlies activity of covalent molecular glues. Nature chemical biology (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Emily C Erickson, Inchul You, Grace E Perry, Aurélien J F Dugourd, Katherine Aleisha Donovan, Claire Crafter, Jeffrey W Johannes, Stuart Charles Williamson, Jennifer I Moss, Susana Ros, Robert E Ziegler, Simon T Barry, Eric S Fischer, Nathanael S Gray, Ralitsa R Madsen, Alex Toker
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Science signaling 17 (825) (2024)
Han-Yuan Liu, Zhengnian Li, Theresia Reindl, Zhixiang He, Xueer Qiu, Ryan P Golden, Katherine Aleisha Donovan, Adam Bailey, Eric S Fischer, Tinghu Zhang, Nathanael S Gray, Priscilla L Yang
Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism. Nature communications 15 (1) (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature (2024)
Jonathan M Tsai, Radosław P Nowak, Benjamin L Ebert, Eric S Fischer
Targeted protein degradation: from mechanisms to clinic. Nature reviews. Molecular cell biology 25 (9) (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature 628 (8007) (2024)
Emily C Erickson, Inchul You, Grace E Perry, Aurélien J F Dugourd, Katherine Aleisha Donovan, Claire Crafter, Jeffrey W Johannes, Stuart Charles Williamson, Jennifer I Moss, Susana Ros, Robert E Ziegler, Simon T Barry, Eric S Fischer, Nathanael S Gray, Ralitsa R Madsen, Alex Toker
Multiomic profiling of breast cancer cells uncovers stress MAPK-associated sensitivity to AKT degradation. Science signaling 17 (825) (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Jonathan M Tsai, Radosław P Nowak, Benjamin L Ebert, Eric S Fischer
Targeted protein degradation: from mechanisms to clinic. Nature reviews. Molecular cell biology 25 (9) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature 628 (8007) (2024)
Hai-Tsang Huang, Ryan J Lumpkin, Ryan W Tsai, Shuyao Su, Xu Zhao, Yuan Xiong, James Chen, Nada Mageed, Katherine Aleisha Donovan, Eric S Fischer, William R Sellers
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates. Nature chemical biology 20 (9) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature 628 (8007) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature 628 (8007) (2024)
Hai-Tsang Huang, Ryan J Lumpkin, Ryan W Tsai, Shuyao Su, Xu Zhao, Yuan Xiong, James Chen, Nada Mageed, Katherine Aleisha Donovan, Eric S Fischer, William R Sellers
Ubiquitin-specific proximity labeling for the identification of E3 ligase substrates. Nature chemical biology 20 (9) (2024)
Yingpeng Liu, Radosław P Nowak, Jianwei Che, Katherine A Donovan, Fidel Huerta, Hu Liu, Rebecca J Metivier, Eric S Fischer, Lyn H Jones
Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators. RSC medicinal chemistry 15 (2) (2024)
Sandi Radko-Juettner, Hong Yue, Jacquelyn A Myers, Raymond D Carter, Alexis N Robertson, Priya Mittal, Zhexin Zhu, Baranda S Hansen, Katherine Aleisha Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G McReynolds, Shourya S Roy Burman, Anna M Schmoker, Nada Mageed, Scott A Brown, Robert J Mobley, Janet F Partridge, Elizabeth A Stewart, Shondra M Pruett-Miller, Behnam Nabet, Junmin Peng, Nathanael S Gray, Eric S Fischer, Charles W M Roberts
Author Correction: Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Han-Yuan Liu, Zhengnian Li, Theresia Reindl, Zhixiang He, Xueer Qiu, Ryan P Golden, Katherine Aleisha Donovan, Adam Bailey, Eric S Fischer, Tinghu Zhang, Nathanael S Gray, Priscilla L Yang
Broad-spectrum activity against mosquito-borne flaviviruses achieved by a targeted protein degradation mechanism. Nature communications 15 (1) (2024)
Zuzanna Kozicka, Dakota J Suchyta, Vivian Focht, Georg Kempf, Georg Petzold, Marius Jentzsch, Charles Zou, Cristina Di Genua, Katherine Aleisha Donovan, Seemon Coomar, Marko Cigler, Cristina Mayor-Ruiz, Jonathan L Schmid-Burgk, Daniel Häussinger, Georg E Winter, Eric S Fischer, Mikołaj Słabicki, Dennis Gillingham, Benjamin L Ebert, Nicolas H Thomä
Design principles for cyclin K molecular glue degraders. Nature chemical biology (2023)
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P Nowak, Thibault Viennet, Esteban A Orellana, Shourya S Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S Fischer, Richard I Gregory
Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature 613 (7943) (2023)
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P Nowak, Thibault Viennet, Esteban A Orellana, Shourya S Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S Fischer, Richard I Gregory
Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature 613 (7943) (2023)
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society 145 (2) (2023)
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P Nowak, Thibault Viennet, Esteban A Orellana, Shourya S Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S Fischer, Richard I Gregory
Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature 613 (7943) (2023)
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P Nowak, Thibault Viennet, Esteban A Orellana, Shourya S Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S Fischer, Richard I Gregory
Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature (2023)
Yang Gao, Baishan Jiang, Hellen Kim, Matthew J Berberich, Jianwei Che, Katherine Aleisha Donovan, John M Hatcher, Fidel Huerta, Nicholas P Kwiatkowski, Yingpeng Liu, Peter P Liuni, Rebecca J Metivier, Vineeth K Murali, Radosław P Nowak, Tinghu Zhang, Eric S Fischer, Nathanael S Gray, Lyn H Jones
Catalytic Degraders Effectively Address Kinase Site Mutations in EML4-ALK Oncogenic Fusions. Journal of medicinal chemistry (2023)
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society 145 (2) (2023)
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society 145 (2) (2023)
Moritz Hunkeler, Cyrus Y Jin, Eric S Fischer
Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases. Science (New York, N.Y.) 379 (6637) (2023)
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P Nowak, Thibault Viennet, Esteban A Orellana, Shourya S Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S Fischer, Richard I Gregory
Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature 613 (7943) (2023)
Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P Nowak, Thibault Viennet, Esteban A Orellana, Shourya S Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S Fischer, Richard I Gregory
Structural basis of regulated m 7 G tRNA modification by METTL1-WDR4. Nature 613 (7943) (2023)
Moritz Hunkeler, Cyrus Y Jin, Eric S Fischer
Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases. Science (New York, N.Y.) 379 (6637) (2023)
Justin T Cruite, Radosław P Nowak, Katherine Aleisha Donovan, Scott B Ficarro, Huang Huang, Hu Liu, Yingpeng Liu, Jarrod A Marto, Rebecca J Metivier, Eric S Fischer, Lyn H Jones
Covalent Stapling of the Cereblon Sensor Loop Histidine Using Sulfur-Heterocycle Exchange. ACS medicinal chemistry letters 14 (11) (2023)
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society (2023)
Radosław P Nowak, Leah Ragosta, Fidel Huerta, Hu Liu, Scott B Ficarro, Justin T Cruite, Rebecca J Metivier, Katherine A Donovan, Jarrod A Marto, Eric S Fischer, Breanna L Zerfas, Lyn H Jones
Development of a covalent cereblon-based PROTAC employing a fluorosulfate warhead. RSC chemical biology 4 (11) (2023)
Moritz Hunkeler, Cyrus Y Jin, Eric S Fischer
Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases. Science (New York, N.Y.) 379 (6637) (2023)
Roman C Sarott, Inchul You, Yen-Der Li, Sean T Toenjes, Katherine Aleisha Donovan, Pooreum Seo, Martha Ordonez, Woong Sub Byun, Muhammad Murtaza Hassan, Franziska Wachter, Edward T Chouchani, Mikołaj Słabicki, Eric S Fischer, Benjamin L Ebert, Stephen P Hinshaw, Nathanael S Gray
Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry. Journal of the American Chemical Society (2023)
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society 145 (2) (2023)
Gongwei Wu, Noriaki Yoshida, Jihe Liu, Xiaoyang Zhang, Yuan Xiong, Tayla B Heavican-Foral, Elisa Mandato, Huiyun Liu, Geoffrey M Nelson, Lu Yang, Renee Chen, Katherine Aleisha Donovan, Marcus Kenneth Jones, Mikhail Roshal, Yanming Zhang, Ran Xu, Ajit J Nirmal, Salvia Jain, Catharine Leahy, Kristen L Jones, Kristen E Stevenson, Natasha Galasso, Nivetha Ganesan, Tiffany Chang, Wen-Chao Wu, Abner Louissaint, Lydie Debaize, Hojong Yoon, Paola Dal Cin, Wing C Chan, Shannan Ho Sui, Samuel Y Ng, Andrew L Feldman, Steven M Horwitz, Karen Adelman, Eric S Fischer, Chun-Wei David Chen, David M Weinstock, Myles A Brown
TP63 fusions drive multicomplex enhancer rewiring, lymphomagenesis, and EZH2 dependence. Science translational medicine 15 (714) (2023)
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society 145 (2) (2023)
Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Ryan Lumpkin, Brittany Sandoval, Cyrus Y Jin, Scott B Ficarro, Michelle Y Wang, Shawn Xu, Brian J Groendyke, Logan H Sigua, Isidoro Tavares, Charles Zou, Jonathan M Tsai, Paul M C Park, Hojong Yoon, Felix C Majewski, Jarrod A Marto, Jun Qi, Radosław P Nowak, Katherine Aleisha Donovan, Mikołaj Słabicki, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. bioRxiv : the preprint server for biology (2023)
Florian Perner, Eytan M Stein, Daniela V Wenge, Sukrit Singh, Jeonghyeon Kim, Athina Apazidis, Homa Rahnamoun, Disha Anand, Christian Marinaccio, Charlie Hatton, Yanhe Wen, Richard M Stone, David Schaller, Shoron Mowla, Wenbin Xiao, Holly A Gamlen, Aaron James Stonestrom, Sonali Persaud, Elizabeth T Ener, Jevon A Cutler, John G Doench, Gerard M McGeehan, Andrea Volkamer, John D Chodera, Radosław P Nowak, Eric S Fischer, Ross L Levine, Scott A Armstrong, Sheng F Cai
MEN1 mutations mediate clinical resistance to menin inhibition. Nature (2023)
Moritz Hunkeler, Cyrus Y Jin, Eric S Fischer
Structures of BIRC6-client complexes provide a mechanism of Smac-mediated release of caspases. Science (New York, N.Y.) (2023)
Alexander Hanzl, Eleonora Barone, Sophie Bauer, Hong Yue, Radosław P Nowak, Elisa Hahn, Eugenia V Pankevich, Anna Koren, Stefan Kubicek, Eric S Fischer, Georg E Winter
E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society 145 (2) (2023)
Longlong Wang, Adeline Unterreiner, Ronan Kapetanovic, Selma Aslani, Yuan Xiong, Katherine Aleisha Donovan, Christopher J Farady, Eric S Fischer, Frédéric Bornancin, Patrick Matthias
HDAC6/aggresome processing pathway importance for inflammasome formation is context dependent. bioRxiv : the preprint server for biology (2023)
Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Ryan Lumpkin, Brittany Sandoval, Cyrus Y Jin, Scott B Ficarro, Michelle Y Wang, Shawn Xu, Brian J Groendyke, Logan H Sigua, Isidoro Tavares, Charles Zou, Jonathan M Tsai, Paul M C Park, Hojong Yoon, Felix C Majewski, Jarrod A Marto, Jun Qi, Radosław P Nowak, Katherine Aleisha Donovan, Mikołaj Słabicki, Nathanael S Gray, Eric S Fischer, Benjamin L Ebert
Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. bioRxiv : the preprint server for biology (2023)
Alyssa L Verano, Inchul You, Katherine Aleisha Donovan, Nada Mageed, Hong Yue, Radosław P Nowak, Eric S Fischer, Eric S Wang, Nathanael S Gray
Redirecting the Neo-Substrate Specificity of Cereblon-Targeting PROTACs to Helios. ACS chemical biology 17 (9) (2022)
Hoi-Yee Chow, Sofiia Karchugina, Brian J Groendyke, Sean Toenjes, John Hatcher, Katherine Aleisha Donovan, Eric S Fischer, Gleb Abalakov, Bulat Faezov, Roland L Dunbrack, Nathanael S Gray, Jonathan Chernoff
Development and Utility of a PAK1-Selective Degrader. Journal of medicinal chemistry 65 (23) (2022)
Eric S Fischer, Lyn H Jones
Small molecule modulation of protein polymerization. Chemical Society reviews 51 (7) (2022)
Brandon J Aubrey, Jevon A Cutler, Wallace Bourgeois, Katherine A Donovan, Shengqing Gu, Charles Hatton, Sarah Perlee, Florian Perner, Homa Rahnamoun, Alexandra C P Theall, Jill A Henrich, Qian Zhu, Radosław P Nowak, Young Joon Kim, Salma Parvin, Anjali Cremer, Sarah Naomi Olsen, Nicholas A Eleuteri, Yana Pikman, Gerard M McGeehan, Kimberly Stegmaier, Anthony G Letai, Eric S Fischer, X Shirley Liu, Scott A Armstrong
IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia. Nature cancer 3 (5) (2022)
Peter G Miller, Murugappan Sathappa, Jamie A Moroco, Wei Jiang, Yue Qian, Sumaiya Iqbal, Qi Guo, Andrew O Giacomelli, Subrata Shaw, Camille Vernier, Besnik Bajrami, Xiaoping Yang, Cerise Raffier, Adam S Sperling, Christopher J Gibson, Josephine Kahn, Cyrus Jin, Matthew J Ranaghan, Alisha Caliman, Merissa Brousseau, Eric S Fischer, Robert Lintner, Federica Piccioni, Arthur J Campbell, David E Root, Colin W Garvie, Benjamin L Ebert
Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state. Nature communications 13 (1) (2022)
Jeffrey A Meyerhardt, Hong Yue, Radosław P Nowak, Lauren Brais, Chao Ma, Samantha Johnson, Joanna Harrod, Shourya S Roy Burman, Lynn M Hendrickson, Stephanie Fischinger, Galit Alter, William Hahn, Bruce E Johnson, Eric S Fischer
Serological testing for SARS-CoV-2 antibodies of employees shows low transmission working in a cancer center. PloS one 17 (4) (2022)
Justin T Cruite, Geoffrey P Dann, Jianwei Che, Katherine A Donovan, Silas Ferrao, Scott B Ficarro, Eric S Fischer, Nathanael S Gray, Fidel Huerta, Nikki R Kong, Hu Liu, Jarrod A Marto, Rebecca J Metivier, Radosław P Nowak, Breanna L Zerfas, Lyn H Jones
Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC chemical biology 3 (9) (2022)
Eric S Wang, Alyssa L Verano, Radosław P Nowak, J Christine Yuan, Katherine Aleisha Donovan, Nicholas A Eleuteri, Hong Yue, Kenneth H Ngo, Patrick H Lizotte, Prafulla C Gokhale, Nathanael S Gray, Eric S Fischer
Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nature chemical biology 17 (6) (2021)
Mingxing Teng, Jie Jiang, Scott B Ficarro, Hyuk-Soo Seo, Jae Hyun Bae, Katherine Aleisha Donovan, Eric S Fischer, Tinghu Zhang, Sirano Dhe-Paganon, Jarrod A Marto, Nathanael S Gray
Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development. ACS medicinal chemistry letters 12 (8) (2021)
Vidyasiri Vemulapalli, Katherine Aleisha Donovan, Tom C M Seegar, Julia M Rogers, Munhyung Bae, Ryan J Lumpkin, Ruili Cao, Matthew T Henke, Soumya S Ray, Eric S Fischer, Gregory D Cuny, Stephen C Blacklow
Targeted Degradation of the Oncogenic Phosphatase SHP2. Biochemistry 60 (34) (2021)
Paulina Kaplonek, Chuangqi Wang, Yannic C Bartsch, Stephanie Fischinger, Matthew J Gorman, Kathryn A Bowman, Jaewon Kang, Diana Dayal, Patrick Martin, Radosław P Nowak, Alexandra-Chloé Villani, Ching-Lin Hsieh, Nicole C Charland, Anna L K Gonye, Irena Gushterova, Hargun K Khanna, Thomas J LaSalle, Kendall M Lavin-Parsons, Brendan M Lilley, Carl L Lodenstein, Kasidet Manakongtreecheep, Justin D Margolin, Brenna N McKaig, Maricarmen Rojas-Lopez, Brian C Russo, Nihaarika Sharma, Jessica Tantivit, Molly Fisher Thomas, Moshe Sade-Feldman, Jared Feldman, Boris Julg, Eric J Nilles, Elon R Musk, Anil S Menon, Eric S Fischer, Jason S Mclellan, Aaron G Schmidt, Marcia B Goldberg, Michael R Filbin, Nir Hacohen, Douglas A Lauffenburger, Galit Alter
Early cross-coronavirus reactive signatures of humoral immunity against COVID-19. Science immunology 6 (64) (2021)
Yannic C Bartsch, Chuangqi Wang, Tomer Zohar, Stephanie Fischinger, Caroline G Atyeo, John S Burke, Jaewon Kang, Andrea G Edlow, Alessio Fasano, Lindsey R Baden, Eric James Nilles, Ann E Woolley, Elizabeth W Karlson, Alex R Hopke, Daniel Irima, Eric S Fischer, Edward T Ryan, Richelle C Charles, Boris D Julg, Douglas A Lauffenburger, Lael M Yonker, Galit Alter
Humoral signatures of protective and pathological SARS-CoV-2 infection in children. Nature medicine 27 (3) (2021)
Radosław P Nowak, Yuan Xiong, Nadia Kirmani, Joann Kalabathula, Katherine Aleisha Donovan, Nicholas A Eleuteri, J Christine Yuan, Eric S Fischer
Structure-Guided Design of a "Bump-and-Hole" Bromodomain-Based Degradation Tag. Journal of medicinal chemistry 64 (15) (2021)
Mingxing Teng, Wen Chao Lu, Katherine Aleisha Donovan, Jialin Sun, Noah M Krupnick, Radosław P Nowak, Yen-Der Li, Adam S Sperling, Tinghu Zhang, Benjamin L Ebert, Eric S Fischer, Nathanael S Gray
Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. Journal of medicinal chemistry 65 (1) (2021)
Qing Li, Baishan Jiang, Jiaye Guo, Hong Shao, Isabella S Del Priore, Qing Chang, Rei Kudo, Zhiqiang Li, Pedram Razavi, Bo Liu, Andrew S Boghossian, Matthew G Rees, Melissa A Ronan, Jennifer A Roth, Katherine Aleisha Donovan, Marta Palafox, Jorge S Reis-Filho, Elisa de Stanchina, Eric S Fischer, Neal X Rosen, Violeta Serra, Andrew Koff, John D Chodera, Nathanael S Gray, Sarat Chandarlapaty
INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors. Cancer discovery (2021)
Vidyasagar Koduri, Leslie Duplaquet, Benjamin L Lampson, Adam C Wang, Amin H Sabet, Mette Ishoey, Joshiawa Paulk, Mingxing Teng, Isaac S Harris, Jennifer E Endress, Xiaoxi Liu, Ethan Dasilva, Joao A Paulo, Kimberly J Briggs, John G Doench, Christopher J Ott, Tinghu Zhang, Katherine Aleisha Donovan, Eric S Fischer, Steven P Gygi, Nathanael S Gray, James E Bradner, Jeffrey A Medin, Sara J Buhrlage, Matthew G Oser, William G Kaelin
Targeting oncoproteins with a positive selection assay for protein degraders. Science advances 7 (6) (2021)
Tao Wu, Hojong Yoon, Yuan Xiong, Sarah E Dixon-Clarke, Radosław P Nowak, Eric S Fischer
Targeted protein degradation as a powerful research tool in basic biology and drug target discovery. Nature structural & molecular biology 27 (7) (2020)
Ivana Gasic, Brian J Groendyke, Radosław P Nowak, J Christine Yuan, Joann Kalabathula, Eric S Fischer, Nathanael S Gray, Timothy J Mitchison
Tubulin Resists Degradation by Cereblon-Recruiting PROTACs. Cells 9 (5) (2020)
Mikołaj Słabicki, Zuzanna Kozicka, Georg Petzold, Yen-Der Li, Manisha Manojkumar, Richard D Bunker, Katherine Aleisha Donovan, Quinlan L Sievers, Jonas Koeppel, Dakota Suchyta, Adam S Sperling, Emma C Fink, Jessica A Gasser, Li R Wang, Steven M Corsello, Rob S Sellar, Max Jan, Dennis Gillingham, Claudia Scholl, Stefan Fröhling, Todd R Golub, Eric S Fischer, Nicolas H Thomä, Benjamin L Ebert
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature 585 (7824) (2020)
Hong Yue, Radosław P Nowak, Daan Overwijn, N Connor Payne, Stephanie Fischinger, Caroline Atyeo, Lindsey R Baden, Eric James Nilles, Elizabeth W Karlson, Xu G Yu, Jonathan Z Li, Galit Alter, Ralph Mazitschek, Eric S Fischer
Rapid 'mix and read' assay for scalable detection of SARS-CoV-2 antibodies in patient plasma. medRxiv : the preprint server for health sciences (2020)
Mikołaj Słabicki, Hojong Yoon, Jonas Koeppel, Lena Nitsch, Shourya S Roy Burman, Cristina Di Genua, Katherine Aleisha Donovan, Adam S Sperling, Moritz Hunkeler, Jonathan M Tsai, Rohan Sharma, Andrew A Guirguis, Charles Zou, Priya Chudasama, Jessica A Gasser, Peter G Miller, Claudia Scholl, Stefan Fröhling, Radosław P Nowak, Eric S Fischer, Benjamin L Ebert
Small-molecule-induced polymerization triggers degradation of BCL6. Nature 588 (7836) (2020)
M Catarina Silva, Fleur M Ferguson, Quan Cai, Katherine Aleisha Donovan, Ghata A Nandi, Debasis Patnaik, Tinghu Zhang, Hai-Tsang Huang, Diane E Lucente, Bradford C Dickerson, Timothy J Mitchison, Eric S Fischer, Nathanael S Gray, Stephen J Haggarty
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. eLife 8 (2019)
Mélissanne de Wispelaere, Guangyan Du, Katherine Aleisha Donovan, Tinghu Zhang, Nicholas A Eleuteri, Jingting C Yuan, Joann Kalabathula, Radosław P Nowak, Eric S Fischer, Nathanael S Gray, Priscilla L Yang
Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations. Nature communications 10 (1) (2019)
Tyler B Faust, Hojong Yoon, Radosław P Nowak, Katherine Aleisha Donovan, Zhengnian Li, Quan Cai, Nicholas A Eleuteri, Tinghu Zhang, Nathanael S Gray, Eric S Fischer
Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nature chemical biology 16 (1) (2019)
Quinlan L Sievers, Jessica A Gasser, Glenn S Cowley, Eric S Fischer, Benjamin L Ebert
Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity. Blood 132 (12) (2018)
Radosław P Nowak, Stephen L DeAngelo, Dennis Buckley, Zhixiang He, Katherine A Donovan, Jian An, Nozhat Safaee, Mark P Jedrychowski, Charles M Ponthier, Mette Ishoey, Tinghu Zhang, Joseph D Mancias, Nathanael S Gray, James E Bradner, Eric S Fischer
Plasticity in binding confers selectivity in ligand-induced protein degradation. Nature chemical biology 14 (7) (2018)
Katherine A Donovan, Jian An, Radosław P Nowak, Jingting C Yuan, Emma C Fink, Bethany C Berry, Benjamin L Ebert, Eric S Fischer
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. eLife 7 (2018)
Jian An, Charles M Ponthier, Ragna Sack, Jan Seebacher, Michael B Stadler, Katherine A Donovan, Eric S Fischer
pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase. Nature communications 8 (2017)
Calla M Olson, Baishan Jiang, Michael A Erb, Yanke Liang, Zainab M Doctor, Zinan Z Zhang, Tinghu Zhang, Nicholas Kwiatkowski, Myriam Boukhali, Jennifer L Green, Wilhelm Haas, Tyzoon Nomanbhoy, Eric S Fischer, Richard A Young, James E Bradner, Georg E Winter, Nathanael S Gray
Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nature chemical biology 14 (2) (2017)

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Eric S Fischer