Amin Rostami-Hodjegan (A Rostami-Hodjegan)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 44

Top Venues

Biopharmaceutics & drug disposition

CPT: pharmacometrics & systems pharmacology

Clinical pharmacology and therapeutics

Drug metabolism and disposition: the biological fate of chemicals

The University of Manchester

This page only lists publications with an associated author ORCID identifier.

Affiliation History

The University of Manchester Dec 10 2009

United Kingdom

The Director & Professor of Systems Pharmacology :: Centre for Applied Pharmacokinetics Research (CAPKR)

University of Sheffield Nov 01 1997 - Nov 01 2009

United Kingdom

Professor of Systems Pharmacology :: Clinical Pharmacology, School of Medicine

Publications

Bhagwat Prasad, Zubida M Al-Majdoub, Christine Wegler, Amin Rostami-Hodjegan, Brahim Achour
Quantitative Proteomics for Translational Pharmacology and Precision Medicine: State of The Art and Future Outlook. Drug metabolism and disposition: the biological fate of chemicals (2024)
Amin Rostami-Hodjegan, Zubida M Al-Majdoub, Yannick von Grabowiecki, Ka Lai Yee, Sudhakar Sahoo, Wolfgang Breitwieser, Aleksandra Galetin, Christopher Gibson, Brahim Achour
Dealing With Variable Drug Exposure Due to Variable Hepatic Metabolism: A Proof-of-Concept Application of Liquid Biopsy in Renal Impairment. Clinical pharmacology and therapeutics 116 (3) (2024)
Sam Mostafa, Reza Rafizadeh, Thomas M Polasek, Chad A Bousman, Amin Rostami-Hodjegan, Robert M Stowe, Prescilla Carrion, Leslie J Sheffield, Carl M J Kirkpatrick
Virtual twins for model-informed precision dosing of clozapine in patients with treatment-resistant schizophrenia. CPT: pharmacometrics & systems pharmacology 13 (3) (2024)
Sam Mostafa, Reza Rafizadeh, Thomas M Polasek, Chad A Bousman, Amin Rostami-Hodjegan, Robert M Stowe, Prescilla Carrion, Leslie J Sheffield, Carl M J Kirkpatrick
Virtual twins for model-informed precision dosing of clozapine in patients with treatment-resistant schizophrenia. CPT: pharmacometrics & systems pharmacology (2024)
Liam Curry, Sarah Alrubia, Frederic Y Bois, Ruth Clayton, Eman El-Khateeb, Trevor N Johnson, Muhammad Faisal, Sibylle Neuhoff, Kris Wragg, Amin Rostami-Hodjegan
A guide to developing population files for physiologically-based pharmacokinetic modeling in the Simcyp Simulator. CPT: pharmacometrics & systems pharmacology (2024)
Amin Rostami-Hodjegan, Zubida M Al-Majdoub, Yannick von Grabowiecki, Ka Lai Yee, Sudhakar Sahoo, Wolfgang Breitwieser, Aleksandra Galetin, Christopher Gibson, Brahim Achour
Dealing With Variable Drug Exposure Due to Variable Hepatic Metabolism: A Proof-of-Concept Application of Liquid Biopsy in Renal Impairment. Clinical pharmacology and therapeutics (2024)
Sam Mostafa, Reza Rafizadeh, Thomas M Polasek, Chad A Bousman, Amin Rostami-Hodjegan, Robert M Stowe, Prescilla Carrion, Leslie J Sheffield, Carl M J Kirkpatrick
Virtual twins for model-informed precision dosing of clozapine in patients with treatment-resistant schizophrenia. CPT: pharmacometrics & systems pharmacology 13 (3) (2024)
Sam Mostafa, Reza Rafizadeh, Thomas M Polasek, Chad A Bousman, Amin Rostami-Hodjegan, Robert M Stowe, Prescilla Carrion, Leslie J Sheffield, Carl M J Kirkpatrick
Virtual twins for model-informed precision dosing of clozapine in patients with treatment-resistant schizophrenia. CPT: pharmacometrics & systems pharmacology 13 (3) (2024)
Caroline Sychterz, Hong Shen, Yueping Zhang, Michael Sinz, Amin Rostami-Hodjegan, Brian James Schmidt, Lu Gaohua, Aleksandra Galetin
A close examination of BCRP's role in lactation and methods for predicting drug distribution into milk. CPT: pharmacometrics & systems pharmacology (2024)
Sam Mostafa, Reza Rafizadeh, Thomas M Polasek, Chad A Bousman, Amin Rostami-Hodjegan, Robert M Stowe, Prescilla Carrion, Leslie J Sheffield, Carl M J Kirkpatrick
Virtual twins for model-informed precision dosing of clozapine in patients with treatment-resistant schizophrenia. CPT: pharmacometrics & systems pharmacology 13 (3) (2024)
Sam Mostafa, Reza Rafizadeh, Thomas M Polasek, Chad A Bousman, Amin Rostami-Hodjegan, Robert M Stowe, Prescilla Carrion, Leslie J Sheffield, Carl M J Kirkpatrick
Virtual twins for model-informed precision dosing of clozapine in patients with treatment-resistant schizophrenia. CPT: pharmacometrics & systems pharmacology 13 (3) (2024)
Arham Jamaal Rajput, Hamza Khaled Abdelmajed Aldibani, Amin Rostami-Hodjegan
In-depth analysis of patterns in selection of different physiologically based pharmacokinetic modeling tools: PartI - Applications and rationale behind the use of open source-code software. Biopharmaceutics & drug disposition (2023)
Shawn Pei Feng Tan, Marie-Emilie Willemin, Jan Snoeys, Hong Shen, Amin Rostami-Hodjegan, Daniel Scotcher, Aleksandra Galetin
Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker-Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease. Clinical pharmacology and therapeutics (2023)
Hamza Khaled Abdelmajed Aldibani, Arham Jamaal Rajput, Amin Rostami-Hodjegan
In-depth analysis of patterns in selection of different physiologically-based pharmacokinetic modeling tools: Part II - Assessment of model reusability and comparison between open and non-open source-code software. Biopharmaceutics & drug disposition (2023)
Chunyan Han, Tiancheng Sun, Siri Kalyan Chirumamilla, Frederic Y Bois, Mandy Xu, Amin Rostami-Hodjegan
Understanding Discordance between In Vitro Dissolution, Local Gut and Systemic Bioequivalence of Budesonide in Healthy and Crohn's Disease Patients through PBPK Modeling. Pharmaceutics 15 (9) (2023)
Arham Jamaal Rajput, Hamza Khaled Abdelmajed Aldibani, Amin Rostami-Hodjegan
In-depth analysis of patterns in selection of different physiologically based pharmacokinetic modeling tools: PartI - Applications and rationale behind the use of open source-code software. Biopharmaceutics & drug disposition (2023)
Hamza Khaled Abdelmajed Aldibani, Arham Jamaal Rajput, Amin Rostami-Hodjegan
In-depth analysis of patterns in selection of different physiologically-based pharmacokinetic modeling tools: Part II - Assessment of model reusability and comparison between open and non-open source-code software. Biopharmaceutics & drug disposition (2023)
Hamza Khaled Abdelmajed Aldibani, Arham Jamaal Rajput, Amin Rostami-Hodjegan
In-depth analysis of patterns in selection of different physiologically-based pharmacokinetic modeling tools: Part II - Assessment of model reusability and comparison between open and non-open source-code software. Biopharmaceutics & drug disposition (2023)
Hamza Khaled Abdelmajed Aldibani, Arham Jamaal Rajput, Amin Rostami-Hodjegan
In-depth analysis of patterns in selection of different physiologically-based pharmacokinetic modeling tools: Part II - Assessment of model reusability and comparison between open and non-open source-code software. Biopharmaceutics & drug disposition (2023)
Rodrigo Cristofoletti, Amin Rostami-Hodjegan
Linking in vitro-in vivo extrapolations with physiologically based modeling to inform drug and formulation development. Biopharmaceutics & drug disposition (2023)
Arham Jamaal Rajput, Hamza Khaled Abdelmajed Aldibani, Amin Rostami-Hodjegan
In-depth analysis of patterns in selection of different physiologically based pharmacokinetic modeling tools: PartI - Applications and rationale behind the use of open source-code software. Biopharmaceutics & drug disposition (2023)
Brahim Achour, Pauline Gosselin, Jean Terrier, Yvonne Gloor, Zubida M Al-Majdoub, Thomas M Polasek, Youssef Daali, Amin Rostami-Hodjegan, Jean-Luc Reny
Liquid Biopsy for Patient Characterization in Cardiovascular Disease: Verification against Markers of Cytochrome P450 and P-Glycoprotein Activities. Clinical pharmacology and therapeutics 111 (6) (2022)
Sarah Alrubia, Jialin Mao, Yuan Chen, Jill Barber, Amin Rostami-Hodjegan
Altered Bioavailability and Pharmacokinetics in Crohn's Disease: Capturing Systems Parameters for PBPK to Assist with Predicting the Fate of Orally Administered Drugs. Clinical pharmacokinetics 61 (10) (2022)
Yukiko Murata, Sibylle Neuhoff, Amin Rostami-Hodjegan, Hiroyuki Takita, Zubida M Al-Majdoub, Kayode Ogungbenro
In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition. The AAPS journal 24 (1) (2022)
Brahim Achour, Amin Rostami-Hodjegan
Is Liquid Biopsy Only Restricted to Diagnostics or Can it Go Beyond the Confines of Genotyping and Phenotyping for Quantitative Pharmacology? Clinical pharmacology and therapeutics 112 (6) (2022)
Sam Mostafa, Thomas M Polasek, Chad Bousman, Amin Rostami-Hodjegan, Leslie J Sheffield, Ian Everall, Christos Pantelis, Carl M J Kirkpatrick
Delineating gene-environment effects using virtual twins of patients treated with clozapine. CPT: pharmacometrics & systems pharmacology (2022)
Sebastian Frechen, Amin Rostami-Hodjegan
Quality Assurance of PBPK Modeling Platforms and Guidance on Building, Evaluating, Verifying and Applying PBPK Models Prudently under the Umbrella of Qualification: Why, When, What, How and By Whom? Pharmaceutical research 39 (8) (2022)
Shawn Pei Feng Tan, Daniel Scotcher, Amin Rostami-Hodjegan, Aleksandra Galetin
Effect of Chronic Kidney Disease on the Renal Secretion via Organic Anion Transporters 1/3: Implications for Physiologically-Based Pharmacokinetic Modeling and Dose Adjustment. Clinical pharmacology and therapeutics 112 (3) (2022)
Jill Barber, Zubida M Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan, Brahim Achour
Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters. Drug metabolism and disposition: the biological fate of chemicals 50 (6) (2022)
Eman El-Khateeb, Adam S Darwich, Brahim Achour, Varinder S Athwal, Amin Rostami-Hodjegan
Review article: time to revisit Child-Pugh score as the basis for predicting drug clearance in hepatic impairment. Alimentary pharmacology & therapeutics 54 (4) (2021)
Zubida M Al-Majdoub, Daniel Scotcher, Brahim Achour, Jill Barber, Aleksandra Galetin, Amin Rostami-Hodjegan
Quantitative Proteomic Map of Enzymes and Transporters in the Human Kidney: Stepping Closer to Mechanistic Kidney Models to Define Local Kinetics. Clinical pharmacology and therapeutics 110 (5) (2021)
Fang Wu, Rodrigo Cristofoletti, Liang Zhao, Amin Rostami-Hodjegan
Scientific considerations to move towards biowaiver for biopharmaceutical classification system class III drugs: How modeling and simulation can help. Biopharmaceutics & drug disposition 42 (4) (2021)
Eman El-Khateeb, Susan Burkhill, Susan Murby, Hamza Amirat, Amin Rostami-Hodjegan, Amais Ahmad
Physiological-based pharmacokinetic modeling trends in pharmaceutical drug development over the last 20-years; in-depth analysis of applications, organizations, and platforms. Biopharmaceutics & drug disposition 42 (4) (2021)
Yasmine Elmorsi, Hajar Al Feteisi, Zubida M Al-Majdoub, Jill Barber, Amin Rostami-Hodjegan, Brahim Achour
Proteomic characterisation of drug metabolising enzymes and drug transporters in pig liver. Xenobiotica; the fate of foreign compounds in biological systems 50 (10) (2020)
Daniel Scotcher, Vikram Arya, Xinning Yang, Ping Zhao, Lei Zhang, Shiew Mei Huang, Amin Rostami-Hodjegan, Aleksandra Galetin
A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations. CPT: pharmacometrics & systems pharmacology 9 (6) (2020)
Daniel Scotcher, Vikram Arya, Xinning Yang, Ping Zhao, Lei Zhang, Shiew Mei Huang, Amin Rostami-Hodjegan, Aleksandra Galetin
Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine-Drug Interactions. CPT: pharmacometrics & systems pharmacology 9 (5) (2020)
Hiroyuki Takita, Adam S Darwich, Amais Ahmad, Amin Rostami-Hodjegan
Application of the Nested Enzyme-Within-Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects. CPT: pharmacometrics & systems pharmacology 9 (11) (2020)
Narciso Couto, Zubida M Al-Majdoub, Stephanie Gibson, Pamela J Davies, Brahim Achour, Matthew D Harwood, Gordon Carlson, Jill Barber, Amin Rostami-Hodjegan, Geoffrey Warhurst
Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Intercorrelations in the Human Small Intestine. Drug metabolism and disposition: the biological fate of chemicals 48 (4) (2020)
Takanobu Matsuzaki, Daniel Scotcher, Adam S Darwich, Aleksandra Galetin, Amin Rostami-Hodjegan
Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance. The Journal of pharmacology and experimental therapeutics 368 (2) (2018)
Bo Liu, H Kim Crewe, Mahmut Ozdemir, Karen Rowland Yeo, Geoffrey Tucker, Amin Rostami-Hodjegan
The absorption kinetics of ketoconazole plays a major role in explaining the reported variability in the level of interaction with midazolam: Interplay between formulation and inhibition of gut wall and liver metabolism. Biopharmaceutics & drug disposition 38 (3) (2017)
Oliver J D Hatley, Christopher R Jones, Aleksandra Galetin, Amin Rostami-Hodjegan
Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors. Biopharmaceutics & drug disposition 38 (3) (2017)
Oliver J D Hatley, Christopher R Jones, Aleksandra Galetin, Amin Rostami-Hodjegan
Quantifying gut wall metabolism: methodology matters. Biopharmaceutics & drug disposition 38 (2) (2017)
Devendra Pade, M Jamei, Amin Rostami-Hodjegan, D B Turner
Application of the MechPeff model to predict passive effective intestinal permeability in the different regions of the rodent small intestine and colon. Biopharmaceutics & drug disposition 38 (2) (2017)
Daniel Scotcher, Christopher Jones, Maria Posada, Aleksandra Galetin, Amin Rostami-Hodjegan
Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation. The AAPS journal 18 (5) (2016)

Amin Rostami-Hodjegan.css-eqlu8i{font-size:small;padding-left:4px;} (A Rostami-Hodjegan)

Publication Activity (10 Years)

Top Topics

Top Venues

Amin Rostami-Hodjegan (A Rostami-Hodjegan)