Alessio Lodola (A Lodola)

Scopus Author ID ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 41

Top Venues

Journal of chemical information and modeling

Journal of medicinal chemistry

Pharmaceuticals (Basel, Switzerland)

Scientific reports

Università degli Studi di Parma

Università degli Studi di Pavia (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Università degli Studi di Parma Nov 01 2014

Italy

Associate Professor of Medicinal Chemistry :: Pharmacy Department

Northumbria University Dec 01 2013 - Dec 31 2019

United Kingdom

Visiting Fellow :: Department of Applied Sciences

Università degli Studi di Parma

Italy

Temporary Research Fellow :: Dipartimento di Farmacia

University of Bristol

United Kingdom

Visiting Researcher :: School of Chemistry

Education History

Università degli Studi di Pavia

Italy

PHD

University of Bristol

United Kingdom

PHD :: School of Chemistry

Publications

Francisco Javier Medrano, Sergio de la Hoz-Rodríguez, Sergio Martí, Kemel Arafet, Tanja Schirmeister, Stefan Josef Hammerschmidt, Christin Müller, Águeda González-Martínez, Elena Santillana, John Ziebuhr, Antonio Romero, Collin Zimmer, Annabelle Carolin Weldert, Robert Zimmermann, Alessio Lodola, Katarzyna Świderek, Vicent Moliner, Florenci V González
Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2. Communications chemistry 7 (1) (2024)
Silvia La Monica, Federica Vacondio, Kamal Eltayeb, Alessio Lodola, Francesco Volta, Martina Viglioli, Francesca Ferlenghi, Francesca Galvani, Maricla Galetti, Mara Bonelli, Claudia Fumarola, Andrea Cavazzoni, Lisa Flammini, Michela Verzè, Roberta Minari, Pier Giorgio Petronini, Marcello Tiseo, Marco Mor, Roberta Alfieri
Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models. Scientific reports 14 (1) (2024)
Silvia La Monica, Federica Vacondio, Kamal Eltayeb, Alessio Lodola, Francesco Volta, Martina Viglioli, Francesca Ferlenghi, Francesca Galvani, Maricla Galetti, Mara Bonelli, Claudia Fumarola, Andrea Cavazzoni, Lisa Flammini, Michela Verzè, Roberta Minari, Pier Giorgio Petronini, Marcello Tiseo, Marco Mor, Roberta Alfieri
Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models. Scientific reports 14 (1) (2024)
Silvia La Monica, Federica Vacondio, Kamal Eltayeb, Alessio Lodola, Francesco Volta, Martina Viglioli, Francesca Ferlenghi, Francesca Galvani, Maricla Galetti, Mara Bonelli, Claudia Fumarola, Andrea Cavazzoni, Lisa Flammini, Michela Verzè, Roberta Minari, Pier Giorgio Petronini, Marcello Tiseo, Marco Mor, Roberta Alfieri
Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models. Scientific reports 14 (1) (2024)
Gabriele Carullo, Sara Rossi, Valentina Giudice, Alex Pezzotta, Ugo Chianese, Pasqualina Scala, Sabrina Carbone, Anna Fontana, Giovanna Panzeca, Silvia Pasquini, Chiara Contri, Sandra Gemma, Anna Ramunno, Simona Saponara, Francesca Galvani, Alessio Lodola, Marco Mor, Rosaria Benedetti, Carmine Selleri, Katia Varani, Stefania Butini, Lucia Altucci, Fabrizio Vincenzi, Anna Pistocchi, Giuseppe Campiani
Development of Epigenetic Modifiers with Therapeutic Potential in FMS-Related Tyrosine Kinase 3/Internal Tandem Duplication (FLT3/ITD) Acute Myeloid Leukemia and Other Blood Malignancies. ACS pharmacology & translational science 7 (7) (2024)
Francisco Javier Medrano, Sergio de la Hoz-Rodríguez, Sergio Martí, Kemel Arafet, Tanja Schirmeister, Stefan Josef Hammerschmidt, Christin Müller, Águeda González-Martínez, Elena Santillana, John Ziebuhr, Antonio Romero, Collin Zimmer, Annabelle Carolin Weldert, Robert Zimmermann, Alessio Lodola, Katarzyna Świderek, Vicent Moliner, Florenci V González
Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2. Communications chemistry 7 (1) (2024)
Gabriele Carullo, Sara Rossi, Valentina Giudice, Alex Pezzotta, Ugo Chianese, Pasqualina Scala, Sabrina Carbone, Anna Fontana, Giovanna Panzeca, Silvia Pasquini, Chiara Contri, Sandra Gemma, Anna Ramunno, Simona Saponara, Francesca Galvani, Alessio Lodola, Marco Mor, Rosaria Benedetti, Carmine Selleri, Katia Varani, Stefania Butini, Lucia Altucci, Fabrizio Vincenzi, Anna Pistocchi, Giuseppe Campiani
Development of Epigenetic Modifiers with Therapeutic Potential in FMS-Related Tyrosine Kinase 3/Internal Tandem Duplication (FLT3/ITD) Acute Myeloid Leukemia and Other Blood Malignancies. ACS pharmacology & translational science 7 (7) (2024)
Silvia La Monica, Federica Vacondio, Kamal Eltayeb, Alessio Lodola, Francesco Volta, Martina Viglioli, Francesca Ferlenghi, Francesca Galvani, Maricla Galetti, Mara Bonelli, Claudia Fumarola, Andrea Cavazzoni, Lisa Flammini, Michela Verzè, Roberta Minari, Pier Giorgio Petronini, Marcello Tiseo, Marco Mor, Roberta Alfieri
Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models. Scientific reports 14 (1) (2024)
Lorenzo Guidetti, Alfonso Zappia, Laura Scalvini, Francesca Romana Ferrari, Carmine Giorgio, Riccardo Castelli, Francesca Galvani, Federica Vacondio, Silvia Rivara, Marco Mor, Chiara Urbinati, Marco Rusnati, Massimiliano Tognolini, Alessio Lodola
Molecular Determinants of EphA2 and EphB2 Antagonism Enable the Design of Ligands with Improved Selectivity. Journal of chemical information and modeling (2023)
Kemel Arafet, Laura Scalvini, Francesca Galvani, Sergio de la Hoz-Rodríguez, Vicent Moliner, Marco Mor, Alessio Lodola
Mechanistic Modeling of Lys745 Sulfonylation in EGFR C797S Reveals Chemical Determinants for Inhibitor Activity and Discriminates Reversible from Irreversible Agents. Journal of chemical information and modeling 63 (4) (2023)
Kemel Arafet, Laura Scalvini, Francesca Galvani, Sergio de la Hoz-Rodríguez, Vicent Moliner, Marco Mor, Alessio Lodola
Mechanistic Modeling of Lys745 Sulfonylation in EGFR C797S Reveals Chemical Determinants for Inhibitor Activity and Discriminates Reversible from Irreversible Agents. Journal of chemical information and modeling 63 (4) (2023)
Claudio Festuccia, Miriam Corrado, Alessandra Rossetti, Riccardo Castelli, Alessio Lodola, Giovanni Luca Gravina, Massimiliano Tognolini, Carmine Giorgio
A Pharmacological Investigation of Eph-Ephrin Antagonism in Prostate Cancer: UniPR1331 Efficacy Evidence. Pharmaceuticals (Basel, Switzerland) 16 (10) (2023)
Francesca Galvani, Daniele Pala, Alberto Cuzzolin, Laura Scalvini, Alessio Lodola, Marco Mor, Andrea Rizzi
Unbinding Kinetics of Muscarinic M3 Receptor Antagonists Explained by Metadynamics Simulations. Journal of chemical information and modeling (2023)
Kemel Arafet, Laura Scalvini, Francesca Galvani, Sergio de la Hoz-Rodríguez, Vicent Moliner, Marco Mor, Alessio Lodola
Mechanistic Modeling of Lys745 Sulfonylation in EGFR C797S Reveals Chemical Determinants for Inhibitor Activity and Discriminates Reversible from Irreversible Agents. Journal of chemical information and modeling 63 (4) (2023)
Kemel Arafet, Laura Scalvini, Francesca Galvani, Sergio de la Hoz-Rodríguez, Vicent Moliner, Marco Mor, Alessio Lodola
Mechanistic Modeling of Lys745 Sulfonylation in EGFR C797S Reveals Chemical Determinants for Inhibitor Activity and Discriminates Reversible from Irreversible Agents. Journal of chemical information and modeling 63 (4) (2023)
Kemel Arafet, Laura Scalvini, Francesca Galvani, Sergio de la Hoz-Rodríguez, Vicent Moliner, Marco Mor, Alessio Lodola
Mechanistic Modeling of Lys745 Sulfonylation in EGFR C797S Reveals Chemical Determinants for Inhibitor Activity and Discriminates Reversible from Irreversible Agents. Journal of chemical information and modeling (2023)
Francesca Galvani, Laura Scalvini, Silvia Rivara, Alessio Lodola, Marco Mor
Mechanistic Modeling of Monoglyceride Lipase Covalent Modification Elucidates the Role of Leaving Group Expulsion and Discriminates Inhibitors with High and Low Potency. Journal of chemical information and modeling 62 (11) (2022)
Lorenzo Guidetti, Riccardo Castelli, Laura Scalvini, Francesca Ferlenghi, Miriam Corrado, Carmine Giorgio, Massimiliano Tognolini, Alessio Lodola
Protein-Protein Interaction Inhibitors Targeting the Eph-Ephrin System with a Focus on Amino Acid Conjugates of Bile Acids. Pharmaceuticals (Basel, Switzerland) 15 (2) (2022)
Gian Marco Elisi, Laura Scalvini, Alessio Lodola, Annalida Bedini, Gilberto Spadoni, Silvia Rivara
In silico drug discovery of melatonin receptor ligands with therapeutic potential. Expert opinion on drug discovery 17 (4) (2022)
Marco Rusnati, Giulia Paiardi, Chiara Tobia, Chiara Urbinati, Alessio Lodola, Pasqualina D'Ursi, Miriam Corrado, Riccardo Castelli, Rebecca C Wade, Massimiliano Tognolini, Paola Chiodelli
Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin. Cancer gene therapy (2021)
Francesca Ferlenghi, Carmine Giorgio, Matteo Incerti, Lorenzo Guidetti, Paola Chiodelli, Marco Rusnati, Massimiliano Tognolini, Federica Vacondio, Marco Mor, Alessio Lodola
Metabolic Soft Spot and Pharmacokinetics: Functionalization of C-3 Position of an Eph-Ephrin Antagonist Featuring a Bile Acid Core as an Effective Strategy to Obtain Oral Bioavailability in Mice. Pharmaceuticals (Basel, Switzerland) 15 (1) (2021)
Marco Rusnati, Giulia Paiardi, Chiara Tobia, Chiara Urbinati, Alessio Lodola, Pasqualina D'Ursi, Miriam Corrado, Riccardo Castelli, Rebecca C Wade, Massimiliano Tognolini, Paola Chiodelli
Correction: Cholenic acid derivative UniPR1331 impairs tumor angiogenesis via blockade of VEGF/VEGFR2 in addition to Eph/ephrin. Cancer gene therapy (2021)
Sergio de la Hoz-Rodríguez, Kemel Arafet, Alessio Lodola, Adrian J Mulholland, Katarzyna Świderek, Vicent Moliner
Impact of Warhead Modulations on the Covalent Inhibition of SARS-CoV-2 M pro Explored by QM/MM Simulations. ACS catalysis 12 (1) (2021)
Daniele Pala, Laura Scalvini, Gian Marco Elisi, Alessio Lodola, Marco Mor, Gilberto Spadoni, Fabiana F Ferrara, Emiliano Pavoni, Giuseppe Roscilli, Ferdinando M Milazzo, Gianfranco Battistuzzi, Silvia Rivara, Giuseppe Giannini
New classes of potent heparanase inhibitors from ligand-based virtual screening. Journal of enzyme inhibition and medicinal chemistry 35 (1) (2021)
Aurora Diotallevi, Laura Scalvini, Gloria Buffi, Yolanda Pérez-Pertejo, Mauro De Santi, Michele Verboni, Gianfranco Favi, Mauro Magnani, Alessio Lodola, Simone Lucarini, Luca Galluzzi
Phenotype Screening of an Azole-bisindole Chemical Library Identifies URB1483 as a New Antileishmanial Agent Devoid of Toxicity on Human Cells. ACS omega 6 (51) (2021)
H T Henry Chan, Marc A Moesser, Rebecca K Walters, Tika R Malla, Rebecca M Twidale, Tobias John, Helen M Deeks, Tristan Johnston-Wood, Victor Mikhailov, Richard B Sessions, William Dawson, Eidarus Salah, Petra Lukacik, Claire Strain-Damerell, C David Owen, Takahito Nakajima, Katarzyna Świderek, Alessio Lodola, Vicent Moliner, David R Glowacki, James Spencer, Martin Austin Walsh, Christopher J Schofield, Luigi Genovese, Deborah K Shoemark, Adrian J Mulholland, Fernanda Duarte, Garrett M Morris
Discovery of SARS-CoV-2 Mpro peptide inhibitors from modelling substrate and ligand binding. Chemical science 12 (41) (2021)
Andrea Ghidini, Laura Scalvini, Francesca Palese, Alessio Lodola, Marco Mor, Daniele Piomelli
Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidase. Journal of enzyme inhibition and medicinal chemistry 36 (1) (2021)
Carmine Giorgio, Marika Allodi, Simone Palese, Andrea Grandi, Massimiliano Tognolini, Riccardo Castelli, Alessio Lodola, Lisa Flammini, Anna Maria Cantoni, Elisabetta Barocelli, Simona Bertoni
UniPR1331: Small Eph/Ephrin Antagonist Beneficial in Intestinal Inflammation by Interfering with Type-B Signaling. Pharmaceuticals (Basel, Switzerland) 14 (6) (2021)
Gian Marco Elisi, Laura Scalvini, Alessio Lodola, Marco Mor, Silvia Rivara
Free-Energy Simulations Support a Lipophilic Binding Route for Melatonin Receptors. Journal of chemical information and modeling 62 (1) (2021)
Daniele Piomelli, Laura Scalvini, Yannick Fotio, Alessio Lodola, Gilberto Spadoni, Giorgio Tarzia, Marco Mor
N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition. Journal of medicinal chemistry 63 (14) (2020)
Carmine Giorgio, Ilaria Zanotti, Alessio Lodola, Massimiliano Tognolini
Ephrin or not? Six tough questions on Eph targeting. Expert opinion on therapeutic targets 24 (5) (2020)
Kemel Arafet, Natalia Serrano-Aparicio, Alessio Lodola, Adrian J Mulholland, Florenci V González, Katarzyna Świderek, Vicent Moliner
Mechanism of inhibition of SARS-CoV-2 Mpro by N3 peptidyl Michael acceptor explained by QM/MM simulations and design of new derivatives with tunable chemical reactivity. Chemical science 12 (4) (2020)
Riccardo Castelli, Laura Scalvini, Federica Vacondio, Alessio Lodola, Mattia Anselmi, Stefano Vezzosi, Caterina Carmi, Michele Bassi, Francesca Ferlenghi, Silvia Rivara, Ingvar R Möller, Kasper Dyrberg Rand, Jennifer Daglian, Don Wei, Emmanuel Y Dotsey, Faizy Ahmed, Kwang-Mook Jung, Nephi Stella, Simar Singh, Marco Mor, Daniele Piomelli
Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines. Journal of medicinal chemistry 63 (3) (2019)
Giuseppe Marseglia, Alessio Lodola, Marco Mor, Riccardo Castelli
Fibroblast growth factor receptor inhibitors: patent review (2015-2019). Expert opinion on therapeutic patents 29 (12) (2019)
Silvia Rivara, Laura Scalvini, Alessio Lodola, Marco Mor, Daniel-Henri Caignard, Philippe Delagrange, Simona Collina, Valeria Lucini, Francesco Scaglione, Lucia Furiassi, Michele Mari, Simone Lucarini, Annalida Bedini, Gilberto Spadoni
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands. Journal of medicinal chemistry 61 (8) (2018)
Gilberto Spadoni, Annalida Bedini, Lucia Furiassi, Michele Mari, Marco Mor, Laura Scalvini, Alessio Lodola, Andrea Ghidini, Valeria Lucini, Silvana Dugnani, Francesco Scaglione, Daniele Piomelli, Kwang-Mook Jung, Claudiu T Supuran, Laura Lucarini, Mariaconcetta Durante, Silvia Sgambellone, Emanuela Masini, Silvia Rivara
Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit. Journal of medicinal chemistry 61 (17) (2018)
Donatella Callegari, Kara E Ranaghan, Christopher Woods, Roberta Minari, Marcello Tiseo, Marco Mor, A J Mulholland, Alessio Lodola
L718Q mutant EGFR escapes covalent inhibition by stabilizing a non-reactive conformation of the lung cancer drug osimertinib. Chemical science 9 (10) (2018)
Matteo Incerti, Simonetta Russo, Donatella Callegari, Daniele Pala, Carmine Giorgio, Ilaria Zanotti, Elisabetta Barocelli, Paola Vicini, Federica Vacondio, Silvia Rivara, Riccardo Castelli, Massimiliano Tognolini, Alessio Lodola
Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor. Journal of medicinal chemistry 60 (2) (2017)
Alessio Lodola, Serena Bertolini, Matteo Biagetti, Silvia Capacchi, Fabrizio Facchinetti, Paola Maria Gallo, Alice Pappani, Marco Mor, Daniele Pala, Silvia Rivara, Filippo Visentini, Mauro Corsi, Anna Maria Capelli
Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs. Journal of medicinal chemistry 60 (10) (2017)
Donatella Callegari, Alessio Lodola, Daniele Pala, Silvia Rivara, Marco Mor, Andrea Rizzi, Anna Maria Capelli
Metadynamics Simulations Distinguish Short- and Long-Residence-Time Inhibitors of Cyclin-Dependent Kinase 8. Journal of chemical information and modeling 57 (2) (2017)
Donatella Callegari, Alessio Lodola, Daniele Pala, Silvia Rivara, Marco Mor, Andrea Rizzi, Anna Maria Capelli
Correction to Metadynamics Simulations Distinguish Short- and Long-Residence-Time Inhibitors of Cyclin-Dependent Kinase 8. Journal of chemical information and modeling 57 (2) (2017)

Alessio Lodola.css-eqlu8i{font-size:small;padding-left:4px;} (A Lodola)

Publication Activity (10 Years)

Top Topics

Top Venues

Alessio Lodola (A Lodola)