Bruce R Blazar

ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 104

Top Venues

Blood

Blood advances

Science translational medicine

Journal of immunology (Baltimore, Md. : 1950)

University of Minnesota

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Minnesota Jun 08 2009

United States

Regents Professor :: Pediatrics

Publications

Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark J Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice. Blood 143 (21) (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice. Blood (2024)
Janaki Manoja Vinnakota, Francesca Biavasco, Marius Schwabenland, Chintan Chhatbar, Rachael C Adams, Daniel Erny, Sandra Duquesne, Nadia El Khawanky, Dominik Schmidt, Viktor Fetsch, Alexander Zähringer, Henrike Salié, Dimitrios Athanassopoulos, Lukas M Braun, Nora R Javorniczky, Jenny N H G Ho, Katrin Kierdorf, Reinhard Marks, Ralph Wäsch, Federico Simonetta, Geoffroy Andrieux, Dietmar Pfeifer, Gianni Monaco, Christian M Capitini, Terry J Fry, Thomas Blank, Bruce R Blazar, Eva Maria Wagner-Drouet, Matthias Theobald, Clemens Sommer, Matthias Stelljes, Christian Reicherts, Astrid Jeibmann, Jens Schittenhelm, Camelia-Maria Monoranu, Andreas Rosenwald, Klaus Martin Kortüm, Leo Rasche, Hermann Einsele, Philipp T Meyer, Joachim Brumberg, Simon Völkl, Andreas Mackensen, Roland Coras, Michael von Bergwelt-Baildon, Nathalie L Albert, Laura M Bartos, Matthias Brendel, Adrien Holzgreve, Matthias Mack, Melanie Börries, Crystal L Mackall, Justus Duyster, Philipp Henneke, Josef Priller, Natalie Stickel, Felix L Strübing, Bertram Bengsch, Marco Ruella, Marion Subklewe, Louisa von Baumgarten, Saar Gill, Marco Prinz, Robert Zeiser
Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome. Nature cancer (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice. Blood (2024)
Kristina Maas-Bauer, Anna-Verena Stell, Kai-Li Yan, Enrique de Vega, Janaki Manoja Vinnakota, Susanne Unger, Nicolas Núñez, Johana Norona, Nana Talvard-Balland, Stefanie Koßmann, Carsten Schwan, Christoph Cornelius Miething, Uta S Martens, Khalid Shoumariyeh, Rosa P Nestor, Sandra Duquesne, Kathrin Hanke, Michal Rackiewicz, Zehan Hu, Nadia El Khawanky, Sanaz Taromi, Hana Andrlova, Hemin Faraidun, Stefanie Walter, Dietmar Pfeifer, Marie Follo, Johannes Waldschmidt, Wolfgang Melchinger, Michael Rassner, Claudia Wehr, Annette Schmitt-Graeff, Sebastian Halbach, James K Liao, Georg Häcker, Tilman Brummer, Joern Dengjel, Geoffroy Andrieux, Robert Grosse, Sonia Tugues, Bruce R Blazar, Burkhard Becher, Melanie Börries, Robert Zeiser
ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease. Nature communications 15 (1) (2024)
Kristina Maas-Bauer, Anna-Verena Stell, Kai-Li Yan, Enrique de Vega, Janaki Manoja Vinnakota, Susanne Unger, Nicolas Núñez, Johana Norona, Nana Talvard-Balland, Stefanie Koßmann, Carsten Schwan, Christoph Cornelius Miething, Uta S Martens, Khalid Shoumariyeh, Rosa P Nestor, Sandra Duquesne, Kathrin Hanke, Michal Rackiewicz, Zehan Hu, Nadia El Khawanky, Sanaz Taromi, Hana Andrlova, Hemin Faraidun, Stefanie Walter, Dietmar Pfeifer, Marie Follo, Johannes Waldschmidt, Wolfgang Melchinger, Michael Rassner, Claudia Wehr, Annette Schmitt-Graeff, Sebastian Halbach, James K Liao, Georg Häcker, Tilman Brummer, Joern Dengjel, Geoffroy Andrieux, Robert Grosse, Sonia Tugues, Bruce R Blazar, Burkhard Becher, Melanie Börries, Robert Zeiser
ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease. Nature communications 15 (1) (2024)
Katie E Lineburg, Lucie Leveque-El Mouttie, Christopher R Hunter, Laetitia Le Texier, Crystal McGirr, Bianca Teal, Bruce R Blazar, Steven W Lane, Geoffrey R Hill, Jean-Pierre Lévesque, Kelli P A MacDonald
Autophagy prevents graft failure during murine graft-versus-host disease. Blood advances 8 (8) (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice. Blood (2024)
Janaki Manoja Vinnakota, Rachael C Adams, Dimitrios Athanassopoulos, Dominik Schmidt, Francesca Biavasco, Alexander Zähringer, Daniel Erny, Marius Schwabenland, Marlene Langenbach, Valentin Wenger, Henrike Salié, James R Cook, Omar Mossad, Geoffroy Andrieux, Rick Dersch, Sebastian Rauer, Sandra Duquesne, Gianni Monaco, Phillipp Wolf, Thomas Blank, Philipp Häne, Melanie Greter, Burkhard Becher, Philipp Henneke, Dietmar Pfeifer, Bruce R Blazar, Justus Duyster, Melanie Börries, Natalie Stickel, Chintan M Chhatbar, Bertram Bengsch, Marco Prinz, Robert Zeiser
Anti-PD-1 cancer immunotherapy induces central nervous system immune-related adverse events by microglia activation. Science translational medicine 16 (751) (2024)
Janaki Manoja Vinnakota, Francesca Biavasco, Marius Schwabenland, Chintan Chhatbar, Rachael C Adams, Daniel Erny, Sandra Duquesne, Nadia El Khawanky, Dominik Schmidt, Viktor Fetsch, Alexander Zähringer, Henrike Salié, Dimitrios Athanassopoulos, Lukas M Braun, Nora R Javorniczky, Jenny N H G Ho, Katrin Kierdorf, Reinhard Marks, Ralph Wäsch, Federico Simonetta, Geoffroy Andrieux, Dietmar Pfeifer, Gianni Monaco, Christian M Capitini, Terry J Fry, Thomas Blank, Bruce R Blazar, Eva Maria Wagner-Drouet, Matthias Theobald, Clemens Sommer, Matthias Stelljes, Christian Reicherts, Astrid Jeibmann, Jens Schittenhelm, Camelia-Maria Monoranu, Andreas Rosenwald, Klaus Martin Kortüm, Leo Rasche, Hermann Einsele, Philipp T Meyer, Joachim Brumberg, Simon Völkl, Andreas Mackensen, Roland Coras, Michael von Bergwelt-Baildon, Nathalie L Albert, Laura M Bartos, Matthias Brendel, Adrien Holzgreve, Matthias Mack, Melanie Börries, Crystal L Mackall, Justus Duyster, Philipp Henneke, Josef Priller, Natalie Stickel, Felix L Strübing, Bertram Bengsch, Marco Ruella, Marion Subklewe, Louisa von Baumgarten, Saar Gill, Marco Prinz, Robert Zeiser
Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome. Nature cancer 5 (8) (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark J Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice. Blood 143 (21) (2024)
Katie E Lineburg, Lucie Leveque-El Mouttie, Christopher R Hunter, Laetitia Le Texier, Crystal McGirr, Bianca Teal, Bruce R Blazar, Steven W Lane, Geoffrey R Hill, Jean-Pierre Lévesque, Kelli P A MacDonald
Autophagy prevents graft failure during murine graft-versus-host disease. Blood advances 8 (8) (2024)
Katie E Lineburg, Lucie Leveque-El Mouttie, Christopher R Hunter, Laeitia Le Texier, Crystal McGirr, Bianca Teal, Bruce R Blazar, Steven W Lane, Geoffrey R Hill, Jean-Pierre Levesque, Kelli P A MacDonald
Autophagy prevents graft failure during murine Graft versus Host Disease. Blood advances (2024)
Janaki Manoja Vinnakota, Francesca Biavasco, Marius Schwabenland, Chintan Chhatbar, Rachael C Adams, Daniel Erny, Sandra Duquesne, Nadia El Khawanky, Dominik Schmidt, Viktor Fetsch, Alexander Zähringer, Henrike Salié, Dimitrios Athanassopoulos, Lukas M Braun, Nora R Javorniczky, Jenny N H G Ho, Katrin Kierdorf, Reinhard Marks, Ralph Wäsch, Federico Simonetta, Geoffroy Andrieux, Dietmar Pfeifer, Gianni Monaco, Christian M Capitini, Terry J Fry, Thomas Blank, Bruce R Blazar, Eva Maria Wagner-Drouet, Matthias Theobald, Clemens Sommer, Matthias Stelljes, Christian Reicherts, Astrid Jeibmann, Jens Schittenhelm, Camelia-Maria Monoranu, Andreas Rosenwald, Klaus Martin Kortüm, Leo Rasche, Hermann Einsele, Philipp T Meyer, Joachim Brumberg, Simon Völkl, Andreas Mackensen, Roland Coras, Michael von Bergwelt-Baildon, Nathalie L Albert, Laura M Bartos, Matthias Brendel, Adrien Holzgreve, Matthias Mack, Melanie Börries, Crystal L Mackall, Justus Duyster, Philipp Henneke, Josef Priller, Natalie Stickel, Felix L Strübing, Bertram Bengsch, Marco Ruella, Marion Subklewe, Louisa von Baumgarten, Saar Gill, Marco Prinz, Robert Zeiser
Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome. Nature cancer 5 (8) (2024)
Kristina Maas-Bauer, Anna-Verena Stell, Kai-Li Yan, Enrique de Vega, Janaki Manoja Vinnakota, Susanne Unger, Nicolas Núñez, Johana Norona, Nana Talvard-Balland, Stefanie Koßmann, Carsten Schwan, Christoph Cornelius Miething, Uta S Martens, Khalid Shoumariyeh, Rosa P Nestor, Sandra Duquesne, Kathrin Hanke, Michal Rackiewicz, Zehan Hu, Nadia El Khawanky, Sanaz Taromi, Hana Andrlova, Hemin Faraidun, Stefanie Walter, Dietmar Pfeifer, Marie Follo, Johannes Waldschmidt, Wolfgang Melchinger, Michael Rassner, Claudia Wehr, Annette Schmitt-Graeff, Sebastian Halbach, James K Liao, Georg Häcker, Tilman Brummer, Joern Dengjel, Geoffroy Andrieux, Robert Grosse, Sonia Tugues, Bruce R Blazar, Burkhard Becher, Melanie Börries, Robert Zeiser
ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease. Nature communications 15 (1) (2024)
Joseph A Pidala, Shernan G Holtan, Kelly Walton, Jongphil Kim, Biwei Cao, Hany Elmariah, Asmita Mishra, Nelli Bejanyan, Taiga Nishihori, Farhad Khimani, Lia E Perez, Rawan G Faramand, Marco L Davila, Shannon McSain, Jordan Pleskow, Jeffrey Baron, Claudio Anasetti, Carlos Moran Segura, Daniel J Weisdorf, Bruce R Blazar, Jeffrey S Miller, Veronika Bachanova, Najla El Jurdi, Brian C Betts
JAK2/mTOR Inhibition Fails to Prevent Acute GVHD Despite Reduced Th1/Th17 cells: Final Phase II Trial Results. Blood (2024)
Kristina Maas-Bauer, Anna-Verena Stell, Kai-Li Yan, Enrique de Vega, Janaki Manoja Vinnakota, Susanne Unger, Nicolas Núñez, Johana Norona, Nana Talvard-Balland, Stefanie Koßmann, Carsten Schwan, Christoph Cornelius Miething, Uta S Martens, Khalid Shoumariyeh, Rosa P Nestor, Sandra Duquesne, Kathrin Hanke, Michal Rackiewicz, Zehan Hu, Nadia El Khawanky, Sanaz Taromi, Hana Andrlova, Hemin Faraidun, Stefanie Walter, Dietmar Pfeifer, Marie Follo, Johannes Waldschmidt, Wolfgang Melchinger, Michael Rassner, Claudia Wehr, Annette Schmitt-Graeff, Sebastian Halbach, James K Liao, Georg Häcker, Tilman Brummer, Joern Dengjel, Geoffroy Andrieux, Robert Grosse, Sonia Tugues, Bruce R Blazar, Burkhard Becher, Melanie Börries, Robert Zeiser
ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease. Nature communications 15 (1) (2024)
Joseph A Pidala, Theodore A Gooley, Leo Luznik, Bruce R Blazar
Chronic graft-versus-host disease: Unresolved complication or ancient history? Blood (2024)
Francesco Mazziotta, Luca Biavati, Joseph Cataquiz Rimando, Sergio Rutella, Nicholas Borcherding, Sonali Parbhoo, Rupkatha Mukhopadhyay, Hanna A Knaus, Peter Valent, Hubert Hackl, Ivan M Borrello, Bruce R Blazar, Katerina Hatzi, Ivana Gojo, Leo Luznik
CD8+ T-cell Differentiation and Dysfunction Inform Treatment Response in Acute Myeloid Leukemia. Blood (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice. Blood (2024)
Janaki Manoja Vinnakota, Francesca Biavasco, Marius Schwabenland, Chintan Chhatbar, Rachael C Adams, Daniel Erny, Sandra Duquesne, Nadia El Khawanky, Dominik Schmidt, Viktor Fetsch, Alexander Zähringer, Henrike Salié, Dimitrios Athanassopoulos, Lukas M Braun, Nora R Javorniczky, Jenny N H G Ho, Katrin Kierdorf, Reinhard Marks, Ralph Wäsch, Federico Simonetta, Geoffroy Andrieux, Dietmar Pfeifer, Gianni Monaco, Christian M Capitini, Terry J Fry, Thomas Blank, Bruce R Blazar, Eva Maria Wagner-Drouet, Matthias Theobald, Clemens Sommer, Matthias Stelljes, Christian Reicherts, Astrid Jeibmann, Jens Schittenhelm, Camelia-Maria Monoranu, Andreas Rosenwald, Klaus Martin Kortüm, Leo Rasche, Hermann Einsele, Philipp T Meyer, Joachim Brumberg, Simon Völkl, Andreas Mackensen, Roland Coras, Michael von Bergwelt-Baildon, Nathalie L Albert, Laura M Bartos, Matthias Brendel, Adrien Holzgreve, Matthias Mack, Melanie Börries, Crystal L Mackall, Justus Duyster, Philipp Henneke, Josef Priller, Natalie Stickel, Felix L Strübing, Bertram Bengsch, Marco Ruella, Marion Subklewe, Louisa von Baumgarten, Saar Gill, Marco Prinz, Robert Zeiser
Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome. Nature cancer (2024)
Kristina Maas-Bauer, Anna-Verena Stell, Kai-Li Yan, Enrique de Vega, Janaki Manoja Vinnakota, Susanne Unger, Nicolas Núñez, Johana Norona, Nana Talvard-Balland, Stefanie Koßmann, Carsten Schwan, Christoph Cornelius Miething, Uta S Martens, Khalid Shoumariyeh, Rosa P Nestor, Sandra Duquesne, Kathrin Hanke, Michal Rackiewicz, Zehan Hu, Nadia El Khawanky, Sanaz Taromi, Hana Andrlova, Hemin Faraidun, Stefanie Walter, Dietmar Pfeifer, Marie Follo, Johannes Waldschmidt, Wolfgang Melchinger, Michael Rassner, Claudia Wehr, Annette Schmitt-Graeff, Sebastian Halbach, James K Liao, Georg Häcker, Tilman Brummer, Joern Dengjel, Geoffroy Andrieux, Robert Grosse, Sonia Tugues, Bruce R Blazar, Burkhard Becher, Melanie Börries, Robert Zeiser
ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease. Nature communications 15 (1) (2024)
Katie E Lineburg, Lucie Leveque-El Mouttie, Christopher R Hunter, Laetitia Le Texier, Crystal McGirr, Bianca Teal, Bruce R Blazar, Steven W Lane, Geoffrey R Hill, Jean-Pierre Lévesque, Kelli P A MacDonald
Autophagy prevents graft failure during murine graft-versus-host disease. Blood advances 8 (8) (2024)
Kristina Maas-Bauer, Anna-Verena Stell, Kai-Li Yan, Enrique de Vega, Janaki Manoja Vinnakota, Susanne Unger, Nicolas Núñez, Johana Norona, Nana Talvard-Balland, Stefanie Koßmann, Carsten Schwan, Christoph Cornelius Miething, Uta S Martens, Khalid Shoumariyeh, Rosa P Nestor, Sandra Duquesne, Kathrin Hanke, Michal Rackiewicz, Zehan Hu, Nadia El Khawanky, Sanaz Taromi, Hana Andrlova, Hemin Faraidun, Stefanie Walter, Dietmar Pfeifer, Marie Follo, Johannes Waldschmidt, Wolfgang Melchinger, Michael Rassner, Claudia Wehr, Annette Schmitt-Graeff, Sebastian Halbach, James K Liao, Georg Häcker, Tilman Brummer, Joern Dengjel, Geoffroy Andrieux, Robert Grosse, Sonia Tugues, Bruce R Blazar, Burkhard Becher, Melanie Börries, Robert Zeiser
ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease. Nature communications 15 (1) (2024)
Katie E Lineburg, Lucie Leveque-El Mouttie, Christopher R Hunter, Laetitia Le Texier, Crystal McGirr, Bianca Teal, Bruce R Blazar, Steven W Lane, Geoffrey R Hill, Jean-Pierre Lévesque, Kelli P A MacDonald
Autophagy prevents graft failure during murine graft-versus-host disease. Blood advances 8 (8) (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice. Blood (2024)
Katie E Lineburg, Lucie Leveque-El Mouttie, Christopher R Hunter, Laetitia Le Texier, Crystal McGirr, Bianca Teal, Bruce R Blazar, Steven W Lane, Geoffrey R Hill, Jean-Pierre Lévesque, Kelli P A MacDonald
Autophagy prevents graft failure during murine graft-versus-host disease. Blood advances 8 (8) (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark J Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice. Blood 143 (21) (2024)
Katie E Lineburg, Lucie Leveque-El Mouttie, Christopher R Hunter, Laeitia Le Texier, Crystal McGirr, Bianca Teal, Bruce R Blazar, Steven W Lane, Geoffrey R Hill, Jean-Pierre Levesque, Kelli P A MacDonald
Autophagy prevents graft failure during murine Graft versus Host Disease. Blood advances (2024)
Dominik Schmidt, Cornelia Endres, Rouven Hoefflin, Geoffroy Andrieux, Melissa Zwick, Nikolaos Karantzelis, Hans F Staehle, Janaki Manoja Vinnakota, Sandra Duquesne, Miriam Mozaffari Jovein, Dietmar Pfeifer, Heiko Becker, Bruce R Blazar, Alexander Zähringer, Justus Duyster, Tilman Brummer, Melanie Börries, Julian Baumeister, Khalid Shoumariyeh, Juan Li, Anthony R Green, Florian H Heidel, Michael Mints, Heike Luise Pahl, Nils Bastian Leimkühler, Natalie Stickel, Marcelo Augusto Szymanski de Toledo, Steffen Koschmieder, Robert Zeiser
Oncogenic Calreticulin Induces Immune Escape by Stimulating TGF-β Expression and Regulatory T Cell Expansion in the Bone Marrow Microenvironment. Cancer research (2024)
Kristina Maas-Bauer, Anna-Verena Stell, Kai-Li Yan, Enrique de Vega, Janaki Manoja Vinnakota, Susanne Unger, Nicolas Núñez, Johana Norona, Nana Talvard-Balland, Stefanie Koßmann, Carsten Schwan, Christoph Cornelius Miething, Uta S Martens, Khalid Shoumariyeh, Rosa P Nestor, Sandra Duquesne, Kathrin Hanke, Michal Rackiewicz, Zehan Hu, Nadia El Khawanky, Sanaz Taromi, Hana Andrlova, Hemin Faraidun, Stefanie Walter, Dietmar Pfeifer, Marie Follo, Johannes Waldschmidt, Wolfgang Melchinger, Michael Rassner, Claudia Wehr, Annette Schmitt-Graeff, Sebastian Halbach, James K Liao, Georg Häcker, Tilman Brummer, Joern Dengjel, Geoffroy Andrieux, Robert Grosse, Sonia Tugues, Bruce R Blazar, Burkhard Becher, Melanie Börries, Robert Zeiser
ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease. Nature communications 15 (1) (2024)
Asim Saha, Rahul Palchaudhuri, Leanne Lanieri, Sharon Hyzy, Megan J Riddle, Jamie Panthera, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, Lev Gorfinkel, Victor Tkachev, Ulrike Gerdemann, Francesca Alvarez Calderon, Elisa Rojas Palato, Margaret L MacMillan, John E Wagner, Leslie S Kean, Mark J Osborn, Hans-Peter Kiem, David T Scadden, Lisa M Olson, Bruce R Blazar
Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate-conditioned Fanconi anemia mice. Blood 143 (21) (2024)
Katie E Lineburg, Lucie Leveque-El Mouttie, Christopher R Hunter, Laeitia Le Texier, Crystal McGirr, Bianca Teal, Bruce R Blazar, Steven W Lane, Geoffrey R Hill, Jean-Pierre Levesque, Kelli P A MacDonald
Autophagy prevents graft failure during murine Graft versus Host Disease. Blood advances (2024)
Janaki Manoja Vinnakota, Rachael C Adams, Dimitrios Athanassopoulos, Dominik Schmidt, Francesca Biavasco, Alexander Zähringer, Daniel Erny, Marius Schwabenland, Marlene Langenbach, Valentin Wenger, Henrike Salié, James R Cook, Omar Mossad, Geoffroy Andrieux, Rick Dersch, Sebastian Rauer, Sandra Duquesne, Gianni Monaco, Phillipp Wolf, Thomas Blank, Philipp Häne, Melanie Greter, Burkhard Becher, Philipp Henneke, Dietmar Pfeifer, Bruce R Blazar, Justus Duyster, Melanie Börries, Natalie Stickel, Chintan M Chhatbar, Bertram Bengsch, Marco Prinz, Robert Zeiser
Anti-PD-1 cancer immunotherapy induces central nervous system immune-related adverse events by microglia activation. Science translational medicine 16 (751) (2024)
Jamie Truscott, Xiaoqun Guan, Hope Fury, Tyler Atagozli, Ahmed Metwali, Weiren Liu, Yue Li, Robert W Li, David E Elliott, Bruce R Blazar, M Nedim Ince
After Bone Marrow Transplantation, the Cell-Intrinsic Th2 Pathway Promotes Recipient T Lymphocyte Survival and Regulates Graft-versus-Host Disease. ImmunoHorizons 7 (6) (2023)
Marlene Langenbach, Sophie Giesler, Stefan Richtsfeld, Sara Costa-Pereira, Lukas Rindlisbacher, Tobias Wertheimer, Lukas M Braun, Geoffroy Andrieux, Sandra Duquesne, Dietmar Pfeifer, Nadine M Woessner, Hans D Menssen, Sanaz Taromi, Justus Duyster, Melanie Börries, Tilman Brummer, Bruce R Blazar, Susana Minguet, Patrick Turko, Mitchell Paul Levesque, Burkhard Becher, Robert Zeiser
MDM2 inhibition enhances immune checkpoint inhibitor efficacy by increasing IL-15 and MHC class II production. Molecular cancer research : MCR (2023)
Shernan G Holtan, Constanza Savid-Frontera, Kelly Walton, Anne A Eaton, Connor Demorest, Andrea Hoeschen, Ling Zhang, Kayla M Reid, Tony Kurian, Zena Sayegh, Estefania Julia, Joseph E Maakaron, Veronika Bachanova, Najla El Jurdi, Margaret L MacMillan, Daniel J Weisdorf, Martin Felices, Jeffrey S Miller, Bruce R Blazar, Marco L Davila, Brian C Betts
Human effectors of acute and chronic GVHD overexpress CD83 and predict mortality. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Victor Tkachev, Ashley Vanderbeck, Eric Perkey, Scott N Furlan, Connor McGuckin, Daniela Gómez Atria, Ulrike Gerdemann, Xianliang Rui, Jennifer Lane, Daniel J Hunt, Hengqi Betty Zheng, Lucrezia Colonna, Michelle Hoffman, Alison Yu, Riley Outen, Samantha Kelly, Anneka Allman, Ute Koch, Freddy Radtke, Burkhard Ludewig, Brandon J Burbach, Yoji Shimizu, Angela Panoskaltsis-Mortari, Guoying Chen, Stephen M Carpenter, Olivier Harari, Frank Kuhnert, Gavin Thurston, Bruce R Blazar, Leslie S Kean, Ivan P Maillard
Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates. Science translational medicine 15 (702) (2023)
Shernan G Holtan, Constanza Savid-Frontera, Kelly Walton, Anne A Eaton, Connor Demorest, Andrea Hoeschen, Ling Zhang, Kayla M Reid, Tony Kurian, Zena Sayegh, Estefania Julia, Joseph E Maakaron, Veronika Bachanova, Najla El Jurdi, Margaret L MacMillan, Daniel J Weisdorf, Martin Felices, Jeffrey S Miller, Bruce R Blazar, Marco L Davila, Brian C Betts
Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Teresa Lopes Ramos, Sara Bolivar-Wagers, Sujeong Jin, Govindarajan Thangavelu, Federico Simonetta, Po-Yu Lin, Toshihito Hirai, Asim Saha, Brent H Koehn, Leon L Su, Lora K Picton, Jeanette Baker, Juliane K Lohmeyer, Megan Riddle, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, John E Wagner, K Christopher Garcia, Robert S Negrin, Bruce R Blazar
Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo. Blood 141 (11) (2023)
Shernan G Holtan, Constanza Savid-Frontera, Kelly Walton, Anne A Eaton, Connor Demorest, Andrea Hoeschen, Ling Zhang, Kayla M Reid, Tony Kurian, Zena Sayegh, Estefania Julia, Joseph E Maakaron, Veronika Bachanova, Najla El Jurdi, Margaret L MacMillan, Daniel J Weisdorf, Martin Felices, Jeffrey S Miller, Bruce R Blazar, Marco L Davila, Brian C Betts
Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Victor Tkachev, Ashley Vanderbeck, Eric Perkey, Scott N Furlan, Connor McGuckin, Daniela Gómez Atria, Ulrike Gerdemann, Xianliang Rui, Jennifer Lane, Daniel J Hunt, Hengqi Betty Zheng, Lucrezia Colonna, Michelle Hoffman, Alison Yu, Riley Outen, Samantha Kelly, Anneka Allman, Ute Koch, Freddy Radtke, Burkhard Ludewig, Brandon J Burbach, Yoji Shimizu, Angela Panoskaltsis-Mortari, Guoying Chen, Stephen M Carpenter, Olivier Harari, Frank Kuhnert, Gavin Thurston, Bruce R Blazar, Leslie S Kean, Ivan P Maillard
Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates. Science translational medicine 15 (702) (2023)
Takuto Takahashi, Mahmoud Al-Kofahi, Mutaz Jaber, Brandi Bratrude, Kayla M Betz, Yvonne Suessmuth, Alison Yu, Donna S Neuberg, Sung Won Choi, Jeffrey H Davis, Christine Duncan, Roger H Giller, Michael S Grimley, Andrew C Harris, David A Jacobsohn, Nahal Rose Lalefar, Nosha Farhadfar, Michael A Pulsipher, Shalini Shenoy, Aleksandra Petrovic, Kirk R Schultz, Gregory A Yanik, Bruce R Blazar, John T Horan, Benjamin Watkins, Amelia A Langston, Muna Qayed, Leslie S Kean
Higher Abatacept Exposure Decreases Acute GVHD Risk Without Increasing Adverse Events. Blood (2023)
Shernan G Holtan, Constanza Savid-Frontera, Kelly Walton, Anne A Eaton, Connor Demorest, Andrea Hoeschen, Ling Zhang, Kayla M Reid, Tony Kurian, Zena Sayegh, Estefania Julia, Joseph E Maakaron, Veronika Bachanova, Najla El Jurdi, Margaret L MacMillan, Daniel J Weisdorf, Martin Felices, Jeffrey S Miller, Bruce R Blazar, Marco L Davila, Brian C Betts
Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Shernan G Holtan, Constanza Savid-Frontera, Kelly Walton, Anne A Eaton, Connor Demorest, Andrea Hoeschen, Ling Zhang, Kayla M Reid, Tony Kurian, Zena Sayegh, Estefania Julia, Joseph E Maakaron, Veronika Bachanova, Najla El Jurdi, Margaret L MacMillan, Daniel J Weisdorf, Martin Felices, Jeffrey S Miller, Bruce R Blazar, Marco L Davila, Brian C Betts
Human effectors of acute and chronic GVHD overexpress CD83 and predict mortality. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Shernan G Holtan, Constanza Savid-Frontera, Kelly Walton, Anne A Eaton, Connor Demorest, Andrea Hoeschen, Ling Zhang, Kayla M Reid, Tony Kurian, Zena Sayegh, Estefania Julia, Joseph E Maakaron, Veronika Bachanova, Najla El Jurdi, Margaret L MacMillan, Daniel J Weisdorf, Martin Felices, Jeffrey S Miller, Bruce R Blazar, Marco L Davila, Brian C Betts
Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Teresa Lopes Ramos, Sara Bolivar-Wagers, Sujeong Jin, Govindarajan Thangavelu, Federico Simonetta, Po-Yu Lin, Toshihito Hirai, Asim Saha, Brent H Koehn, Leon L Su, Lora K Picton, Jeanette Baker, Juliane K Lohmeyer, Megan Riddle, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, John E Wagner, K Christopher Garcia, Robert S Negrin, Bruce R Blazar
Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo. Blood 141 (11) (2023)
Victor Tkachev, Ashley Vanderbeck, Eric Perkey, Scott N Furlan, Connor McGuckin, Daniela Gómez Atria, Ulrike Gerdemann, Xianliang Rui, Jennifer Lane, Daniel J Hunt, Hengqi Betty Zheng, Lucrezia Colonna, Michelle Hoffman, Alison Yu, Riley Outen, Samantha Kelly, Anneka Allman, Ute Koch, Freddy Radtke, Burkhard Ludewig, Brandon J Burbach, Yoji Shimizu, Angela Panoskaltsis-Mortari, Guoying Chen, Stephen M Carpenter, Olivier Harari, Frank Kuhnert, Gavin Thurston, Bruce R Blazar, Leslie S Kean, Ivan P Maillard
Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates. Science translational medicine 15 (702) (2023)
Teresa Lopes Ramos, Sara Bolivar-Wagers, Sujeong Jin, Govindarajan Thangavelu, Federico Simonetta, Po-Yu Lin, Toshihito Hirai, Asim Saha, Brent H Koehn, Leon L Su, Lora K Picton, Jeanette Baker, Juliane K Lohmeyer, Megan J Riddle, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, John E Wagner, K Christopher Garcia, Robert S Negrin, Bruce R Blazar
Prevention of acute GVHD disease using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T-cells in vivo. Blood (2022)
Nataliya Prokopenko Buxbaum, Gerard Socié, Geoffrey R Hill, Kelli Pa MacDonald, Victor Tkachev, Takanori Teshima, Stephanie J Lee, Jerome Ritz, Stefanie Sarantopoulos, Leo Luznik, Defu Zeng, Sophie Paczesny, Paul J Martin, Steven Z Pavletic, Kirk R Schultz, Bruce R Blazar
Chronic GvHD NIH Consensus Project Biology Task Force: Evolving path to personalized treatment of chronic GvHD. Blood advances (2022)
Zachariah DeFilipp, Haesook T Kim, Zhongming Yang, John Noonan, Bruce R Blazar, Stephanie J Lee, Steven Z Pavletic, Corey S Cutler
Clinical response to belumosudil in bronchiolitis obliterans syndrome: a combined analysis from 2 prospective trials. Blood advances (2022)
Heather E Stefanski, Yan Xing, Jemma Nicholls, Leslie Jonart, Emily Goren, Patricia A Taylor, Alea A Mills, Megan Riddle, John McGrath, Jakub Tolar, Georg A Hollander, Bruce R Blazar
P63 targeted deletion under the FOXN1 promoter disrupts pre-and post-natal thymus development, function and maintenance as well as induces severe hair loss. PloS one 17 (1) (2022)
Carrie L Kitko, Mukta Arora, Zachariah DeFilipp, Mohammad Abu Zaid, Antonio Di Stasi, Vedran Radojcic, Courtney B Betts, Lisa M Coussens, Michael L Meyers, Hope Qamoos, Peter Ordentlich, Vinit Kumar, Christine Quaranto, Aaron Schmitt, Yu Gu, Bruce R Blazar, Trent P Wang, Amandeep Salhotra, Iskra Pusic, Madan Jagasia, Stephanie J Lee
Axatilimab for Chronic Graft-Versus-Host Disease After Failure of at Least Two Prior Systemic Therapies: Results of a Phase I/II Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
Michael C Zaiken, Ryan Flynn, Katelyn G Paz, Stephanie Y Rhee, Sujeong Jin, Fathima A Mohamed, Asim Saha, Govindarajan Thangavelu, Paul M C Park, Matthew L Hemming, Peter T Sage, Arlene H Sharpe, Michel DuPage, Jeffrey A Bluestone, Angela Panoskaltsis-Mortari, Corey S Cutler, John Koreth, Joseph H Antin, Robert J Soiffer, Jerome Ritz, Leo Luznik, Ivan Maillard, Geoffrey R Hill, Kelli P A MacDonald, David H Munn, Jonathan S Serody, William J Murphy, Leslie S Kean, Yi Zhang, James E Bradner, Jun Qi, Bruce R Blazar
BET-bromodomain and EZH2 inhibitor-treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes. Blood 139 (19) (2022)
Jenny N H G Ho, Dominik Schmidt, Theresa Lowinus, Jeongmin Ryoo, Elaine-Pashupati Dopfer, Nicolás Gonzalo Núñez, Sara Costa-Pereira, Cristina Toffalori, Marco Punta, Viktor Fetsch, Tobias Wertheimer, Marie-Claire Rittmann, Lukas M Braun, Marie Follo, Christelle Briere, Janaki Manoja Vinnakota, Marlene Langenbach, Felicitas Koppers, Khalid Shoumariyeh, Helena Engel, Tamina Rückert, Melanie Märklin, Samuel Holzmayer, Anna L Illert, Federica Magon, Geoffroy Andrieux, Sandra Duquesne, Dietmar Pfeifer, Julian Staniek, Marta Rizzi, Christoph Cornelius Miething, Natalie Stickel, Justus Duyster, Hans D Menssen, Melanie Börries, Joerg M Buescher, Nina Cabezas-Wallscheid, Bruce R Blazar, Petya Apostolova, Luca Vago, Erika L Pearce, Burkhard Becher, Robert Zeiser
Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation. Blood 140 (10) (2022)
Teresa Lopes Ramos, Sara Bolivar-Wagers, Sujeong Jin, Govindarajan Thangavelu, Federico Simonetta, Po-Yu Lin, Toshihito Hirai, Asim Saha, Brent H Koehn, Leon L Su, Lora K Picton, Jeanette Baker, Juliane K Lohmeyer, Megan J Riddle, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, John E Wagner, K Christopher Garcia, Robert S Negrin, Bruce R Blazar
Prevention of acute GVHD disease using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T-cells in vivo. Blood (2022)
Teresa Lopes Ramos, Sara Bolivar-Wagers, Sujeong Jin, Govindarajan Thangavelu, Federico Simonetta, Po-Yu Lin, Toshihito Hirai, Asim Saha, Brent H Koehn, Leon L Su, Lora K Picton, Jeanette Baker, Juliane K Lohmeyer, Megan J Riddle, Cindy R Eide, Jakub Tolar, Angela Panoskaltsis-Mortari, John E Wagner, K Christopher Garcia, Robert S Negrin, Bruce R Blazar
Prevention of acute GVHD disease using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T-cells in vivo. Blood (2022)
Asim Saha, Sharon Hyzy, Tahirih Lamothe, Katelyn Hammond, Nicholas Clark, Leanne Lanieri, Prashant Bhattarai, Rahul Palchaudhuri, Geoffrey O Gillard, Jennifer Proctor, Megan J Riddle, Angela Panoskaltsis-Mortari, Margaret L MacMillan, John E Wagner, Hans-Peter Kiem, Lisa M Olson, Bruce R Blazar
A CD45-targeted antibody-drug conjugate successfully conditions for allogeneic hematopoietic stem cell transplantation in mice. Blood 139 (11) (2022)
Corey Cutler, Stephanie J Lee, Sally Arai, Marcello Rotta, Behyar Zoghi, Aleksander Lazaryan, Aravind Ramakrishnan, Zachariah DeFilipp, Amandeep Salhotra, Wanxing Chai-Ho, Rohtesh Mehta, Trent Wang, Mukta Arora, Iskra Pusic, Ayman Saad, Nirav N Shah, Sunil Abhyankar, Carlos Bachier, John Galvin, Annie Im, Amelia A Langston, Jane Liesveld, Mark B Juckett, Aaron Logan, Levanto Schachter, Asif Alavi, Dianna Howard, Harlan W Waksal, John Ryan, David Eiznhamer, Sanjay K Aggarwal, Jonathan Ieyoub, Olivier Schueller, Laurie Green, Zhongming Yang, Heidi Krenz, Madan Jagasia, Bruce R Blazar, Steven Pavletic
Belumosudil for chronic graft-versus-host disease after 2 or more prior lines of therapy: the ROCKstar Study. Blood 138 (22) (2022)
Lam T Khuat, Catherine T Le, Chien-Chun Steven Pai, Robin R Shields-Cutler, Shernan G Holtan, Armin Rashidi, Sarah L Parker, Dan Knights, Jesus I Luna, Cordelia Dunai, Ziming Wang, Ian R Sturgill, Kevin M Stoffel, Alexander A Merleev, Shyam K More, Emanual Maverakis, Helen E Raybould, Mingyi Chen, Robert J Canter, Arta M Monjazeb, Maneesh Dave, James L M Ferrara, John E Levine, Dan L Longo, Mehrdad Abedi, Bruce R Blazar, William J Murphy
Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation. Science translational medicine 12 (571) (2021)
Zhi-Chun Ding, Huidong Shi, Nada S Aboelella, Kateryna Fesenkova, Eun-Jeong Park, Zhuoqi Liu, Lirong Pei, Jiaqi Li, Richard A McIndoe, Hongyan Xu, Gary A Piazza, Bruce R Blazar, David H Munn, Gang Zhou
Persistent STAT5 activation reprograms the epigenetic landscape in CD4+ T cells to drive polyfunctionality and antitumor immunity. Science immunology 5 (52) (2021)
Frank Cichocki, Ryan Bjordahl, Svetlana Gaidarova, Sajid Mahmood, Ramzey Abujarour, Hongbo Wang, Katie Tuininga, Martin Felices, Zachary B Davis, Laura Bendzick, Raedun Clarke, Laurel Stokely, Paul Rogers, Moyar Ge, Megan Robinson, Betsy Rezner, David L Robbins, Tom T Lee, Dan S Kaufman, Bruce R Blazar, Bahram Valamehr, Jeffrey S Miller
iPSC-derived NK cells maintain high cytotoxicity and enhance in vivo tumor control in concert with T cells and anti-PD-1 therapy. Science translational medicine 12 (568) (2021)
Rachael C Adams, Dylan Carter-Cusack, Samreen N Shaikh, Genesis T Llanes, Rebecca L Johnston, Gregory A Quaife-Ryan, Glen M Boyle, Lambros T Koufariotis, Andreas Möller, Bruce R Blazar, Jana Vukovic, Kelli Pa MacDonald
Donor bone marrow-derived macrophage MHC II drives neuroinflammation and altered behaviour during chronic GVHD in mice. Blood (2021)
Benjamin K Watkins, Muna Qayed, Courtney McCracken, Brandi Bratrude, Kayla Betz, Yvonne Suessmuth, Alison Yu, Shauna Sinclair, Scott N Furlan, Steven Bosinger, Victor Tkachev, James Rhodes, Audrey Grizzle Tumlin, Alexandria Narayan, Kayla Cribbin, Scott Gillespie, Ted A Gooley, Marcelo C Pasquini, Kyle Hebert, Urvi Kapoor, Andre Rogatko, Mourad Tighiouart, Sungjin Kim, Catherine Bresee, Sung Won Choi, Jeffrey H Davis, Christine Duncan, Roger H Giller, Michael S Grimley, Andrew C Harris, David Jacobsohn, Nahal Lalefar, Maxim Norkin, Nosha Farhadfar, Michael A Pulsipher, Shalini Shenoy, Aleksandra Petrovic, Kirk R Schultz, Gregory A Yanik, Edmund K Waller, John E Levine, James L M Ferrara, Bruce R Blazar, Amelia A Langston, John T Horan, Leslie S Kean
Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 39 (17) (2021)
Mehrdad Hefazi, Sara Bolivar-Wagers, Bruce R Blazar
Regulatory T Cell Therapy of Graft-versus-Host Disease: Advances and Challenges. International journal of molecular sciences 22 (18) (2021)
Ashley C Kramer, Yuliana Astuti, Alexis Elfstrum, Michael Jonathan Lehrke, Jakub Tolar, Bruce R Blazar, Amanda L Blake, Mandy E Taisto, Justin W Furcich, Erin E Nolan, Wilaiwan Wisessmith Durose, Beau R Webber, Athena Geisness, David K Wood, Troy C Lund
An irradiated marrow niche reveals a small noncollagenous protein mediator of homing, dermatopontin. Blood advances 5 (18) (2021)
Franziska Maria Uhl, Sophia Chen, David O'Sullivan, Joy Edwards-Hicks, Gesa Richter, Eileen Haring, Geoffroy Andrieux, Sebastian Halbach, Petya Apostolova, Jörg Büscher, Sandra Duquesne, Wolfgang Melchinger, Barbara Sauer, Khalid Shoumariyeh, Annette Schmitt-Graeff, Marina Kreutz, Michael Lübbert, Justus Duyster, Tilman Brummer, Melanie Börries, Tobias Madl, Bruce R Blazar, Olaf Gross, Erika L Pearce, Robert Zeiser
Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans. Science translational medicine 12 (567) (2021)
Danny W Bruce, Oleg Kolupaev, Sonia J Laurie, Hemamalini Bommiasamy, Heather Stefanski, Bruce R Blazar, James M Coghill, Jonathan S Serody
Third-party type 2 innate lymphoid cells prevent and treat GI tract GvHD. Blood advances 5 (22) (2021)
Joseph Pidala, Kelly Walton, Hany Elmariah, Jongphil Kim, Asmita Mishra, Nelli Bejanyan, Taiga Nishihori, Farhad Khimani, Lia Perez, Rawan G Faramand, Marco L Davila, Michael L Nieder, Elizabeth M Sagatys, Shernan G Holtan, Nicholas J Lawrence, Harshani R Lawrence, Bruce R Blazar, Claudio Anasetti, Said M Sebti, Brian C Betts
Pacritinib Combined with Sirolimus and Low-Dose Tacrolimus for GVHD Prevention after Allogeneic Hematopoietic Cell Transplantation: Preclinical and Phase I Trial Results. Clinical cancer research : an official journal of the American Association for Cancer Research 27 (10) (2021)
Ethan G Aguilar, Cordelia Dunai, Sean J Judge, Anthony E Zamora, Lam T Khuat, Logan V Vick, Craig P Collins, Kevin M Stoffel, Maite Alvarez, Isabel Barao, Jeffrey S Miller, Bruce R Blazar, Patrice Chevallier, Christelle Retiere, Robert J Canter, William J Murphy
Activation status dictates the function of unlicensed natural killer cells in mice and humans. Blood advances 5 (20) (2021)
Madan Jagasia, Aleksander Lazaryan, Carlos R Bachier, Amandeep Salhotra, Daniel J Weisdorf, Behyar Zoghi, James Essell, Laurie Green, Olivier Schueller, Jeegar Patel, Alexandra Zanin-Zhorov, Jonathan M Weiss, Zhongming Yang, David Eiznhamer, Sanjay K Aggarwal, Bruce R Blazar, Stephanie J Lee
ROCK2 Inhibition With Belumosudil (KD025) for the Treatment of Chronic Graft-Versus-Host Disease. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 39 (17) (2021)
Victor Tkachev, James Kaminski, E Lake Potter, Scott N Furlan, Alison Yu, Daniel J Hunt, Connor McGuckin, Hengqi Betty Zheng, Lucrezia Colonna, Ulrike Gerdemann, Judith Carlson, Michelle Hoffman, Joe Olvera, Chris English, Audrey Baldessari, Angela Panoskaltsis-Mortari, Benjamin K Watkins, Muna Qayed, Yvonne Suessmuth, Kayla Betz, Brandi Bratrude, Amelia A Langston, John T Horan, José Ordovas-Montañes, Alex K Shalek, Bruce R Blazar, Mario Roederer, Leslie S Kean
Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8+ T cells drive gastrointestinal acute graft-versus-host disease. Science translational medicine 13 (576) (2021)
Djamilatou Adom, Stacey R Dillon, Jinfeng Yang, Hao Liu, Abdulraouf Ramadan, Kushi Kushekhar, Samantha Hund, Amanda Albright, Maykala Kirksey, Titilayo Adeniyan, Katherine E Lewis, Lawrence Evans, Rebecca Wu, Steven D Levin, Sherri Mudri, Jing Yang, Erika Rickel, Michelle Seaberg, Katherine Henderson, Chelsea J Gudgeon, Martin F Wolfson, Ryan M Swanson, Kristine M Swiderek, Stanford L Peng, Keli L Hippen, Bruce R Blazar, Sophie Paczesny
ICOSL+ plasmacytoid dendritic cells as inducer of graft-versus-host disease, responsive to a dual ICOS/CD28 antagonist. Science translational medicine 12 (564) (2021)
Nancy Danielle Ebelt, Vic Zamloot, Edith Zuniga, Kevin B Passi, Lukas J Sobocinski, Cari A Young, Bruce R Blazar, Edwin R Manuel
Collagenase-Expressing Salmonella Targets Major Collagens in Pancreatic Cancer Leading to Reductions in Immunosuppressive Subsets and Tumor Growth. Cancers 13 (14) (2021)
Lam T Khuat, Logan V Vick, Cordelia Dunai, Craig P Collins, Shyam K More, Catherine T Le, Chien-Chun Steven Pai, Kevin M Stoffel, Emanual Maverakis, Robert J Canter, Arta M Monjazeb, Dan L Longo, Mehrdad Abedi, Eunju Choi, Bruce R Blazar, Maneesh Dave, William J Murphy
Increased efficacy of dual pro-inflammatory cytokine blockade on acute GVHD while maintaining GVT effects. Blood (2021)
Andrea S Henden, Motoko Koyama, Renee J Robb, Adriana Forero, Rachel D Kuns, Karshing Chang, Kathleen S Ensbey, Antiopi Varelias, Stephen H Kazakoff, Nicole Waddell, Andrew D Clouston, Rabina Giri, Jacob Begun, Bruce R Blazar, Mariapia A Degli-Esposti, Sergei V Kotenko, Steven W Lane, Kate L Ormerod, Ram Savan, Philip Hugenholtz, Kate H Gartlan, Geoffrey R Hill
IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease. Blood 138 (8) (2021)
Zachariah DeFilipp, Mehrdad Hefazi, Yi-Bin Chen, Bruce R Blazar
Emerging approaches to improve allogeneic hematopoietic cell transplantation outcomes for non-malignant diseases. Blood (2021)
Mark J Osborn, Akshay Bhardwaj, Samuel P Bingea, Friederike Knipping, Colby J Feser, Christopher J Lees, Daniel P Collins, Clifford J Steer, Bruce R Blazar, Jakub Tolar
CRISPR/Cas9-Based Lateral Flow and Fluorescence Diagnostics. Bioengineering (Basel, Switzerland) 8 (2) (2021)
Robert B Levy, Hazem M Mousa, Casey O Lightbourn, Eric J Shiuey, David Latoni, Stephanie Duffort, Ryan Flynn, Jing Du, Henry Barreras, Michael C Zaiken, Katelyn Paz, Bruce R Blazar, Victor L Perez
Analyses and Correlation of Pathologic and Ocular Cutaneous Changes in Murine Graft versus Host Disease. International journal of molecular sciences 23 (1) (2021)
Cameron S Bader, Henry Barreras, Casey O Lightbourn, Sabrina N Copsel, Dietlinde Wolf, Jingjing Meng, Jeonghyun Ahn, Krishna V Komanduri, Bruce R Blazar, Lei Jin, Glen N Barber, Sabita Roy, Robert B Levy
STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets. Science translational medicine 12 (552) (2021)
Yanbao Xiong, Wenji Piao, C Colin Brinkman, Lushen Li, Joseph M Kulinski, Ana Olivera, Andreane Cartier, Timothy Hla, Keli L Hippen, Bruce R Blazar, Susan R Schwab, Jonathan S Bromberg
CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration. Science immunology 4 (33) (2020)
Mohamed A ElTanbouly, Yanding Zhao, Elizabeth C Nowak, Jiannan Li, Evelien Schaafsma, Isabelle Le Mercier, Sabrina Ceeraz, J Louise Lines, Changwei Peng, Catherine Carriere, Xin Huang, Maria Day, Brent H Koehn, Sam W Lee, Milagros Silva Morales, Kristin A Hogquist, Stephen C Jameson, Daniel L Mueller, Jay Rothstein, Bruce R Blazar, Chao Cheng, Randolph J Noelle
VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance. Science (New York, N.Y.) 367 (6475) (2020)
Bruce R Blazar, Geoffrey R Hill, William J Murphy
Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD. Nature reviews. Clinical oncology 17 (8) (2020)
Eric Perkey, Dave Maurice De Sousa, Léolène J Carrington, Jooho Chung, Alexander Dils, David Granadier, Ute Koch, Freddy Radtke, Burkhard Ludewig, Bruce R Blazar, Christian W Siebel, Todd V Brennan, Jeffrey C Nolz, Nathalie Labrecque, Ivan P Maillard
GCNT1-Mediated O-Glycosylation of the Sialomucin CD43 Is a Sensitive Indicator of Notch Signaling in Activated T Cells. Journal of immunology (Baltimore, Md. : 1950) 204 (6) (2020)
Ranjeet K Sinha, Ryan Flynn, Michael C Zaiken, Katelyn Paz, Amanda L Gavin, David Nemazee, José A Fernández, Xiao Xu, John H Griffin, Bruce R Blazar
Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells. Blood 134 (9) (2019)
Govindarajan Thangavelu, Yu-Chi Lee, Michael Loschi, K Melanie Schaechter, Colby J Feser, Brent H Koehn, Elizabeth C Nowak, Robert Zeiser, Jonathan S Serody, William J Murphy, David H Munn, Pierre Chambon, Randolph J Noelle, Bruce R Blazar
Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality. Journal of immunology (Baltimore, Md. : 1950) 202 (9) (2019)
Shenda Hou, Rachel L Clement, Alos Diallo, Bruce R Blazar, Alexander Y Rudensky, Arlene H Sharpe, Peter T Sage
FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program. The Journal of experimental medicine 216 (3) (2019)
Jooho Chung, Vedran Radojcic, Eric Perkey, Timothy J Parnell, Yashar Niknafs, Xi Jin, Ann Friedman, Nathalie Labrecque, Bruce R Blazar, Todd V Brennan, Christian W Siebel, Ivan P Maillard
Early Notch Signals Induce a Pathogenic Molecular Signature during Priming of Alloantigen-Specific Conventional CD4+ T Cells in Graft-versus-Host Disease. Journal of immunology (Baltimore, Md. : 1950) 203 (2) (2019)
Alessandro Prestipino, Alica J Emhardt, Konrad Aumann, David O'Sullivan, Sivahari P Gorantla, Sandra Duquesne, Wolfgang Melchinger, Lukas M Braun, Slavica Vuckovic, Melanie Boerries, Hauke Busch, Sebastian Halbach, Sandra Pennisi, Teresa Poggio, Petya Apostolova, Pia Veratti, Michael Hettich, Gabriele Niedermann, Mark D Bartholomä, Khalid Shoumariyeh, Jonas Samuel Jutzi, Julius Wehrle, Christine Dierks, Heiko Becker, Annette Schmitt-Graeff, Marie Follo, Dietmar Pfeifer, Jan C Rohr, Sebastian Fuchs, Stephan Ehl, Frederike A Hartl, Susana Minguet, Christoph Cornelius Miething, Florian H Heidel, Nicolaus M Kröger, Ioanna Triviai, Tilman Brummer, Jürgen Finke, Anna L Illert, Eliana Ruggiero, Chiara Bonini, Justus Duyster, Heike Luise Pahl, Steven W Lane, Geoffrey R Hill, Bruce R Blazar, Nikolas von Bubnoff, Erika L Pearce, Robert Zeiser
Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms. Science translational medicine 10 (429) (2019)
Samantha M Jaglowski, Bruce R Blazar
How ibrutinib, a B-cell malignancy drug, became an FDA-approved second-line therapy for steroid-resistant chronic GVHD. Blood advances 2 (15) (2019)
Yue Li, Weiren Liu, Xiaqun Guan, Jamie Truscott, John W M Creemers, Hung-Lin Chen, Marko Pesu, Rami El Abiad, Bahri Karacay, Joseph F Urban, David E Elliott, Mark H Kaplan, Bruce R Blazar, M Nedim Ince
STAT6 and Furin Are Successive Triggers for the Production of TGF-β by T Cells. Journal of immunology (Baltimore, Md. : 1950) 201 (9) (2018)
Jing Du, Ryan Flynn, Katelyn Paz, Hong-Gang Ren, Yuko Ogata, Qing Zhang, Philip R Gafken, Barry E Storer, Nathan H Roy, Janis K Burkhardt, Wendy Mathews, Jakub Tolar, Stephanie J Lee, Bruce R Blazar, Sophie Paczesny
Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients. Blood 131 (15) (2018)
Victor Tkachev, Scott N Furlan, Benjamin Watkins, Daniel J Hunt, Hengqi Betty Zheng, Angela Panoskaltsis-Mortari, Kayla Betz, Melanie Brown, John B Schell, Katie Zeleski, Alison Yu, Ian Kirby, Sarah Cooley, Jeffrey S Miller, Bruce R Blazar, Duncan Casson, Phil Bland-Ward, Leslie S Kean
Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant. Science translational medicine 9 (408) (2018)
Nina C Zitzer, Katiri Snyder, Xiamoei Meng, Patricia A Taylor, Yvonne A Efebera, Steven M Devine, Bruce R Blazar, Ramiro Garzon, Parvathi Ranganathan
MicroRNA-155 Modulates Acute Graft-versus-Host Disease by Impacting T Cell Expansion, Migration, and Effector Function. Journal of immunology (Baltimore, Md. : 1950) 200 (12) (2018)
Yan Xing, Michelle J Smith, Christine A Goetz, Ron T McElmurry, Sarah L Parker, Dullei Min, Georg A Hollander, Kenneth I Weinberg, Jakub Tolar, Heather E Stefanski, Bruce R Blazar
Thymic Epithelial Cell Support of Thymopoiesis Does Not Require Klotho. Journal of immunology (Baltimore, Md. : 1950) 201 (11) (2018)
David L Owen, Shawn A Mahmud, Kieng B Vang, Ryan M Kelly, Bruce R Blazar, Kendall A Smith, Michael A Farrar
Identification of Cellular Sources of IL-2 Needed for Regulatory T Cell Development and Homeostasis. Journal of immunology (Baltimore, Md. : 1950) 200 (12) (2018)
Bhavana Priyadharshini, Michael Loschi, Ryan H Newton, Jian-Wen Zhang, Kelsey K Finn, Valerie A Gerriets, Alexandria Huynh, Jeffery C Rathmell, Bruce R Blazar, Laurence A Turka
Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets. Journal of immunology (Baltimore, Md. : 1950) 201 (8) (2018)
Yue Li, Xiaoqun Guan, Weiren Liu, Hung-Lin Chen, Jamie Truscott, Sonay Beyatli, Ahmed Metwali, George J Weiner, Nicholas Zavazava, Richard S Blumberg, Joseph F Urban, Bruce R Blazar, David E Elliott, M Nedim Ince
Helminth-Induced Production of TGF-β and Suppression of Graft-versus-Host Disease Is Dependent on IL-4 Production by Host Cells. Journal of immunology (Baltimore, Md. : 1950) 201 (10) (2018)
Frank Cichocki, Cheng-Ying Wu, Bin Zhang, Martin Felices, Bianca Tesi, Katie Tuininga, Phillip Dougherty, Emily Taras, Peter Hinderlie, Bruce R Blazar, Yenan T Bryceson, Jeffrey S Miller
ARID5B regulates metabolic programming in human adaptive NK cells. The Journal of experimental medicine 215 (9) (2018)
Ruan Zhang, Peter T Sage, Kelsey Finn, Alexandria Huynh, Bruce R Blazar, Francesco Marangoni, Thorsten R Mempel, Arlene H Sharpe, Laurence A Turka
B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. Journal of immunology (Baltimore, Md. : 1950) 199 (12) (2017)

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Bruce R Blazar