David N Cooper

ResearcherID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 39

Top Venues

Nature communications

Nature genetics

Proceedings of the National Academy of Sciences of the United States of America

Genes

Cardiff University School of Medicine

University of Edinburgh (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Cardiff University School of Medicine Nov 01 1995

United Kingdom

Professor of Human Molecular Genetics :: Institute of Medical Genetics

Education History

University of Edinburgh Oct 01 1979 - Feb 28 1983

United Kingdom

PHD :: MRC Mammalian Genome Unit

Publications

Áine Duffy, Ben Omega Petrazzini, David Stein, Joshua K Park, Iain S Forrest, Kyle Gibson, Ha My Vy, Robert Chen, Carla Márquez-Luna, Matthew Mort, Marie Verbanck, Avner Schlessinger, Yuval Itan, David N Cooper, Ghislain Rocheleau, Daniel M Jordan, Ron Do
Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications. Nature genetics 56 (1) (2024)
Áine Duffy, Ben Omega Petrazzini, David Stein, Joshua K Park, Iain S Forrest, Kyle Gibson, Ha My Vy, Robert Chen, Carla Márquez-Luna, Matthew Mort, Marie Verbanck, Avner Schlessinger, Yuval Itan, David N Cooper, Ghislain Rocheleau, Daniel M Jordan, Ron Do
Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications. Nature genetics 56 (1) (2024)
Áine Duffy, Ben Omega Petrazzini, David Stein, Joshua K Park, Iain S Forrest, Kyle Gibson, Ha My Vy, Robert Chen, Carla Márquez-Luna, Matthew Mort, Marie Verbanck, Avner Schlessinger, Yuval Itan, David N Cooper, Ghislain Rocheleau, Daniel M Jordan, Ron Do
Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications. Nature genetics 56 (1) (2024)
Áine Duffy, Ben Omega Petrazzini, David Stein, Joshua K Park, Iain S Forrest, Kyle Gibson, Ha My Vy, Robert Chen, Carla Márquez-Luna, Matthew Mort, Marie Verbanck, Avner Schlessinger, Yuval Itan, David N Cooper, Ghislain Rocheleau, Daniel M Jordan, Ron Do
Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications. Nature genetics (2024)
Áine Duffy, Ben Omega Petrazzini, David Stein, Joshua K Park, Iain S Forrest, Kyle Gibson, Ha My Vy, Robert Chen, Carla Márquez-Luna, Matthew Mort, Marie Verbanck, Avner Schlessinger, Yuval Itan, David N Cooper, Ghislain Rocheleau, Daniel M Jordan, Ron Do
Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications. Nature genetics 56 (1) (2024)
Áine Duffy, Ben Omega Petrazzini, David Stein, Joshua K Park, Iain S Forrest, Kyle Gibson, Ha My Vy, Robert Chen, Carla Márquez-Luna, Matthew Mort, Marie Verbanck, Avner Schlessinger, Yuval Itan, David N Cooper, Ghislain Rocheleau, Daniel M Jordan, Ron Do
Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications. Nature genetics 56 (1) (2024)
Yang Zhou, Xiaoyu Zhan, Jiazheng Jin, Long Zhou, Juraj Bergman, Xuemei Li, Marjolaine Marie C Rousselle, Meritxell Riera Belles, Lan Zhao, Miaoquan Fang, Jiawei Chen, Qi Fang, Lukas F K Kuderna, Tomas Marques-Bonet, Haruka Kitayama, Takashi Hayakawa, Yong-Gang Yao, Huanming Yang, David N Cooper, Xiao-Guang Qi, Dong-Dong Wu, Mikkel Heide Schierup, Guo-Jie Zhang
Eighty million years of rapid evolution of the primate Y chromosome. Nature ecology & evolution (2023)
Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman T Van Vleck, Girish Nitin Nadkarni, Lee A Denson, Harry Ostrer, Adam P Levine, Elena R Schiff, Anthony Walter Segal, Subra Kugathasan, Peter D Stenson, David N Cooper, L Philip Schumm, Scott B Snapper, Mark J Daly, Talin Haritunians, Richard H Duerr, Mark S Silverberg, John D Rioux, Steven R Brant, Dermot P B McGovern, Judy H Cho, Yuval Itan
Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients. Nature communications 14 (1) (2023)
Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman T Van Vleck, Girish Nitin Nadkarni, Lee A Denson, Harry Ostrer, Adam P Levine, Elena R Schiff, Anthony Walter Segal, Subra Kugathasan, Peter D Stenson, David N Cooper, L Philip Schumm, Scott B Snapper, Mark J Daly, Talin Haritunians, Richard H Duerr, Mark S Silverberg, John D Rioux, Steven R Brant, Dermot P B McGovern, Judy H Cho, Yuval Itan
Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients. Nature communications 14 (1) (2023)
Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman T Van Vleck, Girish Nitin Nadkarni, Lee A Denson, Harry Ostrer, Adam P Levine, Elena R Schiff, Anthony Walter Segal, Subra Kugathasan, Peter D Stenson, David N Cooper, L Philip Schumm, Scott B Snapper, Mark J Daly, Talin Haritunians, Richard H Duerr, Mark S Silverberg, John D Rioux, Steven R Brant, Dermot P B McGovern, Judy H Cho, Yuval Itan
Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients. Nature communications 14 (1) (2023)
Yong Shao, Long Zhou, Fang Li, Lan Zhao, Bao-Lin Zhang, Feng Shao, Jia-Wei Chen, Chun-Yan Chen, Xupeng Bi, Xiao-Lin Zhuang, Hong-Liang Zhu, Jiang Hu, Zongyi Sun, Xin Li, De-Peng Wang, Iker Rivas-González, Sheng Wang, Yun-Mei Wang, Wu Chen, Gang Li, Hui-Meng Lu, Yang Liu, Lukas F K Kuderna, Kyle Kai-How Farh, Peng-Fei Fan, Li Yu, Ming Li, Zhi-Jin Liu, George P Tiley, Anne D Yoder, Christian Roos, Takashi Hayakawa, Tomas Marques-Bonet, Jeffrey Rogers, Peter D Stenson, David N Cooper, Mikkel Heide Schierup, Yong-Gang Yao, Ya-Ping Zhang, Wen Wang, Xiao-Guang Qi, Guo-Jie Zhang, Dong-Dong Wu
Phylogenomic analyses provide insights into primate evolution. Science (New York, N.Y.) 380 (6648) (2023)
Peng Zhang, Matthieu Chaldebas, Masato Ogishi, Fahd Al Qureshah, Khoren Ponsin, Yi Feng, Darawan Rinchai, Baptiste Milisavljevic, Ji Eun Han, Marcela Moncada-Vélez, Sevgi Keles, Bernd Schröder, Peter D Stenson, David N Cooper, Aurélie Cobat, Bertrand Boisson, Qian Zhang, Stéphanie Boisson-Dupuis, Laurent Abel, Jean Laurent Casanova
Genome-wide detection of human intronic AG-gain variants located between splicing branchpoints and canonical splice acceptor sites. Proceedings of the National Academy of Sciences of the United States of America 120 (46) (2023)
Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman T Van Vleck, Girish Nitin Nadkarni, Lee A Denson, Harry Ostrer, Adam P Levine, Elena R Schiff, Anthony Walter Segal, Subra Kugathasan, Peter D Stenson, David N Cooper, L Philip Schumm, Scott B Snapper, Mark J Daly, Talin Haritunians, Richard H Duerr, Mark S Silverberg, John D Rioux, Steven R Brant, Dermot P B McGovern, Judy H Cho, Yuval Itan
Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients. Nature communications 14 (1) (2023)
Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman T Van Vleck, Girish Nitin Nadkarni, Lee A Denson, Harry Ostrer, Adam P Levine, Elena R Schiff, Anthony Walter Segal, Subra Kugathasan, Peter D Stenson, David N Cooper, L Philip Schumm, Scott B Snapper, Mark J Daly, Talin Haritunians, Richard H Duerr, Mark S Silverberg, John D Rioux, Steven R Brant, Dermot P B McGovern, Judy H Cho, Yuval Itan
Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients. Nature communications 14 (1) (2023)
Xupeng Bi, Long Zhou, Jin-Jin Zhang, Shaohong Feng, Mei Hu, David N Cooper, Jiangwei Lin, Jiali Li, Dong-Dong Wu, Guo-Jie Zhang
Lineage-specific accelerated sequences underlying primate evolution. Science advances 9 (22) (2023)
Bao-Lin Zhang, Wu Chen, Zefu Wang, Wei Pang, Meng-Ting Luo, Sheng Wang, Yong Shao, Wen-Qiang He, Yuan Deng, Long Zhou, Jiawei Chen, Min-Min Yang, Yajiang Wu, Lu Wang, Hugo Fernández-Bellon, Sandra Molloy, Hélène Meunier, Fanélie Wanert, Lukas F K Kuderna, Tomas Marques-Bonet, Christian Roos, Xiao-Guang Qi, Ming Li, Zhijin Liu, Mikkel Heide Schierup, David N Cooper, Jian-Quan Liu, Yong-Tang Zheng, Guo-Jie Zhang, Dong-Dong Wu
Comparative genomics reveals the hybrid origin of a macaque group. Science advances 9 (22) (2023)
Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman T Van Vleck, Girish Nitin Nadkarni, Lee A Denson, Harry Ostrer, Adam P Levine, Elena R Schiff, Anthony Walter Segal, Subra Kugathasan, Peter D Stenson, David N Cooper, L Philip Schumm, Scott B Snapper, Mark J Daly, Talin Haritunians, Richard H Duerr, Mark S Silverberg, John D Rioux, Steven R Brant, Dermot P B McGovern, Judy H Cho, Yuval Itan
Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients. Nature communications 14 (1) (2023)
Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman T Van Vleck, Girish Nitin Nadkarni, Lee A Denson, Harry Ostrer, Adam P Levine, Elena R Schiff, Anthony Walter Segal, Subra Kugathasan, Peter D Stenson, David N Cooper, L Philip Schumm, Scott B Snapper, Mark J Daly, Talin Haritunians, Richard H Duerr, Mark S Silverberg, John D Rioux, Steven R Brant, Dermot P B McGovern, Judy H Cho, Yuval Itan
Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients. Nature communications 14 (1) (2023)
Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman T Van Vleck, Girish Nitin Nadkarni, Lee A Denson, Harry Ostrer, Adam P Levine, Elena R Schiff, Anthony Walter Segal, Subra Kugathasan, Peter D Stenson, David N Cooper, L Philip Schumm, Scott B Snapper, Mark J Daly, Talin Haritunians, Richard H Duerr, Mark S Silverberg, John D Rioux, Steven R Brant, Dermot P B McGovern, Judy H Cho, Yuval Itan
Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients. Nature communications 14 (1) (2023)
Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman T Van Vleck, Girish Nitin Nadkarni, Lee A Denson, Harry Ostrer, Adam P Levine, Elena R Schiff, Anthony Walter Segal, Subra Kugathasan, Peter D Stenson, David N Cooper, L Philip Schumm, Scott B Snapper, Mark J Daly, Talin Haritunians, Richard H Duerr, Mark S Silverberg, John D Rioux, Steven R Brant, Dermot P B McGovern, Judy H Cho, Yuval Itan
Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients. Nature communications 14 (1) (2023)
Wen-Bin Zou, David N Cooper, Emmanuelle Masson, Na Pu, Zhuan Liao, Claude Férec, Jian-Min Chen
Trypsinogen (PRSS1 and PRSS2) gene dosage correlates with pancreatitis risk across genetic and transgenic studies: a systematic review and re-analysis. Human genetics 141 (8) (2022)
Peng Zhang, Quentin Philippot, Weicheng Ren, Wei-Te Lei, Juan Li, Peter D Stenson, Pere Soler Palacín, Roger Colobran, Bertrand Boisson, Shen-Ying Zhang, Anne Puel, Qiang Pan-Hammarström, Qian Zhang, David N Cooper, Laurent Abel, Jean Laurent Casanova
Genome-wide detection of human variants that disrupt intronic branchpoints. Proceedings of the National Academy of Sciences of the United States of America 119 (44) (2022)
Meltem Ece Kars, Ayse Nazli Basak, Onur Emre Onat, Kaya Bilguvar, Jungmin Choi, Yuval Itan, Caner Çağlar, Robin Palvadeau, Jean Laurent Casanova, David N Cooper, Peter D Stenson, Alper Yavuz, Hakan Buluş, Murat Günel, Jeffrey M Friedman, Tayfun Özçelik
The genetic structure of the Turkish population reveals high levels of variation and admixture. Proceedings of the National Academy of Sciences of the United States of America 118 (36) (2022)
Ming-Li Li, Sheng Wang, Penghui Xu, Hang-Yu Tian, Mixue Bai, Ya-Ping Zhang, Yong Shao, Zi-Jun Xiong, Xiao-Guang Qi, David N Cooper, Guo-Jie Zhang, He Helen Zhu, Dong-Dong Wu
Functional genomics analysis reveals the evolutionary adaptation and demographic history of pygmy lorises. Proceedings of the National Academy of Sciences of the United States of America 119 (40) (2022)
Dan He, Cong Fan, Mengling Qi, Yuedong Yang, David N Cooper, Huiying Zhao
Prioritization of schizophrenia risk genes from GWAS results by integrating multi-omics data. Translational psychiatry 11 (1) (2021)
Robin Steinhaus, Sebastian Proft, Markus Schuelke, David N Cooper, Jana Marie Schwarz, Dominik Seelow
MutationTaster2021. Nucleic acids research 49 (W1) (2021)
Johannes Birgmeier, Maximilian Haeussler, Cole A Deisseroth, Ethan H Steinberg, Karthik A Jagadeesh, Alexander J Ratner, Harendra Guturu, Aaron M Wenger, Mark E Diekhans, Peter D Stenson, David N Cooper, Christopher Ré, Alan H Beggs, Jonathan A Bernstein, Gill Bejerano
AMELIE speeds Mendelian diagnosis by matching patient phenotype and genotype to primary literature. Science translational medicine 12 (544) (2021)
Jian-Min Chen, Anthony Francis Herzig, French Exome Consortium, Emmanuelle Masson, David N Cooper, Claude Férec
Scale and Scope of Gene-Alcohol Interactions in Chronic Pancreatitis: A Systematic Review. Genes 12 (4) (2021)
Hildegard Kehrer-Sawatzki, Ute Wahlländer, David N Cooper, Victor-Felix Mautner
Atypical NF1 Microdeletions: Challenges and Opportunities for Genotype/Phenotype Correlations in Patients with Large NF1 Deletions. Genes 12 (10) (2021)
Na Pu, Emmanuelle Masson, David N Cooper, French Exome Consortium, Claude Férec, Jian-Min Chen
Chronic Pancreatitis: The True Pathogenic Culprit within the SPINK1 N34S-Containing Haplotype Is No Longer at Large. Genes 12 (11) (2021)
Mónica Lopes-Marques, Ana Rita Pacheco, Maria João Peixoto, Ana Rita Cardoso, Catarina Serrano, Antonio Amorim, Maria João Prata, David N Cooper, Luisa Azevedo
Common polymorphic OTC variants can act as genetic modifiers of enzymatic activity. Human mutation 42 (8) (2021)
Antonio Rausell, Yufei Luo, Marie Lopez, Yoann Seeleuthner, Franck Rapaport, Antoine Favier, Peter D Stenson, David N Cooper, Etienne Patin, Jean-Laurent Casanova, Lluis Quintana-Murci, Laurent Abel
Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes. Proceedings of the National Academy of Sciences of the United States of America 117 (24) (2020)
Vikas Pejaver, Jorge Urresti, Jose Lugo-Martinez, Kymberleigh A Pagel, Guan Ning Lin, Hyun-Jun Nam, Matthew Mort, David N Cooper, Jonathan Sebat, Lilia M Iakoucheva, Sean D Mooney, Predrag Radivojac
Inferring the molecular and phenotypic impact of amino acid variants with MutPred2. Nature communications 11 (1) (2020)
Jin-Huan Lin, Emmanuelle Masson, Arnaud Boulling, Matthew Hayden, David N Cooper, Claude Férec, Zhuan Liao, Jian-Min Chen
5' splice site GC>GT and GT>GC variants differ markedly in terms of their functionality and pathogenicity. Human mutation 41 (8) (2020)
Anthony F Herzig, French Exome Consortium, David N Cooper, Emmanuelle Masson, Claude Férec, Jian-Min Chen
Role of the Common PRSS1-PRSS2 Haplotype in Alcoholic and Non-Alcoholic Chronic Pancreatitis: Meta- and Re-Analyses. Genes 11 (11) (2020)
Xiao-Lei Shi, Qi Yang, Na Pu, Xiao-Yao Li, Wei-Wei Chen, Jing Zhou, Gang Li, Zhi-Hui Tong, Claude Férec, David N Cooper, Jian-Min Chen, Wei-Qin Li
Identification and functional characterization of a novel heterozygous missense variant in the LPL associated with recurrent hypertriglyceridemia-induced acute pancreatitis in pregnancy. Molecular genetics & genomic medicine 8 (3) (2020)
Karthik A Jagadeesh, Joseph M Paggi, James S Ye, Peter D Stenson, David N Cooper, Jonathan A Bernstein, Gill Bejerano
S-CAP extends pathogenicity prediction to genetic variants that affect RNA splicing. Nature genetics 51 (4) (2019)
Robert Fragoza, Jishnu Das, Shayne D Wierbowski, Jin Liang, Tina N Tran, Siqi Liang, Juan F Beltran, Christen A Rivera-Erick, Kaixiong Ye, Jean-Philippe Pellois, Li Yao, Matthew Mort, Peter D Stenson, David N Cooper, Xiaomu Wei, Alon Keinan, John C Schimenti, Andrew G Clark, Haiyuan Yu
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Nature communications 10 (1) (2019)
Karthik A Jagadeesh, Aaron M Wenger, Mark J Berger, Harendra Guturu, Peter D Stenson, David N Cooper, Jonathan A Bernstein, Gill Bejerano
M-CAP eliminates a majority of variants of uncertain significance in clinical exomes at high sensitivity. Nature genetics 48 (12) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

David N Cooper