Jark Böttcher

ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 22

Top Venues

ChemMedChem

Archiv der Pharmazie

Nature chemical biology

RSC medicinal chemistry

Boehringer Ingelheim RCV GmbH & Co KG

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Boehringer Ingelheim RCV GmbH & Co KG Jun 01 2012

Austria

Senior Principal Scientist

Proteros biostructures GmbH Apr 01 2008 - May 31 2012

Germany

Research Scientist

Philipp University of Marburg Sep 01 2004 - Mar 31 2008

Germany

PhD Student :: Pharmazie

Publications

Jark Böttcher, Julian E Fuchs, Moriz Mayer, Jan Kahmann, Krzysztof M Zak, Tobias Wunberg, Simon Wöhrle, Dirk Kessler
Ligandability assessment of the C-terminal Rel-homology domain of NFAT1. Archiv der Pharmazie 357 (6) (2024)
Lena Münzker, Serah W Kimani, Milan M Fowkes, Aiping Dong, Hong Zheng, Yanjun Li, Morgan Dasovich, Krzysztof M Zak, Anthony K L Leung, Jonathan M Elkins, Dirk Kessler, Cheryl H Arrowsmith, Levon Halabelian, Jark Böttcher
A ligand discovery toolbox for the WWE domain family of human E3 ligases. Communications biology 7 (1) (2024)
Jark Böttcher, Julian E Fuchs, Moriz Mayer, Jan Kahmann, Krzysztof M Zak, Tobias Wunberg, Simon Wöhrle, Dirk Kessler
Ligandability assessment of the C-terminal Rel-homology domain of NFAT1. Archiv der Pharmazie 357 (6) (2024)
Lena Münzker, Serah W Kimani, Milan M Fowkes, Aiping Dong, Hong Zheng, Yanjun Li, Morgan Dasovich, Krzysztof M Zak, Anthony K L Leung, Jonathan M Elkins, Dirk Kessler, Cheryl H Arrowsmith, Levon Halabelian, Jark Böttcher
A ligand discovery toolbox for the WWE domain family of human E3 ligases. Communications biology 7 (1) (2024)
Jark Böttcher, Julian E Fuchs, Moriz Mayer, Jan Kahmann, Krzysztof M Zak, Tobias Wunberg, Simon Wöhrle, Dirk Kessler
Ligandability assessment of the C-terminal Rel-homology domain of NFAT1. Archiv der Pharmazie (2024)
Paola Martinelli, Otmar Schaaf, Andreas Mantoulidis, Laetitia J Martin, Julian E Fuchs, Gerd Bader, Andreas Gollner, Bernhard Wolkerstorfer, Catherine Rogers, Esra Balıkçı, Jesse J Lipp, Nikolai Mischerikow, Sandra Doebel, Thomas Gerstberger, Wolfgang Sommergruber, Kilian V M Huber, Jark Böttcher
Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments. ChemMedChem 18 (6) (2023)
Suzanne Ackloo, Albert A Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex N Bullock, Ulrich A K Betz, Jark Böttcher, Peter J Brown, Menorca Chaturvedi, Alisa Crisp, Danette L Daniels, Jan Dreher, Kristina Edfeldt, Aled Morgan Edwards, Ursula Egner, Jon Elkins, Christian Fischer, Tine Glendorf, Steven Goldberg, Ingo V Hartung, Alexander Hillisch, Evert J Homan, Stefan Knapp, Markus Köster, Oliver Krämer, Josep Llaveria, Uta Lessel, Sven Lindemann, Lars Linderoth, Hisanori Matsui, Maurice Michel, Florian Montel, Anke Mueller-Fahrnow, Susanne Müller, Dafydd R Owen, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Wendy Sanderson, Cora Scholten, Matthieu Schapira, Sujata Sharma, Brock Shireman, Michael Sundström, Matthew H Todd, Claudia Tredup, Jennifer Venable, Timothy M Willson, Cheryl H Arrowsmith
Target 2035 - an update on private sector contributions. RSC medicinal chemistry 14 (6) (2023)
Suzanne Ackloo, Albert A Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex N Bullock, Ulrich A K Betz, Jark Böttcher, Peter J Brown, Menorca Chaturvedi, Alisa Crisp, Danette L Daniels, Jan Dreher, Kristina Edfeldt, Aled Morgan Edwards, Ursula Egner, Jon Elkins, Christian Fischer, Tine Glendorf, Steven Goldberg, Ingo V Hartung, Alexander Hillisch, Evert J Homan, Stefan Knapp, Markus Köster, Oliver Krämer, Josep Llaveria, Uta Lessel, Sven Lindemann, Lars Linderoth, Hisanori Matsui, Maurice Michel, Florian Montel, Anke Mueller-Fahrnow, Susanne Müller, Dafydd R Owen, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Wendy Sanderson, Cora Scholten, Matthieu Schapira, Sujata Sharma, Brock Shireman, Michael Sundström, Matthew H Todd, Claudia Tredup, Jennifer Venable, Timothy M Willson, Cheryl H Arrowsmith
Target 2035 - an update on private sector contributions. RSC medicinal chemistry 14 (6) (2023)
Paola Martinelli, Otmar Schaaf, Andreas Mantoulidis, Laetitia J Martin, Julian E Fuchs, Gerd Bader, Andreas Gollner, Bernhard Wolkerstorfer, Catherine Rogers, Esra Balıkçı, Jesse J Lipp, Nikolai Mischerikow, Sandra Doebel, Thomas Gerstberger, Wolfgang Sommergruber, Kilian V M Huber, Jark Böttcher
Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments. ChemMedChem 18 (6) (2023)
Dongsung Kim, Lorenz Herdeis, Dorothea Rudolph, Yulei Zhao, Jark Böttcher, Alberto Vides, Carlos I Ayala-Santos, Yasin Pourfarjam, Antonio Cuevas-Navarro, Jenny Y Xue, Andreas Mantoulidis, Joachim Bröker, Tobias Wunberg, Otmar Schaaf, Johannes Popow, Bernhard Wolkerstorfer, Katrin Gabriele Kropatsch, Rui Qu, Elisa de Stanchina, Ben Sang, Chuanchuan Li, Darryl B McConnell, Norbert Kraut, Piro Lito
Pan-KRAS inhibitor disables oncogenic signalling and tumour growth. Nature (2023)
Gerald Platzer, Aleksandra L Ptaszek, Jark Böttcher, Julian E Fuchs, Leonhard Geist, Daniel Braun, Darryl B McConnell, Robert Konrat, Pedro A Sánchez-Murcia, Moriz Mayer
Ligand 1 H NMR Chemical Shifts as Accurate Reporters for Protein-Ligand Binding Interfaces in Solution. Chemphyschem : a European journal of chemical physics and physical chemistry (2023)
Paola Martinelli, Otmar Schaaf, Andreas Mantoulidis, Laetitia J Martin, Julian E Fuchs, Gerd Bader, Andreas Gollner, Bernhard Wolkerstorfer, Catherine Rogers, Esra Balıkçı, Jesse J Lipp, Nikolai Mischerikow, Sandra Doebel, Thomas Gerstberger, Wolfgang Sommergruber, Kilian V M Huber, Jark Böttcher
Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments. ChemMedChem (2023)
Paola Martinelli, Otmar Schaaf, Andreas Mantoulidis, Laetitia J Martin, Julian E Fuchs, Gerd Bader, Andreas Gollner, Bernhard Wolkerstorfer, Catherine Rogers, Esra Balıkçı, Jesse J Lipp, Nikolai Mischerikow, Sandra Doebel, Thomas Gerstberger, Wolfgang Sommergruber, Kilian V M Huber, Jark Böttcher
Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments. ChemMedChem 18 (6) (2023)
Paola Martinelli, Otmar Schaaf, Andreas Mantoulidis, Laetitia J Martin, Julian E Fuchs, Gerd Bader, Andreas Gollner, Bernhard Wolkerstorfer, Catherine Rogers, Esra Balıkçı, Jesse J Lipp, Nikolai Mischerikow, Sandra Doebel, Thomas Gerstberger, Wolfgang Sommergruber, Kilian V M Huber, Jark Böttcher
Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments. ChemMedChem 18 (6) (2023)
Dirk Kessler, Moriz Mayer, Stephan K Zahn, Markus Zeeb, Simon Wöhrle, Andreas Bergner, Jens Bruchhaus, Tuncay Ciftci, Georg Dahmann, Maike Dettling, Sandra Döbel, Julian E Fuchs, Leonhard Geist, Wolfgang Hela, Christiane Kofink, Roland Kousek, Franziska Moser, Teresa Puchner, Klaus Rumpel, Maximilian Scharnweber, Patrick Werni, Bernhard Wolkerstorfer, Dennis Breitsprecher, Philipp Baaske, Mark Pearson, Darryl B McConnell, Jark Böttcher
Getting a Grip on the Undrugged: Targeting β-Catenin with Fragment-Based Methods. ChemMedChem 16 (9) (2021)
Daniel B Grabarczyk, Olga A Petrova, Luiza Deszcz, Robert Kurzbauer, Paul Murphy, Juraj Ahel, Antonia Vogel, Rebeca Gogova, Victoria Faas, Darja Kordic, Alexander Schleiffer, Anton Meinhart, Richard Imre, Anita Lehner, Jana Neuhold, Gerd Bader, Peggy Stolt-Bergner, Jark Böttcher, Bernhard Wolkerstorfer, Gerhard Fischer, Irina Grishkovskaya, David Haselbach, Dirk Kessler, Tim Clausen
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain. Nature chemical biology 17 (10) (2021)
Melanie Wurm, Otmar Schaaf, Katharina Reutner, Rajkumar Ganesan, Sven Mostböck, Christina Pelster, Jark Böttcher, Bruna de Andrade Pereira, Christina Taubert, Isabella Alt, Garazi Serna, Aurelie Auguste, Kai Bernd Stadermann, Denis Delic, Fei Han, Jaume Capdevila, Paolo G Nuciforo, Rachel Kroe-Barrett, Paul J Adam, Anne B Vogt, Irmgard Hofmann
A Novel Antagonistic CD73 Antibody for Inhibition of the Immunosuppressive Adenosine Pathway. Molecular cancer therapeutics 20 (11) (2021)
Marco H Hofmann, Michael Gmachl, Juergen Ramharter, Fabio Savarese, Daniel Gerlach, Joseph R Marszalek, Michael P Sanderson, Dirk Kessler, Francesca Trapani, Heribert Arnhof, Klaus Rumpel, Dana-Adriana Botesteanu, Peter Ettmayer, Thomas Gerstberger, Christiane Kofink, Tobias Wunberg, Andreas Zoephel, Szu-Chin Fu, Jessica L F Teh, Jark Böttcher, Nikolai Pototschnig, Franziska Schachinger, Katharina Schipany, Simone Lieb, Christopher P Vellano, Jonathan C O'Connell, Rachel L Mendes, Jurgen Moll, Mark Petronczki, Timothy P Heffernan, Mark Pearson, Darryl B McConnell, Norbert Kraut
BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition. Cancer discovery 11 (1) (2020)
Marco H Hofmann, Rajeswaran Mani, Harald Engelhardt, Maria A Impagnatiello, Sebastian Carotta, Marc Kerenyi, Seila Lorenzo-Herrero, Jark Böttcher, Dirk Scharn, Heribert Arnhof, Andreas Zoephel, Renate Schnitzer, Thomas Gerstberger, Michael P Sanderson, Girish Rajgolikar, Swagata Goswami, Sumithira Vasu, Peter Ettmayer, Segundo González, Mark Pearson, Darryl B McConnell, Norbert Kraut, Natarajan Muthusamy, Jürgen Moll
Selective and Potent CDK8/19 Inhibitors Enhance NK-Cell Activity and Promote Tumor Surveillance. Molecular cancer therapeutics 19 (4) (2020)
Dirk Kessler, Andreas Bergner, Jark Böttcher, Gerhard Fischer, Sandra Döbel, Melanie Hinkel, Barbara Müllauer, Alexander Weiss-Puxbaum, Darryl B McConnell
Drugging all RAS isoforms with one pocket. Future medicinal chemistry 12 (21) (2020)
Joseph A Newman, Angeline E Gavard, Simone Lieb, Madhwesh C Ravichandran, Katja Hauer, Patrick Werni, Leonhard Geist, Jark Böttcher, John R Engen, Klaus Rumpel, Matthias Samwer, Mark Petronczki, Opher Gileadi
Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers. Life science alliance 4 (1) (2020)
Jark Böttcher, David Dilworth, Ulrich Reiser, Ralph A Neumüller, Michael Schleicher, Mark Petronczki, Markus Zeeb, Nikolai Mischerikow, Abdellah Allali-Hassani, Magdalena M Szewczyk, Fengling Li, Steven Kennedy, Masoud Vedadi, Dalia Barsyte-Lovejoy, Peter J Brown, Kilian V M Huber, Catherine M Rogers, Carrow I Wells, Oleg Fedorov, Klaus Rumpel, Andreas Zoephel, Moriz Mayer, Tobias Wunberg, Dietrich Böse, Stephan Zahn, Heribert Arnhof, Helmut Berger, Christoph Reiser, Alexandra Hörmann, Teresa Krammer, Maja Corcokovic, Bernadette Sharps, Sandra Winkler, Daniela Häring, Xiao-Ling Cockcroft, Julian E Fuchs, Barbara Müllauer, Alexander Weiss-Puxbaum, Thomas Gerstberger, Guido Boehmelt, Christopher R Vakoc, Cheryl H Arrowsmith, Mark Pearson, Darryl B McConnell
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nature chemical biology 15 (8) (2019)

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Publication Activity (10 Years)

Top Topics

Top Venues

Jark Böttcher