Lari Lehtiö

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 28

Top Venues

Journal of medicinal chemistry

bioRxiv : the preprint server for biology

SLAS discovery : advancing life sciences R & D

Cancer research communications

University of Helsinki (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

University of Helsinki Dec 20o 2006

Finland

PHD

Publications

Sudarshan Murthy, Maria Giulia Nizi, Mirko M Maksimainen, Serena Massari, Juho Alaviuhkola, Barbara E Lippok, Chiara Vagaggini, Sven T Sowa, Albert Galera-Prat, Yashwanth Ashok, Harikanth Venkannagari, Renata Prunskaite-Hyyryläinen, Elena Dreassi, Bernhard Lüscher, Patricia Korn, Oriana Tabarrini, Lari Lehtiö
[1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. Journal of medicinal chemistry 66 (2) (2023)
Sudarshan Murthy, Maria Giulia Nizi, Mirko M Maksimainen, Serena Massari, Juho Alaviuhkola, Barbara E Lippok, Chiara Vagaggini, Sven T Sowa, Albert Galera-Prat, Yashwanth Ashok, Harikanth Venkannagari, Renata Prunskaite-Hyyryläinen, Elena Dreassi, Bernhard Lüscher, Patricia Korn, Oriana Tabarrini, Lari Lehtiö
[1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. Journal of medicinal chemistry 66 (2) (2023)
Sudarshan Murthy, Maria Giulia Nizi, Mirko M Maksimainen, Serena Massari, Juho Alaviuhkola, Barbara E Lippok, Chiara Vagaggini, Sven T Sowa, Albert Galera-Prat, Yashwanth Ashok, Harikanth Venkannagari, Renata Prunskaite-Hyyryläinen, Elena Dreassi, Bernhard Lüscher, Patricia Korn, Oriana Tabarrini, Lari Lehtiö
[1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. Journal of medicinal chemistry 66 (2) (2023)
Sudarshan Murthy, Maria Giulia Nizi, Mirko M Maksimainen, Serena Massari, Juho Alaviuhkola, Barbara E Lippok, Chiara Vagaggini, Sven T Sowa, Albert Galera-Prat, Yashwanth Ashok, Harikanth Venkannagari, Renata Prunskaite-Hyyryläinen, Elena Dreassi, Bernhard Lüscher, Patricia Korn, Oriana Tabarrini, Lari Lehtiö
[1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. Journal of medicinal chemistry 66 (2) (2023)
Sudarshan Murthy, Maria Giulia Nizi, Mirko M Maksimainen, Serena Massari, Juho Alaviuhkola, Barbara E Lippok, Chiara Vagaggini, Sven T Sowa, Albert Galera-Prat, Yashwanth Ashok, Harikanth Venkannagari, Renata Prunskaite-Hyyryläinen, Elena Dreassi, Bernhard Lüscher, Patricia Korn, Oriana Tabarrini, Lari Lehtiö
[1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. Journal of medicinal chemistry (2023)
Sven Wijngaarden, Chunsong Yang, Carlos Vela-Rodríguez, Lari Lehtiö, Herman S Overkleeft, Bryce M Paschal, Dmitri V Filippov
Synthetic Dual Cysteine-ADP Ribosylated Peptides from the Androgen Receptor are Recognized by the DTX3L/PARP9 Complex. ACS chemical biology (2023)
Sudarshan Murthy, Maria Giulia Nizi, Mirko M Maksimainen, Serena Massari, Juho Alaviuhkola, Barbara E Lippok, Chiara Vagaggini, Sven T Sowa, Albert Galera-Prat, Yashwanth Ashok, Harikanth Venkannagari, Renata Prunskaite-Hyyryläinen, Elena Dreassi, Bernhard Lüscher, Patricia Korn, Oriana Tabarrini, Lari Lehtiö
[1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. Journal of medicinal chemistry 66 (2) (2023)
Shoshy A Brinch, Enya Amundsen-Isaksen, Sandra Espada, Clara Hammarström, Aleksandra Aizenshtadt, Petter Angell Olsen, Lone Holmen, Merete Høyem, Hanne Scholz, Gunnveig Grødeland, Sven T Sowa, Albert Galera-Prat, Lari Lehtiö, Ilonka A T M Meerts, Ruben G G Leenders, Anita Wegert, Stefan Krauss, Jo Waaler
The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models. Cancer research communications 2 (4) (2022)
Maria Giulia Nizi, Mirko M Maksimainen, Lari Lehtiö, Oriana Tabarrini
Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules. Journal of medicinal chemistry 65 (11) (2022)
Shoshy A Brinch, Enya Amundsen-Isaksen, Sandra Espada, Clara Hammarström, Aleksandra Aizenshtadt, Petter Angell Olsen, Lone Holmen, Merete Høyem, Hanne Scholz, Gunnveig Grødeland, Sven T Sowa, Albert Galera-Prat, Lari Lehtiö, Ilonka A T M Meerts, Ruben G G Leenders, Anita Wegert, Stefan Krauss, Jo Waaler
The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models. Cancer research communications 2 (4) (2022)
Lavinia M Sherrill, Elva E Joya, AnnMarie Walker, Anuradha Roy, Yousef M Alhammad, Moriama Atobatele, Sarah Wazir, George Abbas, Patrick Keane, Junlin Zhuo, Anthony K L Leung, David K Johnson, Lari Lehtiö, Anthony R Fehr, Dana V Ferraris
Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV2 nsp3 Macrodomain. bioRxiv : the preprint server for biology (2022)
Sven T Sowa, Chiara Bosetti, Albert Galera-Prat, Mark S Johnson, Lari Lehtiö
An Evolutionary Perspective on the Origin, Conservation and Binding Partner Acquisition of Tankyrases. Biomolecules 12 (11) (2022)
Sven T Sowa, Lari Lehtiö
The zinc-binding motif in tankyrases is required for the structural integrity of the catalytic ADP-ribosyltransferase domain. Open biology 12 (3) (2022)
Albert Galera-Prat, Juho Alaviuhkola, Heli I Alanen, Lari Lehtiö
Protein engineering approach to enhance activity assays of mono-ADP-ribosyltransferases through proximity. Protein engineering, design & selection : PEDS 35 (2022)
Anu Roy, Yousef M O Alhammad, Peter McDonald, David K Johnson, Junlin Zhuo, Sarah Wazir, Dana V Ferraris, Lari Lehtiö, Anthony K L Leung, Anthony R Fehr
Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening. bioRxiv : the preprint server for biology (2022)
Patricia Korn, Arno Classen, Sudarshan Murthy, Riccardo Guareschi, Mirko M Maksimainen, Barbara E Lippok, Albert Galera-Prat, Sven T Sowa, Catharina Voigt, Sybille Krauß, Lari Lehtiö, Carsten Bolm, Bernhard Lüscher
Evaluation of 3- and 4-Phenoxybenzamides as Selective Inhibitors of the Mono-ADP-Ribosyltransferase PARP10. ChemistryOpen 10 (10) (2021)
Tuomo Glumoff, Sven T Sowa, Lari Lehtiö
Assay technologies facilitating drug discovery for ADP-ribosyl writers, readers and erasers. BioEssays : news and reviews in molecular, cellular and developmental biology (2021)
Ed Daniel, Mirko M Maksimainen, Neil Smith, Ville Ratas, Ekaterina Biterova, Sudarshan N Murthy, M Tanvir Rahman, Tiila Riikka Kiema, Shruthi Sridhar, Gabriele Cordara, Subhadra Dalwani, Rajaram Venkatesan, Jaime Prilusky, Orly Dym, Lari Lehtiö, M Kristian Koski, Alun W Ashton, Joel L Sussman, Rikkert K Wierenga
IceBear: an intuitive and versatile web application for research-data tracking from crystallization experiment to PDB deposition. Acta crystallographica. Section D, Structural biology 77 (Pt 2) (2021)
Ruben G G Leenders, Shoshy Alam Brinch, Sven T Sowa, Enya Amundsen-Isaksen, Albert Galera-Prat, Sudarshan Murthy, Sjoerd Aertssen, Johannes N Smits, Piotr Nieczypor, Eddy Damen, Anita Wegert, Marc Nazare, Lari Lehtiö, Shoshy A Brinch, Stefan Krauss
Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. Journal of medicinal chemistry (2021)
Ezeogo Obaji, Mirko M Maksimainen, Albert Galera-Prat, Lari Lehtiö
Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition. Nature communications 12 (1) (2021)
Yashwanth Ashok, Mirko M Maksimainen, Tuija Kallio, Pekka Kilpeläinen, Lari Lehtiö
FMN-dependent oligomerization of putative lactate oxidase from Pediococcus acidilactici. PloS one 15 (2) (2020)
Sarah Wazir, Mirko M Maksimainen, Lari Lehtiö
Multiple crystal forms of human MacroD2. Acta crystallographica. Section F, Structural biology communications 76 (Pt 10) (2020)
Shoshy A Brinch, Ruben G G Leenders, Sven T Sowa, Shoshy Alam Brinch, Max Lycke, Piotr Nieczypor, Sjoerd Aertssen, Sudarshan Murthy, Albert Galera-Prat, Eddy Damen, Anita Wegert, Marc Nazaré, Lari Lehtiö, Stefan Krauss
Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor. Journal of medicinal chemistry 63 (13) (2020)
Yashwanth Ashok, Moona Miettinen, Danilo Kimio Hirabae de Oliveira, Mahlet Z Tamirat, Katja Näreoja, Avlokita Tiwari, Michael O Hottiger, Mark S Johnson, Lari Lehtiö, Arto T Pulliainen
Discovery of Compounds Inhibiting the ADP-Ribosyltransferase Activity of Pertussis Toxin. ACS infectious diseases 6 (4) (2020)
Sarah Wazir, Mirko M Maksimainen, Heli I Alanen, Albert Galera-Prat, Lari Lehtiö
Activity-Based Screening Assay for Mono-ADP-Ribosylhydrolases. SLAS discovery : advancing life sciences R & D 26 (1) (2020)
Philip Brennecke, Dace Rasina, Oscar Aubi, Katja Herzog, Johannes Landskron, Bastien Cautain, Francisca Vicente, Jordi Quintana, Jordi Mestres, Bahne Stechmann, Bernhard Ellinger, Jose Brea, Jacek L Kolanowski, Radosław Pilarski, Mar Orzaez, Antonio Pineda-Lucena, Luca Laraia, Faranak Nami, Piotr Zielenkiewicz, Kamil Paruch, Espen Holst Hansen, Jens P von Kries, Martin Neuenschwander, Edgar Specker, Petr Bartunek, Sarka Simova, Zbigniew Leśnikowski, Stefan Krauss, Lari Lehtiö, Ursula Bilitewski, Mark Brönstrup, Kjetil Taskén, Aigars Jirgensons, Heiko Lickert, Mads H Clausen, Jeanette H Andersen, Maria J Vicent, Olga Genilloud, Aurora Martinez, Marc Nazaré, Wolfgang Fecke, Philip Gribbon
EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology. SLAS discovery : advancing life sciences R & D 24 (3) (2019)
Yves Nkizinkiko, Jenny Desantis, Jarkko Koivunen, Teemu Haikarainen, Sudarshan Murthy, Luca Sancineto, Serena Massari, Federica Ianni, Ezeogo Obaji, Maria I Loza, Taina Pihlajaniemi, Jose Brea, Oriana Tabarrini, Lari Lehtiö
2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Scientific reports 8 (1) (2018)
Upendra Rao Anumala, Jo Waaler, Yves Nkizinkiko, Alexander Ignatev, Katina Lazarow, Peter Lindemann, Petter Angell Olsen, Sudarshan Murthy, Ezeogo Obaji, Alexander G Majouga, Sergey Leonov, Jens Peter von Kries, Lari Lehtiö, Stefan Krauss, Marc Nazare
Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. Journal of medicinal chemistry 60 (24) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Lari Lehtiö