Vijayaratnam Santhakumar

ORCID

Publication Activity (10 Years)

Years Active: 2021-2024
Publications (10 Years): 24

Top Venues

Journal of medicinal chemistry

RSC medicinal chemistry

Communications biology

PNAS nexus

This page only lists publications with an associated author ORCID identifier.

Publications

Germanna Lima Righetto, Yanting Yin, David M Duda, Victoria Vu, Magdalena M Szewczyk, Hong Zeng, Yanjun Li, Peter Loppnau, Tony Mei, Yen-Yen Li, Alma Seitova, Aaron N Patrick, Jean-Francois Brazeau, Charu Chaudhry, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Levon Halabelian
Probing the CRL4 DCAF12 interactions with MAGEA3 and CCT5 di-Glu C-terminal degrons. PNAS nexus 3 (4) (2024)
Aliakbar Khalili Yazdi, Sumera Perveen, Cheng Dong, Xiaosheng Song, Aiping Dong, Magdalena M Szewczyk, Matthew F Calabrese, Agustin Casimiro-Garcia, Subramanyam Chakrapani, Matthew S Dowling, Emel Ficici, Jisun Lee, Justin I Montgomery, Thomas N O'Connell, Grzegorz J Skrzypek, Tuan P Tran, Matthew D Troutman, Feng Wang, Jennifer A Young, Jinrong Min, Dalia Barsyte-Lovejoy, Peter J Brown, Vijayaratnam Santhakumar, Cheryl H Arrowsmith, Masoud Vedadi, Dafydd R Owen
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex. RSC medicinal chemistry 15 (3) (2024)
Germanna Lima Righetto, Yanting Yin, David M Duda, Victoria Vu, Magdalena M Szewczyk, Hong Zeng, Yanjun Li, Peter Loppnau, Tony Mei, Yen-Yen Li, Alma Seitova, Aaron N Patrick, Jean-Francois Brazeau, Charu Chaudhry, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Levon Halabelian
Probing the CRL4 DCAF12 interactions with MAGEA3 and CCT5 di-Glu C-terminal degrons. PNAS nexus 3 (4) (2024)
Aliakbar Khalili Yazdi, Sumera Perveen, Cheng Dong, Xiaosheng Song, Aiping Dong, Magdalena M Szewczyk, Matthew F Calabrese, Agustin Casimiro-Garcia, Subramanyam Chakrapani, Matthew S Dowling, Emel Ficici, Jisun Lee, Justin I Montgomery, Thomas N O'Connell, Grzegorz J Skrzypek, Tuan P Tran, Matthew D Troutman, Feng Wang, Jennifer A Young, Jinrong Min, Dalia Barsyte-Lovejoy, Peter J Brown, Vijayaratnam Santhakumar, Cheryl H Arrowsmith, Masoud Vedadi, Dafydd R Owen
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex. RSC medicinal chemistry 15 (3) (2024)
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Norbert Schmees, Kirstin Petersen
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. Journal of medicinal chemistry 66 (5) (2023)
Ahmed Fnaiche, Hwai-Chien Chan, Alexis Paquin, Narjara González Suárez, Victoria Vu, Fengling Li, Abdellah Allali-Hassani, Michelle Ada Cao, Magdalena M Szewczyk, Albina Bolotokova, Frédéric Allemand, Muriel Gelin, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Jean-François Guichou, Borhane Annabi, Alexandre Gagnon
Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration. ACS medicinal chemistry letters 14 (12) (2023)
Suzanne Ackloo, Albert A Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex N Bullock, Ulrich A K Betz, Jark Böttcher, Peter J Brown, Menorca Chaturvedi, Alisa Crisp, Danette L Daniels, Jan Dreher, Kristina Edfeldt, Aled Morgan Edwards, Ursula Egner, Jon Elkins, Christian Fischer, Tine Glendorf, Steven Goldberg, Ingo V Hartung, Alexander Hillisch, Evert J Homan, Stefan Knapp, Markus Köster, Oliver Krämer, Josep Llaveria, Uta Lessel, Sven Lindemann, Lars Linderoth, Hisanori Matsui, Maurice Michel, Florian Montel, Anke Mueller-Fahrnow, Susanne Müller, Dafydd R Owen, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Wendy Sanderson, Cora Scholten, Matthieu Schapira, Sujata Sharma, Brock Shireman, Michael Sundström, Matthew H Todd, Claudia Tredup, Jennifer Venable, Timothy M Willson, Cheryl H Arrowsmith
Target 2035 - an update on private sector contributions. RSC medicinal chemistry 14 (6) (2023)
Shabbir Ahmad, Jin Xu, Jianwen A Feng, Ashley Hutchinson, Hong Zeng, Pegah Ghiabi, Aiping Dong, Paolo A Centrella, Matthew A Clark, Marie-Aude Guié, John P Guilinger, Anthony D Keefe, Ying Zhang, Thomas Cerruti, John W Cuozzo, Moritz von Rechenberg, Albina Bolotokova, Yanjun Li, Peter Loppnau, Alma Seitova, Yen-Yen Li, Vijayaratnam Santhakumar, Peter J Brown, Suzanne Ackloo, Levon Halabelian
Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning. Journal of medicinal chemistry (2023)
Suzanne Ackloo, Albert A Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex N Bullock, Ulrich A K Betz, Jark Böttcher, Peter J Brown, Menorca Chaturvedi, Alisa Crisp, Danette L Daniels, Jan Dreher, Kristina Edfeldt, Aled Morgan Edwards, Ursula Egner, Jon Elkins, Christian Fischer, Tine Glendorf, Steven Goldberg, Ingo V Hartung, Alexander Hillisch, Evert J Homan, Stefan Knapp, Markus Köster, Oliver Krämer, Josep Llaveria, Uta Lessel, Sven Lindemann, Lars Linderoth, Hisanori Matsui, Maurice Michel, Florian Montel, Anke Mueller-Fahrnow, Susanne Müller, Dafydd R Owen, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Wendy Sanderson, Cora Scholten, Matthieu Schapira, Sujata Sharma, Brock Shireman, Michael Sundström, Matthew H Todd, Claudia Tredup, Jennifer Venable, Timothy M Willson, Cheryl H Arrowsmith
Target 2035 - an update on private sector contributions. RSC medicinal chemistry 14 (6) (2023)
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Norbert Schmees, Kirstin Petersen
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. Journal of medicinal chemistry 66 (5) (2023)
Rachel J Harding, Ivan Franzoni, Mandeep K Mann, Magdalena M Szewczyk, Bijan Mirabi, Renato Ferreira de Freitas, Dominic D G Owens, Suzanne Ackloo, Alexej Scheremetjew, Kevin A Juarez-Ornelas, Randy Sanichar, Rachel J Baker, Christian Dank, Peter J Brown, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Matthieu Schapira, Mark Lautens, Cheryl H Arrowsmith
Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6. Journal of medicinal chemistry (2023)
Serah W Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Communications biology 6 (1) (2023)
Darren Yong, Stuart R Green, Pegah Ghiabi, Vijayaratnam Santhakumar, Masoud Vedadi
Discovery of Nedd4 auto-ubiquitination inhibitors. Scientific reports 13 (1) (2023)
Serah W Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Communications biology 6 (1) (2023)
Serah W Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Communications biology 6 (1) (2023)
Alice Shi Ming Li, Serah Kimani, Brian Wilson, Mahmoud Noureldin, Héctor González-Álvarez, Ahmed Mamai, Laurent Hoffer, John P Guilinger, Ying Zhang, Moritz von Rechenberg, Jeremy S Disch, Christopher J Mulhern, Belinda L Slakman, John W Cuozzo, Aiping Dong, Gennady Poda, Mohammed Mohammed, Punit Saraon, Manish Mittal, Pratik Modh, Vaibhavi Rathod, Bhashant Patel, Suzanne Ackloo, Vijayaratnam Santhakumar, Magdalena M Szewczyk, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Richard Marcellus, Marie-Aude Guié, Anthony D Keefe, Peter J Brown, Levon Halabelian, Rima Al-Awar, Masoud Vedadi
Discovery of Nanomolar DCAF1 Small Molecule Ligands. Journal of medicinal chemistry (2023)
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Norbert Schmees, Kirstin Petersen
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. Journal of medicinal chemistry 66 (5) (2023)
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Norbert Schmees, Kirstin Petersen
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. Journal of medicinal chemistry 66 (5) (2023)
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Norbert Schmees, Kirstin Petersen
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. Journal of medicinal chemistry (2023)
Serah W Kimani, Sumera Perveen, Magdalena Szewezyk, Hong Zeng, Aiping Dong, Fengling Li, Pegah Ghiabi, Yanjun Li, Irene Chau, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Levon Halabelian
The co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition. Communications biology 6 (1) (2023)
Ahmed Fnaiche, Hwai-Chien Chan, Alexis Paquin, Narjara González Suárez, Victoria Vu, Fengling Li, Abdellah Allali-Hassani, Michelle Ada Cao, Magdalena M Szewczyk, Albina Bolotokova, Frédéric Allemand, Muriel Gelin, Dalia Barsyte-Lovejoy, Vijayaratnam Santhakumar, Masoud Vedadi, Jean-François Guichou, Borhane Annabi, Alexandre Gagnon
Development of HC-258, a Covalent Acrylamide TEAD Inhibitor That Reduces Gene Expression and Cell Migration. ACS medicinal chemistry letters 14 (12) (2023)
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H Arrowsmith, Norbert Schmees, Kirstin Petersen
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21. Journal of medicinal chemistry 66 (5) (2023)
Aliakbar Khalili Yazdi, Paknoosh Pakarian, Sumera Perveen, Taraneh Hajian, Vijayaratnam Santhakumar, Albina Bolotokova, Fengling Li, Masoud Vedadi
Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors. ACS infectious diseases 8 (8) (2022)
Mathew Sutherland, Alice Li, Anissa Kaghad, Dimitrios Panagopoulos, Fengling Li, Magdalena Szewczyk, David Smil, Cora Scholten, Léa Bouché, Timo Stellfeld, Cheryl H Arrowsmith, Dalia Barsyte, Masoud Vedadi, Ingo V Hartung, Holger Steuber, Robert Britton, Vijayaratnam Santhakumar
Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics*. ChemMedChem 16 (7) (2021)

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Publication Activity (10 Years)

Top Topics

Top Venues

Vijayaratnam Santhakumar