Jason G Kettle

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 27

Top Venues

Journal of medicinal chemistry

ACS chemical biology

ACS medicinal chemistry letters

Expert opinion on therapeutic patents

This page only lists publications with an associated author ORCID identifier.

Publications

Nils Pemberton, Nina Compagne, Argyrides Argyrou, Emma Evertsson, Anders Gunnarsson, Jason G Kettle, Jonathan P Orme, Richard A Ward
Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR. ACS medicinal chemistry letters 15 (5) (2024)
Nils Pemberton, Nina Compagne, Argyrides Argyrou, Emma Evertsson, Anders Gunnarsson, Jason G Kettle, Jonathan P Orme, Richard A Ward
Vinylpyridine as a Tunable Covalent Warhead Targeting C797 in EGFR. ACS medicinal chemistry letters 15 (5) (2024)
Simon C C Lucas, Alexander G Milbradt, J Henry Blackwell, Silvia Bonomo, Andrew Brierley, Doyle J Cassar, Jared Freeman, Thomas E Hadfield, Lucas A Morrill, Rick Riemens, Sunil Sarda, Stefan Schiesser, Daniel Wiktelius, Samiyah Ahmed, Mark J Bostock, Ulf Börjesson, Claudia De Fusco, Carine Guerot, David Hargreaves, Sarah Hewitt, Michelle L Lamb, Nancy Su, Ryan Whatling, Matthew Wheeler, Jason G Kettle
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1. Journal of medicinal chemistry 67 (13) (2024)
Simon C C Lucas, Alexander G Milbradt, J Henry Blackwell, Silvia Bonomo, Andrew Brierley, Doyle J Cassar, Jared Freeman, Thomas E Hadfield, Lucas A Morrill, Rick Riemens, Sunil Sarda, Stefan Schiesser, Daniel Wiktelius, Samiyah Ahmed, Mark J Bostock, Ulf Börjesson, Claudia De Fusco, Carine Guerot, David Hargreaves, Sarah Hewitt, Michelle L Lamb, Nancy Su, Ryan Whatling, Matthew Wheeler, Jason G Kettle
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1. Journal of medicinal chemistry 67 (13) (2024)
Simon C C Lucas, Alexander G Milbradt, J Henry Blackwell, Silvia Bonomo, Andrew Brierley, Doyle J Cassar, Jared Freeman, Thomas E Hadfield, Lucas A Morrill, Rick Riemens, Sunil Sarda, Stefan Schiesser, Daniel Wiktelius, Samiyah Ahmed, Mark J Bostock, Ulf Börjesson, Claudia De Fusco, Carine Guerot, David Hargreaves, Sarah Hewitt, Michelle L Lamb, Nancy Su, Ryan Whatling, Matthew Wheeler, Jason G Kettle
Design of a Lead-Like Cysteine-Targeting Covalent Library and the Identification of Hits to Cys55 of Bfl-1. Journal of medicinal chemistry (2024)
Magnus Nilsson, Kristina Berggren, Susanne Berglund, Silvia Cerboni, Mia Collins, Göran Dahl, David Elmqvist, Neil P Grimster, Ramon Hendrickx, Johan R Johansson, Jason G Kettle, Matti Lepistö, Magdalena Rhedin, Amir Smailagic, Qibin Su, Tiiu Wennberg, Allan Wu, Torben Österlund, Thomas Naessens, Suman Mitra
Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization. Journal of medicinal chemistry (2023)
Aarti Kawatkar, Roger A Clark, Lorna Hopcroft, Debora Ann Roaquin, Ronald Tomlinson, Andrea M Zuhl, Gillian M Lamont, Jason G Kettle, Susan E Critchlow, M Paola Castaldi, Frederick W Goldberg, Andrew X Zhang
Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit. ACS chemical biology 18 (2) (2023)
Aarti Kawatkar, Roger A Clark, Lorna Hopcroft, Debora Ann Roaquin, Ronald Tomlinson, Andrea M Zuhl, Gillian M Lamont, Jason G Kettle, Susan E Critchlow, M Paola Castaldi, Frederick W Goldberg, Andrew X Zhang
Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit. ACS chemical biology 18 (2) (2023)
Aarti Kawatkar, Roger A Clark, Lorna Hopcroft, Debora Ann Roaquin, Ronald Tomlinson, Andrea M Zuhl, Gillian M Lamont, Jason G Kettle, Susan E Critchlow, M Paola Castaldi, Frederick W Goldberg, Andrew X Zhang
Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit. ACS chemical biology 18 (2) (2023)
Aarti Kawatkar, Roger A Clark, Lorna Hopcroft, Debora Ann Roaquin, Ronald Tomlinson, Andrea M Zuhl, Gillian M Lamont, Jason G Kettle, Susan E Critchlow, M Paola Castaldi, Frederick W Goldberg, Andrew X Zhang
Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit. ACS chemical biology 18 (2) (2023)
Aarti Kawatkar, Roger A Clark, Lorna Hopcroft, Debora Ann Roaquin, Ronald Tomlinson, Andrea M Zuhl, Gillian M Lamont, Jason G Kettle, Susan E Critchlow, M Paola Castaldi, Frederick W Goldberg, Andrew X Zhang
Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit. ACS chemical biology (2023)
Aarti Kawatkar, Roger A Clark, Lorna Hopcroft, Debora Ann Roaquin, Ronald Tomlinson, Andrea M Zuhl, Gillian M Lamont, Jason G Kettle, Susan E Critchlow, M Paola Castaldi, Frederick W Goldberg, Andrew X Zhang
Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit. ACS chemical biology (2023)
Aarti Kawatkar, Roger A Clark, Lorna Hopcroft, Debora Ann Roaquin, Ronald Tomlinson, Andrea M Zuhl, Gillian M Lamont, Jason G Kettle, Susan E Critchlow, M Paola Castaldi, Frederick W Goldberg, Andrew X Zhang
Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit. ACS chemical biology (2023)
Jason G Kettle, Sharan K Bagal, Derek Barratt, Michael S Bodnarchuk, Scott Boyd, Erin Braybrooke, Jason Breed, Doyle J Cassar, Sabina Cosulich, Michael Davies, Nichola L Davies, Chao Deng, Andrew Eatherton, Laura Evans, Lyman J Feron, Shaun M Fillery, Emma S Gleave, Frederick W Goldberg, Miguel A Cortés González, Carine Guerot, Afreen Haider, Stephanie Harlfinger, Rachel Howells, Anne Jackson, Peter Johnström, Paul D Kemmitt, Alex Koers, Mikhail Kondrashov, Gillian M Lamont, Scott Lamont, Hilary J Lewis, Libin Liu, Megan Mylrea, Samuel Nash, Michael J Niedbala, Alison Peter, Christopher Phillips, Kurt Pike, Piotr Raubo, Graeme R Robb, Sarah Ross, Matthew G Sanders, Magnus Schou, Iain Simpson, Oliver Steward
Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS G12C with Demonstrable CNS Penetration. Journal of medicinal chemistry (2023)
Jason G Kettle, Sharan K Bagal, Sue Bickerton, Michael S Bodnarchuk, Scott Boyd, Jason Breed, Rodrigo J Carbajo, Doyle J Cassar, Atanu Chakraborty, Sabina Cosulich, Iain Cumming, Michael Davies, Nichola L Davies, Andrew Eatherton, Laura Evans, Lyman Feron, Shaun M Fillery, Emma S Gleave, Frederick W Goldberg, Lyndsey Hanson, Stephanie Harlfinger, Martin Howard, Rachel Howells, Anne Jackson, Paul Kemmitt, Gillian Lamont, Scott Lamont, Hilary J Lewis, Libin Liu, Michael J Niedbala, Christopher Phillips, Radek Polanski, Piotr Raubo, Graeme R Robb, David M Robinson, Sarah Ross, Matthew G Sanders, Michael Tonge, Rebecca Whiteley, Stephen Wilkinson, Junsheng Yang, Wenman Zhang
Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS G12C . Journal of medicinal chemistry 65 (9) (2022)
Frederick W Goldberg, Jason G Kettle, Gillian M Lamont, David Buttar, Attilla K T Ting, Thomas M McGuire, Calum R Cook, David Beattie, Pablo Morentin Gutierrez, Stefan L Kavanagh, Jasper C Komen, Aarti Kawatkar, Roger Clark, Lorna Hopcroft, Gareth Hughes, Susan E Critchlow
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology. Journal of medicinal chemistry 66 (1) (2022)
Frederick W Goldberg, Jason G Kettle, Gillian M Lamont, David Buttar, Attilla K T Ting, Thomas M McGuire, Calum R Cook, David Beattie, Pablo Morentin Gutierrez, Stefan L Kavanagh, Jasper C Komen, Aarti Kawatkar, Roger Clark, Lorna Hopcroft, Gareth Hughes, Susan E Critchlow
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology. Journal of medicinal chemistry 66 (1) (2022)
Atanu Chakraborty, Lyndsey Hanson, David Robinson, Hilary J Lewis, Sue Bickerton, Michael Davies, Radoslaw Polanski, Rebecca Whiteley, Alex Koers, James Atkinson, Tamara Baker, Ivan Del Barco Barrantes, Giovanni Ciotta, Jason G Kettle, Lukasz Magiera, Carla P Martins, Alison Peter, Eleanor M Wigmore, Zoe E Underwood, Sabina Cosulich, Michael Niedbala, Sarah J Ross
AZD4625 is a Potent and Selective Inhibitor of KRASG12C. Molecular cancer therapeutics 21 (10) (2022)
Frederick W Goldberg, Jason G Kettle, Gillian M Lamont, David Buttar, Attilla K T Ting, Thomas M McGuire, Calum R Cook, David Beattie, Pablo Morentin Gutierrez, Stefan L Kavanagh, Jasper C Komen, Aarti Kawatkar, Roger Clark, Lorna Hopcroft, Gareth Hughes, Susan E Critchlow
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology. Journal of medicinal chemistry 66 (1) (2022)
Frederick W Goldberg, Jason G Kettle, Gillian M Lamont, David Buttar, Attilla K T Ting, Thomas M McGuire, Calum R Cook, David Beattie, Pablo Morentin Gutierrez, Stefan L Kavanagh, Jasper C Komen, Aarti Kawatkar, Roger Clark, Lorna Hopcroft, Gareth Hughes, Susan E Critchlow
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology. Journal of medicinal chemistry (2022)
Erica Banks, Michael Grondine, Deepa Bhavsar, Evan Barry, Jason G Kettle, Venkatesh Pilla Reddy, Crystal Brown, Haiyun Wang, Jerome T Mettetal, Teresa Collins, Oladipupo Adeyemi, Ross Overman, Deborah Lawson, Alexander R Harmer, Corinne Reimer, Lisa Drew, Martin J Packer, Sabina Cosulich, Rhys D O Jones, Wenlin Shao, David Wilson, Sylvie M Guichard, Stephen E Fawell, Rana Anjum
Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors. Science translational medicine 12 (541) (2021)
Venkatesh Pilla Reddy, Rana Anjum, Michael Grondine, Aaron Smith, Deepa Bhavsar, Evan Barry, Sylvie M Guichard, Wenlin Shao, Jason G Kettle, Crystal Brown, Erica Banks, Rhys D O Jones
The Pharmacokinetic-Pharmacodynamic (PKPD) Relationships of AZD3229, a Novel and Selective Inhibitor of KIT, in a Range of Mouse Xenograft Models of GIST. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (14) (2020)
Kirsten McAulay, Emily A Hoyt, Morgan Thomas, Marianne Schimpl, Michael S Bodnarchuk, Hilary J Lewis, Derek Barratt, Deepa Bhavsar, David M Robinson, Michael J Deery, Derek J Ogg, Gonçalo J L Bernardes, Richard A Ward, Michael J Waring, Jason G Kettle
Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors. Journal of the American Chemical Society 142 (23) (2020)
Qibin Su, Erica Banks, Geraldine Bebernitz, Kirsten Bell, Cassandra F Borenstein, Huawei Chen, Claudio E Chuaqui, Nanhua Deng, Andrew D Ferguson, Sameer Kawatkar, Neil P Grimster, Linette Ruston, Paul D Lyne, Jon A Read, Xianyou Peng, Xiaohui Pei, Stephen Fawell, Zhanlei Tang, Scott Throner, Melissa M Vasbinder, Haoyu Wang, Jon Winter-Holt, Richard Woessner, Allan Wu, Wenzhan Yang, Michael Zinda, Jason G Kettle
Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor. Journal of medicinal chemistry 63 (9) (2020)
Jason G Kettle, Doyle J Cassar
Covalent inhibitors of the GTPase KRASG12C: a review of the patent literature. Expert opinion on therapeutic patents 30 (2) (2020)
Jason G Kettle, Sharan K Bagal, Sue Bickerton, Michael S Bodnarchuk, Jason Breed, Rodrigo J Carbajo, Doyle J Cassar, Atanu Chakraborty, Sabina Cosulich, Iain Cumming, Michael Davies, Andrew Eatherton, Laura Evans, Lyman Feron, Shaun M Fillery, Emma S Gleave, Frederick W Goldberg, Stephanie Harlfinger, Lyndsey Hanson, Martin Howard, Rachel Howells, Anne Jackson, Paul Kemmitt, Jennifer K Kingston, Scott Lamont, Hilary J Lewis, Songlei Li, Libin Liu, Derek Ogg, Christopher Phillips, Radek Polanski, Graeme R Robb, David Robinson, Sarah Ross, James M Smith, Michael Tonge, Rebecca Whiteley, Junsheng Yang, Longfei Zhang, Xiliang Zhao
Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRASG12C. Journal of medicinal chemistry 63 (9) (2020)
Jason G Kettle, Rana Anjum, Evan Barry, Deepa Bhavsar, Crystal Brown, Scott Boyd, Andrew Campbell, Kristin Goldberg, Michael Grondine, Sylvie Guichard, Christopher J Hardy, Tom Hunt, Rhys D O Jones, Xiuwei Li, Olga Moleva, Derek Ogg, Ross C Overman, Martin J Packer, Stuart Pearson, Marianne Schimpl, Wenlin Shao, Aaron Smith, James M Smith, Darren Stead, Steve Stokes, Michael Tucker, Yang Ye
Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors. Journal of medicinal chemistry 61 (19) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Jason G Kettle