Stephen J Elledge (Stephen Elledge)

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 49

Top Topics

Positive Breast Cancer

Epstein Barr Virus

Quality Control

Top Venues

Nature communications

Science (New York, N.Y.)

Proceedings of the National Academy of Sciences of the United States of America

Nature genetics

This page only lists publications with an associated author ORCID identifier.

Publications

Alissandra L Hillis, Timothy D Martin, Haley E Manchester, Jenny Högström, Na Zhang, Emmalyn Lecky, Nina Kozlova, Jonah Lee, Nicole S Persky, David E Root, Myles A Brown, Karen Cichowski, Stephen J Elledge, Taru Muranen, David A Fruman, Simon T Barry, John Gerard Clohessy, Ralitsa R Madsen, Alex Toker
Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer. Cancer research (2024)
Emma V Watson, Jake June-Koo Lee, Doga C Gulhan, Giorgio E M Melloni, Sergey V Venev, Rayna Y Magesh, Abdulrazak Frederick, Kunitoshi Chiba, Eric C Wooten, Kamila Naxerova, Job Dekker, Peter J Park, Stephen J Elledge
Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns. Nature genetics 56 (5) (2024)
Anna-Maria Liebhoff, Thiagarajan Venkataraman, William R Morgenlander, Miso Na, Tomasz Kula, Kathleen Waugh, Charles Morrison, Marian J Rewers, Randy Longman, June L Round, Stephen J Elledge, Ingo Ruczinski, Ben Langmead, H Benjamin Larman
Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn. Nature communications 15 (1) (2024)
Emma V Watson, Jake June-Koo Lee, Doga C Gulhan, Giorgio E M Melloni, Sergey V Venev, Rayna Y Magesh, Abdulrazak Frederick, Kunitoshi Chiba, Eric C Wooten, Kamila Naxerova, Job Dekker, Peter J Park, Stephen J Elledge
Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns. Nature genetics (2024)
Xinyan Chen, Anat Raiff, Shanshan Li, Qiong Guo, Jiahai Zhang, Hualin Zhou, Richard T Timms, Xuebiao Yao, Stephen J Elledge, Itay Koren, Kaiming Zhang, Chao Xu
Mechanism of Ψ-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nature communications 15 (1) (2024)
Xinyan Chen, Anat Raiff, Shanshan Li, Qiong Guo, Jiahai Zhang, Hualin Zhou, Richard T Timms, Xuebiao Yao, Stephen J Elledge, Itay Koren, Kaiming Zhang, Chao Xu
Mechanism of Ψ-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nature communications 15 (1) (2024)
Ayano C Kohlgruber, Mohammad H Dezfulian, Brandon M Sie, Charlotte I Wang, Tomasz Kula, Uri Laserson, H Benjamin Larman, Stephen J Elledge
High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits. Nature biotechnology (2024)
Xinyan Chen, Anat Raiff, Shanshan Li, Qiong Guo, Jiahai Zhang, Hualin Zhou, Richard T Timms, Xuebiao Yao, Stephen J Elledge, Itay Koren, Kaiming Zhang, Chao Xu
Mechanism of Ψ-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nature communications 15 (1) (2024)
Xinyan Chen, Anat Raiff, Shanshan Li, Qiong Guo, Jiahai Zhang, Hualin Zhou, Richard T Timms, Xuebiao Yao, Stephen J Elledge, Itay Koren, Kaiming Zhang, Chao Xu
Mechanism of Ψ-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nature communications 15 (1) (2024)
Anna-Maria Liebhoff, Thiagarajan Venkataraman, William R Morgenlander, Miso Na, Tomasz Kula, Kathleen Waugh, Charles Morrison, Marian J Rewers, Randy Longman, June L Round, Stephen J Elledge, Ingo Ruczinski, Ben Langmead, H Benjamin Larman
Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn. Nature communications 15 (1) (2024)
Anna-Maria Liebhoff, Thiagarajan Venkataraman, William R Morgenlander, Miso Na, Tomasz Kula, Kathleen Waugh, Charles Morrison, Marian J Rewers, Randy Longman, June L Round, Stephen J Elledge, Ingo Ruczinski, Ben Langmead, H Benjamin Larman
Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn. Nature communications 15 (1) (2024)
Anna-Maria Liebhoff, Thiagarajan Venkataraman, William R Morgenlander, Miso Na, Tomasz Kula, Kathleen Waugh, Charles Morrison, Marian J Rewers, Randy Longman, June L Round, Stephen J Elledge, Ingo Ruczinski, Ben Langmead, H Benjamin Larman
Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn. Nature communications 15 (1) (2024)
Emma V Watson, Jake June-Koo Lee, Doga C Gulhan, Giorgio E M Melloni, Sergey V Venev, Rayna Y Magesh, Abdulrazak Frederick, Kunitoshi Chiba, Eric C Wooten, Kamila Naxerova, Job Dekker, Peter J Park, Stephen J Elledge
Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns. Nature genetics 56 (5) (2024)
Emma V Watson, Jake June-Koo Lee, Doga C Gulhan, Giorgio E M Melloni, Sergey V Venev, Rayna Y Magesh, Abdulrazak Frederick, Kunitoshi Chiba, Eric C Wooten, Kamila Naxerova, Job Dekker, Peter J Park, Stephen J Elledge
Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns. Nature genetics 56 (5) (2024)
Adi Shimshon, Karin Dahan, Mor Israel-Gueta, Diana Olmayev-Yaakobov, Richard T Timms, Aizat Bekturova, Yaara Makaros, Stephen J Elledge, Itay Koren
Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability. The Journal of cell biology 223 (8) (2024)
Timothy D Martin, Emma V Watson, Mei Yuk Choi, Behnam Nabet, Nathanael S Gray, Qikai Xu, Stephen J Elledge
Proteasomal control of anti-CRISPRs for the regulation of CRISPR/Cas9 activity using Cas9-ACROBAT. bioRxiv : the preprint server for biology (2024)
Emma V Watson, Jake June-Koo Lee, Doga C Gulhan, Giorgio E M Melloni, Sergey V Venev, Rayna Y Magesh, Abdulrazak Frederick, Kunitoshi Chiba, Eric C Wooten, Kamila Naxerova, Job Dekker, Peter J Park, Stephen J Elledge
Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns. Nature genetics (2024)
Adi Shimshon, Karin Dahan, Mor Israel-Gueta, Diana Olmayev-Yaakobov, Richard T Timms, Aizat Bekturova, Yaara Makaros, Stephen J Elledge, Itay Koren
Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability. The Journal of cell biology 223 (8) (2024)
Adi Shimshon, Karin Dahan, Mor Israel-Gueta, Diana Olmayev-Yaakobov, Richard T Timms, Aizat Bekturova, Yaara Makaros, Stephen J Elledge, Itay Koren
Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability. The Journal of cell biology 223 (8) (2024)
Anna-Maria Liebhoff, Thiagarajan Venkataraman, William R Morgenlander, Miso Na, Tomasz Kula, Kathleen Waugh, Charles Morrison, Marian J Rewers, Randy Longman, June L Round, Stephen J Elledge, Ingo Ruczinski, Ben Langmead, H Benjamin Larman
Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn. Nature communications 15 (1) (2024)
Emma V Watson, Jake June-Koo Lee, Doga C Gulhan, Giorgio E M Melloni, Sergey V Venev, Rayna Y Magesh, Abdulrazak Frederick, Kunitoshi Chiba, Eric C Wooten, Kamila Naxerova, Job Dekker, Peter J Park, Stephen J Elledge
Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns. Nature genetics 56 (5) (2024)
Anna-Maria Liebhoff, Thiagarajan Venkataraman, William R Morgenlander, Miso Na, Tomasz Kula, Kathleen Waugh, Charles Morrison, Marian J Rewers, Randy Longman, June L Round, Stephen J Elledge, Ingo Ruczinski, Ben Langmead, H Benjamin Larman
Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn. Nature communications 15 (1) (2024)
Anna-Maria Liebhoff, Thiagarajan Venkataraman, William R Morgenlander, Miso Na, Tomasz Kula, Kathleen Waugh, Charles Morrison, Marian J Rewers, Randy Longman, June L Round, Stephen J Elledge, Ingo Ruczinski, Ben Langmead, H Benjamin Larman
Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn. Nature communications 15 (1) (2024)
Xin Gu, Christopher Nardone, Nolan Kamitaki, Aoyue Mao, Stephen J Elledge, Michael Eldon Greenberg
The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation. Science (New York, N.Y.) 381 (6660) (2023)
Jake June-Koo Lee, Youngsook Lucy Jung, Taek-Chin Cheong, Jose Espejo Valle-Inclan, Chong Chu, Doga C Gulhan, Viktor Ljungström, Hu Jin, Vinayak V Viswanadham, Emma V Watson, Isidro Cortes-Ciriano, Stephen J Elledge, Roberto Chiarle, David Pellman, Peter J Park
ERα-associated translocations underlie oncogene amplifications in breast cancer. Nature (2023)
Peter M Bruno, Richard T Timms, Nouran S Abdelfattah, Yumei Leng, Felipe J N Lelis, Duane R Wesemann, Xu G Yu, Stephen J Elledge
High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform. Nature biotechnology (2023)
Richard T Timms, Elijah L Mena, Yumei Leng, Mamie Z Li, Iva A Tchasovnikarova, Itay Koren, Stephen J Elledge
Defining E3 ligase-substrate relationships through multiplex CRISPR screening. Nature cell biology (2023)
Richard T Timms, Elijah L Mena, Yumei Leng, Mamie Z Li, Iva A Tchasovnikarova, Itay Koren, Stephen J Elledge
Author Correction: Defining E3 ligase-substrate relationships through multiplex CRISPR screening. Nature cell biology (2023)
Peter M Bruno, Richard T Timms, Nouran S Abdelfattah, Yumei Leng, Felipe J N Lelis, Duane R Wesemann, Xu G Yu, Stephen J Elledge
High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform. Nature biotechnology (2023)
Anna-Maria Liebhoff, Thiagarajan Venkataraman, William R Morgenlander, Miso Na, Tomasz Kula, Kathleen Waugh, Charles S Morrison, Marian J Rewers, Randy S Longman, June L Round, Stephen J Elledge, Ingo Ruczinski, Ben Langmead, H Benjamin Larman
Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn. bioRxiv : the preprint server for biology (2023)
Ellen L Shrock, Richard T Timms, Tomasz Kula, Elijah L Mena, Anthony P West, Rui Guo, I-Hsiu Lee, Alexander A Cohen, Lindsay G A McKay, Caihong Bi, Yumei Leng, Eric Fujimura, Felix Horns, Mamie Z Li, Duane R Wesemann, Anthony Griffths, Benjamin E Gewurz, Pamela J Bjorkman, Stephen J Elledge
Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses. Science (New York, N.Y.) 380 (6640) (2023)
Moriah M Mitchell, Yumei Leng, Suresh B Boppana, William J Britt, Luz Helena Gutierrez Sanchez, Stephen J Elledge
Signatures of AAV-2 immunity are enriched in children with severe acute hepatitis of unknown etiology. Science translational medicine 15 (706) (2023)
Shuo Li, Nianchao Qian, Chao Jiang, Wenhong Zu, Anthony Liang, Mamie Z Li, Stephen J Elledge, Xu Tan
Gain-of-function genetic screening identifies the antiviral function of TMEM120A via STING activation. Nature communications 13 (1) (2022)
Xi-Zhi J Guo, Stephen J Elledge
V-CARMA: A tool for the detection and modification of antigen-specific T cells. Proceedings of the National Academy of Sciences of the United States of America 119 (4) (2022)
Kjetil Bjornevik, Marianna Cortese, Brian C Healy, Jens Kuhle, Michael Joseph Mina, Yumei Leng, Stephen J Elledge, David W Niebuhr, Ann I Scher, Kassandra L Munger, Alberto Ascherio
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science (New York, N.Y.) 375 (6578) (2022)
Rupesh S Patel, Rodrigo Romero, Emma V Watson, Anthony C Liang, Megan Burger, Peter M K Westcott, Kim L Mercer, Roderick T Bronson, Eric C Wooten, Arjun Bhutkar, Tyler Jacks, Stephen J Elledge
A GATA4-regulated secretory program suppresses tumors through recruitment of cytotoxic CD8 T cells. Nature communications 13 (1) (2022)
Ena Oreskovic, Emily C Wheeler, Kristen E Mengwasser, Eric Fujimura, Timothy D Martin, Zuzana Tothova, Stephen J Elledge
Genetic analysis of cancer drivers reveals cohesin and CTCF as suppressors of PD-L1. Proceedings of the National Academy of Sciences of the United States of America 119 (7) (2022)
Timothy D Martin, Rupesh S Patel, Danielle R Cook, Mei Yuk Choi, Ajinkya Patil, Anthony C Liang, Mamie Z Li, Kevin M Haigis, Stephen J Elledge
The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation. Science (New York, N.Y.) 373 (6561) (2021)
Elijah L Mena, Callie J Donahue, Laura Pontano Vaites, Jie Li, Gergely Rona, Colin O'Leary, Luca Lignitto, Bearach Miwatani-Minter, Joao A Paulo, Avantika Dhabaria, Beatrix Ueberheide, Steven P Gygi, Michele Pagano, J Wade Harper, Robert A Davey, Stephen J Elledge
ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection. Proceedings of the National Academy of Sciences of the United States of America 118 (17) (2021)
Scott B Biering, David L Akey, Marcus P Wong, W Clay Brown, Nicholas T N Lo, Henry Puerta-Guardo, Francielle Tramontini Gomes de Souza Cardozo, Chunling Wang, Jamie R Konwerski, Diego A Espinosa, Nicholas J Bockhaus, Dustin R Glasner, Jeffrey Li, Sophie F Blanc, Evan Y Juan, Stephen J Elledge, Michael Joseph Mina, P Robert Beatty, Janet L Smith, Eva Harris
Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction. Science (New York, N.Y.) 371 (6525) (2021)
Peter M Bruno, Mengrou Lu, Kady A Dennis, Haider Inam, Connor J Moore, John Sheehe, Stephen J Elledge, Michael T Hemann, Justin R Pritchard
The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning. Proceedings of the National Academy of Sciences of the United States of America 117 (8) (2020)
Michael Joseph Mina, Tomasz Kula, Yumei Leng, Mamie Li, Rory D de Vries, Olli H Laitinen, Heli Siljander, Marian J Rewers, David F Choy, Mark S Wilson, H Benjamin Larman, Ashley N Nelson, Diane E Griffin, Rik L de Swart, Stephen J Elledge
Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens. Science (New York, N.Y.) 366 (6465) (2020)
Ellen L Shrock, Eric Fujimura, Tomasz Kula, Richard T Timms, I-Hsiu Lee, Yumei Leng, Matthew L Robinson, Brandon M Sie, Mamie Z Li, Yuezhou Chen, Jennifer Logue, Adam Zuiani, Denise J McCulloch, Felipe J N Lelis, Stephanie Henson, Daniel R Monaco, Meghan Travers, Shaghayegh Habibi, William A Clarke, Patrizio Caturegli, Oliver Laeyendecker, Alicja Piechocka-Trocha, Jonathan Z Li, Ashok Khatri, Helen Y Chu, null null, Alexandra-Chloé Villani, Kyle Kays, Marcia B Goldberg, Nir Hacohen, Michael R Filbin, Xu G Yu, Bruce D Walker, Duane R Wesemann, H Benjamin Larman, James A Lederer, Stephen J Elledge
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. Science (New York, N.Y.) 370 (6520) (2020)
Richard T Timms, Zhiqian Zhang, David Y Rhee, J Wade Harper, Itay Koren, Stephen J Elledge
A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Science (New York, N.Y.) 365 (6448) (2020)
Rachel Bender Ignacio, Sayan Dasgupta, Terry Stevens-Ayers, Tomasz Kula, Joshua A Hill, Stephanie J Lee, Marco Mielcarek, Ann C Duerr, Stephen J Elledge, Michael Boeckh
Comprehensive viromewide antibody responses by systematic epitope scanning after hematopoietic cell transplantation. Blood 134 (6) (2019)
Jin-Mi Heo, Nathan J Harper, Joao A Paulo, Mamie Li, Qikai Xu, Margaret Coughlin, Stephen J Elledge, J Wade Harper
Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy. Science advances 5 (11) (2019)
Pierre Isnard, Tomasz Kula, Véronique Avettand Fenoel, Dany Anglicheau, Fabiola Terzi, Christophe Legendre, Stephen J Elledge, Guillaume Canaud
Temporal virus serological profiling of kidney graft recipients using VirScan. Proceedings of the National Academy of Sciences of the United States of America 116 (22) (2019)
Jonathan Zirin, Xiaochun Ni, Laura M Sack, Donghui Yang-Zhou, Yanhui Hu, Roderick Brathwaite, Martha L Bulyk, Stephen J Elledge, Norbert Perrimon
Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells. Proceedings of the National Academy of Sciences of the United States of America 116 (29) (2019)
Kamila Naxerova, Johannes G Reiter, Elena Brachtel, Jochen K Lennerz, Marc van de Wetering, Andrew Rowan, Tianxi Cai, Hans Clevers, Charles Swanton, Martin A Nowak, Stephen J Elledge, Rakesh K Jain
Origins of lymphatic and distant metastases in human colorectal cancer. Science (New York, N.Y.) 357 (6346) (2018)
Kamila Naxerova, Stephen J Elledge
Taking the brakes off telomerase. eLife 4 (2015)