Gobec Izidor Sosič (Izidor Sosič)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 30

Top Topics

Metastatic Colorectal Cancer

Structure Activity Relationship

Protein Protein

Top Venues

Chemistry (Weinheim an der Bergstrasse, Germany)

Journal of medicinal chemistry

RSC chemical biology

This page only lists publications with an associated author ORCID identifier.

Publications

Katarina Grabrijan, Nika Strašek Benedik, Alen Krajnc, Krištof Bozovičar, Damijan Knez, Matic Proj, Irena Zdovc, Gobec Izidor Sosič, Carlos Contreras-Martel, Andrea Dessen, Martina Hrast Rambaher, Stanislav Gobec
Synthesis and biochemical evaluation of new 3-amido-4-substituted monocyclic ß-lactams as inhibitors of penicillin-binding protein(s). Acta pharmaceutica (Zagreb, Croatia) 74 (3) (2024)
Nika Strašek Benedik, Ana Dolšak, Urban Švajger, Gobec Izidor Sosič, Stanislav Gobec, Matej Sova
Structural Optimization and Biological Evaluation of Isoxazolo[5,4 -d ]pyrimidines as Selective Toll-Like Receptor 7 Agonists. ACS omega 9 (2) (2024)
Aleša Bricelj, Yuen Lam Dora Ng, Martina Gobec, Robert Kuchta, Wanyi Hu, Špela Javornik, Miha Rožič, Michael Gütschow, Guangrong Zheng, Jan Krönke, Christian Steinebach, Gobec Izidor Sosič
Design, Synthesis, and Evaluation of BCL-2 Targeting PROTACs. Chemistry (Weinheim an der Bergstrasse, Germany) 30 (45) (2024)
Aleša Bricelj, Yuen Lam Dora Ng, Martina Gobec, Robert Kuchta, Wanyi Hu, Špela Javornik, Miha Rožič, Michael Gütschow, Guangrong Zheng, Jan Krönke, Christian Steinebach, Gobec Izidor Sosič
Design, Synthesis, and Evaluation of BCL-2 Targeting PROTACs. Chemistry (Weinheim an der Bergstrasse, Germany) (2024)
Nika Strašek Benedik, Ana Dolšak, Urban Švajger, Gobec Izidor Sosič, Stanislav Gobec, Matej Sova
Structural Optimization and Biological Evaluation of Isoxazolo[5,4 -d ]pyrimidines as Selective Toll-Like Receptor 7 Agonists. ACS omega 9 (2) (2024)
Christian Steinebach, Aleša Bricelj, Arunima Murgai, Gobec Izidor Sosič, Luca Bischof, Yuen Lam Dora Ng, Christopher Heim, Samuel Maiwald, Matic Proj, Rabea Voget, Felix Feller, Janez Košmrlj, Valeriia Sapozhnikova, Annika Schmidt, Maximilian Rudolf Zuleeg, Patricia Lemnitzer, Philipp Mertins, Finn K Hansen, Michael Gütschow, Jan Krönke, Marcus D Hartmann
Leveraging Ligand Affinity and Properties: Discovery of Novel Benzamide-Type Cereblon Binders for the Design of PROTACs. Journal of medicinal chemistry (2023)
Yuen Lam Dora Ng, Aleša Bricelj, Jacqueline A Jansen, Arunima Murgai, Kirsten Peter, Katherine Aleisha Donovan, Michael Gütschow, Jan Krönke, Christian Steinebach, Gobec Izidor Sosič
Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins. Journal of medicinal chemistry (2023)
Martina Gobec, Aleš Obreza, Marko Jukič, Ana Baumgartner, Nja Mihelčič, Špela Potočnik, Julija Virant, Irena Mlinarič, Raščan Stanislav, Gobec Izidor Sosič
Design and synthesis of amino-substituted N -arylpiperidinyl-based inhibitors of the (immuno)proteasome. Acta pharmaceutica (Zagreb, Croatia) 73 (3) (2023)
Robert Kuchta, Christopher Heim, Alexander Herrmann, Samuel Maiwald, Yuen Lam Dora Ng, Gobec Izidor Sosič, Tim Keuler, Jan Krönke, Michael Gütschow, Marcus D Hartmann, Christian Steinebach
Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design. RSC chemical biology 4 (3) (2023)
Matic Proj, Nika Strašek, Stane Pajk, Damijan Knez, Gobec Izidor Sosič
Tunable Heteroaromatic Nitriles for Selective Bioorthogonal Click Reaction with Cysteine. Bioconjugate chemistry (2023)
Robert Kuchta, Christopher Heim, Alexander Herrmann, Samuel Maiwald, Yuen Lam Dora Ng, Gobec Izidor Sosič, Tim Keuler, Jan Krönke, Michael Gütschow, Marcus D Hartmann, Christian Steinebach
Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design. RSC chemical biology 4 (3) (2023)
Lan Phuong Vu, Claudia J Diehl, Ryan Casement, Adam G Bond, Christian Steinebach, Nika Strašek Benedik, Aleša Bricelj, Andrej Perdih, Gregor Schnakenburg, Gobec Izidor Sosič, Alessio Ciulli, Michael Gütschow
Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers. Journal of medicinal chemistry (2023)
Bianca Schulte, Maria König, Beate I Escher, Sophie Wittenburg, Matic Proj, Valentina Wolf, Carina Lemke, Gregor Schnakenburg, Gobec Izidor Sosič, Hendrik Streeck, Christa Elisabeth Müller, Michael Gütschow, Christian Steinebach
Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti-SARS-CoV-2 Activity. ChemMedChem 17 (5) (2022)
Andrej Šterman, Gobec Izidor Sosič, Zdenko Časar
Primary trifluoroborate-iminiums enable facile access to chiral α-aminoboronic acids via Ru-catalyzed asymmetric hydrogenation and simple hydrolysis of the trifluoroborate moiety. Chemical science 13 (10) (2022)
Arunima Murgai, Gobec Izidor Sosič, Martina Gobec, Patricia Lemnitzer, Matic Proj, Sophie Wittenburg, Rabea Voget, Michael Gütschow, Jan Krönke, Christian Steinebach
Targeting the deubiquitinase USP7 for degradation with PROTACs. Chemical communications (Cambridge, England) 58 (63) (2022)
Gobec Izidor Sosič, Aleša Bricelj, Christian Steinebach
E3 ligase ligand chemistries: from building blocks to protein degraders. Chemical Society reviews 51 (9) (2022)
Mihajlo Gajic, Damijan Knez, Gobec Izidor Sosič, Janez Mravljak, Anže Meden, Urban Košak, Luisa Leitzbach, Sven George, Bettina Hofmann, Aleksandra Zivkovic, Dieter Steinhilber, Holger Stark, Stanislav Gobec, Andrija Šmelcerović, Marko Anderluh
Repurposing of 8-Hydroxyquinoline-Based Butyrylcholinesterase and Cathepsin B Ligands as Potent Nonpeptidic Deoxyribonuclease I Inhibitors. ChemMedChem 17 (5) (2022)
Daniel S J Miller, Sabine A Voell, Gobec Izidor Sosič, Matic Proj, Olivia W Rossanese, Gregor Schnakenburg, Michael Gütschow, Ian Collins, Christian Steinebach
Encoding BRAF inhibitor functions in protein degraders. RSC medicinal chemistry 13 (6) (2022)
Eva Shannon Schiffrer, Matic Proj, Martina Gobec, Luka Rejc, Andrej Šterman, Janez Mravljak, Stanislav Gobec, Gobec Izidor Sosič
Synthesis and Biochemical Evaluation of Warhead-Decorated Psoralens as (Immuno)Proteasome Inhibitors. Molecules (Basel, Switzerland) 26 (2) (2021)
Katja Pirc, Vesna Hodnik, Tina Snoj, Tea Lenarčič, Simon Caserman, Marjetka Podobnik, Hannah Böhm, Isabell Albert, Anita Kotar, Janez Plavec, Jure Borišek, Martina Damuzzo, Alessandra Magistrato, Boris Brus, Gobec Izidor Sosič, Stanislav Gobec, Thorsten Nürnberger, Gregor Anderluh
Nep1-like proteins as a target for plant pathogen control. PLoS pathogens 17 (4) (2021)
Tihomir Tomašič, Asta Zubrienė, Žiga Skok, Riccardo Martini, Stane Pajk, Gobec Izidor Sosič, Janez Ilaš, Daumantas Matulis, Sharon D Bryant
Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores. Pharmaceuticals (Basel, Switzerland) 14 (8) (2021)
Aleša Bricelj, Yuen Lam Dora Ng, Dominic Ferber, Robert Kuchta, Sina Müller, Marius Monschke, Karl G Wagner, Jan Krönke, Gobec Izidor Sosič, Michael Gütschow, Christian Steinebach
Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands. ACS medicinal chemistry letters 12 (11) (2021)
Levente Kollár, Martina Gobec, Matic Proj, Lara Smrdel, Damijan Knez, Tímea Imre, Ágnes Gömöry, László Petri, Péter Ábrányi-Balogh, Dorottya Csányi, György G Ferenczy, Stanislav Gobec, Gobec Izidor Sosič, György Miklós Keserű
Fragment-Sized and Bidentate (Immuno)Proteasome Inhibitors Derived from Cysteine and Threonine Targeting Warheads. Cells 10 (12) (2021)
Christian Steinebach, Yuen Lam Dora Ng, Gobec Izidor Sosič, Chih-Shia Lee, Sirui Chen, Stefanie Lindner, Lan Phuong Vu, Aleša Bricelj, Reza Haschemi, Marius Monschke, Elisabeth Steinwarz, Karl G Wagner, Gerd Bendas, Ji Luo, Michael Gütschow, Jan Krönke
Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders. Chemical science 11 (13) (2020)
Kaja Rožman, Evan M Alexander, Eva Ogorevc, Krištof Bozovičar, Gobec Izidor Sosič, Courtney C Aldrich, Stanislav Gobec
Psoralen Derivatives as Inhibitors of Mycobacterium tuberculosis Proteasome. Molecules (Basel, Switzerland) 25 (6) (2020)
Christian Steinebach, Gobec Izidor Sosič, Stefanie Lindner, Aleša Bricelj, Franziska Kohl, Yuen Lam Dora Ng, Marius Monschke, Karl G Wagner, Jan Krönke, Michael Gütschow
A MedChem toolbox for cereblon-directed PROTACs. MedChemComm 10 (6) (2019)
Ana Mitrović, Jakob Kljun, Gobec Izidor Sosič, Matija Uršič, Anton Meden, Stanislav Gobec, Janko Kos, Iztok Turel
Organoruthenated Nitroxoline Derivatives Impair Tumor Cell Invasion through Inhibition of Cathepsin B Activity. Inorganic chemistry 58 (18) (2019)
Eva Shannon Schiffrer, Gobec Izidor Sosič, Andrej Šterman, Janez Mravljak, Irena Mlinarič Raščan, Stanislav Gobec, Martina Gobec
A focused structure-activity relationship study of psoralen-based immunoproteasome inhibitors. MedChemComm 10 (11) (2019)
Lena Decuyper, Katarina Magdalenić, Marie Verstraete, Marko Jukič, Gobec Izidor Sosič, Eric Sauvage, Ana Maria Amoroso, Olivier Verlaine, Bernard Joris, Stanislav Gobec, Matthias D'hooghe
α-Unsaturated 3-Amino-1-carboxymethyl-β-lactams as Bacterial PBP Inhibitors: Synthesis and Biochemical Assessment. Chemistry (Weinheim an der Bergstrasse, Germany) (2019)
Lena Decuyper, Sari Deketelaere, Lore Vanparys, Marko Jukič, Gobec Izidor Sosič, Eric Sauvage, Ana Maria Amoroso, Olivier Verlaine, Bernard Joris, Stanislav Gobec, Matthias D'hooghe
In Silico Design and Enantioselective Synthesis of Functionalized Monocyclic 3-Amino-1-carboxymethyl-β-lactams as Inhibitors of Penicillin-Binding Proteins of Resistant Bacteria. Chemistry (Weinheim an der Bergstrasse, Germany) 24 (57) (2018)