Howard Y Chang (Howard Chang)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 126

Top Venues

Nature genetics

Nature communications

eLife

Nature

This page only lists publications with an associated author ORCID identifier.

Publications

Xiaowei Yan, Paul S Mischel, Howard Y Chang
Extrachromosomal DNA in cancer. Nature reviews. Cancer 24 (4) (2024)
Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M Ryan Corces, Patrick Neuhöfer, Victoria M Gillespie, Peggie Cheung, Julia A Belk, Yung-Hsin Huang, Yuning Wei, Lu Chen, Howard Y Chang, Steven E Artandi
Clonal inactivation of TERT impairs stem cell competition. Nature 632 (8023) (2024)
Xiaowei Yan, Paul S Mischel, Howard Y Chang
Extrachromosomal DNA in cancer. Nature reviews. Cancer (2024)
Naomi M Pacalin, Zachary Steinhart, Quanming Shi, Julia A Belk, Dmytro Dorovskyi, Katerina Kraft, Kevin R Parker, Brian R Shy, Alexander Marson, Howard Y Chang
Bidirectional epigenetic editing reveals hierarchies in gene regulation. Nature biotechnology (2024)
Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M Ryan Corces, Patrick Neuhöfer, Victoria M Gillespie, Peggie Cheung, Julia A Belk, Yung-Hsin Huang, Yuning Wei, Lu Chen, Howard Y Chang, Steven E Artandi
Clonal inactivation of TERT impairs stem cell competition. Nature 632 (8023) (2024)
Xiaowei Yan, Paul S Mischel, Howard Y Chang
Extrachromosomal DNA in cancer. Nature reviews. Cancer (2024)
Peng Dong, Shu Zhang, Valentina Gandin, Liangqi Xie, Lihua Wang, Andrew L Lemire, Wenhong Li, Hideo Otsuna, Takashi Kawase, Arthur D Lander, Howard Y Chang, Zhe J Liu
Cohesin prevents cross-domain gene coactivation. Nature genetics 56 (8) (2024)
António J M Santos, Vincent van Unen, Zhongqi Lin, Steven M Chirieleison, Nhi Ha, Arpit Batish, Joshua E Chan, Jose Cedano, Elisa T Zhang, Qinghui Mu, Alexander Guh-Siesel, Madeline Tomaske, Deana Colburg, Sushama Varma, Shannon S Choi, Asbjørn Christophersen, Ani Baghdasaryan, Kathryn E Yost, Kasper Karlsson, Andrew Ha, Jing Li, Hongjie Dai, Zachary M Sellers, Howard Y Chang, James C Y Dunn, Bing M Zhang, Elizabeth D Mellins, Ludvig M Sollid, Nielsen Q Fernandez-Becker, Mark M Davis, Calvin J Kuo
A human autoimmune organoid model reveals IL-7 function in coeliac disease. Nature 632 (8024) (2024)
António J M Santos, Vincent van Unen, Zhongqi Lin, Steven M Chirieleison, Nhi Ha, Arpit Batish, Joshua E Chan, Jose Cedano, Elisa T Zhang, Qinghui Mu, Alexander Guh-Siesel, Madeline Tomaske, Deana Colburg, Sushama Varma, Shannon S Choi, Asbjørn Christophersen, Ani Baghdasaryan, Kathryn E Yost, Kasper Karlsson, Andrew Ha, Jing Li, Hongjie Dai, Zachary M Sellers, Howard Y Chang, James C Y Dunn, Bing M Zhang, Elizabeth D Mellins, Ludvig M Sollid, Nielsen Q Fernandez-Becker, Mark M Davis, Calvin J Kuo
A human autoimmune organoid model reveals IL-7 function in coeliac disease. Nature 632 (8024) (2024)
John C Rose, Julia A Belk, Ivy Tsz-Lo Wong, Jens Luebeck, Hudson T Horn, Bence Daniel, Matthew G Jones, Kathryn E Yost, King L Hung, Kevin S Kolahi, Ellis J Curtis, Calvin J Kuo, Vineet Bafna, Paul S Mischel, Howard Y Chang
Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair. Cancer discovery (2024)
Xiaowei Yan, Paul S Mischel, Howard Y Chang
Extrachromosomal DNA in cancer. Nature reviews. Cancer 24 (4) (2024)
Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M Ryan Corces, Patrick Neuhöfer, Victoria M Gillespie, Peggie Cheung, Julia A Belk, Yung-Hsin Huang, Yuning Wei, Lu Chen, Howard Y Chang, Steven E Artandi
Clonal inactivation of TERT impairs stem cell competition. Nature 632 (8023) (2024)
Peng Dong, Shu Zhang, Valentina Gandin, Liangqi Xie, Lihua Wang, Andrew L Lemire, Wenhong Li, Hideo Otsuna, Takashi Kawase, Arthur D Lander, Howard Y Chang, Zhe J Liu
Cohesin prevents cross-domain gene coactivation. Nature genetics 56 (8) (2024)
Miin S Lin, Se-Young Jo, Jens Luebeck, Howard Y Chang, Sihan Wu, Paul S Mischel, Vineet Bafna
Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors. eLife 12 (2024)
Peng Dong, Shu Zhang, Valentina Gandin, Liangqi Xie, Lihua Wang, Andrew L Lemire, Wenhong Li, Hideo Otsuna, Takashi Kawase, Arthur D Lander, Howard Y Chang, Zhe J Liu
Cohesin prevents cross-domain gene coactivation. Nature genetics 56 (8) (2024)
Miin S Lin, Se-Young Jo, Jens Luebeck, Howard Y Chang, Sihan Wu, Paul S Mischel, Vineet Bafna
Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors. eLife 12 (2024)
Miin S Lin, Se-Young Jo, Jens Luebeck, Howard Y Chang, Sihan Wu, Paul S Mischel, Vineet Bafna
Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors. eLife 12 (2024)
Laksshman Sundaram, Arvind Kumar, Matthew Zatzman, Adriana Salcedo, Neal G Ravindra, Shadi Shams, Brian H Louie, S Tansu Bagdatli, Matthew A Myers, Shahab Sarmashghi, Hyo Young Choi, Won-Young Choi, Kathryn E Yost, Yanding Zhao, Jeffrey M Granja, Toshinori Hinoue, David Neil Hayes, Andrew D Cherniak, Ina Felau, Hani Choudhry, Jean Claude Zenklusen, Kyle Kai-How Farh, Andrew W McPherson, Christina Curtis, Peter W Laird, null null, M Ryan Corces, Howard Y Chang, William J Greenleaf, John A Demchok, Liming Yang, Roy Tarnuzzer, Samantha J Caesar-Johnson, Zhining Wang, Ashley S Doane, Ekta Khurana, Mauro A A Castro, Alexander J Lazar, Bradley M Broom, John N Weinstein, Rehan Akbani, Shwetha V Kumar, Benjamin J Raphael, Christopher K Wong, Joshua M Stuart, Rojin Safavi, Christopher C Benz, Benjamin K Johnson, Cindy Kyi, Hui Shen
Single-cell chromatin accessibility reveals malignant regulatory programs in primary human cancers. Science (New York, N.Y.) 385 (6713) (2024)
António J M Santos, Vincent van Unen, Zhongqi Lin, Steven M Chirieleison, Nhi Ha, Arpit Batish, Joshua E Chan, Jose Cedano, Elisa T Zhang, Qinghui Mu, Alexander Guh-Siesel, Madeline Tomaske, Deana Colburg, Sushama Varma, Shannon S Choi, Asbjørn Christophersen, Ani Baghdasaryan, Kathryn E Yost, Kasper Karlsson, Andrew Ha, Jing Li, Hongjie Dai, Zachary M Sellers, Howard Y Chang, James C Y Dunn, Bing M Zhang, Elizabeth D Mellins, Ludvig M Sollid, Nielsen Q Fernandez-Becker, Mark M Davis, Calvin J Kuo
A human autoimmune organoid model reveals IL-7 function in coeliac disease. Nature 632 (8024) (2024)
Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M Ryan Corces, Patrick Neuhöfer, Victoria M Gillespie, Peggie Cheung, Julia A Belk, Yung-Hsin Huang, Yuning Wei, Lu Chen, Howard Y Chang, Steven E Artandi
Clonal inactivation of TERT impairs stem cell competition. Nature (2024)
Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M Ryan Corces, Patrick Neuhöfer, Victoria M Gillespie, Peggie Cheung, Julia A Belk, Yung-Hsin Huang, Yuning Wei, Lu Chen, Howard Y Chang, Steven E Artandi
Clonal inactivation of TERT impairs stem cell competition. Nature 632 (8023) (2024)
Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M Ryan Corces, Patrick Neuhöfer, Victoria M Gillespie, Peggie Cheung, Julia A Belk, Yung-Hsin Huang, Yuning Wei, Lu Chen, Howard Y Chang, Steven E Artandi
Clonal inactivation of TERT impairs stem cell competition. Nature 632 (8023) (2024)
Miin S Lin, Se-Young Jo, Jens Luebeck, Howard Y Chang, Sihan Wu, Paul S Mischel, Vineet Bafna
Transcriptional immune suppression and up-regulation of double-stranded DNA damage and repair repertoires in ecDNA-containing tumors. eLife 12 (2024)
António J M Santos, Vincent van Unen, Zhongqi Lin, Steven M Chirieleison, Nhi Ha, Arpit Batish, Joshua E Chan, Jose Cedano, Elisa T Zhang, Qinghui Mu, Alexander Guh-Siesel, Madeline Tomaske, Deana Colburg, Sushama Varma, Shannon S Choi, Asbjørn Christophersen, Ani Baghdasaryan, Kathryn E Yost, Kasper Karlsson, Andrew Ha, Jing Li, Hongjie Dai, Zachary M Sellers, Howard Y Chang, James C Y Dunn, Bing M Zhang, Elizabeth D Mellins, Ludvig M Sollid, Nielsen Q Fernandez-Becker, Mark M Davis, Calvin J Kuo
A human autoimmune organoid model reveals IL-7 function in coeliac disease. Nature (2024)
Xiaowei Yan, Paul S Mischel, Howard Y Chang
Extrachromosomal DNA in cancer. Nature reviews. Cancer 24 (4) (2024)
Peng Dong, Shu Zhang, Valentina Gandin, Liangqi Xie, Lihua Wang, Andrew L Lemire, Wenhong Li, Hideo Otsuna, Takashi Kawase, Arthur D Lander, Howard Y Chang, Zhe J Liu
Cohesin prevents cross-domain gene coactivation. Nature genetics (2024)
John C Rose, Julia A Belk, Ivy Tsz-Lo Wong, Jens Luebeck, Hudson T Horn, Bence Daniel, Matthew G Jones, Kathryn E Yost, King L Hung, Kevin S Kolahi, Ellis J Curtis, Calvin J Kuo, Vineet Bafna, Paul S Mischel, Howard Y Chang
Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair. Cancer discovery (2024)
Kazuteru Hasegawa, Yang Zhao, Alina Garbuzov, M Ryan Corces, Patrick Neuhöfer, Victoria M Gillespie, Peggie Cheung, Julia A Belk, Yung-Hsin Huang, Yuning Wei, Lu Chen, Howard Y Chang, Steven E Artandi
Clonal inactivation of TERT impairs stem cell competition. Nature 632 (8023) (2024)
Eloise Berson, Anjali Sreenivas, Thanaphong Phongpreecha, Amalia Perna, Fiorella C Grandi, Lei Xue, Neal G Ravindra, Neelufar Payrovnaziri, Samson J Mataraso, Yeasul Kim, Camilo A Espinosa, Alan L Chang, Martin Becker, Kathleen S Montine, Edward J Fox, Howard Y Chang, M Ryan Corces, Nima Aghaeepour, Thomas J Montine
Whole genome deconvolution unveils Alzheimer's resilient epigenetic signature. Nature communications 14 (1) (2023)
Adriana Gonzalez-Sandoval, Katja Pekrun, Shinnosuke Tsuji, Feijie Zhang, King L Hung, Howard Y Chang, Mark A Kay
The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner. Nature communications 14 (1) (2023)
Rocío Chamorro González, Thomas Conrad, Maja C Cwikla, Robin Xu, Madalina Giurgiu, Elias Rodriguez-Fos, Katharina Kasack, Lotte Brueckner, Elias Rodriguez-Fos, Konstantin Helmsauer, Heathcliff Dorado Garcia, Maria E Stefanova, King L Hung, Yi Bei, Karin Schmelz, Marco Lodrini, Stefan Mundlos, Howard Y Chang, Hedwig E Deubzer, Sascha Sauer, Angelika Eggert, Johannes Hubertus Schulte, Roland F Schwarz, Kerstin Haase, Richard P Koche, Anton G Henssen
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells. Nature genetics (2023)
Jens Luebeck, Alvin Wei Tian Ng, Patricia C Galipeau, Xiaohong Li, Carissa A Sanchez, Annalise C Katz-Summercorn, Hoon Kim, Sriganesh Jammula, Yudou He, Scott M Lippman, Roel G W Verhaak, Carlo C Maley, Ludmil B Alexandrov, Brian J Reid, Rebecca C Fitzgerald, Thomas G Paulson, Howard Y Chang, Sihan Wu, Vineet Bafna, Paul S Mischel
Extrachromosomal DNA in the cancerous transformation of Barrett's oesophagus. Nature (2023)
Adriana Gonzalez-Sandoval, Katja Pekrun, Shinnosuke Tsuji, Feijie Zhang, King L Hung, Howard Y Chang, Mark A Kay
The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner. Nature communications 14 (1) (2023)
Ling-Ling Chen, Albrecht Bindereif, Irene Bozzoni, Howard Y Chang, A Gregory Matera, Myriam Gorospe, Thomas Birkballe Hansen, Jørgen Kjems, Xu-Kai Ma, Jun Wei Pek, Nikolaus Rajewsky, Julia Salzman, Jeremy E Wilusz, Li Yang, Fangqing Zhao
A guide to naming eukaryotic circular RNAs. Nature cell biology 25 (1) (2023)
Adriana Gonzalez-Sandoval, Katja Pekrun, Shinnosuke Tsuji, Feijie Zhang, King L Hung, Howard Y Chang, Mark A Kay
The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner. Nature communications 14 (1) (2023)
Adriana Gonzalez-Sandoval, Katja Pekrun, Shinnosuke Tsuji, Feijie Zhang, King L Hung, Howard Y Chang, Mark A Kay
The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner. Nature communications 14 (1) (2023)
Laura C Amaya Hernandez, Lilit Grigoryan, Zhijian Li, Audrey Lee, Paul A Wender, Bali Pulendran, Howard Y Chang
Circular RNA vaccine induces potent T cell responses. Proceedings of the National Academy of Sciences of the United States of America 120 (20) (2023)
Rocío Chamorro González, Thomas Conrad, Maja C Cwikla, Robin Xu, Madalina Giurgiu, Elias Rodriguez-Fos, Katharina Kasack, Lotte Brueckner, Elias Rodriguez-Fos, Konstantin Helmsauer, Heathcliff Dorado Garcia, Maria E Stefanova, King L Hung, Yi Bei, Karin Schmelz, Marco Lodrini, Stefan Mundlos, Howard Y Chang, Hedwig E Deubzer, Sascha Sauer, Angelika Eggert, Johannes Hubertus Schulte, Roland F Schwarz, Kerstin Haase, Richard P Koche, Anton G Henssen
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells. Nature genetics 55 (5) (2023)
Rocío Chamorro González, Thomas Conrad, Maja C Cwikla, Robin Xu, Madalina Giurgiu, Elias Rodriguez-Fos, Katharina Kasack, Lotte Brueckner, Elias Rodriguez-Fos, Konstantin Helmsauer, Heathcliff Dorado Garcia, Maria E Stefanova, King L Hung, Yi Bei, Karin Schmelz, Marco Lodrini, Stefan Mundlos, Howard Y Chang, Hedwig E Deubzer, Sascha Sauer, Angelika Eggert, Johannes Hubertus Schulte, Roland F Schwarz, Kerstin Haase, Richard P Koche, Anton G Henssen
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells. Nature genetics 55 (5) (2023)
John S Mattick, Paulo P Amaral, Piero Carnici, Susan Carpenter, Howard Y Chang, Ling-Ling Chen, Runsheng Chen, Caroline Dean, Marcel E Dinger, Katherine A Fitzgerald, Thomas R Gingeras, Mitchell Guttman, Tetsuro Hirose, Maite Huarte, Rory Johnson, Chandrasekhar Kanduri, Philipp Kapranov, Jeanne B Lawrence, Jeannie T Lee, Joshua T Mendell, Timothy R Mercer, Kathryn J Moore, Shinichi Nakagawa, John L Rinn, David L Spector, Igor Ulitsky, Yue Wan, Jeremy E Wilusz, Mian Wu
Long non-coding RNAs: definitions, functions, challenges and recommendations. Nature reviews. Molecular cell biology (2023)
Zhijian Li, Laura C Amaya Hernandez, Ruoxi Pi, Sean K Wang, Alok Ranjan, Robert M Waymouth, Catherine A Blish, Howard Y Chang, Paul A Wender
Charge-altering releasable transporters enhance mRNA delivery in vitro and exhibit in vivo tropism. Nature communications 14 (1) (2023)
Ling-Ling Chen, Albrecht Bindereif, Irene Bozzoni, Howard Y Chang, A Gregory Matera, Myriam Gorospe, Thomas Birkballe Hansen, Jørgen Kjems, Xu-Kai Ma, Jun Wei Pek, Nikolaus Rajewsky, Julia Salzman, Jeremy E Wilusz, Li Yang, Fangqing Zhao
A guide to naming eukaryotic circular RNAs. Nature cell biology (2023)
Laura C Amaya Hernandez, Lilit Grigoryan, Zhijian Li, Audrey Lee, Paul A Wender, Bali Pulendran, Howard Y Chang
Circular RNA vaccine induces potent T cell responses. Proceedings of the National Academy of Sciences of the United States of America 120 (20) (2023)
Laura C Amaya Hernandez, Lilit Grigoryan, Zhijian Li, Audrey Lee, Paul A Wender, Bali Pulendran, Howard Y Chang
Circular RNA vaccine induces potent T cell responses. Proceedings of the National Academy of Sciences of the United States of America 120 (20) (2023)
Rocío Chamorro González, Thomas Conrad, Maja C Cwikla, Robin Xu, Madalina Giurgiu, Elias Rodriguez-Fos, Katharina Kasack, Lotte Brueckner, Elias Rodriguez-Fos, Konstantin Helmsauer, Heathcliff Dorado Garcia, Maria E Stefanova, King L Hung, Yi Bei, Karin Schmelz, Marco Lodrini, Stefan Mundlos, Howard Y Chang, Hedwig E Deubzer, Sascha Sauer, Angelika Eggert, Johannes Hubertus Schulte, Roland F Schwarz, Kerstin Haase, Richard P Koche, Anton G Henssen
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells. Nature genetics 55 (5) (2023)
Rocío Chamorro González, Thomas Conrad, Maja C Cwikla, Robin Xu, Madalina Giurgiu, Elias Rodriguez-Fos, Katharina Kasack, Lotte Brueckner, Elias Rodriguez-Fos, Konstantin Helmsauer, Heathcliff Dorado Garcia, Maria E Stefanova, King L Hung, Yi Bei, Karin Schmelz, Marco Lodrini, Stefan Mundlos, Howard Y Chang, Hedwig E Deubzer, Sascha Sauer, Angelika Eggert, Johannes Hubertus Schulte, Roland F Schwarz, Kerstin Haase, Richard P Koche, Anton G Henssen
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells. Nature genetics 55 (5) (2023)
Owen S Chapman, Jens Luebeck, Sunita Sridhar, Ivy Tsz-Lo Wong, Deobrat Dixit, Shanqing Wang, Gino Prasad, Utkrisht Rajkumar, Meghana S Pagadala, Jon D Larson, Britney Jiayu He, King L Hung, Joshua T Lange, Siavash R Dehkordi, Sahaana Chandran, Miriam Adam, Ling Morgan, Sameena Wani, Ashutosh Tiwari, Caitlin Guccione, Yingxi Lin, Aditi Dutta, Yan Yuen Lo, Edwin Juarez, James T Robinson, Andrey Korshunov, John-Edward A Michaels, Yoon-Jae Cho, Denise M Malicki, Nicole G Coufal, Michael L Levy, Charlotte Hobbs, Richard H Scheuermann, John R Crawford, Scott L Pomeroy, Jeremy N Rich, Xinlian Zhang, Howard Y Chang, Jesse R Dixon, Anindya Bagchi, Aniruddha J Deshpande, Hannah Carter, Ernest Fraenkel, Paul S Mischel, Robert J Wechsler-Reya, Vineet Bafna, Jill P Mesirov, Lukas Chavez
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma. Nature genetics (2023)
Laura C Amaya Hernandez, Lilit Grigoryan, Zhijian Li, Audrey Lee, Paul A Wender, Bali Pulendran, Howard Y Chang
Circular RNA vaccine induces potent T cell responses. Proceedings of the National Academy of Sciences of the United States of America 120 (20) (2023)
Laura C Amaya Hernandez, Lilit Grigoryan, Zhijian Li, Audrey Lee, Paul A Wender, Bali Pulendran, Howard Y Chang
Circular RNA vaccine induces potent T cell responses. Proceedings of the National Academy of Sciences of the United States of America 120 (20) (2023)
Ling-Ling Chen, Albrecht Bindereif, Irene Bozzoni, Howard Y Chang, A Gregory Matera, Myriam Gorospe, Thomas Birkballe Hansen, Jørgen Kjems, Xu-Kai Ma, Jun Wei Pek, Nikolaus Rajewsky, Julia Salzman, Jeremy E Wilusz, Li Yang, Fangqing Zhao
A guide to naming eukaryotic circular RNAs. Nature cell biology 25 (1) (2023)
Adriana Gonzalez-Sandoval, Katja Pekrun, Shinnosuke Tsuji, Feijie Zhang, King L Hung, Howard Y Chang, Mark A Kay
The AAV capsid can influence the epigenetic marking of rAAV delivered episomal genomes in a species dependent manner. Nature communications 14 (1) (2023)
Rocío Chamorro González, Thomas Conrad, Maja C Cwikla, Robin Xu, Madalina Giurgiu, Elias Rodriguez-Fos, Katharina Kasack, Lotte Brueckner, Elias Rodriguez-Fos, Konstantin Helmsauer, Heathcliff Dorado Garcia, Maria E Stefanova, King L Hung, Yi Bei, Karin Schmelz, Marco Lodrini, Stefan Mundlos, Howard Y Chang, Hedwig E Deubzer, Sascha Sauer, Angelika Eggert, Johannes Hubertus Schulte, Roland F Schwarz, Kerstin Haase, Richard P Koche, Anton G Henssen
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells. Nature genetics (2023)
Rocío Chamorro González, Thomas Conrad, Maja C Cwikla, Robin Xu, Madalina Giurgiu, Elias Rodriguez-Fos, Katharina Kasack, Lotte Brueckner, Elias Rodriguez-Fos, Konstantin Helmsauer, Heathcliff Dorado Garcia, Maria E Stefanova, King L Hung, Yi Bei, Karin Schmelz, Marco Lodrini, Stefan Mundlos, Howard Y Chang, Hedwig E Deubzer, Sascha Sauer, Angelika Eggert, Johannes Hubertus Schulte, Roland F Schwarz, Kerstin Haase, Richard P Koche, Anton G Henssen
Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells. Nature genetics 55 (5) (2023)
Qing Ma, Liuyi Yang, Karen Tolentino, Guiping Wang, Yang Zhao, Ulrike M Litzenburger, Quanming Shi, Lin Zhu, Chen Yang, Huiyuan Jiao, Feng Zhang, Rui Li, Miao-Chih Tsai, Jun-An Chen, Ian Lai, Hong Zeng, Lingjie Li, Howard Y Chang
Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis. eLife 11 (2022)
Katherine A Freitas, Julia A Belk, Elena Sotillo, Patrick J Quinn, Maria C Ramello, Meena Malipatlolla, Bence Daniel, Katalin D Sandor, Dorota D Klysz, Jeremy Bjelajac, Peng Xu, Kylie A Burdsall, Victor Tieu, Vandon T Duong, Micah G Donovan, Evan W Weber, Howard Y Chang, Robbie G Majzner, Joaquín Maximiliano Espinosa, Ansuman T Satpathy, Crystal L Mackall
Enhanced T cell effector activity by targeting the Mediator kinase module. Science (New York, N.Y.) 378 (6620) (2022)
Howard Y Chang
Personal regulome navigation of cancer. Nature reviews. Cancer 21 (10) (2022)
Qing Ma, Liuyi Yang, Karen Tolentino, Guiping Wang, Yang Zhao, Ulrike M Litzenburger, Quanming Shi, Lin Zhu, Chen Yang, Huiyuan Jiao, Feng Zhang, Rui Li, Miao-Chih Tsai, Jun-An Chen, Ian Lai, Hong Zeng, Lingjie Li, Howard Y Chang
Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis. eLife 11 (2022)
Robert Chen, Sean K Wang, Julia A Belk, Laura C Amaya Hernandez, Zhijian Li, Angel Cardenas, Brian T Abe, Chun-Kan Chen, Paul A Wender, Howard Y Chang
Engineering circular RNA for enhanced protein production. Nature biotechnology (2022)
Bence Daniel, Kathryn E Yost, Sunnie Hsiung, Katalin D Sandor, Yu Xia, Yanyan Qi, Kamir J Hiam-Galvez, Mollie Black, Colin J Raposo, Quanming Shi, Stefanie L Meier, Julia A Belk, Josephine R Giles, E John Wherry, Howard Y Chang, Takashi Ebihara, Ansuman T Satpathy
Divergent clonal differentiation trajectories of T cell exhaustion. Nature immunology 23 (11) (2022)
Qing Ma, Liuyi Yang, Karen Tolentino, Guiping Wang, Yang Zhao, Ulrike M Litzenburger, Quanming Shi, Lin Zhu, Chen Yang, Huiyuan Jiao, Feng Zhang, Rui Li, Miao-Chih Tsai, Jun-An Chen, Ian Lai, Hong Zeng, Lingjie Li, Howard Y Chang
Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis. eLife 11 (2022)
Qing Ma, Liuyi Yang, Karen Tolentino, Guiping Wang, Yang Zhao, Ulrike M Litzenburger, Quanming Shi, Lin Zhu, Chen Yang, Huiyuan Jiao, Feng Zhang, Rui Li, Miao-Chih Tsai, Jun-An Chen, Ian Lai, Hong Zeng, Lingjie Li, Howard Y Chang
Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis. eLife 11 (2022)
Robert Chen, Sean K Wang, Julia A Belk, Laura C Amaya Hernandez, Zhijian Li, Angel Cardenas, Brian T Abe, Chun-Kan Chen, Paul A Wender, Howard Y Chang
Author Correction: Engineering circular RNA for enhanced protein production. Nature biotechnology (2022)
King L Hung, Paul S Mischel, Howard Y Chang
Gene regulation on extrachromosomal DNA. Nature structural & molecular biology 29 (8) (2022)
Qing Ma, Liuyi Yang, Karen Tolentino, Guiping Wang, Yang Zhao, Ulrike M Litzenburger, Quanming Shi, Lin Zhu, Chen Yang, Huiyuan Jiao, Feng Zhang, Rui Li, Miao-Chih Tsai, Jun-An Chen, Ian Lai, Hong Zeng, Lingjie Li, Howard Y Chang
Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis. eLife 11 (2022)
Liangqi Xie, Peng Dong, Yifeng Qi, Tsung-Han S Hsieh, Brian P English, SeolKyoung Jung, Xingqi Chen, Margherita De Marzio, Rafael Casellas, Howard Y Chang, Bin Zhang, Robert Tse Nan Tjian, Zhe J Liu
BRD2 compartmentalizes the accessible genome. Nature genetics 54 (4) (2022)
King L Hung, Jens Luebeck, Siavash R Dehkordi, Caterina I Colón, Rui Li, Ivy Tsz-Lo Wong, Ceyda Coruh, Prashanthi Dharanipragada, Shirley H Lomeli, Natasha E Weiser, Gatien Moriceau, Xiao Zhang, Chris Bailey, Kathleen E Houlahan, Wenting Yang, Rocio Chamorro González, Charles Swanton, Christina Curtis, Mariam Jamal-Hanjani, Anton G Henssen, Julie A Law, William J Greenleaf, Roger S Lo, Paul S Mischel, Vineet Bafna, Howard Y Chang
Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH. Nature genetics 54 (11) (2022)
Qing Ma, Liuyi Yang, Karen Tolentino, Guiping Wang, Yang Zhao, Ulrike M Litzenburger, Quanming Shi, Lin Zhu, Chen Yang, Huiyuan Jiao, Feng Zhang, Rui Li, Miao-Chih Tsai, Jun-An Chen, Ian Lai, Hong Zeng, Lingjie Li, Howard Y Chang
Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis. eLife 11 (2022)
Joshua T Lange, John C Rose, Celine Y Chen, Yuriy Pichugin, Liangqi Xie, Jun Tang, King L Hung, Kathryn E Yost, Quanming Shi, Marcella L Erb, Utkrisht Rajkumar, Sihan Wu, Sabine Taschner-Mandl, Marie Bernkopf, Charles Swanton, Zhe J Liu, Weini Huang, Howard Y Chang, Vineet Bafna, Anton G Henssen, Benjamin Werner, Paul S Mischel
The evolutionary dynamics of extrachromosomal DNA in human cancers. Nature genetics 54 (10) (2022)
Natasha E Weiser, King L Hung, Howard Y Chang
Oncogene Convergence in Extrachromosomal DNA Hubs. Cancer discovery 12 (5) (2022)
Jan Renier Moonen, James Chappell, Minyi Shi, Tsutomu Shinohara, Dan Li, Maxwell R Mumbach, Fan Zhang, Ramesh V Nair, Joseph Nasser, Daniel H Mai, Shalina Taylor, Lingli Wang, Ross J Metzger, Howard Y Chang, Jesse M Engreitz, Michael Paul Snyder, Marlene Rabinovitch
KLF4 recruits SWI/SNF to increase chromatin accessibility and reprogram the endothelial enhancer landscape under laminar shear stress. Nature communications 13 (1) (2022)
Joshua R Wheeler, Oscar N Whitney, Thomas O Vogler, Eric D Nguyen, Bradley Pawlikowski, Evan Lester, Alicia A Cutler, Tiffany Elston, Nicole Dalla Betta, Kevin R Parker, Kathryn E Yost, Hannes Vogel, Thomas A Rando, Howard Y Chang, Aaron M Johnson, Roy Parker, Bradley B Olwin
RNA-binding proteins direct myogenic cell fate decisions. eLife 11 (2022)
Katerina Kraft, Kathryn E Yost, Sedona E Murphy, Andreas Magg, Yicheng Long, M Ryan Corces, Jeffrey M Granja, Lars Wittler, Stefan Mundlos, Thomas R Cech, Alistair N Boettiger, Howard Y Chang
Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation. Proceedings of the National Academy of Sciences of the United States of America 119 (22) (2022)
Akshay Sanghi, Joshua J Gruber, Ahmed A Metwally, Lihua Jiang, Warren Reynolds, John B Sunwoo, Lisa Orloff, Howard Y Chang, Maya Kasowski, Michael Paul Snyder
Chromatin accessibility associates with protein-RNA correlation in human cancer. Nature communications 12 (1) (2021)
Jeffrey M Granja, M Ryan Corces, Sarah E Pierce, S Tansu Bagdatli, Hani Choudhry, Howard Y Chang, William J Greenleaf
ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis. Nature genetics 53 (3) (2021)
Deshka S Foster, Michael Januszyk, Kathryn E Yost, Malini S Chinta, Gunsagar S Gulati, Alan T Nguyen, Austin R Burcham, Ankit Salhotra, R Chase Ransom, Dominic Henn, Kellen Chen, Shamik Mascharak, Karen Tolentino, Ashley L Titan, R Ellen Jones, Oscar da Silva, W Tripp Leavitt, Clement D Marshall, Heather E des Jardins-Park, Michael S Hu, Derrick C Wan, Gerlinde Wernig, Dhananjay Wagh, John Coller, Jeffrey A Norton, Geoffrey C Gurtner, Aaron M Newman, Howard Y Chang, Michael T Longaker
Integrated spatial multiomics reveals fibroblast fate during tissue repair. Proceedings of the National Academy of Sciences of the United States of America 118 (41) (2021)
Michelle F Griffin, Mimi R Borrelli, Julia T Garcia, Michael Januszyk, Megan King, Tristan Lerbs, Lu Cui, Alessandra L Moore, Abra H Shen, Shamik Mascharak, Nestor M Diaz Deleon, Sandeep Adem, Walter L Taylor, Heather E desJardins-Park, Marc Gastou, Ronak A Patel, Bryan A Duoto, Jan Sokol, Yuning Wei, Deshka S Foster, Kellen Chen, Derrick C Wan, Geoffrey C Gurtner, Hermann P Lorenz, Howard Y Chang, Gerlinde Wernig, Michael T Longaker
JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models. Science translational medicine 13 (609) (2021)
Sarah E Pierce, Jeffrey M Granja, M Ryan Corces, Jennifer J Brady, Min K Tsai, Aubrey B Pierce, Rui Tang, Pauline Chu, David M Feldser, Howard Y Chang, Michael C Bassik, William J Greenleaf, Monte M Winslow
LKB1 inactivation modulates chromatin accessibility to drive metastatic progression. Nature cell biology 23 (8) (2021)
Lucile Marion-Poll, Benjamin Forêt, Dina Zielinski, Florian Massip, Mikael Attia, Ava C Carter, Laurène Syx, Howard Y Chang, Anne-Valerie Gendrel, Edith Heard
Locus specific epigenetic modalities of random allelic expression imbalance. Nature communications 12 (1) (2021)
Jason P Smith, M Ryan Corces, Jin Xu, Vincent P Reuter, Howard Y Chang, Nathan C Sheffield
PEPATAC: an optimized pipeline for ATAC-seq data analysis with serial alignments. NAR genomics and bioinformatics 3 (4) (2021)
Justus M Kebschull, Ethan B Richman, Noam Ringach, Drew Friedmann, Eddy Albarran, Sai Saroja Kolluru, Robert C Jones, William E Allen, Ying Wang, Seung Woo Cho, Huaijun Zhou, Jun B Ding, Howard Y Chang, Karl Deisseroth, Stephen R Quake, Liqun Luo
Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set. Science (New York, N.Y.) 370 (6523) (2021)
Evan W Weber, Kevin R Parker, Elena Sotillo, Rachel C Lynn, Hima Anbunathan, John Lattin, Zinaida Good, Julia A Belk, Bence Daniel, Dorota D Klysz, Meena Malipatlolla, Peng Xu, Malek Bashti, Sabine Heitzeneder, Louai Labanieh, Panayiotis Vandris, Robbie G Majzner, Yanyan Qi, Katalin D Sandor, Ling-Chun Chen, Snehit Prabhu, Andrew J Gentles, Thomas J Wandless, Ansuman T Satpathy, Howard Y Chang, Crystal L Mackall
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling. Science (New York, N.Y.) 372 (6537) (2021)
David G Gennert, Rachel C Lynn, Jeff M Granja, Evan W Weber, Maxwell R Mumbach, Yang Zhao, Zhana Duren, Elena Sotillo, William J Greenleaf, Wing Hung Wong, Ansuman T Satpathy, Crystal L Mackall, Howard Y Chang
Dynamic chromatin regulatory landscape of human CAR T cell exhaustion. Proceedings of the National Academy of Sciences of the United States of America 118 (30) (2021)
King L Hung, Kathryn E Yost, Liangqi Xie, Quanming Shi, Konstantin Helmsauer, Jens Luebeck, Robert Schöpflin, Joshua T Lange, Rocio Chamorro González, Natasha E Weiser, Celine Y Chen, Maria E Stefanova, Ivy Tsz-Lo Wong, Sihan Wu, Siavash R Dehkordi, Connor V Duffy, Katerina Kraft, Jun Tang, Julia A Belk, John C Rose, M Ryan Corces, Jeffrey M Granja, Rui Li, Utkrisht Rajkumar, Jordan Friedlein, Anindya Bagchi, Ansuman T Satpathy, Robert Tjian, Stefan Mundlos, Vineet Bafna, Anton G Henssen, Paul S Mischel, Zhe J Liu, Howard Y Chang
ecDNA hubs drive cooperative intermolecular oncogene expression. Nature (2021)
Daniel S Kim, Viviana I Risca, David L Reynolds, James Chappell, Adam J Rubin, Namyoung Jung, Laura K H Donohue, Vanessa Lopez-Pajares, Arwa Kathiria, Minyi Shi, Zhixin Zhao, Harsh Deep, Mahfuza Sharmin, Deepti Rao, Shin Lin, Howard Y Chang, Michael Paul Snyder, William J Greenleaf, Anshul Kundaje, Paul A Khavari
The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation. Nature genetics 53 (11) (2021)
Kevin E Wu, Kathryn E Yost, Howard Y Chang, James Zou
BABEL enables cross-modality translation between multiomic profiles at single-cell resolution. Proceedings of the National Academy of Sciences of the United States of America 118 (15) (2021)
Edward A Stadtmauer, Joseph A Fraietta, Megan M Davis, Adam David Cohen, Kristy L Weber, Eric Lancaster, Patricia A Mangan, Irina Kulikovskaya, Minnal Gupta, Fang Chen, Lifeng Tian, Vanessa E Gonzalez, Jun Xu, In-Young Jung, J Joseph Melenhorst, Gabriela Plesa, Joanne Shea, Tina Matlawski, Amanda Cervini, Avery L Gaymon, Stephanie Desjardins, Anne Lamontagne, January Salas-Mckee, Andrew D Fesnak, Donald L Siegel, Bruce L Levine, Julie K Jadlowsky, Regina M Young, Anne Chew, Wei-Ting Hwang, Elizabeth O Hexner, Beatriz M Carreno, Christopher L Nobles, Frederic D Bushman, Kevin R Parker, Yanyan Qi, Ansuman T Satpathy, Howard Y Chang, Yangbing Zhao, Simon F Lacey, Carl H June
CRISPR-engineered T cells in patients with refractory cancer. Science (New York, N.Y.) 367 (6481) (2020)
Alexandro E Trevino, Nicholas A Sinnott-Armstrong, Jimena Andersen, Se-Jin Yoon, Nina Huber, Jonathan K Pritchard, Howard Y Chang, William J Greenleaf, Sergiu P Pașca
Chromatin accessibility dynamics in a model of human forebrain development. Science (New York, N.Y.) 367 (6476) (2020)
M Ryan Corces, Anna Shcherbina, Soumya Kundu, Michael J Gloudemans, Laure Frésard, Jeffrey M Granja, Bryan H Louie, Tiffany Eulalio, Shadi Shams, S Tansu Bagdatli, Maxwell R Mumbach, Boxiang Liu, Kathleen S Montine, William J Greenleaf, Anshul Kundaje, Stephen B Montgomery, Howard Y Chang, Thomas J Montine
Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases. Nature genetics 52 (11) (2020)
Rabab Nasrallah, Charlotte J Imianowski, Lara Bossini-Castillo, Francis M Grant, Mikail Dogan, Lindsey Placek, Lina Kozhaya, Paula Kuo, Firas Sadiyah, Sarah K Whiteside, Maxwell R Mumbach, Dafni Glinos, Panagiota Vardaka, Carly E Whyte, Teresa Lozano, Toshitsugu Fujita, Hodaka Fujii, Adrian Liston, Simon R Andrews, Adeline Cozzani, Jie Yang, Suman Mitra, Enrico Lugli, Howard Y Chang, Derya Unutmaz, Gosia Trynka, Rahul Roychoudhuri
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells. Nature 583 (7816) (2020)
Amy L McGuire, Stacey Gabriel, Sarah A Tishkoff, Ambroise Wonkam, Aravinda Chakravarti, Eileen E M Furlong, Barbara Treutlein, Alexander Meissner, Howard Y Chang, Núria López-Bigas, Eran Segal, Jin-Soo Kim
The road ahead in genetics and genomics. Nature reviews. Genetics 21 (10) (2020)
Qian Liu, Lisa C Zaba, Ansuman T Satpathy, Michelle Longmire, Wen Zhang, Kun Li, Jeffrey Granja, Chuang Guo, Jun Lin, Rui Li, Karen Tolentino, Gabriela Kania, Oliver Distler, David Fiorentino, Lorinda Chung, Kun Qu, Howard Y Chang
Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis. Nature communications 11 (1) (2020)
Ava C Carter, Jin Xu, Meagan Y Nakamoto, Yuning Wei, Brian J Zarnegar, Quanming Shi, James P Broughton, Ryan C Ransom, Ankit Salhotra, Surya D Nagaraja, Rui Li, Diana R Dou, Kathryn E Yost, Seung-Woo Cho, Anil Mistry, Michael T Longaker, Paul A Khavari, Robert T Batey, Deborah S Wuttke, Howard Y Chang
Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation. eLife 9 (2020)
Yang Li, Joshua J Gruber, Ulrike M Litzenburger, Yiren Zhou, Yu Rebecca Miao, Edward L LaGory, Albert M Li, Zhen Hu, Michaela Yip, Lori S Hart, John M Maris, Howard Y Chang, Amato J Giaccia, Jiangbin Ye
Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia. Cell death & disease 11 (2) (2020)
Max A Horlbeck, S John Liu, Howard Y Chang, Daniel A Lim, Jonathan S Weissman
Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes. Nature biotechnology 38 (5) (2020)
Liangqi Xie, Peng Dong, Xingqi Chen, Tsung-Han S Hsieh, Sambashiva Banala, Margherita De Marzio, Brian P English, Yifeng Qi, Seol Kyoung Jung, Kyong-Rim Kieffer-Kwon, Wesley R Legant, Anders S Hansen, Anton Schulmann, Rafael Casellas, Bin Zhang, Eric Betzig, Luke D Lavis, Howard Y Chang, Robert Tse Nan Tjian, Zhe J Liu
3D ATAC-PALM: super-resolution imaging of the accessible genome. Nature methods 17 (4) (2020)
Santosha A Vardhana, Madeline A Hwee, Mirela Berisa, Daniel K Wells, Kathryn E Yost, Bryan H King, Melody Smith, Pamela S Herrera, Howard Y Chang, Ansuman T Satpathy, Marcel R M van den Brink, Justin R Cross, Craig B Thompson
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen. Nature immunology 21 (9) (2020)
Zhipeng Lu, Jimmy K Guo, Yuning Wei, Diana R Dou, Brian Zarnegar, Qing Ma, Rui Li, Yang Zhao, Fan Liu, Hani Choudhry, Paul A Khavari, Howard Y Chang
Structural modularity of the XIST ribonucleoprotein complex. Nature communications 11 (1) (2020)
Hoon Kim, Nam-Phuong Nguyen, Kristen Turner, Sihan Wu, Amit D Gujar, Jens Luebeck, Jihe Liu, Viraj Deshpande, Utkrisht Rajkumar, Sandeep Namburi, Samirkumar B Amin, Eunhee Yi, Francesca Menghi, Johannes H Schulte, Anton G Henssen, Howard Y Chang, Christine R Beck, Paul S Mischel, Vineet Bafna, Roel G W Verhaak
Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers. Nature genetics 52 (9) (2020)
Qian Liu, Lisa C Zaba, Ansuman T Satpathy, Michelle Longmire, Wen Zhang, Kun Li, Jeffrey Granja, Chuang Guo, Jun Lin, Rui Li, Karen Tolentino, Gabriela Kania, Oliver Distler, David Fiorentino, Lorinda Chung, Kun Qu, Howard Y Chang
Author Correction: Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis. Nature communications 11 (1) (2020)
Qian Yi Lee, Moritz Mall, Soham Chanda, Bo Zhou, Kylesh S Sharma, Katie Schaukowitch, Juan M Adrian-Segarra, Sarah D Grieder, Michael S Kareta, Orly L Wapinski, Cheen Euong Ang, Rui Li, Thomas C Südhof, Howard Y Chang, Marius Wernig
Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes. Nature cell biology 22 (4) (2020)

Howard Y Chang.css-eqlu8i{font-size:small;padding-left:4px;} (Howard Chang)

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Howard Y Chang (Howard Chang)