Matthew H Porteus (Matthew Porteus, M Porteus, M H Porteus)

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 50

Top Topics

Highly Efficient

Top Venues

Nature communications

bioRxiv : the preprint server for biology

Nature biotechnology

This page only lists publications with an associated author ORCID identifier.

Publications

Hana Y Ghanim, Matthew H Porteus
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy. Immunological reviews (2024)
Jacob E Corn, M Kyle Cromer, Steve E Glenn, Christopher A Vakulskas, Kay O Chmielewski, Amanda M Dudek, William N Feist, Julia Klermund, Suzette Shipp, Toni Cathomen, Daniel P Dever, Matthew H Porteus
Transient inhibition of 53BP1 increases the frequency of targeted integration in human hematopoietic stem and progenitor cells. Nature communications 15 (1) (2024)
Jacob E Corn, M Kyle Cromer, Steve E Glenn, Christopher A Vakulskas, Kay O Chmielewski, Amanda M Dudek, William N Feist, Julia Klermund, Suzette Shipp, Toni Cathomen, Daniel P Dever, Matthew H Porteus
Transient inhibition of 53BP1 increases the frequency of targeted integration in human hematopoietic stem and progenitor cells. Nature communications 15 (1) (2024)
Hana Y Ghanim, Matthew H Porteus
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy. Immunological reviews 322 (1) (2024)
Jacob E Corn, M Kyle Cromer, Steve E Glenn, Christopher A Vakulskas, Kay O Chmielewski, Amanda M Dudek, William N Feist, Julia Klermund, Suzette Shipp, Toni Cathomen, Daniel P Dever, Matthew H Porteus
Transient inhibition of 53BP1 increases the frequency of targeted integration in human hematopoietic stem and progenitor cells. Nature communications 15 (1) (2024)
Jacob E Corn, M Kyle Cromer, Steve E Glenn, Christopher A Vakulskas, Kay O Chmielewski, Amanda M Dudek, William N Feist, Julia Klermund, Suzette Shipp, Toni Cathomen, Daniel P Dever, Matthew H Porteus
Transient inhibition of 53BP1 increases the frequency of targeted integration in human hematopoietic stem and progenitor cells. Nature communications 15 (1) (2024)
Sofia E Luna, Joab Camarena, Jessica P Hampton, Kiran R Majeti, Carsten T Charlesworth, Eric Soupene, Sridhar Selvaraj, Kun Jia, Vivien A Sheehan, M Kyle Cromer, Matthew H Porteus
Enhancement of erythropoietic output by Cas9-mediated insertion of a natural variant in haematopoietic stem and progenitor cells. Nature biomedical engineering (2024)
Simon N Chu, Eric Soupene, Beeke Wienert, Han Yin, Devesh Sharma, Travis McCreary, Kun Jia, Shota Homma, Jessica P Hampton, James M Gardner, Bruce R Conklin, Tippi C Mackenzie, Matthew H Porteus, M Kyle Cromer
Dual α-globin and truncated EPO receptor knockin restores hemoglobin production in α-thalassemia-derived red blood cells. bioRxiv : the preprint server for biology (2024)
Hana Y Ghanim, Matthew H Porteus
Gene regulation in inborn errors of immunity: Implications for gene therapy design and efficacy. Immunological reviews 322 (1) (2024)
Jacob E Corn, M Kyle Cromer, Steve E Glenn, Christopher A Vakulskas, Kay O Chmielewski, Amanda M Dudek, William N Feist, Julia Klermund, Suzette Shipp, Toni Cathomen, Daniel P Dever, Matthew H Porteus
Transient inhibition of 53BP1 increases the frequency of targeted integration in human hematopoietic stem and progenitor cells. Nature communications 15 (1) (2024)
Alma-Martina Cepika, Laura Amaya, Colin Waichler, Mansi Narula, Michelle M Mantilla, Benjamin C Thomas, Pauline P Chen, Robert Arthur Freeborn, Mara Pavel-Dinu, Jason Nideffer, Matthew H Porteus, Rosa Bacchetta, Fabian Müller, William J Greenleaf, Howard Y Chang, Maria Grazia Roncarolo
Epigenetic signature and key transcriptional regulators of human antigen-specific type 1 regulatory T cells. bioRxiv : the preprint server for biology (2024)
Jacob E Corn, M Kyle Cromer, Steve E Glenn, Christopher A Vakulskas, Kay O Chmielewski, Amanda M Dudek, William N Feist, Julia Klermund, Suzette Shipp, Toni Cathomen, Daniel P Dever, Matthew H Porteus
Transient inhibition of 53BP1 increases the frequency of targeted integration in human hematopoietic stem and progenitor cells. Nature communications 15 (1) (2024)
Simon N Chu, Eric Soupene, Beeke Wienert, Han Yin, Devesh Sharma, Travis McCreary, Kun Jia, Shota Homma, Jessica P Hampton, James M Gardner, Bruce R Conklin, Tippi C Mackenzie, Matthew H Porteus, M Kyle Cromer
Dual α-globin and truncated EPO receptor knockin restores hemoglobin production in α-thalassemia-derived red blood cells. bioRxiv : the preprint server for biology (2024)
Francisco Xavier Galdos, Carissa Lee, Soah Lee, Sharon Paige, William Goodyer, Sidra Xu, Tahmina Samad, Gabriela V Escobar, Adrija Darsha, Aimee Beck, Rasmus O Bak, Matthew H Porteus, Sean M Wu
Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation. eLife 12 (2023)
Romina Marone, Emmanuelle Landmann, Anna Devaux, Rosalba Lepore, Denis Seyres, Jessica Zuin, Thomas Burgold, Corinne Engdahl, Giuseppina Capoferri, Alessandro Dell'Aglio, Clément Larrue, Federico Simonetta, Julia Rositzka, Manuel Rhiel, Geoffroy Andrieux, Danielle N Gallagher, Markus S Schröder, Amélie Wiederkehr, Alessandro Sinopoli, Valentin Do Sacramento, Anna Haydn, Laura Garcia-Prat, Christopher Divsalar, Anna Camus, Liwen Xu, Lorenza Bordoli, Torsten Schwede, Matthew H Porteus, Jérome Tamburini, Jacob E Corn, Toni Cathomen, Tatjana I Cornu, Stefanie Urlinger, Lukas T Jeker
Epitope-engineered human hematopoietic stem cells are shielded from CD123-targeted immunotherapy. The Journal of experimental medicine 220 (12) (2023)
Celeste Riepe, Magda Wąchalska, Kirandeep K Deol, Anais K Amaya, Matthew H Porteus, James A Olzmann, Ron R Kopito
Small molecule correctors divert CFTR-F508del from ERAD by stabilizing sequential folding states. bioRxiv : the preprint server for biology (2023)
Sridhar Selvaraj, William N Feist, Sebastien Viel, Sriram Vaidyanathan, Amanda M Dudek, Marc Gastou, Sarah J Rockwood, Freja K Ekman, Aluya R Oseghale, Liwen Xu, Mara Pavel-Dinu, Sofia E Luna, M Kyle Cromer, Ruhi Sayana, Natalia Gomez-Ospina, Matthew H Porteus
High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition. Nature biotechnology (2023)
Marcus A Toral, Carsten T Charlesworth, Benjamin Ng, Teja Chemudupati, Shota Homma, Hiromitsu Nakauchi, Alexander G Bassuk, Matthew H Porteus, Vinit B Mahajan
Author Correction: Investigation of Cas9 antibodies in the human eye. Nature communications 13 (1) (2022)
M Kyle Cromer, Valentin V Barsan, Erich Jaeger, Mengchi Wang, Jessica P Hampton, Feng Chen, Drew Kennedy, Jenny Xiao, Irina Khrebtukova, Ana Granat, Tiffany Truong, Matthew H Porteus
Ultra-deep sequencing validates safety of CRISPR/Cas9 genome editing in human hematopoietic stem and progenitor cells. Nature communications 13 (1) (2022)
Marcus A Toral, Carsten T Charlesworth, Benjamin Ng, Teja Chemudupati, Shota Homma, Hiromitsu Nakauchi, Alexander G Bassuk, Matthew H Porteus, Vinit B Mahajan
Investigation of Cas9 antibodies in the human eye. Nature communications 13 (1) (2022)
Annalisa Lattanzi, Joab Camarena, Premanjali Lahiri, Helen Segal, Waracharee Srifa, Christopher A Vakulskas, Richard L Frock, Josefin Kenrick, Ciaran M Lee, Narae Talbott, Jason Skowronski, M Kyle Cromer, Carsten T Charlesworth, Rasmus O Bak, Sruthi Mantri, Gang Bao, David DiGiusto, John F Tisdale, J Fraser Wright, Neehar Bhatia, Maria Grazia Roncarolo, Daniel P Dever, Matthew H Porteus
Development of β-globin gene correction in human hematopoietic stem cells as a potential durable treatment for sickle cell disease. Science translational medicine 13 (598) (2021)
Adam C Wilkinson, Daniel P Dever, Ron Baik, Joab Camarena, Ian Hsu, Carsten T Charlesworth, Chika Morita, Hiromitsu Nakauchi, Matthew H Porteus
Cas9-AAV6 gene correction of beta-globin in autologous HSCs improves sickle cell disease erythropoiesis in mice. Nature communications 12 (1) (2021)
M Kyle Cromer, Joab Camarena, Renata M Martin, Benjamin J Lesch, Christopher A Vakulskas, Nicole M Bode, Gavin L Kurgan, Michael A Collingwood, Garrett R Rettig, Mark A Behlke, Viktor T Lemgart, Yankai Zhang, Ankush Goyal, Feifei Zhao, Ezequiel Ponce, Waracharee Srifa, Rasmus O Bak, Naoya Uchida, Ravindra Majeti, Vivien A Sheehan, John F Tisdale, Daniel P Dever, Matthew H Porteus
Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells. Nature medicine 27 (4) (2021)
A Booth, Vence L Bonham, Matthew H Porteus, Kelly E Ormond
Treatment decision-making in sickle cell disease patients. Journal of community genetics (2021)
Colin L Sweeney, Mara Pavel-Dinu, Uimook Choi, Julie Brault, Taylor Q Liu, Sherry Koontz, Linhong Li, Narda Theobald, Janet Lee, Ezekiel A Bello, Xiaolin Wu, Ronald J Meis, Gary A Dahl, Matthew H Porteus, Harry L Malech, Suk See De Ravin
Correction of X-CGD patient HSPCs by targeted CYBB cDNA insertion using CRISPR/Cas9 with 53BP1 inhibition for enhanced homology-directed repair. Gene therapy 28 (6) (2021)
Rajiv Sharma, Daniel P Dever, Ciaran M Lee, Armon Azizi, Yidan Pan, Joab Camarena, Thomas Köhnke, Gang Bao, Matthew H Porteus, Ravindra Majeti
The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells. Nature communications 12 (1) (2021)
Suk See De Ravin, Julie Brault, Ronald J Meis, Siyuan Liu, Linhong Li, Mara Pavel-Dinu, Cicera R Lazzarotto, Taylor Q Liu, Sherry M Koontz, Uimook Choi, Colin L Sweeney, Narda Theobald, GaHyun Lee, Aaron B Clark, Sandra Sczerba Burkett, Benjamin P Kleinstiver, Matthew H Porteus, Shengdar Tsai, Douglas B Kuhns, Gary A Dahl, Stephen J Headey, Xiaolin Wu, Harry L Malech
Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells. Blood 137 (19) (2021)
Samantha G Scharenberg, Edina Poletto, Katherine L Lucot, Pasqualina Colella, Adam Sheikali, Thomas J Montine, Matthew H Porteus, Natalia Gomez-Ospina
Engineering monocyte/macrophage-specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing. Nature communications 11 (1) (2020)
M Goodwin, Ciaran M Lee, U Lakshmanan, S Shipp, Luise J Froessl, F Barzaghi, L Passerini, M Narula, A Sheikali, C M Lee, G Bao, C S Bauer, H K Miller, M Garcia-Lloret, Manish J Butte, Alice Bertaina, Ami J Shah, Matthew H Porteus, A Hendel, Matthew H Porteus, M G Roncarolo, Rosa Bacchetta
CRISPR-based gene editing enables FOXP3 gene repair in IPEX patient cells. Science advances 6 (19) (2020)
Waracharee Srifa, Nina Kosaric, Alvaro Amorin, Othmane Jadi, Yujin Park, Sruthi Mantri, Joab Camarena, Geoffrey C Gurtner, Matthew H Porteus
Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice. Nature communications 11 (1) (2020)
Themasap A Khan, Omer Revah, Aaron Gordon, Se-Jin Yoon, Anna K Krawisz, Carleton Goold, Yishan Sun, Chul Hoon Kim, Yuan Tian, Min-Yin Li, Julia M Schaepe, Kazuya Ikeda, Neal D Amin, Noriaki Sakai, Masayuki Yazawa, Leila Kushan, Seiji Nishino, Matthew H Porteus, Judith L Rapoport, Jonathan A Bernstein, Ruth O'Hara, Carrie E Bearden, Joachim F Hallmayer, John R Huguenard, Daniel H Geschwind, Ricardo E Dolmetsch, Sergiu P Pașca
Neuronal defects in a human cellular model of 22q11.2 deletion syndrome. Nature medicine 26 (12) (2020)
Johan Jeong, Astraea Jager, Pablo Domizi, Mara Pavel-Dinu, Linda Gojenola, Masayuki Iwasaki, Michael C Wei, Feng Pan, James L Zehnder, Matthew H Porteus, Kara L Davis, Michael L Cleary
High-efficiency CRISPR induction of t(9;11) chromosomal translocations and acute leukemias in human blood stem cells. Blood advances 3 (19) (2020)
Volker Wiebking, James O Patterson, Renata M Martin, Monica K Chanda, Ciaran M Lee, Waracharee Srifa, Gang Bao, Matthew H Porteus
Metabolic engineering generates a transgene-free safety switch for cell therapy. Nature biotechnology 38 (12) (2020)
Renata M Martin, Jonas L Fowler, M Kyle Cromer, Benjamin J Lesch, Ezequiel Ponce, Nobuko Uchida, Toshinobu Nishimura, Matthew H Porteus, Kyle M Loh
Improving the safety of human pluripotent stem cell therapies using genome-edited orthogonal safeguards. Nature communications 11 (1) (2020)
Yuki Miura, Min-Yin Li, Fikri Birey, Kazuya Ikeda, Omer Revah, Mayuri Vijay Thete, Jin-Young Park, Alyssa Puno, Samuel H Lee, Matthew H Porteus, Sergiu P Pașca
Generation of human striatal organoids and cortico-striatal assembloids from human pluripotent stem cells. Nature biotechnology 38 (12) (2020)
Mark C Wilkes, Kavitha Siva, J Chen, G Varetti, M Y Youn, H Chae, Fredrik Ek, Roger Olsson, T Lundbäck, Daniel P Dever, Toshinobu Nishimura, A Narla, B Glader, Hiromitsu Nakauchi, Matthew H Porteus, C E Repellin, H T Gazda, S Lin, Manuel Serrano, Johan Flygare, K M Sakamoto
Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase. Nature communications 11 (1) (2020)
Samantha G Scharenberg, Edina Poletto, Katherine L Lucot, Pasqualina Colella, Adam Sheikali, Thomas J Montine, Matthew H Porteus, Natalia Gomez-Ospina
Author Correction: Engineering monocyte/macrophage-specific glucocerebrosidase expression in human hematopoietic stem cells using genome editing. Nature communications 11 (1) (2020)
Mara Pavel-Dinu, Volker Wiebking, Beruh T Dejene, Waracharee Srifa, Sruthi Mantri, Carmencita E Nicolas, Ciaran M Lee, Gang Bao, Eric J Kildebeck, Niraj Punjya, Camille Sindhu, Matthew A Inlay, Nivedita Saxena, Suk See DeRavin, Harry Malech, Maria Grazia Roncarolo, Kenneth I Weinberg, Matthew H Porteus
Author Correction: Gene correction for SCID-X1 in long-term hematopoietic stem cells. Nature communications 10 (1) (2019)
Mara Pavel-Dinu, Volker Wiebking, Beruh T Dejene, Waracharee Srifa, Sruthi Mantri, Carmencita E Nicolas, Ciaran M Lee, Gang Bao, Eric J Kildebeck, Niraj Punjya, Camille Sindhu, Matthew A Inlay, Nivedita Saxena, Suk See DeRavin, Harry Malech, Maria Grazia Roncarolo, Kenneth I Weinberg, Matthew H Porteus
Author Correction: Gene correction for SCID-X1 in long-term hematopoietic stem cells. Nature communications 10 (1) (2019)
Carsten T Charlesworth, Priyanka S Deshpande, Daniel P Dever, Joab Camarena, Viktor T Lemgart, M Kyle Cromer, Christopher A Vakulskas, Michael A Collingwood, Liyang Zhang, Nicole M Bode, Mark A Behlke, Beruh Dejene, Brandon Cieniewicz, Rosa Romano, Benjamin J Lesch, Natalia Gomez-Ospina, Sruthi Mantri, Mara Pavel-Dinu, Kenneth I Weinberg, Matthew H Porteus
Identification of preexisting adaptive immunity to Cas9 proteins in humans. Nature medicine 25 (2) (2019)
Mohammad S Esfahani, Luke J Lee, Young-Jun Jeon, Ryan A Flynn, Henning Stehr, Angela B Hui, Noriko Ishisoko, Eric Kildebeck, Aaron M Newman, Scott V Bratman, Matthew H Porteus, Howard Y Chang, Ash A Alizadeh, Maximillian Diehn
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas. Nature communications 10 (1) (2019)
Mara Pavel-Dinu, Volker Wiebking, Beruh T Dejene, Waracharee Srifa, Sruthi Mantri, Carmencita E Nicolas, Ciaran M Lee, Gang Bao, Eric J Kildebeck, Niraj Punjya, Camille Sindhu, Matthew A Inlay, Nivedita Saxena, Suk See DeRavin, Harry Malech, Maria Grazia Roncarolo, Kenneth I Weinberg, Matthew H Porteus
Gene correction for SCID-X1 in long-term hematopoietic stem cells. Nature communications 10 (1) (2019)
Natalia Gomez-Ospina, Samantha G Scharenberg, Nathalie Mostrel, Rasmus O Bak, Sruthi Mantri, Rolen M Quadros, Channabasavaiah Basavaraju Gurumurthy, Ciaran M Lee, Gang Bao, Carlos J Suarez, Shaukat Khan, Kazuki Sawamoto, Shunji Tomatsu, Nitin Raj, Laura D Attardi, Laure Aurelian, Matthew H Porteus
Human genome-edited hematopoietic stem cells phenotypically correct Mucopolysaccharidosis type I. Nature communications 10 (1) (2019)
Matthew H Porteus
A New Class of Medicines through DNA Editing. The New England journal of medicine 380 (10) (2019)
Rasmus O Bak, Daniel P Dever, Andreas Reinisch, David Cruz Hernandez, Ravindra Majeti, Matthew H Porteus
Correction: Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6. eLife 7 (2018)
Matthew H Porteus
Knock-in editing: it functionally corrects! Blood 127 (21) (2018)
Chiara Antoniani, Vasco Meneghini, Annalisa Lattanzi, Tristan Felix, Oriana Romano, Elisa Magrin, Leslie Weber, Giulia Pavani, Sara El Hoss, Ryo Kurita, Yukio Nakamura, Thomas J Cradick, Ante S Lundberg, Matthew H Porteus, Mario Amendola, Wassim El Nemer, Marina Cavazzana, Fulvio Mavilio, Annarita Miccio
Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the human β-globin locus. Blood 131 (17) (2018)
Kazuya Ikeda, Nobuko Uchida, Toshinobu Nishimura, Joseph White, Renata M Martin, Hiromitsu Nakauchi, Vittorio Sebastiano, Kenneth I Weinberg, Matthew H Porteus
Efficient scarless genome editing in human pluripotent stem cells. Nature methods 15 (12) (2018)
Rasmus O Bak, Daniel P Dever, Andreas Reinisch, David Cruz Hernandez, Ravindra Majeti, Matthew H Porteus
Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6. eLife 6 (2017)
Donald B Kohn, Matthew H Porteus, Andrew M Scharenberg
Ethical and regulatory aspects of genome editing. Blood 127 (21) (2016)