James C Sacchettini (James Sacchettini)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 37

Top Topics

High Throughput

Mycobacterium Tuberculosis

Top Venues

Nature communications

ACS infectious diseases

Science advances

Journal of medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Inna V Krieger, Subbarao Yalamanchili, Paige Dickson, Curtis A Engelhart, Matthew D Zimmerman, Jeremy Wood, Ethan Clary, Jasmine Nguyen, Natalie Thornton, Paolo A Centrella, Betty Chan, John W Cuozzo, Martin Gengenbacher, Marie-Aude Guié, John P Guilinger, Corey Bienstock, Hajnalka Hartl, Christopher D Hupp, Rachael Jetson, Takashi Satoh, John T S Yeoman, Ying Zhang, Veronique Anne Dartois, Dirk Schnappinger, Anthony D Keefe, James C Sacchettini
Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening. ACS infectious diseases 10 (5) (2024)
Amrita Singh, Samantha Ottavi, Inna V Krieger, Kyle Planck, Andrew J Perkowski, Takushi Kaneko, Andrew M Davis, Christine Suh, David Zhang, Laurent Goullieux, Alexander Alex, Christine Roubert, Mark Gardner, Marian Preston, David M Smith, Yan Ling, Julia Roberts, Bastien Cautain, Anna M Upton, Christopher B Cooper, Natalya Serbina, Zaid Tanvir, John Mosior, Ouathek Ouerfelli, Guangli Yang, Ben S Gold, Kyu Y Rhee, James C Sacchettini, Nader Fotouhi, Jeffrey Aube, Carl F Nathan
Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase. Science advances 10 (11) (2024)
Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M Bean, Inna V Krieger, James C Sacchettini, Sabine Ehrt, Courtney C Aldrich, Dirk Schnappinger
Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin. Nature communications 15 (1) (2024)
Amrita Singh, Samantha Ottavi, Inna V Krieger, Kyle Planck, Andrew J Perkowski, Takushi Kaneko, Andrew M Davis, Christine Suh, David Zhang, Laurent Goullieux, Alexander Alex, Christine Roubert, Mark Gardner, Marian Preston, David M Smith, Yan Ling, Julia Roberts, Bastien Cautain, Anna M Upton, Christopher B Cooper, Natalya Serbina, Zaid Tanvir, John Mosior, Ouathek Ouerfelli, Guangli Yang, Ben S Gold, Kyu Y Rhee, James C Sacchettini, Nader Fotouhi, Jeffrey Aube, Carl F Nathan
Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase. Science advances 10 (11) (2024)
Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M Bean, Inna V Krieger, James C Sacchettini, Sabine Ehrt, Courtney C Aldrich, Dirk Schnappinger
Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin. Nature communications 15 (1) (2024)
Amrita Singh, Samantha Ottavi, Inna V Krieger, Kyle Planck, Andrew J Perkowski, Takushi Kaneko, Andrew M Davis, Christine Suh, David Zhang, Laurent Goullieux, Alexander Alex, Christine Roubert, Mark Gardner, Marian Preston, David M Smith, Yan Ling, Julia Roberts, Bastien Cautain, Anna M Upton, Christopher B Cooper, Natalya Serbina, Zaid Tanvir, John Mosior, Ouathek Ouerfelli, Guangli Yang, Ben S Gold, Kyu Y Rhee, James C Sacchettini, Nader Fotouhi, Jeffrey Aube, Carl F Nathan
Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase. Science advances 10 (11) (2024)
Inna V Krieger, Subbarao Yalamanchili, Paige Dickson, Curtis A Engelhart, Matthew D Zimmerman, Jeremy Wood, Ethan Clary, Jasmine Nguyen, Natalie Thornton, Paolo A Centrella, Betty Chan, John W Cuozzo, Martin Gengenbacher, Marie-Aude Guié, John P Guilinger, Corey Bienstock, Hajnalka Hartl, Christopher D Hupp, Rachael Jetson, Takashi Satoh, John T S Yeoman, Ying Zhang, Veronique Anne Dartois, Dirk Schnappinger, Anthony D Keefe, James C Sacchettini
Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening. ACS infectious diseases (2024)
Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M Bean, Inna V Krieger, James C Sacchettini, Sabine Ehrt, Courtney C Aldrich, Dirk Schnappinger
Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin. Nature communications 15 (1) (2024)
Di Qu, Peng Ge, Laure Botella, Sae Woong Park, Ha-Na Lee, Natalie Thornton, James M Bean, Inna V Krieger, James C Sacchettini, Sabine Ehrt, Courtney C Aldrich, Dirk Schnappinger
Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin. Nature communications 15 (1) (2024)
Amrita Singh, Samantha Ottavi, Inna V Krieger, Kyle Planck, Andrew J Perkowski, Takushi Kaneko, Andrew M Davis, Christine Suh, David Zhang, Laurent Goullieux, Alexander Alex, Christine Roubert, Mark Gardner, Marian Preston, David M Smith, Yan Ling, Julia Roberts, Bastien Cautain, Anna M Upton, Christopher B Cooper, Natalya Serbina, Zaid Tanvir, John Mosior, Ouathek Ouerfelli, Guangli Yang, Ben S Gold, Kyu Y Rhee, James C Sacchettini, Nader Fotouhi, Jeffrey Aube, Carl F Nathan
Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase. Science advances 10 (11) (2024)
Inna V Krieger, Subbarao Yalamanchili, Paige Dickson, Curtis A Engelhart, Matthew D Zimmerman, Jeremy Wood, Ethan Clary, Jasmine Nguyen, Natalie Thornton, Paolo A Centrella, Betty Chan, John W Cuozzo, Martin Gengenbacher, Marie-Aude Guié, John P Guilinger, Corey Bienstock, Hajnalka Hartl, Christopher D Hupp, Rachael Jetson, Takashi Satoh, John T S Yeoman, Ying Zhang, Veronique Anne Dartois, Dirk Schnappinger, Anthony D Keefe, James C Sacchettini
Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening. ACS infectious diseases 10 (5) (2024)
Inna V Krieger, Subbarao Yalamanchili, Paige Dickson, Curtis A Engelhart, Matthew D Zimmerman, Jeremy Wood, Ethan Clary, Jasmine Nguyen, Natalie Thornton, Paolo A Centrella, Betty Chan, John W Cuozzo, Martin Gengenbacher, Marie-Aude Guié, John P Guilinger, Corey Bienstock, Hajnalka Hartl, Christopher D Hupp, Rachael Jetson, Takashi Satoh, John T S Yeoman, Ying Zhang, Veronique Anne Dartois, Dirk Schnappinger, Anthony D Keefe, James C Sacchettini
Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening. ACS infectious diseases 10 (5) (2024)
Inna V Krieger, Subbarao Yalamanchili, Paige Dickson, Curtis A Engelhart, Matthew D Zimmerman, Jeremy Wood, Ethan Clary, Jasmine Nguyen, Natalie Thornton, Paolo A Centrella, Betty Chan, John W Cuozzo, Martin Gengenbacher, Marie-Aude Guié, John P Guilinger, Corey Bienstock, Hajnalka Hartl, Christopher D Hupp, Rachael Jetson, Takashi Satoh, John T S Yeoman, Ying Zhang, Veronique Anne Dartois, Dirk Schnappinger, Anthony D Keefe, James C Sacchettini
Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening. ACS infectious diseases 10 (5) (2024)
Inna V Krieger, Subbarao Yalamanchili, Paige Dickson, Curtis A Engelhart, Matthew D Zimmerman, Jeremy Wood, Ethan Clary, Jasmine Nguyen, Natalie Thornton, Paolo A Centrella, Betty Chan, John W Cuozzo, Martin Gengenbacher, Marie-Aude Guié, John P Guilinger, Corey Bienstock, Hajnalka Hartl, Christopher D Hupp, Rachael Jetson, Takashi Satoh, John T S Yeoman, Ying Zhang, Veronique Anne Dartois, Dirk Schnappinger, Anthony D Keefe, James C Sacchettini
Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered Using DNA-Encoded Chemical Library Screening. ACS infectious diseases 10 (5) (2024)
Samantha Ottavi, Kelin Li, Jackson G Cacioppo, Andrew J Perkowski, Remya Ramesh, Ben S Gold, Yan Ling, Julia Roberts, Amrita Singh, David Zhang, John Mosior, Laurent Goullieux, Christine Roubert, Eric Bacqué, James C Sacchettini, Carl F Nathan, Jeffrey Aube
Mycobacterium tuberculosis PptT Inhibitors Based on Heterocyclic Replacements of Amidinoureas. ACS medicinal chemistry letters 14 (7) (2023)
Siddhant Rath, Saswati Panda, James C Sacchettini, Steven J Berthel
DAIKON: A Data Acquisition, Integration, and Knowledge Capture Web Application for Target-Based Drug Discovery. ACS pharmacology & translational science 6 (7) (2023)
Samantha Ottavi, Sarah M Scarry, John Mosior, Yan Ling, Julia Roberts, Amrita Singh, David Zhang, Laurent Goullieux, Christine Roubert, Eric Bacqué, H Rachel Lagiakos, Jeremie Vendome, Francesca Moraca, Kelin Li, Andrew J Perkowski, Remya Ramesh, Matthew M Bowler, William Tracy, Victoria A Feher, James C Sacchettini, Ben S Gold, Carl F Nathan, Jeffrey Aube
In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas. Journal of medicinal chemistry 65 (3) (2022)
Vinayak Singh, Anna E Grzegorzewicz, Stephen Fienberg, Rudolf Müller, Lutete Peguy Khonde, Olalla Sanz, Salvatore Alfonso, Beatriz Urones, Gerard Drewes, Marcus Bantscheff, Sonja Ghidelli-Disse, Thomas R Ioerger, Bhanupriya Angala, Jiuyu Liu, Richard E Lee, James C Sacchettini, Inna V Krieger, Mary Jackson, Kelly Chibale, Sandeep R Ghorpade
1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis . ACS infectious diseases 8 (11) (2022)
Kaj M Kreutzfeldt, Robert S Jansen, Travis E Hartman, Alexandre Gouzy, Ruojun Wang, Inna V Krieger, Matthew D Zimmerman, Martin Gengenbacher, Jansy P Sarathy, Min Xie, Veronique Anne Dartois, James C Sacchettini, Kyu Y Rhee, Dirk Schnappinger, Sabine Ehrt
CinA mediates multidrug tolerance in Mycobacterium tuberculosis. Nature communications 13 (1) (2022)
Sachin S Katti, Inna V Krieger, Jihyae Ann, Jeewoo Lee, James C Sacchettini, Tatyana I Igumenova
Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists. Nature communications 13 (1) (2022)
Paul D Gordon, Courtney De Ville, James C Sacchettini, Gerard L Coté
A portable brightfield and fluorescence microscope toward automated malarial parasitemia quantification in thin blood smears. PloS one 17 (4) (2022)
Han Wang, Gloria M Conover, Song-I Han, James C Sacchettini, Arum Han
Development of single-cell-level microfluidic technology for long-term growth visualization of living cultures of Mycobacterium smegmatis. Microsystems & nanoengineering 7 (2021)
Katherine A Black, Lijun Duan, Lungelo Mandyoli, Bruna P Selbach, Weizhen Xu, Sabine Ehrt, James C Sacchettini, Kyu Y Rhee
Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis. The Journal of experimental medicine 218 (7) (2021)
Truc Viet Pham, Drake M Mellott, Zahra Moghadamchargari, Kevin Chen, Inna Krieger, Arthur D Laganowsky, James C Sacchettini, Thomas D Meek
Covalent Inactivation of Mycobacterium tuberculosis Isocitrate Lyase by cis-2,3-Epoxy-Succinic Acid. ACS chemical biology 16 (3) (2021)
Caroline Wilson, Peter Ray, Fabio Zuccotto, Jorge Hernandez, Anup Aggarwal, Claire Mackenzie, Nicola Caldwell, Malcolm Taylor, Margaret Huggett, Michael Mathieson, Dinakaran Murugesan, Alasdair Smith, Susan Davis, Mattia Cocco, Maloy K Parai, Arjun Acharya, Fabio Tamaki, Paul Scullion, Ola Epemolu, Jennifer Riley, Laste Stojanovski, Eva Maria Lopez-Román, Pedro Alfonso Torres-Gómez, Ana Maria Toledo, Laura Guijarro-Lopez, Isabel Camino, Curtis A Engelhart, Dirk Schnappinger, Lisa M Massoudi, Anne Lenaerts, Gregory T Robertson, Chris Walpole, David Matthews, David Floyd, James C Sacchettini, Kevin D Read, Lourdes Encinas, Robert H Bates, Simon R Green, Paul G Wyatt
Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target. Journal of medicinal chemistry 65 (1) (2021)
Drake M Mellott, Dan Torres, Inna V Krieger, Scott A Cameron, Zahra Moghadamchargari, Arthur D Laganowsky, James C Sacchettini, Thomas D Meek, Lawrence D Harris
Mechanism-Based Inactivation of Mycobacterium tuberculosis Isocitrate Lyase 1 by (2R,3S)-2-Hydroxy-3-(nitromethyl)succinic acid. Journal of the American Chemical Society 143 (42) (2021)
Dat P Truong, Simon Rousseau, Benjamin W Machala, Jamison P Huddleston, Mingzhao Zhu, Kenneth G Hull, Daniel Romo, Frank M Raushel, James C Sacchettini, Margaret E Glasner
Second-Shell Amino Acid R266 Helps Determine N-Succinylamino Acid Racemase Reaction Specificity in Promiscuous N-Succinylamino Acid Racemase/o-Succinylbenzoate Synthase Enzymes. Biochemistry (2021)
Jared S Mackenzie, Dirk A Lamprecht, Rukaya Asmal, John H Adamson, Khushboo Borah, Dany J V Beste, Bei Shi Lee, Kevin Pethe, Simon Rousseau, Inna V Krieger, James C Sacchettini, Joel N Glasgow, Adrie J C Steyn
Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis. Nature communications 11 (1) (2020)
Junichi Taira, Tomohiro Umei, Keitaro Inoue, Mitsuru Kitamura, Francois Berenger, James C Sacchettini, Hiroshi Sakamoto, Shunsuke Aoki
Improvement of the novel inhibitor for Mycobacterium enoyl-acyl carrier protein reductase (InhA): a structure-activity relationship study of KES4 assisted by in silico structure-based drug screening. The Journal of antibiotics 73 (6) (2020)
Liam M Guthrie, Shivatheja Soma, Sai Yuan, Andres Silva, Mohammad Zulkifli, Thomas C Snavely, Hannah Faith Greene, Elyssa Nunez, Brogan Lynch, Courtney De Ville, Vinit C Shanbhag, Franklin R Lopez, Arjun Acharya, Michael J Petris, Byung-Eun Kim, Vishal M Gohil, James C Sacchettini
Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in mice. Science (New York, N.Y.) 368 (6491) (2020)
Danish Khan, Dongju Lee, Gulcin Gulten, Anup Aggarwal, Joshua Wofford, Inna Krieger, Ashutosh Tripathi, John W Patrick, Debra M Eckert, Arthur Laganowsky, James C Sacchettini, Paul Lindahl, Vytas A Bankaitis
A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins. eLife 9 (2020)
Divya Tiwari, Sae Woong Park, Maram M Essawy, Surendra Dawadi, Alan Mason, Madhumitha Nandakumar, Matthew Zimmerman, Marizel Mina, Hsin Pin Ho, Curtis A Engelhart, Thomas R Ioerger, James C Sacchettini, Kyu Rhee, Sabine Ehrt, Courtney C Aldrich, Veronique Anne Dartois, Dirk Schnappinger
Targeting protein biotinylation enhances tuberculosis chemotherapy. Science translational medicine 10 (438) (2019)
Roberto A Crespo, Qun Dang, Nian E Zhou, Liam M Guthrie, Thomas C Snavely, Wen Dong, Kimberly A Loesch, Takao Suzuki, Lanying You, Wei Wang, Theresa O'Malley, Tanya Parish, David B Olsen, James C Sacchettini
Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase. Journal of medicinal chemistry 62 (9) (2019)
Elaine Ballinger, John Mosior, Travis E Hartman, Kristin Burns-Huang, Ben S Gold, Roxanne Morris, Laurent Goullieux, Isabelle Blanc, Julien Vaubourgeix, Sophie Lagrange, Laurent Fraisse, Stéphanie Sans, Cedric Couturier, Eric Bacqué, Kyu Rhee, Sarah M Scarry, Jeffrey Aube, Guangbin Yang, Ouathek Ouerfelli, Dirk Schnappinger, Thomas R Ioerger, Curtis A Engelhart, Jennifer A McConnell, Kathrine McAulay, Allison Fay, Christine Roubert, James C Sacchettini, Carl F Nathan
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition. Science (New York, N.Y.) 363 (6426) (2019)
Qingquan Chen, Kush N Shah, Fuwu Zhang, Adam J Salazar, Parth N Shah, Richen Li, James C Sacchettini, Karen L Wooley, Carolyn L Cannon
Minocycline and Silver Dual-Loaded Polyphosphoester-Based Nanoparticles for Treatment of Resistant Pseudomonas aeruginosa. Molecular pharmaceutics 16 (4) (2019)
Landry Blanc, Jansy Passiflora Sarathy, Nadine Alvarez Cabrera, Paul O'Brien, Isabela Dias-Freedman, Marizel Mina, James C Sacchettini, Radojka M Savic, Martin Gengenbacher, Brendan K Podell, Brendan Prideaux, Thomas Ioerger, Thomas Dick, Veronique Anne Dartois
Impact of immunopathology on the antituberculous activity of pyrazinamide. The Journal of experimental medicine 215 (8) (2018)
Jill F Ellenbarger, Inna V Krieger, Hsiao-Ling Huang, Silvia Gómez-Coca, Thomas R Ioerger, James C Sacchettini, Steven E Wheeler, Kim R Dunbar
Anion-π Interactions in Computer-Aided Drug Design: Modeling the Inhibition of Malate Synthase by Phenyl-Diketo Acids. Journal of chemical information and modeling 58 (10) (2018)