Uwe Grether

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 34

Top Topics

Molecular Docking

Fluorescent Probe

Top Venues

Journal of medicinal chemistry

Nature communications

ACS pharmacology & translational science

bioRxiv : the preprint server for biology

This page only lists publications with an associated author ORCID identifier.

Publications

Leonard Mach, Anahid Omran, Jara Bouma, Silke Radetzki, David A Sykes, Wolfgang Guba, Xiaoting Li, Calvin Höffelmeyer, Axel Hentsch, Thais Gazzi, Yelena Mostinski, Malgorzata Wasinska-Kalwa, Fabio de Molnier, Cas van der Horst, Jens Peter von Kries, Marc Vendrell, Tian Hua, Dmitry B Veprintsev, Laura H Heitman, Uwe Grether, Marc Nazare
Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB 1 R). Journal of medicinal chemistry (2024)
Andrea Chicca, Daniel Bátora, Christoph Ullmer, Antonello Caruso, Sabine Grüner, Jürgen Fingerle, Thomas Hartung, Roland Degen, Matthias Müller, Uwe Grether, Pal Pacher, Juerg Gertsch
A Highly Potent, Orally Bioavailable Pyrazole-Derived Cannabinoid CB2 Receptor- Selective Full Agonist for In Vivo Studies. ACS pharmacology & translational science 7 (8) (2024)
Stefania Butini, Uwe Grether, Kwang-Mook Jung, Alessia Ligresti, Marco Allarà, Annemarieke G J Postmus, Samuele Maramai, Simone Brogi, Alessandro Papa, Gabriele Carullo, David Sykes, Dmitry B Veprintsev, Stefano Federico, Alessandro Grillo, Bruno Di Guglielmo, Anna Ramunno, Anna Floor Stevens, Dominik Heer, Stefania Lamponi, Sandra Gemma, Jörg Benz, Vincenzo Di Marzo, Mario van der Stelt, Daniele Piomelli, Giuseppe Campiani
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization. Journal of medicinal chemistry 67 (3) (2024)
Miroslav Kosar, Roman C Sarott, David A Sykes, Alexander E G Viray, Rosa Maria Vitale, Nataša Tomašević, Xiaoting Li, Rudolf L Z Ganzoni, Bilal Kicin, Lisa Reichert, Kacper J Patej, Uxía Gómez-Bouzó, Wolfgang Guba, Peter J McCormick, Tian Hua, Christian W Gruber, Dmitry B Veprintsev, James Allen Frank, Uwe Grether, Erick M Carreira
Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists. ACS central science 10 (5) (2024)
Stefania Butini, Uwe Grether, Kwang-Mook Jung, Alessia Ligresti, Marco Allarà, Annemarieke G J Postmus, Samuele Maramai, Simone Brogi, Alessandro Papa, Gabriele Carullo, David Sykes, Dmitry B Veprintsev, Stefano Federico, Alessandro Grillo, Bruno Di Guglielmo, Anna Ramunno, Anna Floor Stevens, Dominik Heer, Stefania Lamponi, Sandra Gemma, Jörg Benz, Vincenzo Di Marzo, Mario van der Stelt, Daniele Piomelli, Giuseppe Campiani
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization. Journal of medicinal chemistry 67 (3) (2024)
Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F Nippa, Michael Iff, Jann Ledergerber, Carl C G Schiebroek, Valentina Romeo, Jan A Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider
Prospective de novo drug design with deep interactome learning. Nature communications 15 (1) (2024)
Leonard Mach, Anahid Omran, Jara Bouma, Silke Radetzki, David A Sykes, Wolfgang Guba, Xiaoting Li, Calvin Höffelmeyer, Axel Hentsch, Thais Gazzi, Yelena Mostinski, Malgorzata Wasinska-Kalwa, Fabio de Molnier, Cas van der Horst, Jens Peter von Kries, Marc Vendrell, Tian Hua, Dmitry B Veprintsev, Laura H Heitman, Uwe Grether, Marc Nazare
Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB 1 R). Journal of medicinal chemistry 67 (14) (2024)
Stefania Butini, Uwe Grether, Kwang-Mook Jung, Alessia Ligresti, Marco Allarà, Annemarieke G J Postmus, Samuele Maramai, Simone Brogi, Alessandro Papa, Gabriele Carullo, David Sykes, Dmitry B Veprintsev, Stefano Federico, Alessandro Grillo, Bruno Di Guglielmo, Anna Ramunno, Anna Floor Stevens, Dominik Heer, Stefania Lamponi, Sandra Gemma, Jörg Benz, Vincenzo Di Marzo, Mario van der Stelt, Daniele Piomelli, Giuseppe Campiani
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization. Journal of medicinal chemistry 67 (3) (2024)
Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F Nippa, Michael Iff, Jann Ledergerber, Carl C G Schiebroek, Valentina Romeo, Jan A Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider
Prospective de novo drug design with deep interactome learning. Nature communications 15 (1) (2024)
Leonard Mach, Anahid Omran, Jara Bouma, Silke Radetzki, David A Sykes, Wolfgang Guba, Xiaoting Li, Calvin Höffelmeyer, Axel Hentsch, Thais Gazzi, Yelena Mostinski, Malgorzata Wasinska-Kalwa, Fabio de Molnier, Cas van der Horst, Jens Peter von Kries, Marc Vendrell, Tian Hua, Dmitry B Veprintsev, Laura H Heitman, Uwe Grether, Marc Nazare
Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB 1 R). Journal of medicinal chemistry 67 (14) (2024)
Kenneth Atz, David F Nippa, Alex T Müller, Vera Jost, Andrea Anelli, Michael Reutlinger, Christian Kramer, Rainer E Martin, Uwe Grether, Gisbert Schneider, Georg Wuitschik
Geometric deep learning-guided Suzuki reaction conditions assessment for applications in medicinal chemistry. RSC medicinal chemistry 15 (7) (2024)
Stefania Butini, Uwe Grether, Kwang-Mook Jung, Alessia Ligresti, Marco Allarà, Annemarieke G J Postmus, Samuele Maramai, Simone Brogi, Alessandro Papa, Gabriele Carullo, David Sykes, Dmitry B Veprintsev, Stefano Federico, Alessandro Grillo, Bruno Di Guglielmo, Anna Ramunno, Anna Floor Stevens, Dominik Heer, Stefania Lamponi, Sandra Gemma, Jörg Benz, Vincenzo Di Marzo, Mario van der Stelt, Daniele Piomelli, Giuseppe Campiani
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization. Journal of medicinal chemistry (2024)
Kenneth Atz, David F Nippa, Alex T Müller, Vera Jost, Andrea Anelli, Michael Reutlinger, Christian Kramer, Rainer E Martin, Uwe Grether, Gisbert Schneider, Georg Wuitschik
Geometric deep learning-guided Suzuki reaction conditions assessment for applications in medicinal chemistry. RSC medicinal chemistry 15 (7) (2024)
Leonard Mach, Anahid Omran, Jara Bouma, Silke Radetzki, David A Sykes, Wolfgang Guba, Xiaoting Li, Calvin Höffelmeyer, Axel Hentsch, Thais Gazzi, Yelena Mostinski, Malgorzata Wasinska-Kalwa, Fabio de Molnier, Cas van der Horst, Jens Peter von Kries, Marc Vendrell, Tian Hua, Dmitry B Veprintsev, Laura H Heitman, Uwe Grether, Marc Nazare
Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB 1 R). Journal of medicinal chemistry 67 (14) (2024)
Stefania Butini, Uwe Grether, Kwang-Mook Jung, Alessia Ligresti, Marco Allarà, Annemarieke G J Postmus, Samuele Maramai, Simone Brogi, Alessandro Papa, Gabriele Carullo, David Sykes, Dmitry B Veprintsev, Stefano Federico, Alessandro Grillo, Bruno Di Guglielmo, Anna Ramunno, Anna Floor Stevens, Dominik Heer, Stefania Lamponi, Sandra Gemma, Jörg Benz, Vincenzo Di Marzo, Mario van der Stelt, Daniele Piomelli, Giuseppe Campiani
Development of Potent and Selective Monoacylglycerol Lipase Inhibitors. SARs, Structural Analysis, and Biological Characterization. Journal of medicinal chemistry 67 (3) (2024)
Andrea Chicca, Daniel Bátora, Christoph Ullmer, Antonello Caruso, Sabine Grüner, Jürgen Fingerle, Thomas Hartung, Roland Degen, Matthias Müller, Uwe Grether, Pal Pacher, Juerg Gertsch
A Highly Potent, Orally Bioavailable Pyrazole-Derived Cannabinoid CB2 Receptor- Selective Full Agonist for In Vivo Studies. ACS pharmacology & translational science 7 (8) (2024)
Andrea Chicca, Daniel Bátora, Christoph Ullmer, Antonello Caruso, Jürgen Fingerle, Thomas Hartung, Roland Degen, Matthias Müller, Uwe Grether, Pal Pacher, Juerg Gertsch
A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for in vivo studies. bioRxiv : the preprint server for biology (2024)
Leonard Mach, Anahid Omran, Jara Bouma, Silke Radetzki, David A Sykes, Wolfgang Guba, Xiaoting Li, Calvin Höffelmeyer, Axel Hentsch, Thais Gazzi, Yelena Mostinski, Malgorzata Wasinska-Kalwa, Fabio de Molnier, Cas van der Horst, Jens Peter von Kries, Marc Vendrell, Tian Hua, Dmitry B Veprintsev, Laura H Heitman, Uwe Grether, Marc Nazare
Highly Selective Drug-Derived Fluorescent Probes for the Cannabinoid Receptor Type 1 (CB 1 R). Journal of medicinal chemistry 67 (14) (2024)
Miroslav Kosar, Roman C Sarott, David A Sykes, Alexander E G Viray, Rosa Maria Vitale, Nataša Tomašević, Xiaoting Li, Rudolf L Z Ganzoni, Bilal Kicin, Lisa Reichert, Kacper J Patej, Uxía Gómez-Bouzó, Wolfgang Guba, Peter J McCormick, Tian Hua, Christian W Gruber, Dmitry B Veprintsev, James Allen Frank, Uwe Grether, Erick M Carreira
Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists. ACS central science 10 (5) (2024)
Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F Nippa, Michael Iff, Jann Ledergerber, Carl C G Schiebroek, Valentina Romeo, Jan A Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider
Prospective de novo drug design with deep interactome learning. Nature communications 15 (1) (2024)
Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F Nippa, Michael Iff, Jann Ledergerber, Carl C G Schiebroek, Valentina Romeo, Jan A Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider
Prospective de novo drug design with deep interactome learning. Nature communications 15 (1) (2024)
Andrea Chicca, Daniel Bátora, Christoph Ullmer, Antonello Caruso, Jürgen Fingerle, Thomas Hartung, Roland Degen, Matthias Müller, Uwe Grether, Pal Pacher, Juerg Gertsch
A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for in vivo studies. bioRxiv : the preprint server for biology (2024)
Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F Nippa, Michael Iff, Jann Ledergerber, Carl C G Schiebroek, Valentina Romeo, Jan A Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider
Prospective de novo drug design with deep interactome learning. Nature communications 15 (1) (2024)
Andrea Chicca, Daniel Bátora, Christoph Ullmer, Antonello Caruso, Sabine Grüner, Jürgen Fingerle, Thomas Hartung, Roland Degen, Matthias Müller, Uwe Grether, Pal Pacher, Juerg Gertsch
A Highly Potent, Orally Bioavailable Pyrazole-Derived Cannabinoid CB2 Receptor- Selective Full Agonist for In Vivo Studies. ACS pharmacology & translational science 7 (8) (2024)
Andrea Chicca, Daniel Bátora, Christoph Ullmer, Antonello Caruso, Jürgen Fingerle, Thomas Hartung, Roland Degen, Matthias Müller, Uwe Grether, Pal Pacher, Juerg Gertsch
A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for in vivo studies. bioRxiv : the preprint server for biology (2024)
Johannes Aebi, Kenneth Atz, Simon M Ametamey, Jörg Benz, Julie Blaising, Stefania Butini, Giuseppe Campiani, Erick M Carreira, Ludovic Collin, Eva De Lago, Thais Gazzi, Jürg Gertsch, Luca Gobbi, Wolfgang Guba, Javier Fernández-Ruiz, Jürgen Fingerle, Ahmed Haider, Yingfang He, Laura H Heitman, Michael Honer, Daniel Hunziker, Bernd Kuhn, Mauro Maccarrone, Hans Peter Märki, Rainer E Martin, Peter Mohr, Linjing Mu, Marc Nazaré, David F Nippa, Sergio Oddi, Fionn O'Hara, Pal Pacher, Julian Romero, Stephan Röver, Arne C Rufer, Roger Schibli, Gisbert Schneider, Antonia F Stepan, David A Sykes, Christoph Ullmer, Mario Van der Stelt, Dmitry B Veprintsev, Matthias B Wittwer, Uwe Grether
Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects. Chimia 78 (7-8) (2024)
David F Nippa, Kenneth Atz, Remo Hohler, Alex T Müller, Andreas Marx, Christian Bartelmus, Georg Wuitschik, Irene Marzuoli, Vera Jost, Jens Wolfard, Martin Binder, Antonia F Stepan, David B Konrad, Uwe Grether, Rainer E Martin, Gisbert Schneider
Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning. Nature chemistry (2023)
David F Nippa, Kenneth Atz, Alex T Müller, Jens Wolfard, Clemens Isert, Martin Binder, Oliver Scheidegger, David B Konrad, Uwe Grether, Rainer E Martin, Gisbert Schneider
Identifying opportunities for late-stage C-H alkylation with high-throughput experimentation and in silico reaction screening. Communications chemistry 6 (1) (2023)
Yves P Auberson, Uwe Grether, Boris Vauzeilles, Olalla Vázquez
Mutually Rewarding Academia-Industry Collaborations in the Field of Chemical Biology. Chembiochem : a European journal of chemical biology (2023)
Ming Jiang, Mirjam C W Huizenga, Jonah L Wirt, Janos Paloczi, Avand Amedi, Richard J B H N van den Berg, Joerg Benz, Ludovic Collin, Hui Deng, Xinyu Di, Wouter F Driever, Bogdan I Florea, Uwe Grether, Antonius P A Janssen, Thomas Hankemeier, Laura H Heitman, Tsang-Wai Lam, Florian Mohr, Anto Pavlovic, Iris Ruf, Helma van den Hurk, Anna F Stevens, Daan van der Vliet, Tom van der Wel, Matthias B Wittwer, Constant A A van Boeckel, Pal Pacher, Andrea G Hohmann, Mario van der Stelt
A monoacylglycerol lipase inhibitor showing therapeutic efficacy in mice without central side effects or dependence. Nature communications 14 (1) (2023)
Mónica Guberman, Miroslav Kosar, Anahid Omran, Erick M Carreira, Marc Nazare, Uwe Grether
Reverse Design toward Optimized Labeled Chemical Probes - Examples from the Endocannabinoid System. Chimia 76 (5) (2022)
Uwe Grether
Patents targeting cannabinoid receptor type 2 ligands: an interview with Uwe Grether. Pharmaceutical patent analyst 10 (4) (2021)
Benjamin Brennecke, Thais Gazzi, Kenneth Atz, Jürgen Fingerle, Pascal Kuner, Torsten Schindler, Guy de Weck, Marc Nazare, Uwe Grether
Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010. Pharmaceutical patent analyst 10 (3) (2021)
Matthias V Westphal, Roman C Sarott, Elisabeth A Zirwes, Anja Osterwald, Wolfgang Guba, Christoph Ullmer, Uwe Grether, Erick M Carreira
Highly Selective, Amine-Derived Cannabinoid Receptor 2 Probes. Chemistry (Weinheim an der Bergstrasse, Germany) 26 (6) (2020)