Nicholas C Wu

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 68

Top Venues

Nature communications

bioRxiv : the preprint server for biology

Nature materials

Science (New York, N.Y.)

University of Illinois at Urbana Champaign

University of California Los Angeles (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Illinois at Urbana Champaign

United States

Assistant Professor :: Department of Biochemistry

Scripps Research Institute

United States

Research Associate :: Department of Integrative Structural and Computational Biology

Education History

University of California Los Angeles

United States

PHD :: Molecular Biology Interdepartmental Doctoral Program

University of Virginia

United States

BSC :: Department of Chemistry

Publications

Wenhao O Ouyang, Huibin Lv, Wenkan Liu, Zongjun Mou, Ruipeng Lei, Tossapol Pholcharee, Yiquan Wang, Katrine E Dailey, Akshita B Gopal, Danbi Choi, Madison R Ardagh, Logan Talmage, Lucia A Rodriguez, Xinghong Dai, Nicholas C Wu
Rapid synthesis and screening of natively paired antibodies against influenza hemagglutinin stem via oPool + display. bioRxiv : the preprint server for biology (2024)
Ruipeng Lei, Enya Qing, Abby Odle, Meng Yuan, Chaminda D Gunawardene, Timothy J C Tan, Natalie So, Wenhao O Ouyang, Ian A Wilson, Thomas Gallagher, Stanley Perlman, Nicholas C Wu, Lok-Yin Roy Wong
Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning. Nature communications 15 (1) (2024)
Marya Y Ornelas, Wenhao O Ouyang, Nicholas C Wu
A library-on-library screen reveals the breadth expansion landscape of a broadly neutralizing betacoronavirus antibody. bioRxiv : the preprint server for biology (2024)
Timothy J C Tan, Abhishek K Verma, Abby Odle, Ruipeng Lei, David K Meyerholz, Kenneth A Matreyek, Stanley Perlman, Lok-Yin Roy Wong, Nicholas C Wu
Evidence of antigenic drift in the fusion machinery core of SARS-CoV-2 spike. Proceedings of the National Academy of Sciences of the United States of America 121 (15) (2024)
Timothy J C Tan, Abhishek K Verma, Abby Odle, Ruipeng Lei, David K Meyerholz, Kenneth A Matreyek, Stanley Perlman, Lok-Yin Roy Wong, Nicholas C Wu
Evidence of antigenic drift in the fusion machinery core of SARS-CoV-2 spike. Proceedings of the National Academy of Sciences of the United States of America 121 (15) (2024)
Ruipeng Lei, Nicholas C Wu, Wenhao O Ouyang, Andrea Hernandez Garcia, Chika Kikuchi, Shengyang Wang, Ryan McBride, Timothy J C Tan, Yuanxin Sun, Chunke Chen, Claire S Graham, Lucia A Rodriguez, Ivana R Shen, Danbi Choi, Roberto Bruzzone, James C Paulson, Satish K Nair, Chris Ka Pun Mok, Nicholas C Wu
Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin. Nature communications 15 (1) (2024)
Timothy J C Tan, Abhishek K Verma, Abby Odle, Ruipeng Lei, David K Meyerholz, Kenneth A Matreyek, Stanley Perlman, Lok-Yin Roy Wong, Nicholas C Wu
Evidence of antigenic drift in the fusion machinery core of SARS-CoV-2 spike. Proceedings of the National Academy of Sciences of the United States of America 121 (15) (2024)
Ruipeng Lei, Enya Qing, Abby Odle, Meng Yuan, Chaminda D Gunawardene, Timothy J C Tan, Natalie So, Wenhao O Ouyang, Ian A Wilson, Thomas Gallagher, Stanley Perlman, Nicholas C Wu, Lok-Yin Roy Wong
Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning. Nature communications 15 (1) (2024)
Ruipeng Lei, Enya Qing, Abby Odle, Meng Yuan, Chaminda D Gunawardene, Timothy J C Tan, Natalie So, Wenhao O Ouyang, Ian A Wilson, Thomas Gallagher, Stanley Perlman, Nicholas C Wu, Lok-Yin Roy Wong
Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning. Nature communications 15 (1) (2024)
Ruipeng Lei, Nicholas C Wu, Wenhao O Ouyang, Andrea Hernandez Garcia, Chika Kikuchi, Shengyang Wang, Ryan McBride, Timothy J C Tan, Yuanxin Sun, Chunke Chen, Claire S Graham, Lucia A Rodriguez, Ivana R Shen, Danbi Choi, Roberto Bruzzone, James C Paulson, Satish K Nair, Chris Ka Pun Mok, Nicholas C Wu
Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin. Nature communications 15 (1) (2024)
Tongyu Liu, William K Reiser, Timothy J C Tan, Huibin Lv, Joel Rivera-Cardona, Kyle Heimburger, Nicholas C Wu, Christopher B Brooke
Natural variation in neuraminidase activity influences the evolutionary potential of the seasonal H1N1 lineage hemagglutinin. bioRxiv : the preprint server for biology (2024)
Tongyu Liu, William K Reiser, Timothy J C Tan, Huibin Lv, Joel Rivera-Cardona, Kyle Heimburger, Nicholas C Wu, Christopher B Brooke
Natural variation in neuraminidase activity influences the evolutionary potential of the seasonal H1N1 lineage hemagglutinin. bioRxiv : the preprint server for biology (2024)
Timothy J C Tan, Abhishek K Verma, Abby Odle, Ruipeng Lei, David K Meyerholz, Kenneth A Matreyek, Stanley Perlman, Lok-Yin Roy Wong, Nicholas C Wu
Evidence of antigenic drift in the fusion machinery core of SARS-CoV-2 spike. Proceedings of the National Academy of Sciences of the United States of America 121 (15) (2024)
Joel Rivera-Cardona, Neeha Kakuturu, Elizabeth F Rowland, Qi Wen Teo, Elizabeth A Thayer, Timothy J C Tan, Jiayi Sun, Collin Kieffer, Nicholas C Wu, Christopher B Brooke
Seasonal influenza A virus lineages exhibit divergent abilities to antagonize interferon induction and signaling. bioRxiv : the preprint server for biology (2024)
Ruipeng Lei, Enya Qing, Abby Odle, Meng Yuan, Chaminda D Gunawardene, Timothy J C Tan, Natalie So, Wenhao O Ouyang, Ian A Wilson, Thomas Gallagher, Stanley Perlman, Nicholas C Wu, Lok-Yin Roy Wong
Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning. Nature communications 15 (1) (2024)
Marya Y Ornelas, Wenhao O Ouyang, Nicholas C Wu
A library-on-library screen reveals the breadth expansion landscape of a broadly neutralizing betacoronavirus antibody. bioRxiv : the preprint server for biology (2024)
Ruipeng Lei, Nicholas C Wu, Wenhao O Ouyang, Andrea Hernandez Garcia, Chika Kikuchi, Shengyang Wang, Ryan McBride, Timothy J C Tan, Yuanxin Sun, Chunke Chen, Claire S Graham, Lucia A Rodriguez, Ivana R Shen, Danbi Choi, Roberto Bruzzone, James C Paulson, Satish K Nair, Chris Ka Pun Mok, Nicholas C Wu
Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin. Nature communications 15 (1) (2024)
Qi Wen Teo, Yiquan Wang, Huibin Lv, Kevin J Mao, Timothy J C Tan, Yang Wei Huan, Joel Rivera-Cardona, Evan K Shao, Danbi Choi, Zahra Tavakoli Dargani, Christopher B Brooke, Nicholas C Wu
Deep mutational scanning of influenza A virus NEP reveals pleiotropic mutations in its N-terminal domain. bioRxiv : the preprint server for biology (2024)
Marya Y Ornelas, Wenhao O Ouyang, Nicholas C Wu
A library-on-library screen reveals the breadth expansion landscape of a broadly neutralizing betacoronavirus antibody. bioRxiv : the preprint server for biology (2024)
Ruipeng Lei, Nicholas C Wu, Wenhao O Ouyang, Andrea Hernandez Garcia, Chika Kikuchi, Shengyang Wang, Ryan McBride, Timothy J C Tan, Yuanxin Sun, Chunke Chen, Claire S Graham, Lucia A Rodriguez, Ivana R Shen, Danbi Choi, Roberto Bruzzone, James C Paulson, Satish K Nair, Chris Ka Pun Mok, Nicholas C Wu
Epistasis mediates the evolution of the receptor binding mode in recent human H3N2 hemagglutinin. Nature communications 15 (1) (2024)
Qian Yin, Wei Luo, Venkata Vamsee Aditya Mallajosyula, Yang Bo, Jing Guo, Jinghang Xie, Meng Sun, Rohit Verma, Chunfeng Li, Christian M Constantz, Lisa E Wagar, Jing Li, Elsa Sola, Neha Gupta, Chunlin Wang, Oliver Kask, Xin Chen, Xue Yuan, Nicholas C Wu, Jianghong Rao, Yueh-Hsiu Chien, Jianjun Cheng, Bali Pulendran, Mark M Davis
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2. Nature materials 22 (3) (2023)
Qian Yin, Wei Luo, Venkata Vamsee Aditya Mallajosyula, Yang Bo, Jing Guo, Jinghang Xie, Meng Sun, Rohit Verma, Chunfeng Li, Christian M Constantz, Lisa E Wagar, Jing Li, Elsa Sola, Neha Gupta, Chunlin Wang, Oliver Kask, Xin Chen, Xue Yuan, Nicholas C Wu, Jianghong Rao, Yueh-Hsiu Chien, Jianjun Cheng, Bali Pulendran, Mark M Davis
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2. Nature materials (2023)
Qian Yin, Wei Luo, Venkata Vamsee Aditya Mallajosyula, Yang Bo, Jing Guo, Jinghang Xie, Meng Sun, Rohit Verma, Chunfeng Li, Christian M Constantz, Lisa E Wagar, Jing Li, Elsa Sola, Neha Gupta, Chunlin Wang, Oliver Kask, Xin Chen, Xue Yuan, Nicholas C Wu, Jianghong Rao, Yueh-Hsiu Chien, Jianjun Cheng, Bali Pulendran, Mark M Davis
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2. Nature materials 22 (3) (2023)
Qian Yin, Wei Luo, Venkata Vamsee Aditya Mallajosyula, Yang Bo, Jing Guo, Jinghang Xie, Meng Sun, Rohit Verma, Chunfeng Li, Christian M Constantz, Lisa E Wagar, Jing Li, Elsa Sola, Neha Gupta, Chunlin Wang, Oliver Kask, Xin Chen, Xue Yuan, Nicholas C Wu, Jianghong Rao, Yueh-Hsiu Chien, Jianjun Cheng, Bali Pulendran, Mark M Davis
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2. Nature materials (2023)
Qian Yin, Wei Luo, Venkata Vamsee Aditya Mallajosyula, Yang Bo, Jing Guo, Jinghang Xie, Meng Sun, Rohit Verma, Chunfeng Li, Christian M Constantz, Lisa E Wagar, Jing Li, Elsa Sola, Neha Gupta, Chunlin Wang, Oliver Kask, Xin Chen, Xue Yuan, Nicholas C Wu, Jianghong Rao, Yueh-Hsiu Chien, Jianjun Cheng, Bali Pulendran, Mark M Davis
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2. Nature materials 22 (3) (2023)
Meng Yuan, Ziqi Feng, Huibin Lv, Natalie So, Ivana R Shen, Timothy J C Tan, Qi Wen Teo, Wenhao O Ouyang, Logan Talmage, Ian A Wilson, Nicholas C Wu
Widespread impact of immunoglobulin V gene allelic polymorphisms on antibody reactivity. bioRxiv : the preprint server for biology (2023)
Qian Yin, Wei Luo, Venkata Vamsee Aditya Mallajosyula, Yang Bo, Jing Guo, Jinghang Xie, Meng Sun, Rohit Verma, Chunfeng Li, Christian M Constantz, Lisa E Wagar, Jing Li, Elsa Sola, Neha Gupta, Chunlin Wang, Oliver Kask, Xin Chen, Xue Yuan, Nicholas C Wu, Jianghong Rao, Yueh-Hsiu Chien, Jianjun Cheng, Bali Pulendran, Mark M Davis
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2. Nature materials 22 (3) (2023)
Timothy J C Tan, Zongjun Mou, Ruipeng Lei, Wenhao O Ouyang, Meng Yuan, Sophie Ge Song, Raiees Andrabi, Ian A Wilson, Collin Kieffer, Xinghong Dai, Kenneth A Matreyek, Nicholas C Wu
High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike. Nature communications 14 (1) (2023)
Qi Wen Teo, Yiquan Wang, Huibin Lv, Timothy J C Tan, Ruipeng Lei, Kevin J Mao, Nicholas C Wu
Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem. bioRxiv : the preprint server for biology (2023)
Qian Yin, Wei Luo, Venkata Vamsee Aditya Mallajosyula, Yang Bo, Jing Guo, Jinghang Xie, Meng Sun, Rohit Verma, Chunfeng Li, Christian M Constantz, Lisa E Wagar, Jing Li, Elsa Sola, Neha Gupta, Chunlin Wang, Oliver Kask, Xin Chen, Xue Yuan, Nicholas C Wu, Jianghong Rao, Yueh-Hsiu Chien, Jianjun Cheng, Bali Pulendran, Mark M Davis
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2. Nature materials (2023)
Yiquan Wang, Huibin Lv, Ruipeng Lei, Yuen-Hei Yeung, Ivana R Shen, Danbi Choi, Qi Wen Teo, Timothy J C Tan, Akshita B Gopal, Xin Chen, Claire S Graham, Nicholas C Wu
An explainable language model for antibody specificity prediction using curated influenza hemagglutinin antibodies. bioRxiv : the preprint server for biology (2023)
Qian Yin, Wei Luo, Venkata Vamsee Aditya Mallajosyula, Yang Bo, Jing Guo, Jinghang Xie, Meng Sun, Rohit Verma, Chunfeng Li, Christian M Constantz, Lisa E Wagar, Jing Li, Elsa Sola, Neha Gupta, Chunlin Wang, Oliver Kask, Xin Chen, Xue Yuan, Nicholas C Wu, Jianghong Rao, Yueh-Hsiu Chien, Jianjun Cheng, Bali Pulendran, Mark M Davis
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2. Nature materials 22 (3) (2023)
Pavithra Daulagala, Brian R Mann, Kathy Leung, Eric H Y Lau, Louise Yung, Ruipeng Lei, Sarea I N Nizami, Joseph T Wu, Susan S Chiu, Rodney S Daniels, Nicholas C Wu, David Wentworth, Joseph S Malik Peiris, Hui Ling Yen
Imprinted Anti-Hemagglutinin and Anti-Neuraminidase Antibody Responses after Childhood Infections of A(H1N1) and A(H1N1)pdm09 Influenza Viruses. mBio (2023)
Qian Yin, Wei Luo, Venkata Vamsee Aditya Mallajosyula, Yang Bo, Jing Guo, Jinghang Xie, Meng Sun, Rohit Verma, Chunfeng Li, Christian M Constantz, Lisa E Wagar, Jing Li, Elsa Sola, Neha Gupta, Chunlin Wang, Oliver Kask, Xin Chen, Xue Yuan, Nicholas C Wu, Jianghong Rao, Yueh-Hsiu Chien, Jianjun Cheng, Bali Pulendran, Mark M Davis
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2. Nature materials 22 (3) (2023)
Qian Yin, Wei Luo, Venkata Vamsee Aditya Mallajosyula, Yang Bo, Jing Guo, Jinghang Xie, Meng Sun, Rohit Verma, Chunfeng Li, Christian M Constantz, Lisa E Wagar, Jing Li, Elsa Sola, Neha Gupta, Chunlin Wang, Oliver Kask, Xin Chen, Xue Yuan, Nicholas C Wu, Jianghong Rao, Yueh-Hsiu Chien, Jianjun Cheng, Bali Pulendran, Mark M Davis
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2. Nature materials 22 (3) (2023)
Lok-Yin Roy Wong, Abby Odle, Emma Luhmann, Douglas C Wu, Yiquan Wang, Qi Wen Teo, Celeste Ptak, Alan Sariol, Shea Lowery, Matthias Mack, David K Meyerholz, Nicholas C Wu, Lilliana Radoshevich, Stanley Perlman
Contrasting roles of MERS-CoV and SARS-CoV-2 internal proteins in pathogenesis in mice. mBio (2023)
Ruipeng Lei, Enya Qing, Abby Odle, Meng Yuan, Timothy J C Tan, Natalie So, Wenhao O Ouyang, Ian A Wilson, Tom Gallagher, Stanley Perlman, Nicholas C Wu, Lok-Yin Roy Wong
Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning. bioRxiv : the preprint server for biology (2023)
C Garrett Rappazzo, Monica L I Fernández-Quintero, Andreas Mayer, Nicholas C Wu, Victor Greiff, Jenna J Guthmiller
Defining and Studying B Cell Receptor and TCR Interactions. Journal of immunology (Baltimore, Md. : 1950) 211 (3) (2023)
Wenhao O Ouyang, Timothy J C Tan, Ruipeng Lei, Sophie Ge Song, Collin Kieffer, Raiees Andrabi, Kenneth A Matreyek, Nicholas C Wu
Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning. Science advances 8 (47) (2022)
Ruipeng Lei, Timothy J C Tan, Andrea Hernandez Garcia, Yiquan Wang, Meghan Diefenbacher, Chuyun Teo, Gopika Gopan, Zahra Tavakoli Dargani, Qi Wen Teo, Claire S Graham, Christopher B Brooke, Satish K Nair, Nicholas C Wu
Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase. Nature communications 13 (1) (2022)
Timothy J C Tan, Zongjun Mou, Ruipeng Lei, Wenhao O Ouyang, Meng Yuan, Ge Song, Raiees Andrabi, Ian A Wilson, Collin Kieffer, Xinghong Dai, Kenneth A Matreyek, Nicholas C Wu
High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike. bioRxiv : the preprint server for biology (2022)
Hyeseon Cho, Kristina Kay Gonzales-Wartz, Deli Huang, Meng Yuan, Mary Peterson, Janie Liang, Nathan Beutler, Jonathan L Torres, Yu Cong, Elena Postnikova, Sandhya Bangaru, Chloe Adrienna Talana, Wei Shi, Eun Sung Yang, Yi Zhang, Kwanyee Leung, Lingshu Wang, Linghang Peng, Jeff Skinner, Shanping Li, Nicholas C Wu, Hejun Liu, Cherrelle Dacon, Thomas Moyer, Melanie Cohen, Ming Zhao, F Eun-Hyung Lee, Rona S Weinberg, Iyadh Douagi, Robin Gross, Connie Schmaljohn, Amarendra Pegu, John R Mascola, Michael R Holbrook, David Nemazee, Thomas F Rogers, Andrew B Ward, Ian A Wilson, Peter D Crompton, Joshua Tan
Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants. bioRxiv : the preprint server for biology (2021)
Chang-Chun David Lee, Yasunori Watanabe, Nicholas C Wu, Julianna Han, Sonu Kumar, Tossapol Pholcharee, Gemma E Seabright, Joel D Allen, Chih-Wei Lin, Ji-Rong Yang, Ming-Tsan Liu, Chung-Yi Wu, Andrew B Ward, Max Crispin, Ian A Wilson
A cross-neutralizing antibody between HIV-1 and influenza virus. PLoS pathogens 17 (3) (2021)
Meng Yuan, Deli Huang, Chang-Chun David Lee, Nicholas C Wu, Abigail M Jackson, Xueyong Zhu, Hejun Liu, Linghang Peng, Marit J VAN Gils, Rogier W Sanders, Dennis R Burton, S Momsen Reincke, Harald Prüss, Jakob Kreye, David Nemazee, Andrew B Ward, Ian A Wilson
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants. Science (New York, N.Y.) 373 (6556) (2021)
Paul-Albert Koenig, Hrishikesh Das, Hejun Liu, Beate M Kümmerer, Florian N Gohr, Lea-Marie Jenster, Lisa D J Schiffelers, Yonas M Tesfamariam, Miki Uchima, Jennifer Deborah Wuerth, Karl Gatterdam, Natalia Ruetalo, Maria H Christensen, Caroline I Fandrey, Sabine Normann, Jan M P Tödtmann, Steffen Pritzl, Leo Hanke, Jannik Boos, Meng Yuan, Xueyong Zhu, Jonathan L Schmid-Burgk, Hiroki Kato, Michael Schindler, Ian A Wilson, Matthias Geyer, Kerstin U Ludwig, B Martin Hällberg, Nicholas C Wu, Florian Ingo Schmidt
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science (New York, N.Y.) 371 (6530) (2021)
Yiquan Wang, Ruipeng Lei, Armita Nourmohammad, Nicholas C Wu
Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing. eLife 10 (2021)
Timothy J C Tan, Meng Yuan, Kaylee Kuzelka, Gilberto C Padron, Jacob R Beal, Xin Chen, Yiquan Wang, Joel Rivera-Cardona, Xueyong Zhu, Beth M Stadtmueller, Christopher B Brooke, Ian A Wilson, Nicholas C Wu
Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain. Nature communications 12 (1) (2021)
Min Qiang, Peixiang Ma, Yu Li, Hejun Liu, Adam Harding, Chenyu Min, Fulian Wang, Lili Liu, Meng Yuan, Qun Ji, Pingdong Tao, Xiaojie Shi, Zhean Li, Teng Li, Xian Wang, Yu Zhang, Nicholas C Wu, Chang-Chun David Lee, Xueyong Zhu, Javier Gilbert Jaramillo, Chuyue Zhang, Abhishek Saxena, Xingxu Huang, Hou Wang, William S James, Raymond A Dwek, Ian A Wilson, Guang Yang, Richard A Lerner
Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2021)
Yiquan Wang, Meng Yuan, Jian Peng, Ian A Wilson, Nicholas C Wu
A large-scale systematic survey of SARS-CoV-2 antibodies reveals recurring molecular features. bioRxiv : the preprint server for biology (2021)
Hyeseon Cho, Kristina Kay Gonzales-Wartz, Deli Huang, Meng Yuan, Mary E Peterson, Janie Liang, Nathan Beutler, Jonathan L Torre, Yu Cong, Elena Postnikova, Sandhya Bangaru, Chloe Adrienna Talana, Wei Shi, Eun Sung Yang, Yi Zhang, Kwanyee Leung, Lingshu Wang, Linghang Peng, Jeff Skinner, Shanping Li, Nicholas C Wu, Hejun Liu, Cherrelle Dacon, Thomas Moyer, Melanie Cohen, Ming Zhao, Frances Eun-Hyung Lee, Rona Singer Weinberg, Iyadh Douagi, Robin Gross, Connie S Schmaljohn, Amarendra Pegu, John R Mascola, Michael R Holbrook, David Nemazee, Thomas F Rogers, Andrew B Ward, Ian A Wilson, Peter Dobbs Crompton, Joshua Tan
Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern. Science translational medicine 13 (616) (2021)
Nicholas C Wu, Andrew J Thompson, Juhye M Lee, Wen Su, Britni M Arlian, Jia Xie, Richard A Lerner, Hui Ling Yen, Jesse D Bloom, Ian A Wilson
Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses. Science (New York, N.Y.) 368 (6497) (2020)
Thomas F Rogers, Fangzhu Zhao, Deli Huang, Nathan Beutler, Alison Burns, Wan-Ting He, Oliver Limbo, Chloe Smith, Sophie Ge Song, Jordan L Woehl, Linlin Yang, Robert K Abbott, Sean Callaghan, Elijah Garcia, Jonathan Hurtado, Mara Parren, Linghang Peng, Sydney I Ramirez, James Ricketts, Michael J Ricciardi, Stephen A Rawlings, Nicholas C Wu, Meng Yuan, Davey M Smith, David Nemazee, John R Teijaro, James E Voss, Ian A Wilson, Raiees Andrabi, Bryan Briney, Elise Landais, Devin Sok, Joseph G Jardine, Dennis R Burton
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model. Science (New York, N.Y.) 369 (6506) (2020)
Meng Yuan, Hejun Liu, Nicholas C Wu, Chang-Chun David Lee, Xueyong Zhu, Fangzhu Zhao, Deli Huang, Wenli Yu, Yuanzi Hua, Henry Tien, Thomas F Rogers, Elise Landais, Devin Sok, Joseph G Jardine, Dennis R Burton, Ian A Wilson
Structural basis of a shared antibody response to SARS-CoV-2. Science (New York, N.Y.) 369 (6507) (2020)
Nicholas C Wu, Ian A Wilson
Structural Biology of Influenza Hemagglutinin: An Amaranthine Adventure. Viruses 12 (9) (2020)
Nicholas C Wu, Jakub Otwinowski, Andrew J Thompson, Corwin M Nycholat, Armita Nourmohammad, Ian A Wilson
Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape. Nature communications 11 (1) (2020)
Meng Yuan, Nicholas C Wu, Xueyong Zhu, Chang-Chun David Lee, Ray T Y So, Huibin Lv, Chris Ka Pun Mok, Ian A Wilson
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV. Science (New York, N.Y.) 368 (6491) (2020)
Huibin Lv, Nicholas C Wu, Chris Ka Pun Mok
COVID-19 vaccines: Knowing the unknown. European journal of immunology 50 (7) (2020)
Nicholas C Wu, Meng Yuan, Hejun Liu, Chang-Chun David Lee, Xueyong Zhu, Sandhya Bangaru, Jonathan L Torre, Tom G Caniels, Philip J M Brouwer, Marit J VAN Gils, Rogier W Sanders, Andrew B Ward, Ian A Wilson
An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain. bioRxiv : the preprint server for biology (2020)
Yao Yao, Rameshwar U Kadam, Chang-Chun David Lee, Jordan L Woehl, Nicholas C Wu, Xueyong Zhu, Seiya Kitamura, Ian A Wilson, Dennis W Wolan
An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen. Proceedings of the National Academy of Sciences of the United States of America 117 (31) (2020)
Nicholas C Wu, Meng Yuan, Sandhya Bangaru, Deli Huang, Xueyong Zhu, Chang-Chun David Lee, Hannah L Turner, Linghang Peng, Linlin Yang, Dennis R Burton, David Nemazee, Andrew B Ward, Ian A Wilson
A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody. PLoS pathogens 16 (12) (2020)
Senlian Hong, Yujie Shi, Nicholas C Wu, Geramie Grande, Lacey Douthit, Hua Wang, Wen Zhou, K Barry Sharpless, Ian A Wilson, Jia Xie, Peng Wu
Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification. Nature communications 10 (1) (2019)
Yifeng Zhang, Fabien Thery, Nicholas C Wu, Emma K Luhmann, Olivier Dussurget, Mariko H Foecke, Clara Bredow, Daniel Jiménez Fernández, Kevin Leandro, Antje Beling, Klaus-Peter Knobeloch, Francis Impens, Pascale Cossart, Lillianna Radoshevich
The in vivo ISGylome links ISG15 to metabolic pathways and autophagy upon Listeria monocytogenes infection. Nature communications 10 (1) (2019)
Nicholas C Wu, Andrew J Thompson, Jia Xie, Chih-Wei Lin, Corwin M Nycholat, Xueyong Zhu, Richard A Lerner, James C Paulson, Ian A Wilson
A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nature communications 9 (1) (2018)
Nicholas C Wu, Ian A Wilson
Structural insights into the design of novel anti-influenza therapies. Nature structural & molecular biology 25 (2) (2018)
Yushen Du, Li Xin, Yuan Shi, Tian-Hao Zhang, Nicholas C Wu, Lei Dai, Danyang Gong, Gurpreet Brar, Sara Shu, Jiadi Luo, William Reiley, Yen-Wen Tseng, Hongyan Bai, Ting-Ting Wu, Jieru Wang, Yuelong Shu, Ren Sun
Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design. Science (New York, N.Y.) 359 (6373) (2018)
Nicholas C Wu, Geramie Grande, Hannah L Turner, Andrew B Ward, Jia Xie, Richard A Lerner, Ian A Wilson
In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity. Nature communications 8 (2017)
Nicholas C Wu, Seth J Zost, Andrew J Thompson, David Oyen, Corwin M Nycholat, Ryan McBride, James C Paulson, Scott E Hensley, Ian A Wilson
A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine. PLoS pathogens 13 (10) (2017)
Nicholas C Wu, Lei Dai, C Anders Olson, James O Lloyd-Smith, Ren Sun
Adaptation in protein fitness landscapes is facilitated by indirect paths. eLife 5 (2016)

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Publication Activity (10 Years)

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Nicholas C Wu