Stephen J Haggarty (Stephen Haggarty)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 32

Top Venues

Nature communications

Proceedings of the National Academy of Sciences of the United States of America

ACS chemical neuroscience

Journal of medicinal chemistry

Harvard Medical School

Harvard University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Harvard Medical School

United States

Associate Professor :: Neurology, Mass. General Hospital

Education History

Harvard University

United States

PHD

Publications

Sarah C Potter, Bettine E Gibbs, Forrest A Hammel, Cassandra M Joiner, Joao A Paulo, John Janetzko, Zebulon G Levine, George Q Fei, Stephen J Haggarty, Suzanne Walker
Dissecting OGT's TPR domain to identify determinants of cellular function. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Sarah C Potter, Bettine E Gibbs, Forrest A Hammel, Cassandra M Joiner, Joao A Paulo, John Janetzko, Zebulon G Levine, George Q Fei, Stephen J Haggarty, Suzanne Walker
Dissecting OGT's TPR domain to identify determinants of cellular function. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Sarah C Potter, Bettine E Gibbs, Forrest A Hammel, Cassandra M Joiner, Joao A Paulo, John Janetzko, Zebulon G Levine, George Q Fei, Stephen J Haggarty, Suzanne Walker
Dissecting OGT's TPR domain to identify determinants of cellular function. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Sarah C Potter, Bettine E Gibbs, Forrest A Hammel, Cassandra M Joiner, Joao A Paulo, John Janetzko, Zebulon G Levine, George Q Fei, Stephen J Haggarty, Suzanne Walker
Dissecting OGT's TPR domain to identify determinants of cellular function. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Rachel Tesla, Charlotte Guhl, Gordon C Werthmann, Danielle Dixon, Basar Cenik, Yesu Addepalli, Jue Liang, Daniel M Fass, Zachary Rosenthal, Stephen J Haggarty, Noelle S Williams, Bruce A Posner, Joseph M Ready, Joachim Herz
Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency. Nature communications 15 (1) (2024)
Sarah C Potter, Bettine E Gibbs, Forrest A Hammel, Cassandra M Joiner, Joao A Paulo, John Janetzko, Zebulon G Levine, George Q Fei, Stephen J Haggarty, Suzanne Walker
Dissecting OGT's TPR domain to identify determinants of cellular function. Proceedings of the National Academy of Sciences of the United States of America 121 (22) (2024)
Rachel Tesla, Charlotte Guhl, Gordon C Werthmann, Danielle Dixon, Basar Cenik, Yesu Addepalli, Jue Liang, Daniel M Fass, Zachary Rosenthal, Stephen J Haggarty, Noelle S Williams, Bruce A Posner, Joseph M Ready, Joachim Herz
Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency. Nature communications 15 (1) (2024)
Rachel Tesla, Charlotte Guhl, Gordon C Werthmann, Danielle Dixon, Basar Cenik, Yesu Addepalli, Jue Liang, Daniel M Fass, Zachary Rosenthal, Stephen J Haggarty, Noelle S Williams, Bruce A Posner, Joseph M Ready, Joachim Herz
Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency. Nature communications 15 (1) (2024)
Rachel Tesla, Charlotte Guhl, Gordon C Werthmann, Danielle Dixon, Basar Cenik, Yesu Addepalli, Jue Liang, Daniel M Fass, Zachary Rosenthal, Stephen J Haggarty, Noelle S Williams, Bruce A Posner, Joseph M Ready, Joachim Herz
Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency. Nature communications 15 (1) (2024)
Anna Krichevsky, Lien D Nguyen, Zhiyun Wei, M Catarina Silva, Sergio Barberán-Soler, Rosalia Rabinovsky, Christina Muratore, Jonathan Stricker, Colin Hortman, Tracy L Young-Pearse, Stephen J Haggarty
Small Molecule Regulators of microRNAs Identified by High-Throughput Screen Coupled with High-Throughput Sequencing. Research square (2023)
Lien D Nguyen, Zhiyun Wei, M Catarina Silva, Sergio Barberán-Soler, Jiarui Zhang, Rosalia Rabinovsky, Christina R Muratore, Jonathan M S Stricker, Colin Hortman, Tracy L Young-Pearse, Stephen J Haggarty, Anna M Krichevsky
Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing. Nature communications 14 (1) (2023)
Tony S Eteläinen, M Catarina Silva, Johanna K Uhari-Väänänen, Francesca De Lorenzo, Maria H Jäntti, Hengjing Cui, Marta Chavero-Pieres, Tommi P Kilpeläinen, Christina Mechtler, Reinis Svarcbahs, Erin Seppälä, Juha R Savinainen, Elena Puris, Gert Fricker, Mikko Gynther, Ulrika H Julku, Henri J Huttunen, Stephen J Haggarty, Timo T Myöhänen
A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy. Science translational medicine 15 (691) (2023)
Ping-Chieh Pao, Jinsoo Seo, Audrey Lee, Oleg Kritskiy, Debasis Patnaik, Jay Penney, Ravikiran M Raju, Ute Geigenmuller, M Catarina Silva, Diane E Lucente, James F Gusella, Bradford C Dickerson, Anjanet Loon, Margaret X Yu, Michael Bula, Melody Yu, Stephen J Haggarty, Li-Huei Tsai
A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes. Proceedings of the National Academy of Sciences of the United States of America 120 (16) (2023)
Morrie Lam, Szu-Yu Kuo, Surya Reis, Jason E Gestwicki, M Catarina Silva, Stephen J Haggarty
Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of Tauopathy. bioRxiv : the preprint server for biology (2023)
Tristen Hewitt, Begüm Alural, Manali Tilak, Jennifer Wang, Natalina Becke, Ellis Chartley, Melissa L Perreault, Stephen J Haggarty, Steven D Sheridan, Roy H Perlis, Nina Jones, Nikolaos Mellios, Jasmin Lalonde
Bipolar disorder-iPSC derived neural progenitor cells exhibit dysregulation of store-operated Ca 2+ entry and accelerated differentiation. Molecular psychiatry (2023)
Daniel M Fass, Michael C Lewis, Rushdy Ahmad, Matthew J Szucs, Qiangge Zhang, Morgan Fleishman, Dongqing Wang, Myung Jong Kim, Jonathan D Biag, Steven A Carr, Edward M Scolnick, Richard T Premont, Stephen J Haggarty
Brain-specific deletion of GIT1 impairs cognition and alters phosphorylation of synaptic protein networks implicated in schizophrenia susceptibility. Molecular psychiatry 27 (8) (2022)
Debasis Patnaik, Ping-Chieh Pao, Wen-Ning Zhao, M Catarina Silva, Norma K Hylton, Peter S Chindavong, Ling Pan, Li-Huei Tsai, Stephen J Haggarty
Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration. ACS chemical neuroscience 12 (2) (2021)
Ping Bai, Yu Lan, Debasis Patnaik, Hao Wang, Yan Liu, Zude Chen, Gengyang Yuan, Sepideh Afshar, Robin Striar, Julia S Zagaroli, Darcy R Tocci, Amelia G Langan, Stephen J Haggarty, Changning Wang
Design, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins. Journal of medicinal chemistry 64 (19) (2021)
Alicyia Walczyk-Mooradally, Jennifer Holborn, Karamjeet Singh, Marshall Tyler, Debasis Patnaik, Hendrik Wesseling, Nicholas J Brandon, Judith Steen, Steffen P Graether, Stephen J Haggarty, Jasmin Lalonde
Phosphorylation-dependent control of Activity-regulated cytoskeleton-associated protein (Arc) protein by TNIK. Journal of neurochemistry 158 (5) (2021)
Marina Kovalenko, Serkan Erdin, Marissa A Andrew, Jason St Claire, Melissa Shaughnessey, Leroy Hubert, João Luís Neto, Alexei Stortchevoi, Daniel M Fass, Ricardo Mouro Pinto, Stephen J Haggarty, John H Wilson, Michael E Talkowski, Vanessa C Wheeler
Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice. eLife 9 (2020)
Israel Hernandez, Gabriel Luna, Jennifer N Rauch, Surya A Reis, Michel Giroux, Celeste M Karch, Daniel Boctor, Youssef E Sibih, Nadia J Storm, Antonio Diaz, Susmita Kaushik, Cezary Zekanowski, Alexander A Kang, Cassidy R Hinman, Vesna Cerovac, Elmer Guzman, Hongjun R Zhou, Stephen J Haggarty, Alison M Goate, Steven K Fisher, Ana M Cuervo, Kenneth S Kosik
A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy. Science translational medicine 11 (485) (2020)
Ping-Chieh Pao, Debasis Patnaik, L Ashley Watson, Fan Gao, Ling Pan, Jun Wang, Chinnakkaruppan Adaikkan, Jay Penney, Hugh P Cam, Wen-Chin Huang, Lorena Pantano, Audrey Lee, Alexi Nott, Trongha X Phan, Elizabeta Gjoneska, Sara Elmsaouri, Stephen J Haggarty, Li-Huei Tsai
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease. Nature communications 11 (1) (2020)
M Catarina Silva, Stephen J Haggarty
Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies. International journal of molecular sciences 21 (23) (2020)
Stephanie L Saundh, Debasis Patnaik, Steve Gagné, Joshua A Bishop, Sean Lipsit, Samat Amat, Narsimha Pujari, Anand Krishnan Nambisan, Robert Bigsby, Mary Murphy, Li-Huei Tsai, Stephen J Haggarty, Adelaine Kwun-Wai Leung
Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein. ACS chemical neuroscience 11 (24) (2020)
M Catarina Silva, Ghata A Nandi, Sharon Tentarelli, Ian K Gurrell, Tanguy Jamier, Diane Lucente, Bradford C Dickerson, Dean G Brown, Nicholas J Brandon, Stephen J Haggarty
Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons. Nature communications 11 (1) (2020)
M Catarina Silva, Fleur M Ferguson, Quan Cai, Katherine Aleisha Donovan, Ghata A Nandi, Debasis Patnaik, Tinghu Zhang, Hai-Tsang Huang, Diane E Lucente, Bradford C Dickerson, Timothy J Mitchison, Eric S Fischer, Nathanael S Gray, Stephen J Haggarty
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. eLife 8 (2019)
Vadim Bernard-Gauthier, Andrew V Mossine, Ashley C Knight, Debasis Patnaik, Wen-Ning Zhao, Chialin Cheng, Hema S Krishnan, Lucius L Xuan, Peter S Chindavong, Surya A Reis, Jinshan Michael Chen, Xia Shao, Jenelle Stauff, Janna Arteaga, Phillip Sherman, Nicolas Salem, David Bonsall, Brenda Amaral, Cassis Varlow, Lisa Wells, Laurent Martarello, Shil Patel, Steven H Liang, Ravi G Kurumbail, Stephen J Haggarty, Peter J H Scott, Neil Vasdev
Structural Basis for Achieving GSK-3β Inhibition with High Potency, Selectivity, and Brain Exposure for Positron Emission Tomography Imaging and Drug Discovery. Journal of medicinal chemistry 62 (21) (2019)
Carlos Moreno-Yruela, Daniel M Fass, Chialin Cheng, Joachim Herz, Christian A Olsen, Stephen J Haggarty
Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression. ACS chemical neuroscience 10 (8) (2019)
Josefa Zaldivar-Diez, Lingling Li, Ana M Garcia, Wen-Ning Zhao, Cristina Medina-Menendez, Stephen J Haggarty, Carmen Gil, Aixa V Morales, Ana Martinez
Benzothiazole-Based LRRK2 Inhibitors as Wnt Enhancers and Promoters of Oligodendrocytic Fate. Journal of medicinal chemistry 63 (5) (2019)
Wen-Ning Zhao, Balaram Ghosh, Marshall W Tyler, Jasmin Lalonde, Nadine F Joseph, Nina Kosaric, Daniel M Fass, Li-Huei Tsai, Ralph Mazitschek, Stephen J Haggarty
Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory. ACS chemical neuroscience 9 (9) (2018)
Xudong Lin, Xin Duan, Claire Jacobs, Jeremy Ullmann, Chung-Yuen Chan, Siya Chen, Shuk-Han Cheng, Wen-Ning Zhao, Annapurna Poduri, Xin Wang, Stephen J Haggarty, Peng Shi
High-throughput brain activity mapping and machine learning as a foundation for systems neuropharmacology. Nature communications 9 (1) (2018)
Jinsoo Seo, Oleg Kritskiy, L Ashley Watson, Scarlett J Barker, Dilip Dey, Waseem K Raja, Yuan-Ta Lin, Tak Ko, Sukhee Cho, Jay Penney, M Catarina Silva, Steven D Sheridan, Diane Lucente, James F Gusella, Bradford C Dickerson, Stephen J Haggarty, Li-Huei Tsai
Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia. The Journal of neuroscience : the official journal of the Society for Neuroscience 37 (41) (2017)

Stephen J Haggarty.css-eqlu8i{font-size:small;padding-left:4px;} (Stephen Haggarty)

Publication Activity (10 Years)

Top Topics

Top Venues

Stephen J Haggarty (Stephen Haggarty)