Daniel Merk

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 93

Top Topics

Acute Lymphoblastic Leukemia

Transcription Factor

Editorial Comment

Top Venues

Journal of medicinal chemistry

Nature communications

Communications chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Max Lewandowski, Melania Carmina, Loris Knümann, Minh Sai, Sabine Willems, Till Kasch, Julius Pollinger, Stefan Knapp, Julian A Marschner, Apirat Chaikuad, Daniel Merk
Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties. Journal of medicinal chemistry 67 (3) (2024)
Victor Hernandez-Olmos, Jan Heering, Beatrice Marinescu, Tina Weiß, Vladimir V Ivanov, Yurii S Moroz, Sheila Nevermann, Marius Mathes, Johanna H M Ehrler, Mohamad Wessam Alnouri, Markus Wolf, Alicia S Haydo, Tessa Schmachtel, Andrea Zaliani, Georg Höfner, Astrid Kaiser, Manfred Schubert-Zsilavecz, Annette G Beck-Sickinger, Stefan Offermanns, Philipp Gribbon, Michael A Rieger, Daniel Merk, Marco Sisignano, Dieter Steinhilber, Ewgenij Proschak
Development of a Potent and Selective G2A (GPR132) Agonist. Journal of medicinal chemistry 67 (13) (2024)
Victor Hernandez-Olmos, Jan Heering, Beatrice Marinescu, Tina Weiß, Vladimir V Ivanov, Yurii S Moroz, Sheila Nevermann, Marius Mathes, Johanna H M Ehrler, Mohamad Wessam Alnouri, Markus Wolf, Alicia S Haydo, Tessa Schmachtel, Andrea Zaliani, Georg Höfner, Astrid Kaiser, Manfred Schubert-Zsilavecz, Annette G Beck-Sickinger, Stefan Offermanns, Philipp Gribbon, Michael A Rieger, Daniel Merk, Marco Sisignano, Dieter Steinhilber, Ewgenij Proschak
Development of a Potent and Selective G2A (GPR132) Agonist. Journal of medicinal chemistry 67 (13) (2024)
Laura Isigkeit, Espen Schallmayer, Romy Busch, Lorene Brunello, Amelie Tjaden, Lewis Elson, Susanne Müller, Stefan Knapp, Alexandra Stolz, Julian A Marschner, Daniel Merk
Chemogenomics for NR1 nuclear hormone receptors. Nature communications 15 (1) (2024)
Sabine Willems, Romy Busch, Felix Nawa, Marco Ballarotto, Felix F Lillich, Till Kasch, Úrsula López-García, Julian A Marschner, Lorena A Rüger, Beatrice Renelt, Julia Ohrndorf, Silvia Arifi, Daniel Zaienne, Ewgenij Proschak, Jörg Pabel, Daniel Merk
Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism. Journal of medicinal chemistry 67 (15) (2024)
Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F Nippa, Michael Iff, Jann Ledergerber, Carl C G Schiebroek, Valentina Romeo, Jan A Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider
Prospective de novo drug design with deep interactome learning. Nature communications 15 (1) (2024)
Laura Isigkeit, Annette Kärcher, Gustave Adouvi, Silvia Arifi, Daniel Merk
Rational design and virtual screening identify mimetics of the RXR agonist valerenic acid. ChemMedChem (2024)
Minh Sai, Niels van Herwijnen, Daniel Merk
Azologs of the Fatty Acid Mimetic Drug Cinalukast Enable Light-Induced PPARα Activation. ChemMedChem (2024)
Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F Nippa, Michael Iff, Jann Ledergerber, Carl C G Schiebroek, Valentina Romeo, Jan A Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider
Prospective de novo drug design with deep interactome learning. Nature communications 15 (1) (2024)
Laura Isigkeit, Espen Schallmayer, Romy Busch, Lorene Brunello, Amelie Tjaden, Lewis Elson, Susanne Müller, Stefan Knapp, Alexandra Stolz, Julian A Marschner, Daniel Merk
Chemogenomics for NR1 nuclear hormone receptors. Nature communications 15 (1) (2024)
Laura Isigkeit, Annette Kärcher, Gustave Adouvi, Silvia Arifi, Daniel Merk
Rational design and virtual screening identify mimetics of the RXR agonist valerenic acid. ChemMedChem 19 (5) (2024)
Victor Hernandez-Olmos, Jan Heering, Beatrice Marinescu, Tina Weiß, Vladimir V Ivanov, Yurii S Moroz, Sheila Nevermann, Marius Mathes, Johanna H M Ehrler, Mohamad Wessam Alnouri, Markus Wolf, Alicia S Haydo, Tessa Schmachtel, Andrea Zaliani, Georg Höfner, Astrid Kaiser, Manfred Schubert-Zsilavecz, Annette G Beck-Sickinger, Stefan Offermanns, Philipp Gribbon, Michael A Rieger, Daniel Merk, Marco Sisignano, Dieter Steinhilber, Ewgenij Proschak
Development of a Potent and Selective G2A (GPR132) Agonist. Journal of medicinal chemistry 67 (13) (2024)
Victor Hernandez-Olmos, Jan Heering, Beatrice Marinescu, Tina Weiß, Vladimir V Ivanov, Yurii S Moroz, Sheila Nevermann, Marius Mathes, Johanna H M Ehrler, Mohamad Wessam Alnouri, Markus Wolf, Alicia S Haydo, Tessa Schmachtel, Andrea Zaliani, Georg Höfner, Astrid Kaiser, Manfred Schubert-Zsilavecz, Annette G Beck-Sickinger, Stefan Offermanns, Philipp Gribbon, Michael A Rieger, Daniel Merk, Marco Sisignano, Dieter Steinhilber, Ewgenij Proschak
Development of a Potent and Selective G2A (GPR132) Agonist. Journal of medicinal chemistry (2024)
Sabine Willems, Romy Busch, Felix Nawa, Marco Ballarotto, Felix F Lillich, Till Kasch, Úrsula López-García, Julian A Marschner, Lorena A Rüger, Beatrice Renelt, Julia Ohrndorf, Silvia Arifi, Daniel Zaienne, Ewgenij Proschak, Jörg Pabel, Daniel Merk
Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism. Journal of medicinal chemistry 67 (15) (2024)
Emily C Hank, Minh Sai, Till Kasch, Isabelle Meijer, Julian A Marschner, Daniel Merk
Development of Tailless Homologue Receptor (TLX) Agonist Chemical Tools. Journal of medicinal chemistry (2024)
Minh Sai, Emily C Hank, Hin-Man Tai, Till Kasch, Max Lewandowski, Michelle Vincendeau, Julian A Marschner, Daniel Merk
Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing. Communications chemistry 7 (1) (2024)
Max Lewandowski, Melania Carmina, Loris Knümann, Minh Sai, Sabine Willems, Till Kasch, Julius Pollinger, Stefan Knapp, Julian A Marschner, Apirat Chaikuad, Daniel Merk
Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties. Journal of medicinal chemistry (2024)
Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F Nippa, Michael Iff, Jann Ledergerber, Carl C G Schiebroek, Valentina Romeo, Jan A Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider
Prospective de novo drug design with deep interactome learning. Nature communications 15 (1) (2024)
Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F Nippa, Michael Iff, Jann Ledergerber, Carl C G Schiebroek, Valentina Romeo, Jan A Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider
Prospective de novo drug design with deep interactome learning. Nature communications 15 (1) (2024)
Laura Isigkeit, Annette Kärcher, Gustave Adouvi, Silvia Arifi, Daniel Merk
Rational design and virtual screening identify mimetics of the RXR agonist valerenic acid. ChemMedChem 19 (5) (2024)
Victor Hernandez-Olmos, Jan Heering, Beatrice Marinescu, Tina Weiß, Vladimir V Ivanov, Yurii S Moroz, Sheila Nevermann, Marius Mathes, Johanna H M Ehrler, Mohamad Wessam Alnouri, Markus Wolf, Alicia S Haydo, Tessa Schmachtel, Andrea Zaliani, Georg Höfner, Astrid Kaiser, Manfred Schubert-Zsilavecz, Annette G Beck-Sickinger, Stefan Offermanns, Philipp Gribbon, Michael A Rieger, Daniel Merk, Marco Sisignano, Dieter Steinhilber, Ewgenij Proschak
Development of a Potent and Selective G2A (GPR132) Agonist. Journal of medicinal chemistry 67 (13) (2024)
Max Lewandowski, Melania Carmina, Loris Knümann, Minh Sai, Sabine Willems, Till Kasch, Julius Pollinger, Stefan Knapp, Julian A Marschner, Apirat Chaikuad, Daniel Merk
Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties. Journal of medicinal chemistry 67 (3) (2024)
Laura Isigkeit, Annette Kärcher, Gustave Adouvi, Silvia Arifi, Daniel Merk
Rational design and virtual screening identify mimetics of the RXR agonist valerenic acid. ChemMedChem 19 (5) (2024)
Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F Nippa, Michael Iff, Jann Ledergerber, Carl C G Schiebroek, Valentina Romeo, Jan A Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider
Prospective de novo drug design with deep interactome learning. Nature communications 15 (1) (2024)
Laura Isigkeit, Espen Schallmayer, Romy Busch, Lorene Brunello, Amelie Tjaden, Lewis Elson, Susanne Müller, Stefan Knapp, Alexandra Stolz, Julian A Marschner, Daniel Merk
Chemogenomics for NR1 nuclear hormone receptors. Nature communications 15 (1) (2024)
Laura Isigkeit, Tim Hörmann, Espen Schallmayer, Katharina Scholz, Felix F Lillich, Johanna H M Ehrler, Benedikt Hufnagel, Jasmin Büchner, Julian A Marschner, Jörg Pabel, Ewgenij Proschak, Daniel Merk
Automated design of multi-target ligands by generative deep learning. Nature communications 15 (1) (2024)
Felix Nawa, Minh Sai, Jan Vietor, Roman Schwarzenbach, Anesa Bitić, Sina Wolff, Niklas Ildefeld, Jörg Pabel, Thomas Wein, Julian A Marschner, Jan Heering, Daniel Merk
Tuning RXR Modulators for PGC1α Recruitment. Journal of medicinal chemistry (2024)
Minh Sai, Emily C Hank, Hin-Man Tai, Till Kasch, Max Lewandowski, Michelle Vincendeau, Julian A Marschner, Daniel Merk
Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing. Communications chemistry 7 (1) (2024)
Sabine Willems, Romy Busch, Felix Nawa, Marco Ballarotto, Felix F Lillich, Till Kasch, Úrsula López-García, Julian A Marschner, Lorena A Rüger, Beatrice Renelt, Julia Ohrndorf, Silvia Arifi, Daniel Zaienne, Ewgenij Proschak, Jörg Pabel, Daniel Merk
Structural Optimization of Oxaprozin for Selective Inverse Nurr1 Agonism. Journal of medicinal chemistry (2024)
Minh Sai, Emily C Hank, Hin-Man Tai, Till Kasch, Max Lewandowski, Michelle Vincendeau, Julian A Marschner, Daniel Merk
Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing. Communications chemistry 7 (1) (2024)
Tanja Stiller, Daniel Merk
Exploring Fatty Acid Mimetics as NR4A Ligands. Journal of medicinal chemistry (2023)
Jan Vietor, Christian Gege, Tanja Stiller, Romy Busch, Espen Schallmayer, Hella Kohlhof, Georg Höfner, Jörg Pabel, Julian A Marschner, Daniel Merk
Development of a Potent Nurr1 Agonist Tool for In Vivo Applications. Journal of medicinal chemistry 66 (9) (2023)
Jan Vietor, Christian Gege, Tanja Stiller, Romy Busch, Espen Schallmayer, Hella Kohlhof, Georg Höfner, Jörg Pabel, Julian A Marschner, Daniel Merk
Development of a Potent Nurr1 Agonist Tool for In Vivo Applications. Journal of medicinal chemistry 66 (9) (2023)
Zhigang Rao, Elena Brunner, Benjamin Giszas, Aishwarya Iyer-Bierhoff, Jana Gerstmeier, Friedemann Börner, Paul M Jordan, Simona Pace, Katharina Paula Lydia Meyer, Robert Klaus Hofstetter, Daniel Merk, Christian Paulenz, Thorsten Heinzel, Philip C Grunert, Andreas Stallmach, Charles Nicholas Serhan, Markus Werner, Oliver Werz
Glucocorticoids regulate lipid mediator networks by reciprocal modulation of 15-lipoxygenase isoforms affecting inflammation resolution. Proceedings of the National Academy of Sciences of the United States of America 120 (35) (2023)
Jan Vietor, Christian Gege, Tanja Stiller, Romy Busch, Espen Schallmayer, Hella Kohlhof, Georg Höfner, Jörg Pabel, Julian A Marschner, Daniel Merk
Development of a Potent Nurr1 Agonist Tool for In Vivo Applications. Journal of medicinal chemistry (2023)
Silvia Arifi, Julian A Marschner, Julius Pollinger, Laura Isigkeit, Pascal Heitel, Astrid Kaiser, Lennart Obeser, Georg Höfner, Ewgenij Proschak, Stefan Knapp, Apirat Chaikuad, Jan Heering, Daniel Merk
Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation. Journal of the American Chemical Society (2023)
Marco Ballarotto, Sabine Willems, Tanja Stiller, Felix Nawa, Julian A Marschner, Francesca Grisoni, Daniel Merk
De Novo Design of Nurr1 Agonists via Fragment-Augmented Generative Deep Learning in Low-Data Regime. Journal of medicinal chemistry (2023)
Jan Vietor, Christian Gege, Tanja Stiller, Romy Busch, Espen Schallmayer, Hella Kohlhof, Georg Höfner, Jörg Pabel, Julian A Marschner, Daniel Merk
Development of a Potent Nurr1 Agonist Tool for In Vivo Applications. Journal of medicinal chemistry 66 (9) (2023)
Minh Sai, Jan Vietor, Moritz Kornmayer, Markus Egner, Úrsula López-García, Georg Höfner, Jörg Pabel, Julian A Marschner, Thomas Wein, Daniel Merk
Structure-Guided Design of Nurr1 Agonists Derived from the Natural Ligand Dihydroxyindole. Journal of medicinal chemistry (2023)
Gustave Adouvi, Felix Nawa, Marco Ballarotto, Lorena Andrea Rüger, Loris Knümann, Till Kasch, Silvia Arifi, Manfred Schubert-Zsilavecz, Sabine Willems, Julian A Marschner, Jörg Pabel, Daniel Merk
Structural Fusion of Natural and Synthetic Ligand Features Boosts RXR Agonist Potency. Journal of medicinal chemistry (2023)
Laura Isigkeit, Daniel Merk
Opportunities and challenges in targeting orphan nuclear receptors. Chemical communications (Cambridge, England) (2023)
Jan Vietor, Christian Gege, Tanja Stiller, Romy Busch, Espen Schallmayer, Hella Kohlhof, Georg Höfner, Jörg Pabel, Julian A Marschner, Daniel Merk
Development of a Potent Nurr1 Agonist Tool for In Vivo Applications. Journal of medicinal chemistry 66 (9) (2023)
Jan Vietor, Christian Gege, Tanja Stiller, Romy Busch, Espen Schallmayer, Hella Kohlhof, Georg Höfner, Jörg Pabel, Julian A Marschner, Daniel Merk
Development of a Potent Nurr1 Agonist Tool for In Vivo Applications. Journal of medicinal chemistry 66 (9) (2023)
Sabine Willems, Daniel Merk
Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strategy in Neurodegeneration. Journal of medicinal chemistry 65 (14) (2022)
Daniel Zaienne, Silvia Arifi, Julian A Marschner, Jan Heering, Daniel Merk
Druggability Evaluation of the Neuron Derived Orphan Receptor (NOR-1) Reveals Inverse NOR-1 Agonists. ChemMedChem 17 (16) (2022)
Moritz Helmstädter, Simone Schierle, Laura Isigkeit, Ewgenij Proschak, Julian Aurelio Marschner, Daniel Merk
Activity Screening of Fatty Acid Mimetic Drugs Identified Nuclear Receptor Agonists. International journal of molecular sciences 23 (17) (2022)
Sabine Willems, Marcel Müller, Julia Ohrndorf, Jan Heering, Ewgenij Proschak, Daniel Merk
Scaffold Hopping from Amodiaquine to Novel Nurr1 Agonist Chemotypes via Microscale Analogue Libraries. ChemMedChem 17 (8) (2022)
Gustave Adouvi, Laura Isigkeit, Úrsula López-García, Apirat Chaikuad, Julian A Marschner, Manfred Schubert-Zsilavecz, Daniel Merk
Rational Design of a New RXR Agonist Scaffold Enabling Single-Subtype Preference for RXRα, RXRβ, and RXRγ. Journal of medicinal chemistry 66 (1) (2022)
Sabine Willems, Julian A Marschner, Whitney Kilu, Giuseppe Faudone, Romy Busch, Silke Duensing-Kropp, Jan Heering, Daniel Merk
Nurr1 Modulation Mediates Neuroprotective Effects of Statins. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 9 (18) (2022)
Giuseppe Faudone, Rezart Zhubi, Fatih Celik, Stefan Knapp, Apirat Chaikuad, Jan Heering, Daniel Merk
Design of a Potent TLX Agonist by Rational Fragment Fusion. Journal of medicinal chemistry 65 (3) (2022)
Gustave Adouvi, Laura Isigkeit, Úrsula López-García, Apirat Chaikuad, Julian A Marschner, Manfred Schubert-Zsilavecz, Daniel Merk
Rational Design of a New RXR Agonist Scaffold Enabling Single-Subtype Preference for RXRα, RXRβ, and RXRγ. Journal of medicinal chemistry 66 (1) (2022)
Jan Heering, Nathalie Jores, Whitney Kilu, Espen Schallmayer, Evelyn Peelen, Andreas Muehler, Hella Kohlhof, Daniel Vitt, Verena Linhard, Santosh L Gande, Apirat Chaikuad, Sridhar Sreeramulu, Harald Schwalbe, Daniel Merk
Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators. ACS chemical biology 17 (11) (2022)
Gustave Adouvi, Laura Isigkeit, Úrsula López-García, Apirat Chaikuad, Julian A Marschner, Manfred Schubert-Zsilavecz, Daniel Merk
Rational Design of a New RXR Agonist Scaffold Enabling Single-Subtype Preference for RXRα, RXRβ, and RXRγ. Journal of medicinal chemistry (2022)
Gustave Adouvi, Laura Isigkeit, Úrsula López-García, Apirat Chaikuad, Julian A Marschner, Manfred Schubert-Zsilavecz, Daniel Merk
Rational Design of a New RXR Agonist Scaffold Enabling Single-Subtype Preference for RXRα, RXRβ, and RXRγ. Journal of medicinal chemistry 66 (1) (2022)
Felix F Lillich, Sabine Willems, Xiaomin Ni, Whitney Kilu, Carmen Borkowsky, Mirko Brodsky, Jan S Kramer, Steffen Brunst, Victor Hernandez-Olmos, Jan Heering, Simone Schierle, Roxane-I Kestner, Franziska M Mayser, Moritz Helmstädter, Tamara Göbel, Lilia Weizel, Dmitry Namgaladze, Astrid Kaiser, Dieter Steinhilber, Waltraud Pfeilschifter, Astrid S Kahnt, Anna Proschak, Apirat Chaikuad, Stefan Knapp, Daniel Merk, Ewgenij Proschak
Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors. Journal of medicinal chemistry 64 (23) (2021)
Alisa Lang, Laura Isigkeit, Manfred Schubert-Zsilavecz, Daniel Merk
The Medicinal Chemistry and Therapeutic Potential of LRH-1 Modulators. Journal of medicinal chemistry 64 (23) (2021)
Daniel Zaienne, Sabine Willems, Simone Schierle, Jan Heering, Daniel Merk
Development and Profiling of Inverse Agonist Tools for the Neuroprotective Transcription Factor Nurr1. Journal of medicinal chemistry 64 (20) (2021)
Sabine Willems, Julia Ohrndorf, Whitney Kilu, Jan Heering, Daniel Merk
Fragment-like Chloroquinolineamines Activate the Orphan Nuclear Receptor Nurr1 and Elucidate Activation Mechanisms. Journal of medicinal chemistry 64 (5) (2021)
Giuseppe Faudone, Whitney Kilu, Xiaomin Ni, Apirat Chaikuad, Sridhar Sreeramulu, Pascal Heitel, Harald Schwalbe, Stefan Knapp, Manfred Schubert-Zsilavecz, Jan Heering, Daniel Merk
The Transcriptional Repressor Orphan Nuclear Receptor TLX Is Responsive to Xanthines. ACS pharmacology & translational science 4 (6) (2021)
Moritz Helmstädter, Astrid Kaiser, Steffen Brunst, Jurema Schmidt, Riccardo Ronchetti, Lilia Weizel, Ewgenij Proschak, Daniel Merk
Second-Generation Dual FXR/sEH Modulators with Optimized Pharmacokinetics. Journal of medicinal chemistry 64 (13) (2021)
Simone Schierle, Apirat Chaikuad, Felix F Lillich, Xiaomin Ni, Stefano Woltersdorf, Espen Schallmayer, Beatrice Renelt, Riccardo Ronchetti, Stefan Knapp, Ewgenij Proschak, Daniel Merk
Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics. Journal of medicinal chemistry 64 (8) (2021)
Giuseppe Faudone, Silvia Arifi, Daniel Merk
The Medicinal Chemistry of Caffeine. Journal of medicinal chemistry 64 (11) (2021)
Michael Moret, Moritz Helmstädter, Francesca Grisoni, Gisbert Schneider, Daniel Merk
Beam Search for Automated Design and Scoring of Novel ROR Ligands with Machine Intelligence*. Angewandte Chemie (International ed. in English) 60 (35) (2021)
Sabine Willems, Johannes Morstein, Konstantin Hinnah, Dirk H Trauner, Daniel Merk
A Photohormone for Light-Dependent Control of PPARα in Live Cells. Journal of medicinal chemistry 64 (14) (2021)
Simone Schierle, Steffen Brunst, Moritz Helmstädter, Roland Ebert, Jan S Kramer, Dieter Steinhilber, Ewgenij Proschak, Daniel Merk
Development and in vitro Profiling of Dual FXR/LTA4H Modulators. ChemMedChem 16 (15) (2021)
John D Imig, Daniel Merk, Eugen Proschak
Multi-Target Drugs for Kidney Diseases. Kidney360 2 (10) (2021)
Sabine Willems, Daniel Zaienne, Daniel Merk
Targeting Nuclear Receptors in Neurodegeneration and Neuroinflammation. Journal of medicinal chemistry 64 (14) (2021)
Markus Hartmann, Sofia-Iris Bibli, Daniel Tews, Xiaomin Ni, Theresa Kircher, Jan S Kramer, Whitney Kilu, Jan Heering, Victor Hernandez-Olmos, Lilia Weizel, Gerhard K E Scriba, Sulaiman Krait, Stefan Knapp, Apirat Chaikuad, Daniel Merk, Ingrid Fleming, Pamela Fischer-Posovszky, Ewgenij Proschak
Combined Cardioprotective and Adipocyte Browning Effects Promoted by the Eutomer of Dual sEH/PPARγ Modulator. Journal of medicinal chemistry 64 (5) (2021)
Giuseppe Faudone, Iris Bischoff-Kont, Lea Rachor, Sabine Willems, Rezart Zhubi, Astrid Kaiser, Apirat Chaikuad, Stefan Knapp, Robert Fürst, Jan Heering, Daniel Merk
Propranolol Activates the Orphan Nuclear Receptor TLX to Counteract Proliferation and Migration of Glioblastoma Cells. Journal of medicinal chemistry 64 (12) (2021)
Francesca Grisoni, Berend J H Huisman, Alexander L Button, Michael Moret, Kenneth Atz, Daniel Merk, Gisbert Schneider
Combining generative artificial intelligence and on-chip synthesis for de novo drug design. Science advances 7 (24) (2021)
Leonie Gellrich, Pascal Heitel, Jan Heering, Whitney Kilu, Julius Pollinger, Tamara Goebel, Astrid Kahnt, Silvia Arifi, Werner Pogoda, Alexander Paulke, Dieter Steinhilber, Ewgenij Proschak, Mario Wurglics, Manfred Schubert-Zsilavecz, Apirat Chaikuad, Stefan Knapp, Iris Bischoff, Robert Fürst, Daniel Merk
l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPARγ. Journal of medicinal chemistry 63 (13) (2020)
Konstantin Hinnah, Sabine Willems, Johannes Morstein, Jan Heering, Felix W W Hartrampf, Johannes Broichhagen, Philipp Leippe, Daniel Merk, Dirk H Trauner
Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ). Journal of medicinal chemistry 63 (19) (2020)
Thomas Hanke, Sun-Yee Cheung, Whitney Kilu, Jan Heering, Xiaomin Ni, Viktoria Planz, Simone Schierle, Giuseppe Faudone, Marius Friedrich, Marek Wanior, Oliver Werz, Maike Windbergs, Ewgenij Proschak, Manfred Schubert-Zsilavecz, Apirat Chaikuad, Stefan Knapp, Daniel Merk
A Selective Modulator of Peroxisome Proliferator-Activated Receptor γ with an Unprecedented Binding Mode. Journal of medicinal chemistry 63 (9) (2020)
Simone Schierle, Sebastian Neumann, Pascal Heitel, Sabine Willems, Astrid Kaiser, Julius Pollinger, Daniel Merk
Design and Structural Optimization of Dual FXR/PPARδ Activators. Journal of medicinal chemistry 63 (15) (2020)
Apirat Chaikuad, Julius Pollinger, Michael Rühl, Xiaomin Ni, Whitney Kilu, Jan Heering, Daniel Merk
Comprehensive Set of Tertiary Complex Structures and Palmitic Acid Binding Provide Molecular Insights into Ligand Design for RXR Isoforms. International journal of molecular sciences 21 (22) (2020)
Simone Schierle, Moritz Helmstädter, Jurema Schmidt, Markus Hartmann, Maximiliane Horz, Astrid Kaiser, Lilia Weizel, Pascal Heitel, Anna Proschak, Victor Hernandez-Olmos, Ewgenij Proschak, Daniel Merk
Dual Farnesoid X Receptor/Soluble Epoxide Hydrolase Modulators Derived from Zafirlukast. ChemMedChem 15 (1) (2019)
Julius Pollinger, Simone Schierle, Sebastian Neumann, Julia Ohrndorf, Astrid Kaiser, Daniel Merk
Computer-Assisted Selective Optimization of Side-Activities-from Cinalukast to a PPARα Modulator. ChemMedChem 14 (14) (2019)
Johannes Morstein, Julie B Trads, Konstantin Hinnah, Sabine Willems, David M Barber, Michael Trauner, Daniel Merk, Dirk H Trauner
Optical control of the nuclear bile acid receptor FXR with a photohormone. Chemical science 11 (2) (2019)
Julius Pollinger, Leonie Gellrich, Simone Schierle, Whitney Kilu, Jurema Schmidt, Lena Kalinowsky, Julia Ohrndorf, Astrid Kaiser, Jan Heering, Ewgenij Proschak, Daniel Merk
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation. Journal of medicinal chemistry 62 (4) (2019)
Jan S Kramer, Stefano Woltersdorf, Thomas Duflot, Kerstin Hiesinger, Felix F Lillich, Felix Knöll, Sandra K Wittmann, Franca-M Klingler, Steffen Brunst, Apirat Chaikuad, Christophe Morisseau, Bruce D Hammock, Carola Buccellati, Angelo Sala, G Enrico Rovati, Matthieu Leuillier, Sylvain Fraineau, Julie Rondeaux, Victor Hernandez-Olmos, Jan Heering, Daniel Merk, Denys Pogoryelov, Dieter Steinhilber, Stefan Knapp, Jeremy Bellien, Ewgenij Proschak
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain. Journal of medicinal chemistry 62 (18) (2019)
Francesca Grisoni, Daniel Merk, Lukas Friedrich, Gisbert Schneider
Design of Natural-Product-Inspired Multitarget Ligands by Machine Learning. ChemMedChem 14 (12) (2019)
Francesca Grisoni, Daniel Merk, Ryan Byrne, Gisbert Schneider
Scaffold-Hopping from Synthetic Drugs by Holistic Molecular Representation. Scientific reports 8 (1) (2018)
Daniel Merk, Francesca Grisoni, Kay Schaller, Lukas Friedrich, Gisbert Schneider
Discovery of Novel Molecular Frameworks of Farnesoid X Receptor Modulators by Ensemble Machine Learning. ChemistryOpen 8 (1) (2018)
Matthias Gabler, Jan Kramer, Jurema Schmidt, Julius Pollinger, Julia Weber, Astrid Kaiser, Frank Löhr, Ewgenij Proschak, Manfred Schubert-Zsilavecz, Daniel Merk
Allosteric modulation of the farnesoid X receptor by a small molecule. Scientific reports 8 (1) (2018)
Simone Schierle, Jurema Schmidt, Astrid Kaiser, Daniel Merk
Selective Optimization of Pranlukast to Farnesoid X Receptor Modulators. ChemMedChem 13 (23) (2018)
Pascal Heitel, Leonie Gellrich, Jan Heering, Tamara Goebel, Astrid Kahnt, Ewgenij Proschak, Manfred Schubert-Zsilavecz, Daniel Merk
Urate transporter inhibitor lesinurad is a selective peroxisome proliferator-activated receptor gamma modulator (sPPARγM) in vitro. Scientific reports 8 (1) (2018)
Daniel Merk, Francesca Grisoni, Lukas Friedrich, Elena Gelzinyte, Gisbert Schneider
Scaffold hopping from synthetic RXR modulators by virtual screening and de novo design. MedChemComm 9 (8) (2018)
David Heidenreich, Moses Moustakim, Jurema Schmidt, Daniel Merk, Paul E Brennan, Oleg Fedorov, Apirat Chaikuad, Stefan Knapp
Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL). Journal of medicinal chemistry 61 (23) (2018)
Daniel Merk, Francesca Grisoni, Kay Schaller, Lukas Friedrich, Gisbert Schneider
Discovery of Novel Molecular Frameworks of Farnesoid X Receptor Modulators by Ensemble Machine Learning. ChemistryOpen 8 (1) (2018)
Ewgenij Proschak, Holger Stark, Daniel Merk
Polypharmacology by Design: A Medicinal Chemist's Perspective on Multitargeting Compounds. Journal of medicinal chemistry 62 (2) (2018)
Simone Schierle, Cathrin Flauaus, Pascal Heitel, Sabine Willems, Jurema Schmidt, Astrid Kaiser, Lilia Weizel, Tamara Goebel, Astrid S Kahnt, Gerd Geisslinger, Dieter Steinhilber, Mario Wurglics, G Enrico Rovati, Achim Schmidtko, Ewgenij Proschak, Daniel Merk
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology. Journal of medicinal chemistry 61 (13) (2018)
Jurema Schmidt, Marco Rotter, Tim Weiser, Sandra Wittmann, Lilia Weizel, Astrid Kaiser, Jan Heering, Tamara Goebel, Carlo Angioni, Mario Wurglics, Alexander Paulke, Gerd Geisslinger, Astrid Kahnt, Dieter Steinhilber, Ewgenij Proschak, Daniel Merk
A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis. Journal of medicinal chemistry 60 (18) (2017)
Daniel Flesch, Sun-Yee Cheung, Jurema Schmidt, Matthias Gabler, Pascal Heitel, Jan Kramer, Astrid Kaiser, Markus Hartmann, Mara Lindner, Kerstin Lüddens-Dämgen, Jan Heering, Christina Lamers, Hartmut Lüddens, Mario Wurglics, Ewgenij Proschak, Manfred Schubert-Zsilavecz, Daniel Merk
Nonacidic Farnesoid X Receptor Modulators. Journal of medicinal chemistry 60 (16) (2017)