Thomas Hanke

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 29

Top Topics

Tyrosine Kinase

Top Venues

Journal of medicinal chemistry

International journal of molecular sciences

bioRxiv : the preprint server for biology

Science signaling

This page only lists publications with an associated author ORCID identifier.

Publications

Marcel Rak, Amelie Menge, Roberta Tesch, Lena M Berger, Dimitrios-Ilias Balourdas, Ekaterina Shevchenko, Andreas Krämer, Lewis Elson, Benedict-Tilmann Berger, Ismahan Abdi, Laurenz M Wahl, Antti Poso, Astrid Kaiser, Thomas Hanke, Thales Kronenberger, Andreas C Joerger, Susanne Müller, Stefan Knapp
Development of Selective Pyrido[2,3- d ]pyrimidin-7(8 H )-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. Journal of medicinal chemistry 67 (5) (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena M Berger, Benedict-Tilman Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity. bioRxiv : the preprint server for biology (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Kraemer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena M Berger, Benedict Tilman Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Mueller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity. bioRxiv : the preprint server for biology (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena Marie Berger, Benedict-Tilmann Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. Journal of medicinal chemistry 67 (15) (2024)
Marcel Rak, Amelie Menge, Roberta Tesch, Lena M Berger, Dimitrios-Ilias Balourdas, Ekaterina Shevchenko, Andreas Krämer, Lewis Elson, Benedict-Tilmann Berger, Ismahan Abdi, Laurenz M Wahl, Antti Poso, Astrid Kaiser, Thomas Hanke, Thales Kronenberger, Andreas C Joerger, Susanne Müller, Stefan Knapp
Development of Selective Pyrido[2,3- d ]pyrimidin-7(8 H )-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. Journal of medicinal chemistry (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena M Berger, Benedict-Tilman Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity. bioRxiv : the preprint server for biology (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena Marie Berger, Benedict-Tilmann Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. Journal of medicinal chemistry (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena M Berger, Benedict-Tilman Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-pocket optimization of 2-aminopyrimidine-based macrocycles leads to potent dual EPHA2/GAK kinase inhibitors with antiviral activity. bioRxiv : the preprint server for biology (2024)
Marcel Rak, Amelie Menge, Roberta Tesch, Lena M Berger, Dimitrios-Ilias Balourdas, Ekaterina Shevchenko, Andreas Krämer, Lewis Elson, Benedict-Tilmann Berger, Ismahan Abdi, Laurenz M Wahl, Antti Poso, Astrid Kaiser, Thomas Hanke, Thales Kronenberger, Andreas C Joerger, Susanne Müller, Stefan Knapp
Development of Selective Pyrido[2,3- d ]pyrimidin-7(8 H )-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. Journal of medicinal chemistry 67 (5) (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena Marie Berger, Benedict-Tilmann Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. Journal of medicinal chemistry 67 (15) (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena Marie Berger, Benedict-Tilmann Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. Journal of medicinal chemistry (2024)
Jennifer Alisa Amrhein, Lena Marie Berger, Dimitrios-Ilias Balourdas, Andreas C Joerger, Amelie Menge, Andreas Krämer, Julia Marie Frischkorn, Benedict-Tilmann Berger, Lewis Elson, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. Journal of medicinal chemistry (2023)
Jennifer Alisa Amrhein, Lena Marie Berger, Dimitrios-Ilias Balourdas, Andreas C Joerger, Amelie Menge, Andreas Krämer, Julia Marie Frischkorn, Benedict-Tilmann Berger, Lewis Elson, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. Journal of medicinal chemistry 67 (1) (2023)
Jennifer Alisa Amrhein, Lena Marie Berger, Dimitrios-Ilias Balourdas, Andreas C Joerger, Amelie Menge, Andreas Krämer, Julia Marie Frischkorn, Benedict-Tilmann Berger, Lewis Elson, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. Journal of medicinal chemistry 67 (1) (2023)
Jennifer A Amrhein, Guiqun Wang, Benedict-Tilmann Berger, Lena Marie Berger, Amalia D Kalampaliki, Andreas Krämer, Stefan Knapp, Thomas Hanke
Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2. ACS medicinal chemistry letters 14 (6) (2023)
Jennifer Alisa Amrhein, Lena Marie Berger, Dimitrios-Ilias Balourdas, Andreas C Joerger, Amelie Menge, Andreas Krämer, Julia Marie Frischkorn, Benedict-Tilmann Berger, Lewis Elson, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. Journal of medicinal chemistry 67 (1) (2023)
Jennifer Alisa Amrhein, Lena Marie Berger, Amelie Tjaden, Andreas Krämer, Lewis Elson, Tuomas Tolvanen, Daniel Martinez-Molina, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Discovery of 3-Amino-1 H -pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family. International journal of molecular sciences 23 (23) (2022)
Jennifer Alisa Amrhein, Lena Marie Berger, Amelie Tjaden, Andreas Krämer, Lewis Elson, Tuomas Tolvanen, Daniel Martinez-Molina, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Discovery of 3-Amino-1 H -pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family. International journal of molecular sciences 23 (23) (2022)
Christian G Kurz, Franziska Preuss, Amelie Tjaden, Martin Cusack, Jennifer Alisa Amrhein, Deep Chatterjee, Sebastian Mathea, Lena Marie Berger, Benedict-Tilmann Berger, Andreas Krämer, Michael Weller, Tobias Weiss, Susanne Müller, Stefan Knapp, Thomas Hanke
Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5- a ]pyrimidine-Based Macrocycles. Journal of medicinal chemistry 65 (11) (2022)
Jennifer Alisa Amrhein, Lena Marie Berger, Amelie Tjaden, Andreas Krämer, Lewis Elson, Tuomas Tolvanen, Daniel Martinez-Molina, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Discovery of 3-Amino-1 H -pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family. International journal of molecular sciences 23 (23) (2022)
Thomas Hanke, Sebastian Mathea, Julia Woortman, Eidarus Salah, Benedict-Tilmann Berger, Anthony Tumber, Risa Kashima, Akiko Hata, Bernhard Kuster, Susanne Müller, Stefan Knapp
Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. Journal of medicinal chemistry 65 (19) (2022)
Jennifer Alisa Amrhein, Lena Marie Berger, Amelie Tjaden, Andreas Krämer, Lewis Elson, Tuomas Tolvanen, Daniel Martinez-Molina, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Discovery of 3-Amino-1 H -pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family. International journal of molecular sciences 23 (23) (2022)
Jennifer A Amrhein, Tyler S Beyett, William W Feng, Andreas Krämer, Janik Weckesser, Ilse K Schaeffner, Jaimin K Rana, Pasi A Jänne, Michael J Eck, Stefan Knapp, Thomas Hanke
Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19. Journal of medicinal chemistry 65 (23) (2022)
Jennifer Alisa Amrhein, Stefan Knapp, Thomas Hanke
Synthetic Opportunities and Challenges for Macrocyclic Kinase Inhibitors. Journal of medicinal chemistry 64 (12) (2021)
Roberta Tesch, Marcel Rak, Monika Raab, Lena Marie Berger, Thales Kronenberger, Andreas C Joerger, Benedict-Tilmann Berger, Ismahan Abdi, Thomas Hanke, Antti Poso, Klaus Strebhardt, Mourad Sanhaji, Stefan Knapp
Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors. Journal of medicinal chemistry 64 (12) (2021)
Thomas Hanke, Sun-Yee Cheung, Whitney Kilu, Jan Heering, Xiaomin Ni, Viktoria Planz, Simone Schierle, Giuseppe Faudone, Marius Friedrich, Marek Wanior, Oliver Werz, Maike Windbergs, Ewgenij Proschak, Manfred Schubert-Zsilavecz, Apirat Chaikuad, Stefan Knapp, Daniel Merk
A Selective Modulator of Peroxisome Proliferator-Activated Receptor γ with an Unprecedented Binding Mode. Journal of medicinal chemistry 63 (9) (2020)
Thomas Hanke, Jong Fu Wong, Benedict-Tilmann Berger, Ismahan Abdi, Lena Marie Berger, Roberta Tesch, Claudia Tredup, Alex N Bullock, Susanne Müller, Stefan Knapp
A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5. ACS chemical biology 15 (4) (2020)
Susanne Müller, Suzanne Ackloo, Cheryl H Arrowsmith, Marcus Bauser, Jeremy L Baryza, Julian Blagg, Jark Böttcher, Chas Bountra, Peter J Brown, Mark E Bunnage, Adrian J Carter, David Damerell, Volker Dötsch, David H Drewry, Aled M Edwards, James Edwards, Jonathan M Elkins, Christian Fischer, Stephen V Frye, Andreas Gollner, Charles E Grimshaw, Adriaan IJzerman, Thomas Hanke, Ingo V Hartung, Steve Hitchcock, Trevor Howe, Terry V Hughes, Stefan Laufer, Volkhart Mj Li, Spiros Liras, Brian D Marsden, Hisanori Matsui, John Mathias, Ronan C O'Hagan, Dafydd R Owen, Vineet Pande, Daniel Rauh, Saul H Rosenberg, Bryan L Roth, Natalie S Schneider, Cora Scholten, Kumar Singh Saikatendu, Anton Simeonov, Masayuki Takizawa, Chris Tse, Paul R Thompson, Daniel K Treiber, Amélia Yi Viana, Carrow I Wells, Timothy M Willson, William J Zuercher, Stefan Knapp, Anke Mueller-Fahrnow
Donated chemical probes for open science. eLife 7 (2018)
Risa Kashima, Patrick L Redmond, Prajakta Ghatpande, Sougata Roy, Thomas B Kornberg, Thomas Hanke, Stefan Knapp, Giorgio Lagna, Akiko Hata
Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome. Science signaling 10 (477) (2017)