Hao Wu

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 88

Top Venues

Nature

Nature structural & molecular biology

Proceedings of the National Academy of Sciences of the United States of America

Science immunology

Harvard Medical School

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Harvard Medical School Jul 01 2012

United States

Professor :: Biological Chemistry and Molecular Pharmacology

Boston Children's Hospital Jul 01 2012

United States

Professor :: Program in Cellular and Molecular Medicine

Publications

Gang Du, Liam Brendan Healy, Liron David, Caitlin Walker, Tarick J El-Baba, Corinne A Lutomski, Byoungsook Goh, Bo-Wen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, Arumugam Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R Luo, Jonathan C Kagan, Sungwhan F Oh, Carol V Robinson, Judy Lieberman, Hao Wu
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature 630 (8016) (2024)
Gang Du, Liam Brendan Healy, Liron David, Caitlin Walker, Tarick J El-Baba, Corinne A Lutomski, Byoungsook Goh, Bo-Wen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, Arumugam Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R Luo, Jonathan C Kagan, Sungwhan F Oh, Carol V Robinson, Judy Lieberman, Hao Wu
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature 630 (8016) (2024)
Arumugam Balasubramanian, Alan Y Hsu, Laxman Ghimire, Muhammad Tahir, Pascal Devant, Pietro Fontana, Gang Du, Xing Liu, Fabin Dang, Hiroto Kambara, Xuemei Xie, Fei Liu, Tomoya Hasegawa, Rong Xu, Hongbo Yu, Mei Chen, Steven Kolakowski, Sunia A Trauger, Martin Røssel Larsen, Wenyi Wei, Hao Wu, Jonathan C Kagan, Judy Lieberman, Hongbo R Luo
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis. Science immunology 9 (94) (2024)
Jianing Fu, Kate Schroder, Hao Wu
Mechanistic insights from inflammasome structures. Nature reviews. Immunology 24 (7) (2024)
Arumugam Balasubramanian, Alan Y Hsu, Laxman Ghimire, Muhammad Tahir, Pascal Devant, Pietro Fontana, Gang Du, Xing Liu, Fabin Dang, Hiroto Kambara, Xuemei Xie, Fei Liu, Tomoya Hasegawa, Rong Xu, Hongbo Yu, Mei Chen, Steven Kolakowski, Sunia A Trauger, Martin Røssel Larsen, Wenyi Wei, Hao Wu, Jonathan C Kagan, Judy Lieberman, Hongbo R Luo
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis. Science immunology 9 (94) (2024)
Arumugam Balasubramanian, Alan Y Hsu, Laxman Ghimire, Muhammad Tahir, Pascal Devant, Pietro Fontana, Gang Du, Xing Liu, Fabin Dang, Hiroto Kambara, Xuemei Xie, Fei Liu, Tomoya Hasegawa, Rong Xu, Hongbo Yu, Mei Chen, Steven Kolakowski, Sunia A Trauger, Martin Røssel Larsen, Wenyi Wei, Hao Wu, Jonathan C Kagan, Judy Lieberman, Hongbo R Luo
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis. Science immunology (2024)
Ying Zhang, Pourya Naderi Yeganeh, Haiwei Zhang, Simon Yuan Wang, Zhouyihan Li, Bo-Wen Gu, Dian-Jang Lee, Zhibin Zhang, Athanasios Ploumakis, Ming Shi, Hao Wu, Eric Lieberman Greer, Winston A Hide, Judy Lieberman
Tumor editing suppresses innate and adaptive antitumor immunity and is reversed by inhibiting DNA methylation. Nature immunology (2024)
Gang Du, Liam Brendan Healy, Liron David, Caitlin Walker, Tarick J El-Baba, Corinne A Lutomski, Byoungsook Goh, Bo-Wen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, Arumugam Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R Luo, Jonathan C Kagan, Sungwhan F Oh, Carol V Robinson, Judy Lieberman, Hao Wu
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature (2024)
Arumugam Balasubramanian, Alan Y Hsu, Laxman Ghimire, Muhammad Tahir, Pascal Devant, Pietro Fontana, Gang Du, Xing Liu, Fabin Dang, Hiroto Kambara, Xuemei Xie, Fei Liu, Tomoya Hasegawa, Rong Xu, Hongbo Yu, Mei Chen, Steven Kolakowski, Sunia A Trauger, Martin Røssel Larsen, Wenyi Wei, Hao Wu, Jonathan C Kagan, Judy Lieberman, Hongbo R Luo
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis. Science immunology (2024)
Gang Du, Liam Brendan Healy, Liron David, Caitlin Walker, Tarick J El-Baba, Corinne A Lutomski, Byoungsook Goh, Bo-Wen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, Arumugam Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R Luo, Jonathan C Kagan, Sungwhan F Oh, Carol V Robinson, Judy Lieberman, Hao Wu
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature (2024)
Gang Du, Liam Brendan Healy, Liron David, Caitlin Walker, Tarick J El-Baba, Corinne A Lutomski, Byoungsook Goh, Bo-Wen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, Arumugam Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R Luo, Jonathan C Kagan, Sungwhan F Oh, Carol V Robinson, Judy Lieberman, Hao Wu
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature 630 (8016) (2024)
Arumugam Balasubramanian, Alan Y Hsu, Laxman Ghimire, Muhammad Tahir, Pascal Devant, Pietro Fontana, Gang Du, Xing Liu, Fabin Dang, Hiroto Kambara, Xuemei Xie, Fei Liu, Tomoya Hasegawa, Rong Xu, Hongbo Yu, Mei Chen, Steven Kolakowski, Sunia A Trauger, Martin Røssel Larsen, Wenyi Wei, Hao Wu, Jonathan C Kagan, Judy Lieberman, Hongbo R Luo
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis. Science immunology 9 (94) (2024)
Runzhi Li, Yang Zan, Decai Wang, Xuequn Chen, Anmin Wang, Haoyuan Tan, Guorong Zhang, Siyuan Ding, Chen Shen, Hao Wu, Shu Zhu
A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions. Proceedings of the National Academy of Sciences of the United States of America 121 (6) (2024)
Runzhi Li, Yang Zan, Decai Wang, Xuequn Chen, Anmin Wang, Haoyuan Tan, Guorong Zhang, Siyuan Ding, Chen Shen, Hao Wu, Shu Zhu
A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions. Proceedings of the National Academy of Sciences of the United States of America 121 (6) (2024)
Ellie Zhang, Liam Brendan Healy, Gang Du, Hao Wu
Cleavage-independent GSDME activation by UVC. Nature cell biology (2024)
Arumugam Balasubramanian, Alan Y Hsu, Laxman Ghimire, Muhammad Tahir, Pascal Devant, Pietro Fontana, Gang Du, Xing Liu, Fabin Dang, Hiroto Kambara, Xuemei Xie, Fei Liu, Tomoya Hasegawa, Rong Xu, Hongbo Yu, Mei Chen, Steven Kolakowski, Sunia A Trauger, Martin Røssel Larsen, Wenyi Wei, Hao Wu, Jonathan C Kagan, Judy Lieberman, Hongbo R Luo
The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis. Science immunology 9 (94) (2024)
Gang Du, Liam Brendan Healy, Liron David, Caitlin Walker, Tarick J El-Baba, Corinne A Lutomski, Byoungsook Goh, Bo-Wen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, Arumugam Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R Luo, Jonathan C Kagan, Sungwhan F Oh, Carol V Robinson, Judy Lieberman, Hao Wu
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature 630 (8016) (2024)
Jianing Fu, Kate Schroder, Hao Wu
Mechanistic insights from inflammasome structures. Nature reviews. Immunology 24 (7) (2024)
Gang Du, Liam Brendan Healy, Liron David, Caitlin Walker, Tarick J El-Baba, Corinne A Lutomski, Byoungsook Goh, Bo-Wen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, Arumugam Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R Luo, Jonathan C Kagan, Sungwhan F Oh, Carol V Robinson, Judy Lieberman, Hao Wu
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature 630 (8016) (2024)
Le Xiao, Xiong Pi, Alissa C Goss, Tarick El-Baba, Julian F Ehrmann, Elizabeth Grinkevich, Silvana Bazua-Valenti, Valeria Padovano, Seth L Alper, Dominique Carey, Namrata D Udeshi, Steven A Carr, Juan Lorenzo Pablo, Carol V Robinson, Anna Greka, Hao Wu
Molecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway. Science advances 10 (38) (2024)
Gang Du, Liam Brendan Healy, Liron David, Caitlin Walker, Tarick J El-Baba, Corinne A Lutomski, Byoungsook Goh, Bo-Wen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, Arumugam Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R Luo, Jonathan C Kagan, Sungwhan F Oh, Carol V Robinson, Judy Lieberman, Hao Wu
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature (2024)
Gang Du, Liam Brendan Healy, Liron David, Caitlin Walker, Tarick J El-Baba, Corinne A Lutomski, Byoungsook Goh, Bo-Wen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, Arumugam Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R Luo, Jonathan C Kagan, Sungwhan F Oh, Carol V Robinson, Judy Lieberman, Hao Wu
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature (2024)
Pascal Devant, Ying Dong, Julian Mintseris, Weiyi Ma, Steven P Gygi, Hao Wu, Jonathan C Kagan
Publisher Correction: Structural insights into cytokine cleavage by inflammatory caspase-4. Nature (2024)
Gang Du, Liam Brendan Healy, Liron David, Caitlin Walker, Tarick J El-Baba, Corinne A Lutomski, Byoungsook Goh, Bo-Wen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, Arumugam Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R Luo, Jonathan C Kagan, Sungwhan F Oh, Carol V Robinson, Judy Lieberman, Hao Wu
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature (2024)
Gang Du, Liam Brendan Healy, Liron David, Caitlin Walker, Tarick J El-Baba, Corinne A Lutomski, Byoungsook Goh, Bo-Wen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, Arumugam Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R Luo, Jonathan C Kagan, Sungwhan F Oh, Carol V Robinson, Judy Lieberman, Hao Wu
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature (2024)
Runzhi Li, Yang Zan, Decai Wang, Xuequn Chen, Anmin Wang, Haoyuan Tan, Guorong Zhang, Siyuan Ding, Chen Shen, Hao Wu, Shu Zhu
A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions. Proceedings of the National Academy of Sciences of the United States of America 121 (6) (2024)
Runzhi Li, Yang Zan, Decai Wang, Xuequn Chen, Anmin Wang, Haoyuan Tan, Guorong Zhang, Siyuan Ding, Chen Shen, Hao Wu, Shu Zhu
A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions. Proceedings of the National Academy of Sciences of the United States of America 121 (6) (2024)
Gang Du, Liam Brendan Healy, Liron David, Caitlin Walker, Tarick J El-Baba, Corinne A Lutomski, Byoungsook Goh, Bo-Wen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, Arumugam Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R Luo, Jonathan C Kagan, Sungwhan F Oh, Carol V Robinson, Judy Lieberman, Hao Wu
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D. Nature 630 (8016) (2024)
Jianing Fu, Kate Schroder, Hao Wu
Mechanistic insights from inflammasome structures. Nature reviews. Immunology (2024)
Runzhi Li, Yang Zan, Decai Wang, Xuequn Chen, Anmin Wang, Haoyuan Tan, Guorong Zhang, Siyuan Ding, Chen Shen, Hao Wu, Shu Zhu
A mouse model to distinguish NLRP6-mediated inflammasome-dependent and -independent functions. Proceedings of the National Academy of Sciences of the United States of America 121 (6) (2024)
Qing Kong, Shiyu Xia, Xingxin Pan, Kaixiong Ye, Zhouyihan Li, Haoyan Li, Xiaoqiang Tang, Nidhi Sahni, S Stephen Yi, Xing Liu, Hao Wu, Michael B Elowitz, Judy Lieberman, Zhibin Zhang
Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis. Science immunology 8 (82) (2023)
Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Michael Bowman, Lih-Ling Lin, Hao Wu, James Jeiwen Chou
Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation. Cell research 33 (2) (2023)
Bhaskar Paidimuddala, Jianhao Cao, Grady Nash, Qing Xie, Hao Wu, Liman Zhang
Author Correction: Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5. Nature structural & molecular biology (2023)
Bhaskar Paidimuddala, Jianhao Cao, Grady Nash, Qing Xie, Hao Wu, Liman Zhang
Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5. Nature structural & molecular biology (2023)
Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Michael Bowman, Lih-Ling Lin, Hao Wu, James Jeiwen Chou
Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation. Cell research 33 (2) (2023)
Pascal Devant, Ying Dong, Julian Mintseris, Weiyi Ma, Steven P Gygi, Hao Wu, Jonathan C Kagan
Structural insights into cytokine cleavage by inflammatory caspase-4. Nature (2023)
Bhaskar Paidimuddala, Jianhao Cao, Grady Nash, Qing Xie, Hao Wu, Liman Zhang
Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5. Nature structural & molecular biology 30 (2) (2023)
Bhaskar Paidimuddala, Jianhao Cao, Grady Nash, Qing Xie, Hao Wu, Liman Zhang
Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5. Nature structural & molecular biology (2023)
Tiantian Cai, Rachel Lenoir Capello, Xiong Pi, Hao Wu, James Jeiwen Chou
Structural basis of γ chain family receptor sharing at the membrane level. Science (New York, N.Y.) 381 (6657) (2023)
Bhaskar Paidimuddala, Jianhao Cao, Grady Nash, Qing Xie, Hao Wu, Liman Zhang
Author Correction: Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5. Nature structural & molecular biology (2023)
Sumit Sen Santara, Dian-Jang Lee, Ângela C Crespo, Jun Jacob Hu, Caitlin Walker, Xiyu Ma, Ying Zhang, Sourav Chowdhury, Karla F Meza-Sosa, Mercedes Lewandrowski, Haiwei Zhang, Marjorie Rowe, Arthur A McClelland, Hao Wu, Caroline Junqueira, Judy Lieberman
Publisher Correction: The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells. Nature (2023)
Ting Du, Yan Song, Arghya Ray, Yao Yao, Mehmet K Samur, Chen Shen, Johany Penailillo, Tomasz Sewastianik, Yu-Tzu Tai, Mariateresa Fulciniti, Nikhil C Munshi, Hao Wu, Ruben D Carrasco, Dharminder Chauhan, Kenneth C Anderson, Xueping Wan
Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma. Blood (2023)
Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Michael Bowman, Lih-Ling Lin, Hao Wu, James Jeiwen Chou
Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation. Cell research (2023)
Sumit Sen Santara, Dian-Jang Lee, Ângela C Crespo, Jun Jacob Hu, Caitlin Walker, Xiyu Ma, Ying Zhang, Sourav Chowdhury, Karla F Meza-Sosa, Mercedes Lewandrowski, Haiwei Zhang, Marjorie Rowe, Arthur A McClelland, Hao Wu, Caroline Junqueira, Judy Lieberman
The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells. Nature (2023)
Bhaskar Paidimuddala, Jianhao Cao, Grady Nash, Qing Xie, Hao Wu, Liman Zhang
Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5. Nature structural & molecular biology (2023)
Bhaskar Paidimuddala, Jianhao Cao, Grady Nash, Qing Xie, Hao Wu, Liman Zhang
Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5. Nature structural & molecular biology 30 (2) (2023)
Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Michael Bowman, Lih-Ling Lin, Hao Wu, James Jeiwen Chou
Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation. Cell research 33 (2) (2023)
Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Michael Bowman, Lih-Ling Lin, Hao Wu, James Jeiwen Chou
Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation. Cell research 33 (2) (2023)
Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Michael Bowman, Lih-Ling Lin, Hao Wu, James Jeiwen Chou
Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation. Cell research 33 (2) (2023)
Qing Kong, Shiyu Xia, Xingxin Pan, Kaixiong Ye, Zhouyihan Li, Haoyan Li, Xiaoqiang Tang, Nidhi Sahni, S Stephen Yi, Xing Liu, Hao Wu, Michael B Elowitz, Judy Lieberman, Zhibin Zhang
Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis. Science immunology 8 (82) (2023)
Qing Kong, Shiyu Xia, Xingxin Pan, Kaixiong Ye, Zhouyihan Li, Haoyan Li, Xiaoqiang Tang, Nidhi Sahni, S Stephen Yi, Xing Liu, Hao Wu, Michael B Elowitz, Judy Lieberman, Zhibin Zhang
Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis. Science immunology 8 (82) (2023)
Ting Du, Yan Song, Arghya Ray, Xueping Wan, Yao Yao, Mehmet K Samur, Chen Shen, Johany Penailillo, Tomasz Sewastianik, Yu-Tzu Tai, Mariateresa Fulciniti, Nikhil C Munshi, Hao Wu, Ruben D Carrasco, Dharminder Chauhan, Kenneth C Anderson
Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma. Blood (2023)
Ting Du, Yan Song, Arghya Ray, Xueping Wan, Yao Yao, Mehmet K Samur, Chen Shen, Johany Penailillo, Tomasz Sewastianik, Yu-Tzu Tai, Mariateresa Fulciniti, Nikhil C Munshi, Hao Wu, Ruben D Carrasco, Dharminder Chauhan, Kenneth C Anderson
Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma. Blood (2023)
Bhaskar Paidimuddala, Jianhao Cao, Grady Nash, Qing Xie, Hao Wu, Liman Zhang
Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5. Nature structural & molecular biology 30 (2) (2023)
Qing Kong, Shiyu Xia, Xingxin Pan, Kaixiong Ye, Zhouyihan Li, Haoyan Li, Xiaoqiang Tang, Nidhi Sahni, S Stephen Yi, Xing Liu, Hao Wu, Michael B Elowitz, Judy Lieberman, Zhibin Zhang
Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis. Science immunology 8 (82) (2023)
Bhaskar Paidimuddala, Jianhao Cao, Grady Nash, Qing Xie, Hao Wu, Liman Zhang
Mechanism of NAIP-NLRC4 inflammasome activation revealed by cryo-EM structure of unliganded NAIP5. Nature structural & molecular biology 30 (2) (2023)
Caroline Junqueira, Ângela Crespo, Shahin Ranjbar, Luna B de Lacerda, Mercedes Lewandrowski, Jacob Ingber, Blair A Parry, Sagi Ravid, Sarah A Clark, Marie Rose Schrimpf, Felicia Ho, Caroline Beakes, Justin D Margolin, Nicole Russell, Kyle Kays, Julie Boucau, Upasana Das Adhikari, Setu M Vora, Valerie Leger, Lee Gehrke, Lauren A Henderson, Erin Janssen, Douglas S Kwon, Chris Sander, Jonathan Abraham, Marcia B Goldberg, Hao Wu, Gautam Mehta, Steven Bell, Anne E Goldfeld, Michael R Filbin, Judy Lieberman
FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation. Nature 606 (7914) (2022)
Min Xia, Liron David, Matthew R Teater, Johana Gutierrez, Xiang Wang, Cem Meydan, Andrew Lytle, Graham W Slack, David W Scott, Ryan D Morin, Özlem Önder, Kojo S J Elenitoba-Johnson, Nahuel Zamponi, Leandro Cerchietti, Tianbao Lu, Ulrike Philippar, Lorena Fontán, Hao Wu, Ari M Melnick
BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL. Cancer discovery 12 (8) (2022)
Liron David, Laurel Martinez, Qiongchao Xi, Kameron A Kooshesh, Ying Zhang, Jagesh V Shah, Richard L Maas, Hao Wu
Piezo mechanosensory channels regulate centrosome integrity and mitotic entry. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Liron David, Laurel Martinez, Qiongchao Xi, Kameron A Kooshesh, Ying Zhang, Jagesh V Shah, Richard L Maas, Hao Wu
Piezo mechanosensory channels regulate centrosome integrity and mitotic entry. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Liron David, Laurel Martinez, Qiongchao Xi, Kameron A Kooshesh, Ying Zhang, Jagesh V Shah, Richard L Maas, Hao Wu
Piezo mechanosensory channels regulate centrosome integrity and mitotic entry. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Liron David, Laurel Martinez, Qiongchao Xi, Kameron A Kooshesh, Ying Zhang, Jagesh V Shah, Richard L Maas, Hao Wu
Piezo mechanosensory channels regulate centrosome integrity and mitotic entry. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Wang Zheng, Chen Shen, Longfei Wang, Shaun Rawson, Wen Jun Xie, Carl Nist-Lund, Jason Wu, Zhangfei Shen, Shiyu Xia, Jeffrey R Holt, Hao Wu, Tian-Min Fu
pH regulates potassium conductance and drives a constitutive proton current in human TMEM175. Science advances 8 (12) (2022)
Setu M Vora, Pietro Fontana, Tianyang Mao, Valerie Leger, Ying Zhang, Tian-Min Fu, Judy Lieberman, Lee Gehrke, Ming Shi, Longfei Wang, Akiko Iwasak, Hao Wu
Targeting stem-loop 1 of the SARS-CoV-2 5' UTR to suppress viral translation and Nsp1 evasion. Proceedings of the National Academy of Sciences of the United States of America 119 (9) (2022)
Le Xiao, Venkat Giri Magupalli, Hao Wu
Cryo-EM structures of the active NLRP3 inflammasome disk. Nature (2022)
Pietro Fontana, Ying Dong, Xiong Pi, Alexander B Tong, Corey W Hecksel, Longfei Wang, Tian-Min Fu, Carlos Bustamante, Hao Wu
Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold. Science (New York, N.Y.) 376 (6598) (2022)
Ying Dong, Xiong Pi, Frauke Bartels-Burgahn, Deniz Saltukoglu, Zhuoyi Liang, Jianying Yang, Frederick W Alt, Michael Reth, Hao Wu
Structural principles of B cell antigen receptor assembly. Nature 612 (7938) (2022)
Liron David, Laurel Martinez, Qiongchao Xi, Kameron A Kooshesh, Ying Zhang, Jagesh V Shah, Richard L Maas, Hao Wu
Piezo mechanosensory channels regulate centrosome integrity and mitotic entry. Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Shiyu Xia, Zhibin Zhang, Venkat Giri Magupalli, Juan Lorenzo Pablo, Ying Dong, Setu M Vora, Longfei Wang, Tian-Min Fu, Matthew P Jacobson, Anna Greka, Judy Lieberman, Jianbin Ruan, Hao Wu
Gasdermin D pore structure reveals preferential release of mature interleukin-1. Nature 593 (7860) (2021)
Wenqing Gao, Yuanyuan Li, Xuehe Liu, Sen Wang, Pucheng Mei, Zijun Chen, Kewei Liu, Suhua Li, Xue-Wei Xu, Jianhua Gan, Jiaxue Wu, Chaoneng Ji, Chen Ding, Xing Liu, Yuping Lai, Housheng Hansen He, Judy Lieberman, Hao Wu, Xiang-Jun Chen, Jixi Li
TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization. Cell death and differentiation (2021)
Zsófia Agnes Bittner, Xiao Liu, Maria Mateo Tortola, Ana Tapia-Abellán, Sangeetha Shankar, Liudmila Andreeva, Matthew S J Mangan, Marianne Rebecca Spalinger, Hubert Kalbacher, Peter Duewell, Marta Lovotti, Karlotta Bosch, Sabine Dickhöfer, Ana Marcu, Stefan Stevanovic, Franziska Herster, Yamel Cardona Gloria, Tzu-Hsuan Chang, Francesca Bork, Carsten L Greve, Markus W Löffler, Olaf-Oliver Wolz, Nadine A Schilling, Jasmin Beate Kuemmerle-Deschner, Samuel Wagner, Anita Delor, Bodo Grimbacher, Oliver Hantschel, Michael Scharl, Hao Wu, Eicke Latz, Alexander N R Weber
BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity. The Journal of experimental medicine 218 (11) (2021)
L Robert Hollingsworth, Humayun Sharif, Andrew R Griswold, Pietro Fontana, Julian Mintseris, Kevin B Dagbay, Joao A Paulo, Steven P Gygi, Daniel A Bachovchin, Hao Wu
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation. Nature 592 (7856) (2021)
Liudmila Andreeva, Hao Wu
STING condensates on ER limit IFN response. Nature cell biology 23 (4) (2021)
Alexander B Tong, Jason D Burch, Daniel McKay, Carlos J Bustamante, Michael A Crackower, Hao Wu
Could AlphaFold revolutionize chemical therapeutics? Nature structural & molecular biology 28 (10) (2021)
Setu M Vora, Judy Lieberman, Hao Wu
Inflammasome activation at the crux of severe COVID-19. Nature reviews. Immunology 21 (11) (2021)
Nathanael R Fillmore, Steven Bell, Ciyue Shen, Vinh Nguyen, Jennifer La, Maureen Dubreuil, Judith Strymish, Mary Brophy, Gautam Mehta, Hao Wu, Judy Lieberman, Nhan V Do, Chris Sander
Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study. PloS one 16 (10) (2021)
L Robert Hollingsworth, Liron David, Yang Li, Andrew R Griswold, Jianbin Ruan, Humayun Sharif, Pietro Fontana, Elizabeth L Orth-He, Tian-Min Fu, Daniel A Bachovchin, Hao Wu
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes. Nature communications 12 (1) (2021)
Xing Liu, Shiyu Xia, Zhibin Zhang, Hao Wu, Judy Lieberman
Channelling inflammation: gasdermins in physiology and disease. Nature reviews. Drug discovery 20 (5) (2021)
Judy Lieberman, Hao Wu, Jonathan C Kagan
Gasdermin D activity in inflammation and host defense. Science immunology 4 (39) (2020)
Jun Jacob Hu, Xing Liu, Shiyu Xia, Zhibin Zhang, Ying Zhang, Jingxia Zhao, Jianbin Ruan, Xuemei Luo, Xiwen Lou, Yang Bai, Junhong Wang, L Robert Hollingsworth, Venkat Giri Magupalli, Li Zhao, Hongbo R Luo, Justin Kim, Judy Lieberman, Hao Wu
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nature immunology 21 (7) (2020)
Jouliana Sadek, Michael G Wuo, David Rooklin, Arthur Hauenstein, Seong Ho Hong, Archana Gautam, Hao Wu, Yingkai Zhang, Ethel Cesarman, Paramjit S Arora
Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics. Nature communications 11 (1) (2020)
Hao Chen, Lei Gu, Esteban A Orellana, Yuanyuan Wang, Jiaojiao Guo, Qi Liu, Longfei Wang, Zhangfei Shen, Hao Wu, Richard I Gregory, Yi Xing, Yang Shi
METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing. Cell research 30 (6) (2020)
Venkat Giri Magupalli, Roberto Negro, Yuzi Tian, Arthur V Hauenstein, Giuseppe Di Caprio, Wesley Skillern, Qiufang Deng, Pontus Orning, Hasan B Alam, Zoltan Maliga, Humayun Sharif, Jun Jacob Hu, Charles L Evavold, Jonathan C Kagan, Florian Ingo Schmidt, Katherine A Fitzgerald, Tomas Kirchhausen, Yongqing Li, Hao Wu
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation. Science (New York, N.Y.) 369 (6510) (2020)
Li Wang, Ryan Ferrao, Qiubai Li, John M Hatcher, Hwan Geun Choi, Sara J Buhrlage, Nathanael S Gray, Hao Wu
Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). The Journal of biological chemistry 294 (12) (2019)
Yu-Ru Lee, Ming Chen, Jonathan D Lee, Jinfang Zhang, Shu-Yu Lin, Tian-Min Fu, Hao Chen, Tomoki Ishikawa, Shang-Yin Chiang, Jesse Katon, Yang Zhang, Yulia V Shulga, Assaf C Bester, Jacqueline Fung, Emanuele Monteleone, Lixin Wan, Chen Shen, Chih-Hung Hsu, Antonella Papa, John Gerard Clohessy, Julie Teruya-Feldstein, Suresh Jain, Hao Wu, Lydia E Matesic, Ruey-Hwa Chen, Wenyi Wei, Pier Paolo Pandolfi
Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science (New York, N.Y.) 364 (6441) (2019)
Pontus Orning, Dan Weng, Kristian Starheim, Dmitry Ratner, Zachary Best, Bettina Lee, Alexandria Brooks, Shiyu Xia, Hao Wu, Michelle A Kelliher, Scott B Berger, Peter J Gough, John Bertin, Megan M Proulx, Jon D Goguen, Nobuhiko Kayagaki, Katherine A Fitzgerald, Egil Lien
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death. Science (New York, N.Y.) 362 (6418) (2018)
Longfei Wang, Tian-Min Fu, Yiming Zhou, Shiyu Xia, Anna Greka, Hao Wu
Structures and gating mechanism of human TRPM2. Science (New York, N.Y.) 362 (6421) (2018)
Heng Ru, Wei Mi, Pengfei Zhang, Frederick W Alt, David G Schatz, Maofu Liao, Hao Wu
DNA melting initiates the RAG catalytic pathway. Nature structural & molecular biology 25 (8) (2018)

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Hao Wu