Lindsey I James

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 33

Top Topics

Structural Basis

Metastatic Colorectal Cancer

Histone Deacetylase

Top Venues

ACS chemical biology

Nature chemical biology

Journal of medicinal chemistry

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

David Y Nie, John R Tabor, Jianping Li, Maria Kutera, Jonathan St-Germain, Ronan P Hanley, Esther Wolf, Ethan Paulakonis, Tristan M G Kenney, Shili Duan, Suman Shrestha, Dominic D G Owens, Matthew E R Maitland, Ailing Pon, Magdalena Szewczyk, Anthony Joseph Lamberto, Michael Menes, Fengling Li, Linda Z Penn, Dalia Barsyte-Lovejoy, Nicholas G Brown, Anthony M Barsotti, Andrew W Stamford, Jon L Collins, Derek J Wilson, Brian Raught, Jonathan D Licht, Lindsey I James, Cheryl H Arrowsmith
Recruitment of FBXO22 for targeted degradation of NSD2. Nature chemical biology (2024)
David Y Nie, John R Tabor, Jianping Li, Maria Kutera, Jonathan St-Germain, Ronan P Hanley, Esther Wolf, Ethan Paulakonis, Tristan M G Kenney, Shili Duan, Suman Shrestha, Dominic D G Owens, Matthew E R Maitland, Ailing Pon, Magdalena Szewczyk, Anthony Joseph Lamberto, Michael Menes, Fengling Li, Linda Z Penn, Dalia Barsyte-Lovejoy, Nicholas G Brown, Anthony M Barsotti, Andrew W Stamford, Jon L Collins, Derek J Wilson, Brian Raught, Jonathan D Licht, Lindsey I James, Cheryl H Arrowsmith
Recruitment of FBXO22 for targeted degradation of NSD2. Nature chemical biology (2024)
Cathy J Spangler, Aleksandra Skrajna, Caroline A Foley, Anh Nguyen, Gabrielle R Budziszewski, Dalal N Azzam, Eyla C Arteaga, Holly C Simmons, Charlotte B Smith, Nathaniel A Wesley, Emily M Wilkerson, Jeanne-Marie E McPherson, Dmitri B Kireev, Lindsey I James, Stephen V Frye, Dennis Goldfarb, Robert K McGinty
Structural basis of paralog-specific KDM2A/B nucleosome recognition. Nature chemical biology (2023)
Frances M Bashore, Caroline A Foley, Han Wee Ong, Justin M Rectenwald, Ronan P Hanley, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Christine A Mills, Kenneth H Pearce, Laura E Herring, Dmitri B Kireev, Stephen V Frye, Lindsey I James
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components. ACS chemical biology 18 (3) (2023)
Gaofeng Cui, Maria Victoria Botuyan, Pascal Drané, Qi Hu, Benoît Bragantini, James Robert Thompson, David J Schuller, Alexandre Detappe, Michael T Perfetti, Lindsey I James, Stephen V Frye, Dipanjan Chowdhury, Georges Mer
An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. Nature communications 14 (1) (2023)
Ronan P Hanley, David Y Nie, John R Tabor, Fengling Li, Amin Sobh, Chenxi Xu, Natalie K Barker, David Dilworth, Taraneh Hajian, Elisa Gibson, Magdalena M Szewczyk, Peter J Brown, Dalia Barsyte-Lovejoy, Laura E Herring, Gang Greg Wang, Jonathan D Licht, Masoud Vedadi, Cheryl H Arrowsmith, Lindsey I James
Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. Journal of the American Chemical Society (2023)
Frances M Bashore, Caroline A Foley, Han Wee Ong, Justin M Rectenwald, Ronan P Hanley, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Christine A Mills, Kenneth H Pearce, Laura E Herring, Dmitri B Kireev, Stephen V Frye, Lindsey I James
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components. ACS chemical biology 18 (3) (2023)
Mélanie Uguen, Yu Deng, Fengling Li, Devan J Shell, Jacqueline L Norris-Drouin, Michael A Stashko, Suzanne Ackloo, Cheryl H Arrowsmith, Lindsey I James, Pengda Liu, Kenneth H Pearce, Stephen V Frye
SETDB1 Triple Tudor Domain Ligand, ( R , R )-59, Promotes Methylation of Akt1 in Cells. ACS chemical biology (2023)
Devan J Shell, Caroline A Foley, Qinhong Wang, Chelsea M Smith, Shiva K R Guduru, Hong Zeng, Aiping Dong, Jacqueline L Norris-Drouin, Matthew Axtman, P Brian Hardy, Gaorav Gupta, Levon Halabelian, Stephen V Frye, Lindsey I James, Kenneth H Pearce
Discovery of a 53BP1 Small Molecule Antagonist Using a Focused DNA-Encoded Library Screen. Journal of medicinal chemistry (2023)
Frances M Bashore, Caroline A Foley, Han Wee Ong, Justin M Rectenwald, Ronan P Hanley, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Christine A Mills, Kenneth H Pearce, Laura E Herring, Dmitri B Kireev, Stephen V Frye, Lindsey I James
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components. ACS chemical biology 18 (3) (2023)
Mélanie Uguen, Yu Deng, Fengling Li, Devan J Shell, Jacqueline L Norris-Drouin, Michael A Stashko, Suzanne Ackloo, Cheryl H Arrowsmith, Lindsey I James, Pengda Liu, Kenneth H Pearce, Stephen V Frye
SETDB1 Triple Tudor Domain Ligand, ( R,R )-59, Promotes Methylation of Akt1 in Cells. bioRxiv : the preprint server for biology (2023)
Frances M Bashore, Caroline A Foley, Han Wee Ong, Justin M Rectenwald, Ronan P Hanley, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Christine A Mills, Kenneth H Pearce, Laura E Herring, Dmitri B Kireev, Stephen V Frye, Lindsey I James
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components. ACS chemical biology (2023)
Frances M Bashore, Caroline A Foley, Han Wee Ong, Justin M Rectenwald, Ronan P Hanley, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Christine A Mills, Kenneth H Pearce, Laura E Herring, Dmitri B Kireev, Stephen V Frye, Lindsey I James
PROTAC Linkerology Leads to an Optimized Bivalent Chemical Degrader of Polycomb Repressive Complex 2 (PRC2) Components. ACS chemical biology 18 (3) (2023)
Dongbo Lu, Caroline A Foley, Shama V Birla, Austin J Hepperla, Jeremy M Simon, Lindsey I James, Nathaniel A Hathaway
Bioorthogonal Chemical Epigenetic Modifiers Enable Dose-Dependent CRISPR Targeted Gene Activation in Mammalian Cells. ACS synthetic biology 11 (4) (2022)
Kelsey M Kean, Stefanie A Baril, Kelsey N Lamb, Sarah N Dishman, Joseph W Treacy, Kendall N Houk, Eric M Brustad, Lindsey I James, Marcey L Waters
Systematic Variation of Both the Aromatic Cage and Dialkyllysine via GCE-SAR Reveal Mechanistic Insights in CBX5 Reader Protein Binding. Journal of medicinal chemistry 65 (3) (2022)
Isabelle A Engelberg, Jiuyang Liu, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Samantha A Ottavi, Stephen V Frye, Tatiana G Kutateladze, Lindsey I James
Discovery of an H3K36me3-Derived Peptidomimetic Ligand with Enhanced Affinity for Plant Homeodomain Finger Protein 1 (PHF1). Journal of medicinal chemistry 64 (12) (2021)
Kelsey N Lamb, Sarah N Dishman, Jarod M Waybright, Isabelle A Engelberg, Justin M Rectenwald, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Kenneth H Pearce, Lindsey I James, Stephen V Frye
Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins. ACS omega 7 (1) (2021)
David Dilworth, Ronan P Hanley, Renato Ferreira de Freitas, Abdellah Allali-Hassani, Mengqi Zhou, Naimee Mehta, Matthew R Marunde, Suzanne Ackloo, Raquel Arminda Carvalho Machado, Aliakbar Khalili Yazdi, Dominic D G Owens, Victoria Vu, David Y Nie, Mona Alqazzaz, Edyta Marcon, Fengling Li, Irene Chau, Albina Bolotokova, Su Qin, Ming Lei, Yanli Liu, Magdalena M Szewczyk, Aiping Dong, Sina Kazemzadeh, Tigran Abramyan, Irina K Popova, Nathan W Hall, Matthew J Meiners, Marcus A Cheek, Elisa Gibson, Dmitri B Kireev, Jack F Greenblatt, Michael-Christopher Keogh, Jinrong Min, Peter J Brown, Masoud Vedadi, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Lindsey I James, Matthieu Schapira
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nature chemical biology (2021)
Renato Ferreira de Freitas, Yanli Liu, Magdalena M Szewczyk, Naimee Mehta, Fengling Li, David McLeod, Carlos Zepeda-Velázquez, David Dilworth, Ronan P Hanley, Elisa Gibson, Peter J Brown, Rima Al-Awar, Lindsey I James, Cheryl H Arrowsmith, Dalia Barsyte-Lovejoy, Jinrong Min, Masoud Vedadi, Matthieu Schapira, Abdellah Allali-Hassani
Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2. Journal of medicinal chemistry 64 (3) (2021)
Jarod M Waybright, Sarah E Clinkscales, Kimberly D Barnash, Gabrielle R Budziszewski, Justin M Rectenwald, Anna M Chiarella, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Kenneth H Pearce, Laura E Herring, Robert K McGinty, Nathaniel A Hathaway, Lindsey I James
A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex. ACS chemical biology 16 (9) (2021)
Stuart R Jefferys, Samuel D Burgos, Jackson J Peterson, Sara R Selitsky, Anne-Marie W Turner, Lindsey I James, Yi-Hsuan Tsai, Alisha R Coffey, David M Margolis, Joel S Parker, Edward P Browne
Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors. PLoS pathogens 17 (2) (2021)
Jarod M Waybright, Lindsey I James
Getting a handle on chemical probes of chomatin readers. Future medicinal chemistry 13 (8) (2020)
Anne-Marie W Turner, Raghuvar Dronamraju, Frances Potjewyd, Katherine S James, Daniel K Winecoff, Jennifer L Kirchherr, Nancie M Archin, Edward P Browne, Brian D Strahl, David M Margolis, Lindsey I James
Evaluation of EED Inhibitors as a Class of PRC2-Targeted Small Molecules for HIV Latency Reversal. ACS infectious diseases 6 (7) (2020)
Junghyun L Suh, Kimberly D Barnash, Tigran M Abramyan, Fengling Li, Juliana The, Isabelle A Engelberg, Masoud Vedadi, Peter J Brown, Dmitri B Kireev, Cheryl H Arrowsmith, Lindsey I James, Stephen V Frye
Discovery of selective activators of PRC2 mutant EED-I363M. Scientific reports 9 (1) (2019)
Samantha M Ervin, Ronan P Hanley, Lauren Lim, William G Walton, Kenneth H Pearce, Aadra P Bhatt, Lindsey I James, Matthew R Redinbo
Targeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial β-Glucuronidases. ACS chemical biology 14 (12) (2019)
Hagar F Moussa, Daniel Bsteh, Ramesh Yelagandula, Carina Pribitzer, Karin Stecher, Katarina Bartalska, Luca Michetti, Jingkui Wang, Jorge A Zepeda-Martinez, Ulrich Elling, Jacob I Stuckey, Lindsey I James, Stephen V Frye, Oliver Bell
Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing. Nature communications 10 (1) (2019)
Caroline A Foley, Frances Potjewyd, Kelsey N Lamb, Lindsey I James, Stephen V Frye
Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay. ACS chemical biology 15 (1) (2019)
Lianxin Hu, Haibiao Xie, Xijuan Liu, Frances Potjewyd, Lindsey I James, Emily M Wilkerson, Laura E Herring, Ling Xie, Xian Chen, Johnny Castillo Cabrera, Kai Hong, Chengheng Liao, Xianming Tan, Albert S Baldwin, Kan Gong, Yang Zhang
TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss. Cancer discovery 10 (3) (2019)
Junghyun L Suh, Brian Watts, Jacob I Stuckey, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Bradley M Dickson, Yi An, Sebastian Mathea, Eidarus Salah, Stefan Knapp, Abid Khan, Alexander T Adams, Brian D Strahl, Cari A Sagum, Mark T Bedford, Lindsey I James, Dmitri B Kireev, Stephen V Frye
Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1. Biochemistry 57 (14) (2018)
Sharon E Hopcraft, Samantha G Pattenden, Lindsey I James, Stephen V Frye, Dirk P Dittmer, Blossom A Damania
Chromatin remodeling controls Kaposi's sarcoma-associated herpesvirus reactivation from latency. PLoS pathogens 14 (9) (2018)
Kimberly D Barnash, Juliana The, Jacqueline L Norris-Drouin, Stephanie H Cholensky, Beau M Worley, Fengling Li, Jacob I Stuckey, Peter J Brown, Masoud Vedadi, Cheryl H Arrowsmith, Stephen V Frye, Lindsey I James
Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2. ACS combinatorial science 19 (3) (2017)
Brandi M Baughman, Samantha G Pattenden, Jacqueline L Norris, Lindsey I James, Stephen V Frye
Retraction of "The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer". ACS chemical biology 13 (1) (2017)
Ling Wang, Yamuna Ariyarathna, Xin Ming, Bing Yang, Lindsey I James, Silvia M Kreda, Melissa Porter, William Janzen, Rudolph L Juliano
A Novel Family of Small Molecules that Enhance the Intracellular Delivery and Pharmacological Effectiveness of Antisense and Splice Switching Oligonucleotides. ACS chemical biology 12 (8) (2017)