Nicholas G Brown

ORCID

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 44

Top Venues

Journal of cell science

Nature communications

ACS chemical biology

Biochemical Society transactions

University of North Carolina

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of North Carolina Sep 01 2017

United States

Assistant Professor :: Pharmacology

Publications

Laura E McCormick, Cristian Suarez, Laura E Herring, Kevin S Cannon, David R Kovar, Nicholas G Brown, Stephanie L Gupton
Multi-monoubiquitylation controls VASP-mediated actin dynamics. Journal of cell science 137 (2) (2024)
Xiuxiu Lu, Monika Chandravanshi, Venkata R Sabbasani, Snehal Gaikwad, V Keith Hughitt, Nana Gyabaah-Kessie, Bradley T Scroggins, Sudipto Das, Wazo Myint, Michelle E Clapp, Charles D Schwieters, Marzena A Dyba, Derek L Bolhuis, Janusz W Koscielniak, Thorkell Andresson, Michael J Emanuele, Nicholas G Brown, Hiroshi Matsuo, Raj Chari, Deborah E Citrin, Beverly A Mock, Rolf E Swenson, Kylie J Walters
A structure-based designed small molecule depletes hRpn13 Pru and a select group of KEN box proteins. Nature communications 15 (1) (2024)
Colton J Treadway, Joshua A Boyer, Shiyue Yang, Hui Yang, Mengxi Liu, Zhijun Li, Meng Cheng, William F Marzluff, Dan Ye, Yue Xiong, Albert S Baldwin, Qi Zhang, Nicholas G Brown
Using NMR to Monitor TET-Dependent Methylcytosine Dioxygenase Activity and Regulation. ACS chemical biology 19 (1) (2024)
Derek L Bolhuis, Michael J Emanuele, Nicholas G Brown
Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases. Biochemical Society transactions (2024)
Colton J Treadway, Joshua A Boyer, Shiyue Yang, Hui Yang, Mengxi Liu, Zhijun Li, Meng Cheng, William F Marzluff, Dan Ye, Yue Xiong, Albert S Baldwin, Qi Zhang, Nicholas G Brown
Using NMR to Monitor TET-Dependent Methylcytosine Dioxygenase Activity and Regulation. ACS chemical biology (2024)
Laura E McCormick, Cristian Suarez, Laura E Herring, Kevin S Cannon, David R Kovar, Nicholas G Brown, Stephanie L Gupton
Multi-monoubiquitylation controls VASP-mediated actin dynamics. Journal of cell science 137 (2) (2024)
Colton J Treadway, Joshua A Boyer, Shiyue Yang, Hui Yang, Mengxi Liu, Zhijun Li, Meng Cheng, William F Marzluff, Dan Ye, Yue Xiong, Albert S Baldwin, Qi Zhang, Nicholas G Brown
Using NMR to Monitor TET-Dependent Methylcytosine Dioxygenase Activity and Regulation. ACS chemical biology 19 (1) (2024)
Colton J Treadway, Joshua A Boyer, Shiyue Yang, Hui Yang, Mengxi Liu, Zhijun Li, Meng Cheng, William F Marzluff, Dan Ye, Yue Xiong, Albert S Baldwin, Qi Zhang, Nicholas G Brown
Using NMR to Monitor TET-Dependent Methylcytosine Dioxygenase Activity and Regulation. ACS chemical biology 19 (1) (2024)
Laura E McCormick, Cristian Suarez, Laura E Herring, Kevin S Cannon, David R Kovar, Nicholas G Brown, Stephanie L Gupton
Multi-monoubiquitylation controls VASP-mediated actin dynamics. Journal of cell science 137 (2) (2024)
Derek L Bolhuis, Michael J Emanuele, Nicholas G Brown
Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases. Biochemical Society transactions (2024)
Xiuxiu Lu, Monika Chandravanshi, Venkata R Sabbasani, Snehal Gaikwad, V Keith Hughitt, Nana Gyabaah-Kessie, Bradley T Scroggins, Sudipto Das, Wazo Myint, Michelle E Clapp, Charles D Schwieters, Marzena A Dyba, Derek L Bolhuis, Janusz W Koscielniak, Thorkell Andresson, Michael J Emanuele, Nicholas G Brown, Hiroshi Matsuo, Raj Chari, Deborah E Citrin, Beverly A Mock, Rolf E Swenson, Kylie J Walters
A structure-based designed small molecule depletes hRpn13 Pru and a select group of KEN box proteins. Nature communications 15 (1) (2024)
Xiuxiu Lu, Monika Chandravanshi, Venkata R Sabbasani, Snehal Gaikwad, V Keith Hughitt, Nana Gyabaah-Kessie, Bradley T Scroggins, Sudipto Das, Wazo Myint, Michelle E Clapp, Charles D Schwieters, Marzena A Dyba, Derek L Bolhuis, Janusz W Koscielniak, Thorkell Andresson, Michael J Emanuele, Nicholas G Brown, Hiroshi Matsuo, Raj Chari, Deborah E Citrin, Beverly A Mock, Rolf E Swenson, Kylie J Walters
A structure-based designed small molecule depletes hRpn13 Pru and a select group of KEN box proteins. Nature communications 15 (1) (2024)
Laura E McCormick, Cristian Suarez, Laura E Herring, Kevin S Cannon, David R Kovar, Nicholas G Brown, Stephanie L Gupton
Multi-monoubiquitylation controls VASP-mediated actin dynamics. Journal of cell science 137 (2) (2024)
Laura E McCormick, Cristian Suarez, Laura E Herring, Kevin S Cannon, David R Kovar, Nicholas G Brown, Stephanie L Gupton
Multi-monoubiquitylation controls VASP-mediated actin dynamics. Journal of cell science 137 (2) (2024)
Xiuxiu Lu, Monika Chandravanshi, Venkata R Sabbasani, Snehal Gaikwad, V Keith Hughitt, Nana Gyabaah-Kessie, Bradley T Scroggins, Sudipto Das, Wazo Myint, Michelle E Clapp, Charles D Schwieters, Marzena A Dyba, Derek L Bolhuis, Janusz W Koscielniak, Thorkell Andresson, Michael J Emanuele, Nicholas G Brown, Hiroshi Matsuo, Raj Chari, Deborah E Citrin, Beverly A Mock, Rolf E Swenson, Kylie J Walters
A structure-based designed small molecule depletes hRpn13 Pru and a select group of KEN box proteins. Nature communications 15 (1) (2024)
Xiuxiu Lu, Monika Chandravanshi, Venkata R Sabbasani, Snehal Gaikwad, V Keith Hughitt, Nana Gyabaah-Kessie, Bradley T Scroggins, Sudipto Das, Wazo Myint, Michelle E Clapp, Charles D Schwieters, Marzena A Dyba, Derek L Bolhuis, Janusz W Koscielniak, Thorkell Andresson, Michael J Emanuele, Nicholas G Brown, Hiroshi Matsuo, Raj Chari, Deborah E Citrin, Beverly A Mock, Rolf E Swenson, Kylie J Walters
A structure-based designed small molecule depletes hRpn13 Pru and a select group of KEN box proteins. Nature communications 15 (1) (2024)
Laura E McCormick, Cristian Suarez, Laura E Herring, Kevin S Cannon, David R Kovar, Nicholas G Brown, Stephanie L Gupton
Multi-monoubiquitylation controls VASP-mediated actin dynamics. Journal of cell science 137 (2) (2024)
Xiuxiu Lu, Monika Chandravanshi, Venkata R Sabbasani, Snehal Gaikwad, V Keith Hughitt, Nana Gyabaah-Kessie, Bradley T Scroggins, Sudipto Das, Wazo Myint, Michelle E Clapp, Charles D Schwieters, Marzena A Dyba, Derek L Bolhuis, Janusz W Koscielniak, Thorkell Andresson, Michael J Emanuele, Nicholas G Brown, Hiroshi Matsuo, Raj Chari, Deborah E Citrin, Beverly A Mock, Rolf E Swenson, Kylie J Walters
A structure-based designed small molecule depletes hRpn13 Pru and a select group of KEN box proteins. Nature communications 15 (1) (2024)
Laura E McCormick, Cristian Suarez, Laura E Herring, Kevin S Cannon, David R Kovar, Nicholas G Brown, Stephanie L Gupton
Multi-monoubiquitylation controls VASP-mediated actin dynamics. Journal of cell science 137 (2) (2024)
Zara Bukhari, Li Gu, Anneroos E Nederstigt, Logan J Cope, Derek L Bolhuis, Kim Harvey, Tristan Allen, Spencer Hill, Yujie Yang, Guy Lawson, Cai Lu, Tommy Tran, Leah Pineda, Leanne Low, Andrew Chiang, Jason Song, Michelle V Fong, Vanessa M Rangel, William K Chan, Gary Kleiger, Dennis Goldfrab, Craig A Vierra, Nicholas G Brown, Joseph S Harrison
Design of linked-domain protein inhibitors of UBE2D as tools to study cellular ubiquitination. bioRxiv : the preprint server for biology (2024)
David Y Nie, John R Tabor, Jianping Li, Maria Kutera, Jonathan St-Germain, Ronan P Hanley, Esther Wolf, Ethan Paulakonis, Tristan M G Kenney, Shili Duan, Suman Shrestha, Dominic D G Owens, Matthew E R Maitland, Ailing Pon, Magdalena Szewczyk, Anthony Joseph Lamberto, Michael Menes, Fengling Li, Linda Z Penn, Dalia Barsyte-Lovejoy, Nicholas G Brown, Anthony M Barsotti, Andrew W Stamford, Jon L Collins, Derek J Wilson, Brian Raught, Jonathan D Licht, Lindsey I James, Cheryl H Arrowsmith
Recruitment of FBXO22 for targeted degradation of NSD2. Nature chemical biology (2024)
Laura E McCormick, Cristian Suarez, Laura E Herring, Kevin S Cannon, David R Kovar, Nicholas G Brown, Stephanie L Gupton
Multi-monoubiquitylation controls VASP-mediated actin dynamics. Journal of cell science 137 (2) (2024)
Derek L Bolhuis, Michael J Emanuele, Nicholas G Brown
Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases. Biochemical Society transactions (2024)
Laura E McCormick, Cristian Suarez, Laura E Herring, Kevin S Cannon, David R Kovar, Nicholas G Brown, Stephanie L Gupton
Multi-monoubiquitylation controls VASP-mediated actin dynamics. Journal of cell science 137 (2) (2024)
David Y Nie, John R Tabor, Jianping Li, Maria Kutera, Jonathan St-Germain, Ronan P Hanley, Esther Wolf, Ethan Paulakonis, Tristan M G Kenney, Shili Duan, Suman Shrestha, Dominic D G Owens, Matthew E R Maitland, Ailing Pon, Magdalena Szewczyk, Anthony Joseph Lamberto, Michael Menes, Fengling Li, Linda Z Penn, Dalia Barsyte-Lovejoy, Nicholas G Brown, Anthony M Barsotti, Andrew W Stamford, Jon L Collins, Derek J Wilson, Brian Raught, Jonathan D Licht, Lindsey I James, Cheryl H Arrowsmith
Recruitment of FBXO22 for targeted degradation of NSD2. Nature chemical biology (2024)
Laura E McCormick, Cristian Suarez, Laura E Herring, Kevin S Cannon, David R Kovar, Nicholas G Brown, Stephanie L Gupton
Multi-monoubiquitylation controls VASP-mediated actin dynamics. Journal of cell science 137 (2) (2024)
Colton J Treadway, Joshua A Boyer, Shiyue Yang, Hui Yang, Mengxi Liu, Zhijun Li, Meng Cheng, William F Marzluff, Dan Ye, Yue Xiong, Albert S Baldwin, Qi Zhang, Nicholas G Brown
Using NMR to Monitor TET-Dependent Methylcytosine Dioxygenase Activity and Regulation. ACS chemical biology 19 (1) (2024)
Colton J Treadway, Joshua A Boyer, Shiyue Yang, Hui Yang, Mengxi Liu, Zhijun Li, Meng Cheng, William F Marzluff, Dan Ye, Yue Xiong, Albert S Baldwin, Qi Zhang, Nicholas G Brown
Using NMR to Monitor TET-Dependent Methylcytosine Dioxygenase Activity and Regulation. ACS chemical biology 19 (1) (2024)
Derek L Bolhuis, Michael J Emanuele, Nicholas G Brown
Friend or foe? Reciprocal regulation between E3 ubiquitin ligases and deubiquitinases. Biochemical Society transactions (2024)
Jianfeng Chen, Derek L Bolhuis, Christian Laggner, Deyu Kong, Le Yu, Xiaodong Wang, Michael J Emanuele, Nicholas G Brown, Pengda Liu
AtomNet-Aided OTUD7B Inhibitor Discovery and Validation. Cancers 15 (2) (2023)
Jianfeng Chen, Derek L Bolhuis, Christian Laggner, Deyu Kong, Le Yu, Xiaodong Wang, Michael J Emanuele, Nicholas G Brown, Pengda Liu
AtomNet-Aided OTUD7B Inhibitor Discovery and Validation. Cancers 15 (2) (2023)
Jianfeng Chen, Derek L Bolhuis, Christian Laggner, Deyu Kong, Le Yu, Xiaodong Wang, Michael J Emanuele, Nicholas G Brown, Pengda Liu
AtomNet-Aided OTUD7B Inhibitor Discovery and Validation. Cancers 15 (2) (2023)
Salvatore Botta, Nicola de Prisco, Alexei Chemiakine, Vicky Brandt, Maximilian Cabaj, Purvi Patel, Ella Doron-Mandel, Colton J Treadway, Marko Jovanovic, Nicholas G Brown, Rajesh Kumar Soni, Vincenzo A Gennarino
Dosage sensitivity to Pumilio1 variants in the mouse brain reflects distinct molecular mechanisms. The EMBO journal (2023)
Zuzana Hodáková, Irina Grishkovskaya, Hanna L Brunner, Derek L Bolhuis, Katarina Belačić, Alexander Schleiffer, Harald Kotisch, Nicholas G Brown, David Haselbach
Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5. The EMBO journal (2023)
Tatyana Bodrug, Kaeli A Welsh, Derek L Bolhuis, Ethan Paulаkonis, Raquel C Martinez-Chacin, Bei Liu, Nicholas Pinkin, Thomas Bonacci, Liying Cui, Pengning Xu, Olivia Roscow, Sascha Josef Amann, Irina Grishkovskaya, Michael J Emanuele, Joseph S Harrison, Joshua P Steimel, Klaus M Hahn, Wei Zhang, Ellen D Zhong, David Haselbach, Nicholas G Brown
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). Nature structural & molecular biology (2023)
Laura E McCormick, Cristian Suarez, Laura E Herring, Kevin S Cannon, David R Kovar, Nicholas G Brown, Stephanie L Gupton
Multi-monoubiquitination controls VASP-mediated actin dynamics. bioRxiv : the preprint server for biology (2023)
Elizaveta T Wick, Colton J Treadway, Zhijun Li, Nathan I Nicely, Zhizhong Ren, Albert S Baldwin, Yue Xiong, Joseph S Harrison, Nicholas G Brown
Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex. Journal of virology 96 (17) (2022)
Derek L Bolhuis, Raquel C Martinez-Chacin, Kaeli A Welsh, Tatyana Bodrug, Liying Cui, Michael J Emanuele, Nicholas G Brown
Examining the mechanistic relationship of APC/C CDH1 and its interphase inhibitor EMI1. Protein science : a publication of the Protein Society 31 (6) (2022)
Kaeli A Welsh, Derek L Bolhuis, Anneroos E Nederstigt, Joshua Boyer, Brenda R S Temple, Thomas Bonacci, Li Gu, Alban Ordureau, J Wade Harper, Joshua P Steimel, Qi Zhang, Michael J Emanuele, Joseph S Harrison, Nicholas G Brown
Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes. The EMBO journal 41 (3) (2021)
Adar Sonn-Segev, Katarina Belačić, Tatyana Bodrug, Gavin Young, Ryan T VanderLinden, Brenda A Schulman, Johannes Schimpf, Thorsten Friedrich, Phat Vinh Dip, Thomas U Schwartz, Benedikt Bauer, Jan-Michael Peters, Weston B Struwe, Justin L P Benesch, Nicholas G Brown, David Haselbach, Philipp Kukura
Quantifying the heterogeneity of macromolecular machines by mass photometry. Nature communications 11 (1) (2020)
Jennifer L Franks, Raquel C Martinez-Chacin, Xianxi Wang, Rochelle L Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L Bolhuis, Taylor P Enrico, Ryan D Mouery, Jeffrey S Damrauer, Feng Yan, Joseph S Harrison, M Ben Major, Katherine A Hoadley, Aussie Suzuki, Scott B Rothbart, Nicholas G Brown, Michael J Emanuele
In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators. PLoS biology 18 (12) (2020)
Raquel C Martinez-Chacin, Tatyana Bodrug, Derek L Bolhuis, Katarzyna M Kedziora, Thomas Bonacci, Alban Ordureau, Morgan E Gibbs, Florian Weissmann, Renping Qiao, Gavin D Grant, Jeanette Gowen Cook, Jan-Michael Peters, J Wade Harper, Michael J Emanuele, Nicholas G Brown
Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming. Nature structural & molecular biology 27 (6) (2020)
Katherine V Richeson, Tatyana Bodrug, Katharine L Sackton, Masaya Yamaguchi, Joao A Paulo, Steven P Gygi, Brenda A Schulman, Nicholas G Brown, Randall W King
Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20. Nature chemical biology 16 (5) (2020)
Lei-Lei Chen, Matthew D Smith, Lei Lv, Tadashi Nakagawa, Zhijun Li, Shao-Cong Sun, Nicholas G Brown, Yue Xiong, Yan-Ping Xu
USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2. Science advances 6 (38) (2020)

Nicholas G Brown.css-eqlu8i{font-size:small;padding-left:4px;}

Publication Activity (10 Years)

Top Topics

Top Venues

Nicholas G Brown