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Nicholas G Brown

ORCID

Publication Activity (10 Years)

Years Active: 2020-2023
Publications (10 Years): 15

Top Venues

The EMBO journal

Cancers

Nature structural & molecular biology

Nature chemical biology

University of North Carolina

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of North Carolina Sep 1o 2017

United States

Assistant Professor :: Pharmacology

Publications

Jianfeng Chen, Derek L Bolhuis, Christian Laggner, Deyu Kong, Le Yu, Xiaodong Wang, Michael J Emanuele, Nicholas G Brown, Pengda Liu
AtomNet-Aided OTUD7B Inhibitor Discovery and Validation. Cancers 15 (2) (2023)
Jianfeng Chen, Derek L Bolhuis, Christian Laggner, Deyu Kong, Le Yu, Xiaodong Wang, Michael J Emanuele, Nicholas G Brown, Pengda Liu
AtomNet-Aided OTUD7B Inhibitor Discovery and Validation. Cancers 15 (2) (2023)
Jianfeng Chen, Derek L Bolhuis, Christian Laggner, Deyu Kong, Le Yu, Xiaodong Wang, Michael J Emanuele, Nicholas G Brown, Pengda Liu
AtomNet-Aided OTUD7B Inhibitor Discovery and Validation. Cancers 15 (2) (2023)
Salvatore Botta, Nicola de Prisco, Alexei Chemiakine, Vicky Brandt, Maximilian Cabaj, Purvi Patel, Ella Doron-Mandel, Colton J Treadway, Marko Jovanovic, Nicholas G Brown, Rajesh Kumar Soni, Vincenzo A Gennarino
Dosage sensitivity to Pumilio1 variants in the mouse brain reflects distinct molecular mechanisms. The EMBO journal (2023)
Zuzana Hodáková, Irina Grishkovskaya, Hanna L Brunner, Derek L Bolhuis, Katarina Belačić, Alexander Schleiffer, Harald Kotisch, Nicholas G Brown, David Haselbach
Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5. The EMBO journal (2023)
Tatyana Bodrug, Kaeli A Welsh, Derek L Bolhuis, Ethan Paulаkonis, Raquel C Martinez-Chacin, Bei Liu, Nicholas Pinkin, Thomas Bonacci, Liying Cui, Pengning Xu, Olivia Roscow, Sascha Josef Amann, Irina Grishkovskaya, Michael J Emanuele, Joseph S Harrison, Joshua P Steimel, Klaus M Hahn, Wei Zhang, Ellen D Zhong, David Haselbach, Nicholas G Brown
Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C). Nature structural & molecular biology (2023)
Laura E McCormick, Cristian Suarez, Laura E Herring, Kevin S Cannon, David R Kovar, Nicholas G Brown, Stephanie L Gupton
Multi-monoubiquitination controls VASP-mediated actin dynamics. bioRxiv : the preprint server for biology (2023)
Elizaveta T Wick, Colton J Treadway, Zhijun Li, Nathan I Nicely, Zhizhong Ren, Albert S Baldwin, Yue Xiong, Joseph S Harrison, Nicholas G Brown
Insight into Viral Hijacking of CRL4 Ubiquitin Ligase through Structural Analysis of the pUL145-DDB1 Complex. Journal of virology 96 (17) (2022)
Derek L Bolhuis, Raquel C Martinez-Chacin, Kaeli A Welsh, Tatyana Bodrug, Liying Cui, Michael J Emanuele, Nicholas G Brown
Examining the mechanistic relationship of APC/C CDH1 and its interphase inhibitor EMI1. Protein science : a publication of the Protein Society 31 (6) (2022)
Kaeli A Welsh, Derek L Bolhuis, Anneroos E Nederstigt, Joshua Boyer, Brenda R S Temple, Thomas Bonacci, Li Gu, Alban Ordureau, J Wade Harper, Joshua P Steimel, Qi Zhang, Michael J Emanuele, Joseph S Harrison, Nicholas G Brown
Functional conservation and divergence of the helix-turn-helix motif of E2 ubiquitin-conjugating enzymes. The EMBO journal 41 (3) (2021)
Adar Sonn-Segev, Katarina Belačić, Tatyana Bodrug, Gavin Young, Ryan T VanderLinden, Brenda A Schulman, Johannes Schimpf, Thorsten Friedrich, Phat Vinh Dip, Thomas U Schwartz, Benedikt Bauer, Jan-Michael Peters, Weston B Struwe, Justin L P Benesch, Nicholas G Brown, David Haselbach, Philipp Kukura
Quantifying the heterogeneity of macromolecular machines by mass photometry. Nature communications 11 (1) (2020)
Jennifer L Franks, Raquel C Martinez-Chacin, Xianxi Wang, Rochelle L Tiedemann, Thomas Bonacci, Rajarshi Choudhury, Derek L Bolhuis, Taylor P Enrico, Ryan D Mouery, Jeffrey S Damrauer, Feng Yan, Joseph S Harrison, M Ben Major, Katherine A Hoadley, Aussie Suzuki, Scott B Rothbart, Nicholas G Brown, Michael J Emanuele
In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators. PLoS biology 18 (12) (2020)
Raquel C Martinez-Chacin, Tatyana Bodrug, Derek L Bolhuis, Katarzyna M Kedziora, Thomas Bonacci, Alban Ordureau, Morgan E Gibbs, Florian Weissmann, Renping Qiao, Gavin D Grant, Jeanette Gowen Cook, Jan-Michael Peters, J Wade Harper, Michael J Emanuele, Nicholas G Brown
Ubiquitin chain-elongating enzyme UBE2S activates the RING E3 ligase APC/C for substrate priming. Nature structural & molecular biology 27 (6) (2020)
Katherine V Richeson, Tatyana Bodrug, Katharine L Sackton, Masaya Yamaguchi, Joao A Paulo, Steven P Gygi, Brenda A Schulman, Nicholas G Brown, Randall W King
Paradoxical mitotic exit induced by a small molecule inhibitor of APC/CCdc20. Nature chemical biology 16 (5) (2020)
Lei-Lei Chen, Matthew D Smith, Lei Lv, Tadashi Nakagawa, Zhijun Li, Shao-Cong Sun, Nicholas G Brown, Yue Xiong, Yan-Ping Xu
USP15 suppresses tumor immunity via deubiquitylation and inactivation of TET2. Science advances 6 (38) (2020)

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Publication Activity (10 Years)

Top Topics

Top Venues

Nicholas G Brown