Gang Greg Wang (Weida Gong, Gang G Wang)

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Publication Activity (10 Years)

Years Active: 2014-2024
Publications (10 Years): 49

Top Venues

Nature communications

Oncogene

Blood

Nucleic acids research

University of North Carolina System

University of California San Diego (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of North Carolina System Jun 01 2018

United States

Associate Prof :: Biochemistry & Biophysics; Lineberger Comprehensive Cancer Center

University of North Carolina at Chapel Hill Jan 08 2012 - Jun 01 2018

United States

Assistant Professor :: Biochemistry & Biophysics; Lineberger Comprehensive Cancer Center

Education History

University of California San Diego Aug 28 2000 - Oct 06 2006

United States

PHD :: Biomedical Sciences

Fudan University - Shanghai Cancer Institute Aug 08 1997 - Jun 06 2000

China

MSC :: State Key Laboratory of Oncogenes & Related Genes

Fudan University Aug 01 1993 - Jun 01 1997

China

BSC :: School of Life Sciences- Department of Biochemistry

Publications

I-Hsin Cheng, Wen-Chieh Pi, Chung-Hao Hsu, Yiran Guo, Jun-Lin Lai, Gang Greg Wang, Bon-Chu Chung, Robert G Roeder, Wei-Yi Chen
TAF2, within the TFIID complex, regulates the expression of a subset of protein-coding genes. Cell death discovery 10 (1) (2024)
Xinyi Chen, Yiran Guo, Ting Zhao, Jiuwei Lu, Jian Fang, Yinsheng Wang, Gang Greg Wang, Jikui Song
Structural basis for the H2AK119ub1-specific DNMT3A-nucleosome interaction. Nature communications 15 (1) (2024)
I-Hsin Cheng, Wen-Chieh Pi, Chung-Hao Hsu, Yiran Guo, Jun-Lin Lai, Gang Greg Wang, Bon-Chu Chung, Robert G Roeder, Wei-Yi Chen
TAF2, within the TFIID complex, regulates the expression of a subset of protein-coding genes. Cell death discovery 10 (1) (2024)
Jiuwei Lu, Yiran Guo, Jiekai Yin, Jianbin Chen, Yinsheng Wang, Gang Greg Wang, Jikui Song
Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations. Nature communications 15 (1) (2024)
Jiuwei Lu, Yiran Guo, Jiekai Yin, Jianbin Chen, Yinsheng Wang, Gang Greg Wang, Jikui Song
Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations. Nature communications 15 (1) (2024)
Jiuwei Lu, Yiran Guo, Jiekai Yin, Jianbin Chen, Yinsheng Wang, Gang Greg Wang, Jikui Song
Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations. Nature communications 15 (1) (2024)
Xinyi Chen, Yiran Guo, Ting Zhao, Jiuwei Lu, Jian Fang, Yinsheng Wang, Gang Greg Wang, Jikui Song
Structural basis for the H2AK119ub1-specific DNMT3A-nucleosome interaction. Nature communications 15 (1) (2024)
I-Hsin Cheng, Wen-Chieh Pi, Chung-Hao Hsu, Yiran Guo, Jun-Lin Lai, Gang Greg Wang, Bon-Chu Chung, Robert G Roeder, Wei-Yi Chen
TAF2, within the TFIID complex, regulates the expression of a subset of protein-coding genes. Cell death discovery 10 (1) (2024)
Joshua Corbin, Xufen Yu, Jian Jin, Ling Cai, Gang Greg Wang
EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth. Oncogene (2024)
Jiuwei Lu, Yiran Guo, Jiekai Yin, Jianbin Chen, Yinsheng Wang, Gang Greg Wang, Jikui Song
Structure-guided functional suppression of AML-associated DNMT3A hotspot mutations. Nature communications 15 (1) (2024)
Xinyi Chen, Yiran Guo, Ting Zhao, Jiuwei Lu, Jian Fang, Yinsheng Wang, Gang Greg Wang, Jikui Song
Structural basis for the H2AK119ub1-specific DNMT3A-nucleosome interaction. Nature communications 15 (1) (2024)
Joshua Corbin, Xufen Yu, Jian Jin, Ling Cai, Gang Greg Wang
EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth. Oncogene 43 (36) (2024)
Xinyi Chen, Yiran Guo, Ting Zhao, Jiuwei Lu, Jian Fang, Yinsheng Wang, Gang Greg Wang, Jikui Song
Structural basis for the H2AK119ub1-specific DNMT3A-nucleosome interaction. Nature communications 15 (1) (2024)
Xufen Yu, Jun Wang, Weida Gong, Anqi Ma, Yudao Shen, Chengwei Zhang, Xijuan Liu, Ling Cai, Jing Liu, Gang Greg Wang, Jian Jin
Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene (2023)
Ping Chi, Peter W Lewis, Andrew O M Wilkie, Janice Lu, Alexander J Ruthenburg, Benjamin R Sabari, David Shechter, Liling Wan, Gang Greg Wang
Charles David Allis (1951-2023). Nature genetics (2023)
Xufen Yu, Jun Wang, Weida Gong, Anqi Ma, Yudao Shen, Chengwei Zhang, Xijuan Liu, Ling Cai, Jing Liu, Gang Greg Wang, Jian Jin
Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene (2023)
Ling Cai, Gang Greg Wang
Through the lens of phase separation: intrinsically unstructured protein and chromatin looping. Nucleus (Austin, Tex.) 14 (1) (2023)
Xufen Yu, Jun Wang, Weida Gong, Anqi Ma, Yudao Shen, Chengwei Zhang, Xijuan Liu, Ling Cai, Jing Liu, Gang Greg Wang, Jian Jin
Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene 42 (13) (2023)
Shuai Zhao, Jiuwei Lu, Bo Pan, Huitao Fan, Stephanie D Byrum, Chenxi Xu, Arum Kim, Yiran Guo, Krishna L Kanchi, Weida Gong, Tongyu Sun, Aaron J Storey, Nathaniel T Burkholder, Samuel G Mackintosh, Peyton C Kuhlers, Ricky D Edmondson, Brian D Strahl, Yarui Diao, Alan J Tackett, Jesse R Raab, Ling Cai, Jikui Song, Gang Greg Wang
TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons. Nature (2023)
Ronan P Hanley, David Y Nie, John R Tabor, Fengling Li, Amin Sobh, Chenxi Xu, Natalie K Barker, David Dilworth, Taraneh Hajian, Elisa Gibson, Magdalena M Szewczyk, Peter J Brown, Dalia Barsyte-Lovejoy, Laura E Herring, Gang Greg Wang, Jonathan D Licht, Masoud Vedadi, Cheryl H Arrowsmith, Lindsey I James
Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. Journal of the American Chemical Society (2023)
Ling Cai, Gang Greg Wang
Through the lens of phase separation: intrinsically unstructured protein and chromatin looping. Nucleus (Austin, Tex.) 14 (1) (2023)
Ling Cai, Gang Greg Wang
Through the lens of phase separation: intrinsically unstructured protein and chromatin looping. Nucleus (Austin, Tex.) 14 (1) (2023)
Xufen Yu, Jun Wang, Weida Gong, Anqi Ma, Yudao Shen, Chengwei Zhang, Xijuan Liu, Ling Cai, Jing Liu, Gang Greg Wang, Jian Jin
Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene (2023)
Xufen Yu, Jun Wang, Weida Gong, Anqi Ma, Yudao Shen, Chengwei Zhang, Xijuan Liu, Ling Cai, Jing Liu, Gang Greg Wang, Jian Jin
Dissecting and targeting noncanonical functions of EZH2 in multiple myeloma via an EZH2 degrader. Oncogene (2023)
Tyler A Herek, Alyssa Bouska, Waseem Lone, Sunandini Sharma, Catalina Amador, Tayla B Heavican-Foral, Yuping Li, Qi Wei, Dylan Jochum, Timothy C Greiner, Lynette M Smith, Stefano A Pileri, Andrew L Feldman, Andreas Rosenwald, German Ott, Soon Thye Lim, Choon-Kiat Ong, Joo Song, Elaine S Jaffe, Gang Greg Wang, Louis Staudt, Lisa M Rimsza, Julie M Vose, Francesco d'Amore, Dennis D Weisenburger, Wing C Chan, Javeed Iqbal
DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T cells in PTCL-NOS. Blood 140 (11) (2022)
Xijuan Liu, Jun Wang, Joshua A Boyer, Weida Gong, Shuai Zhao, Ling Xie, Qiong Wu, Cheng Zhang, Kanishk Jain, Yiran Guo, Javier Rodriguez, Mingjie Li, Hidetaka Uryu, Chengheng Liao, Lianxin Hu, Jin Zhou, Xiaobing Shi, Yi-Hsuan Tsai, Qin Yan, Weibo Luo, Xian Chen, Brian D Strahl, Alex von Kriegsheim, Qi Zhang, Gang Greg Wang, Albert S Baldwin, Yang Zhang
Histone H3 proline 16 hydroxylation regulates mammalian gene expression. Nature genetics 54 (11) (2022)
Jun Wang, Xufen Yu, Weida Gong, Xijuan Liu, Kwang-Su Park, Anqi Ma, Yi-Hsuan Tsai, Yudao Shen, Takashi Onikubo, Wen-Chieh Pi, David F Allison, Jing Liu, Wei-Yi Chen, Ling Cai, Robert G Roeder, Jian Jin, Gang Greg Wang
EZH2 noncanonically binds cMyc and p300 through a cryptic transactivation domain to mediate gene activation and promote oncogenesis. Nature cell biology 24 (3) (2022)
Jun Wang, Kwang-Su Park, Xufen Yu, Weida Gong, H Shelton Earp, Gang Greg Wang, Jian Jin, Ling Cai
A cryptic transactivation domain of EZH2 binds AR and AR's splice variant, promoting oncogene activation and tumorous transformation. Nucleic acids research 50 (19) (2022)
Fanye Meng, Chenxi Xu, Kwang-Su Park, Husnu Ümit Kaniskan, Gang Greg Wang, Jian Jin
Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos. Journal of medicinal chemistry 65 (15) (2022)
Dongxu Li, Xufen Yu, Jithesh Kottur, Weida Gong, Zhao Zhang, Aaron J Storey, Yi-Hsuan Tsai, Hidetaka Uryu, Yudao Shen, Stephanie D Byrum, Rick D Edmondson, Samuel G Mackintosh, Ling Cai, Zhijie Liu, Aneel K Aggarwal, Alan J Tackett, Jing Liu, Jian Jin, Gang Greg Wang
Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic. Oncogene 41 (24) (2022)
Zhihong Ren, Arum Kim, Yu-Ting Huang, Wen-Chieh Pi, Weida Gong, Xufen Yu, Jun Qi, Jian Jin, Ling Cai, Robert G Roeder, Wei-Yi Chen, Gang Greg Wang
A PRC2-Kdm5b axis sustains tumorigenicity of acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America 119 (9) (2022)
Linfeng Gao, Yiran Guo, Mahamaya Biswal, Jiuwei Lu, Jiekai Yin, Jian Fang, Xinyi Chen, Zengyu Shao, Mengjiang Huang, Yinsheng Wang, Gang Greg Wang, Jikui Song
Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations. Nature communications 13 (1) (2022)
Xufen Yu, Dongxu Li, Jithesh Kottur, Yudao Shen, Huen Suk Kim, Kwang-Su Park, Yi-Hsuan Tsai, Weida Gong, Jun Wang, Kyogo Suzuki, Joel S Parker, Laura E Herring, Husnu Ümit Kaniskan, Ling Cai, Rinku Jain, Jing Liu, Aneel K Aggarwal, Gang Greg Wang, Jian Jin
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Science translational medicine 13 (613) (2021)
Chenxi Xu, Yi-Hsuan Tsai, Phillip M Galbo, Gang Greg Wang, Aaron J Storey, Yuemei Xu, Stephanie D Byrum, Lingfan Xu, Young E Whang, Joel S Parker, Samuel G Mackintosh, Ricky D Edmondson, Alan J Tackett, Jiaoti Huang, Deyou Zheng, H Shelton Earp, Gang Greg Wang, Ling Cai
Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer. Nucleic acids research 49 (9) (2021)
Wendan Ren, Huitao Fan, Sara A Grimm, Jae Jin Kim, Linhui Li, Yiran Guo, Christopher James Petell, Xiao-Feng Tan, Zhi-Min Zhang, John P Coan, Jiekai Yin, Dae In Kim, Linfeng Gao, Ling Cai, Nelli Khudaverdyan, Burak Çetin, Dinshaw J Patel, Yinsheng Wang, Qiang Cui, Brian D Strahl, Or Gozani, Kyle M Miller, Seán E O'Leary, Paul A Wade, Gang Greg Wang, Jikui Song
DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation. Nature communications 12 (1) (2021)
Huitao Fan, Yiran Guo, Yi-Hsuan Tsai, Aaron J Storey, Arum Kim, Weida Gong, Ricky D Edmondson, Samuel G Mackintosh, Haitao Li, Stephanie D Byrum, Alan J Tackett, Ling Cai, Gang Greg Wang
A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing. Nucleic acids research 49 (8) (2021)
Jeong Hyun Ahn, Eric S Davis, Timothy A Daugird, Shuai Zhao, Ivana Yoseli Quiroga-Barber, Hidetaka Uryu, Jie Li, Aaron J Storey, Yi-Hsuan Tsai, Daniel P Keeley, Samuel G Mackintosh, Ricky D Edmondson, Stephanie D Byrum, Ling Cai, Alan J Tackett, Deyou Zheng, Wesley R Legant, Douglas H Phanstiel, Gang Greg Wang
Phase separation drives aberrant chromatin looping and cancer development. Nature 595 (7868) (2021)
Shuai Zhao, C David Allis, Gang Greg Wang
The language of chromatin modification in human cancers. Nature reviews. Cancer 21 (7) (2021)
Jieli Wei, Fanye Meng, Kwang-Su Park, Hyerin Yim, Julia Velez, Prashasti Kumar, Li Wang, Ling Xie, He Chen, Yudao Shen, Emily Teichman, Dongxu Li, Gang Greg Wang, Xian Chen, Husnu Ümit Kaniskan, Jian Jin
Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation. Journal of the American Chemical Society 143 (37) (2021)
Jie Li, Phillip M Galbo, Weida Gong, Aaron J Storey, Yi-Hsuan Tsai, Xufen Yu, Jeong Hyun Ahn, Yiran Guo, Samuel G Mackintosh, Ricky D Edmondson, Stephanie D Byrum, Jason E Farrar, Shenghui He, Ling Cai, Jian Jin, Alan J Tackett, Deyou Zheng, Gang Greg Wang
ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism. Nature communications 12 (1) (2021)
Wendan Ren, Huitao Fan, Sara A Grimm, Yiran Guo, Jae Jin Kim, Jiekai Yin, Linhui Li, Christopher J Petell, Xiao-Feng Tan, Zhi-Min Zhang, John P Coan, Linfeng Gao, Ling Cai, Brittany Detrick, Burak Çetin, Qiang Cui, Brian D Strahl, Or Gozani, Yinsheng Wang, Kyle M Miller, Seán E O'Leary, Paul A Wade, Dinshaw J Patel, Gang Greg Wang, Jikui Song
Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation. Proceedings of the National Academy of Sciences of the United States of America 117 (31) (2020)
Huitao Fan, Jiuwei Lu, Yiran Guo, Dongxu Li, Zhi-Min Zhang, Yi-Hsuan Tsai, Wen-Chieh Pi, Jeong Hyun Ahn, Weida Gong, Yu Xiang, David F Allison, Huimin Geng, Shenghui He, Yarui Diao, Wei-Yi Chen, Brian D Strahl, Ling Cai, Jikui Song, Gang Greg Wang
BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. Nature genetics 52 (12) (2020)
Yi Zhang, Yiran Guo, Sheryl M Gough, Jinyong Zhang, Kendra R Vann, Kuai Li, Ling Cai, Xiaobing Shi, Peter D Aplan, Gang Greg Wang, Tatiana G Kutateladze
Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion. Nature communications 11 (1) (2020)
Linfeng Gao, Max Emperle, Yiran Guo, Sara A Grimm, Wendan Ren, Sabrina Adam, Hidetaka Uryu, Zhi-Min Zhang, Dongliang Chen, Jiekai Yin, Michael Dukatz, Hiwot Anteneh, Renata Z Jurkowska, Jiuwei Lu, Yinsheng Wang, Pavel Bashtrykov, Paul A Wade, Gang Greg Wang, Albert Jeltsch, Jikui Song
Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms. Nature communications 11 (1) (2020)
Jun Wang, Gang Greg Wang
No Easy Way Out for EZH2: Its Pleiotropic, Noncanonical Effects on Gene Regulation and Cellular Function. International journal of molecular sciences 21 (24) (2020)
Dinuka De Silva, Zhentao Zhang, Yuanbo Liu, Joel S Parker, Chenxi Xu, Ling Cai, Gang Greg Wang, H Shelton Earp, Young E Whang
Interaction between androgen receptor and coregulator SLIRP is regulated by Ack1 tyrosine kinase and androgen. Scientific reports 9 (1) (2019)
Zhihong Ren, Jeong Hyun Ahn, Hequn Liu, Yi-Hsuan Tsai, Natarajan V Bhanu, Brian Koss, David F Allison, Anqi Ma, Aaron J Storey, Ping Wang, Samuel G Mackintosh, Ricky D Edmondson, Richard W J Groen, Anton C Martens, Benjamin A Garcia, Alan J Tackett, Jian Jin, Ling Cai, Deyou Zheng, Gang Greg Wang
PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation. Blood 134 (14) (2019)
Wendan Ren, Jiuwei Lu, Mengjiang Huang, Linfeng Gao, Dongxu Li, Gang Greg Wang, Jikui Song
Structure and regulation of ZCCHC4 in m6A-methylation of 28S rRNA. Nature communications 10 (1) (2019)
Bing Wu, Yunqi Wang, Chaojun Wang, Gang Greg Wang, Jie Wu, Yisong Y Wan
BPTF Is Essential for T Cell Homeostasis and Function. Journal of immunology (Baltimore, Md. : 1950) 197 (11) (2016)
Gang Greg Wang, Kyle D Konze, Jianguo Tao
Polycomb genes, miRNA, and their deregulation in B-cell malignancies. Blood 125 (8) (2015)
Bowen Xu, Doan M On, Anqi Ma, Trevor Parton, Kyle D Konze, Samantha G Pattenden, David F Allison, Ling Cai, Shira Rockowitz, Shichong Liu, Ying Liu, Fengling Li, Masoud Vedadi, Stephen V Frye, Benjamin A Garcia, Deyou Zheng, Jian Jin, Gang Greg Wang
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood 125 (2) (2014)

Gang Greg Wang.css-eqlu8i{font-size:small;padding-left:4px;} (Weida Gong, Gang G Wang)

Publication Activity (10 Years)

Top Topics

Top Venues

Gang Greg Wang (Weida Gong, Gang G Wang)