Benedict-Tilmann Berger (Benedict-Tilman Berger)

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 42

Top Venues

Journal of medicinal chemistry

ACS chemical biology

Nature chemical biology

ChemMedChem

Structural Genomics Consortium Frankfurt

Goethe-Universität Frankfurt am Main Fachbereich 14 Biochemie Chemie und Pharmazie (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Structural Genomics Consortium Frankfurt Oct 27 2016

Germany

PhD Student :: Pharmaceutical Chemistry

Bayer Healthcare Pharmaceuticals Research and Development Berlin May 01 2016 - Jul 31 2016

Germany

Master Internship :: Lead Discovery Berlin, Structural Biology

Structural Genomics Consortium Oct 01 2015 - Mar 31 2016

United Kingdom

Master Thesis :: Structural Biology

Bayer Healthcare Pharmaceuticals Research and Development Berlin Oct 01 2014 - Dec 31 2014

Germany

Master Internship :: Lead Discovery Berlin, Screening

Bayer Healthcare Pharmaceuticals Research and Development Berlin Mar 01 2014 - Jul 31 2014

Germany

Internship and Bachelor Thesis :: Lead Discovery Berlin, Screening

Education History

Goethe-Universität Frankfurt am Main Fachbereich 14 Biochemie Chemie und Pharmazie Oct 27 2016

Germany

PHD :: Structural Genomics Consortium, Pharmaceutical Chemistry

Freie Universität Berlin Fachbereich Biologie Chemie Pharmazie Oct 01 2014 - Oct 01 2016

Germany

MSC :: Biochemistry

Freie Universität Berlin Fachbereich Biologie Chemie Pharmazie Oct 01 2011 - Oct 01 2014

Germany

BSC :: Biochemistry

Publications

Marcel Rak, Amelie Menge, Roberta Tesch, Lena M Berger, Dimitrios-Ilias Balourdas, Ekaterina Shevchenko, Andreas Krämer, Lewis Elson, Benedict-Tilmann Berger, Ismahan Abdi, Laurenz M Wahl, Antti Poso, Astrid Kaiser, Thomas Hanke, Thales Kronenberger, Andreas C Joerger, Susanne Müller, Stefan Knapp
Development of Selective Pyrido[2,3- d ]pyrimidin-7(8 H )-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. Journal of medicinal chemistry 67 (5) (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena Marie Berger, Benedict-Tilmann Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. Journal of medicinal chemistry 67 (15) (2024)
Marcel Rak, Amelie Menge, Roberta Tesch, Lena M Berger, Dimitrios-Ilias Balourdas, Ekaterina Shevchenko, Andreas Krämer, Lewis Elson, Benedict-Tilmann Berger, Ismahan Abdi, Laurenz M Wahl, Antti Poso, Astrid Kaiser, Thomas Hanke, Thales Kronenberger, Andreas C Joerger, Susanne Müller, Stefan Knapp
Development of Selective Pyrido[2,3- d ]pyrimidin-7(8 H )-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. Journal of medicinal chemistry (2024)
Nicolas Bauer, Dimitrios-Ilias Balourdas, Joel R Schneider, Xin Zhang, Lena Marie Berger, Benedict-Tilmann Berger, Martin Peter Schwalm, Nick A Klopp, Jens T Siveke, Stefan Knapp, Andreas C Joerger
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. ACS chemical biology (2024)
Nicolas Bauer, Dimitrios-Ilias Balourdas, Joel R Schneider, Xin Zhang, Lena Marie Berger, Benedict-Tilmann Berger, Martin Peter Schwalm, Nick A Klopp, Jens T Siveke, Stefan Knapp, Andreas C Joerger
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. ACS chemical biology 19 (2) (2024)
Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Jong Fu Wong, Julien Cros, Eleanor Williams, Lap Hang Tse, David Smil, Deeba Ensan, Methvin B Isaac, Rima Al-Awar, Regina Gomolková, Vlad-Constantin Ursachi, Bohumil Fafílek, Zuzana Kahounová, Ráchel Víchová, Ondřej Vacek, Benedict-Tilmann Berger, Carrow I Wells, Cesear R Corona, James D Vasta, Matthew B Robers, Pavel Krejci, Karel Souček, Alex N Bullock, Stefan Knapp, Kamil Paruch
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2. Journal of medicinal chemistry (2024)
Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Jong Fu Wong, Julien Cros, Eleanor Williams, Lap Hang Tse, David Smil, Deeba Ensan, Methvin B Isaac, Rima Al-Awar, Regina Gomolková, Vlad-Constantin Ursachi, Bohumil Fafílek, Zuzana Kahounová, Ráchel Víchová, Ondřej Vacek, Benedict-Tilmann Berger, Carrow I Wells, Cesear R Corona, James D Vasta, Matthew B Robers, Pavel Krejci, Karel Souček, Alex N Bullock, Stefan Knapp, Kamil Paruch
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2. Journal of medicinal chemistry 67 (15) (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena Marie Berger, Benedict-Tilmann Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. Journal of medicinal chemistry (2024)
Nicolas Bauer, Dimitrios-Ilias Balourdas, Joel R Schneider, Xin Zhang, Lena Marie Berger, Benedict-Tilmann Berger, Martin Peter Schwalm, Nick A Klopp, Jens T Siveke, Stefan Knapp, Andreas C Joerger
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. ACS chemical biology 19 (2) (2024)
Nicolas Bauer, Dimitrios-Ilias Balourdas, Joel R Schneider, Xin Zhang, Lena Marie Berger, Benedict-Tilmann Berger, Martin Peter Schwalm, Nick A Klopp, Jens T Siveke, Stefan Knapp, Andreas C Joerger
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. ACS chemical biology 19 (2) (2024)
Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Jong Fu Wong, Julien Cros, Eleanor Williams, Lap Hang Tse, David Smil, Deeba Ensan, Methvin B Isaac, Rima Al-Awar, Regina Gomolková, Vlad-Constantin Ursachi, Bohumil Fafílek, Zuzana Kahounová, Ráchel Víchová, Ondřej Vacek, Benedict-Tilmann Berger, Carrow I Wells, Cesear R Corona, James D Vasta, Matthew B Robers, Pavel Krejci, Karel Souček, Alex N Bullock, Stefan Knapp, Kamil Paruch
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2. Journal of medicinal chemistry 67 (15) (2024)
Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Jong Fu Wong, Julien Cros, Eleanor Williams, Lap Hang Tse, David Smil, Deeba Ensan, Methvin B Isaac, Rima Al-Awar, Regina Gomolková, Vlad-Constantin Ursachi, Bohumil Fafílek, Zuzana Kahounová, Ráchel Víchová, Ondřej Vacek, Benedict-Tilmann Berger, Carrow I Wells, Cesear R Corona, James D Vasta, Matthew B Robers, Pavel Krejci, Karel Souček, Alex N Bullock, Stefan Knapp, Kamil Paruch
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2. Journal of medicinal chemistry 67 (15) (2024)
Marcel Rak, Amelie Menge, Roberta Tesch, Lena M Berger, Dimitrios-Ilias Balourdas, Ekaterina Shevchenko, Andreas Krämer, Lewis Elson, Benedict-Tilmann Berger, Ismahan Abdi, Laurenz M Wahl, Antti Poso, Astrid Kaiser, Thomas Hanke, Thales Kronenberger, Andreas C Joerger, Susanne Müller, Stefan Knapp
Development of Selective Pyrido[2,3- d ]pyrimidin-7(8 H )-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors. Journal of medicinal chemistry 67 (5) (2024)
Nicolas Bauer, Dimitrios-Ilias Balourdas, Joel R Schneider, Xin Zhang, Lena Marie Berger, Benedict-Tilmann Berger, Martin Peter Schwalm, Nick A Klopp, Jens T Siveke, Stefan Knapp, Andreas C Joerger
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. ACS chemical biology 19 (2) (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena Marie Berger, Benedict-Tilmann Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. Journal of medicinal chemistry 67 (15) (2024)
Václav Němec, Marek Remeš, Petr Beňovský, Michael C Böck, Eliška Šranková, Jong Fu Wong, Julien Cros, Eleanor Williams, Lap Hang Tse, David Smil, Deeba Ensan, Methvin B Isaac, Rima Al-Awar, Regina Gomolková, Vlad-Constantin Ursachi, Bohumil Fafílek, Zuzana Kahounová, Ráchel Víchová, Ondřej Vacek, Benedict-Tilmann Berger, Carrow I Wells, Cesear R Corona, James D Vasta, Matthew B Robers, Pavel Krejci, Karel Souček, Alex N Bullock, Stefan Knapp, Kamil Paruch
Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2. Journal of medicinal chemistry 67 (15) (2024)
Nicolas Bauer, Dimitrios-Ilias Balourdas, Joel R Schneider, Xin Zhang, Lena Marie Berger, Benedict-Tilmann Berger, Martin Peter Schwalm, Nick A Klopp, Jens T Siveke, Stefan Knapp, Andreas C Joerger
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization. ACS chemical biology 19 (2) (2024)
Joshua Gerninghaus, Rezart Zhubi, Andreas Krämer, Marwah Karim, Do Hoang Nhu Tran, Andreas C Joerger, Christian Schreiber, Lena Marie Berger, Benedict-Tilmann Berger, Theresa A L Ehret, Lewis Elson, Christopher Lenz, Krishna Saxena, Susanne Müller, Shirit Einav, Stefan Knapp, Thomas Hanke
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors. Journal of medicinal chemistry (2024)
Jennifer Alisa Amrhein, Lena Marie Berger, Dimitrios-Ilias Balourdas, Andreas C Joerger, Amelie Menge, Andreas Krämer, Julia Marie Frischkorn, Benedict-Tilmann Berger, Lewis Elson, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. Journal of medicinal chemistry (2023)
Jennifer Alisa Amrhein, Lena Marie Berger, Dimitrios-Ilias Balourdas, Andreas C Joerger, Amelie Menge, Andreas Krämer, Julia Marie Frischkorn, Benedict-Tilmann Berger, Lewis Elson, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. Journal of medicinal chemistry 67 (1) (2023)
Jennifer Alisa Amrhein, Lena Marie Berger, Dimitrios-Ilias Balourdas, Andreas C Joerger, Amelie Menge, Andreas Krämer, Julia Marie Frischkorn, Benedict-Tilmann Berger, Lewis Elson, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. Journal of medicinal chemistry 67 (1) (2023)
Jennifer A Amrhein, Guiqun Wang, Benedict-Tilmann Berger, Lena Marie Berger, Amalia D Kalampaliki, Andreas Krämer, Stefan Knapp, Thomas Hanke
Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2. ACS medicinal chemistry letters 14 (6) (2023)
Jennifer Alisa Amrhein, Lena Marie Berger, Dimitrios-Ilias Balourdas, Andreas C Joerger, Amelie Menge, Andreas Krämer, Julia Marie Frischkorn, Benedict-Tilmann Berger, Lewis Elson, Astrid Kaiser, Manfred Schubert-Zsilavecz, Susanne Müller, Stefan Knapp, Thomas Hanke
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3. Journal of medicinal chemistry 67 (1) (2023)
Maria Reinecke, Paul D Brear, Larsen Vornholz, Benedict-Tilmann Berger, Florian Seefried, Stephanie Wilhelm, Patroklos Samaras, Laszlo Gyenis, David William Litchfield, Guillaume Médard, Susanne Müller, Jürgen Ruland, Marko Hyvönen, Mathias Wilhelm, Bernhard Kuster
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors. Nature chemical biology (2023)
Claudia Tredup, Benardina Ndreshkjana, Natalie S Schneider, Amelie Tjaden, Aurino M Kemas, Sonia Youhanna, Volker Martin Lauschke, Benedict-Tilmann Berger, Andreas Krämer, Lena Marie Berger, Sandra Röhm, Stefan Knapp, Henner F Farin, Susanne Müller
Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum. ACS chemical biology (2023)
Sandrine Baltzer, Timur Bulatov, Christopher Schmied, Andreas Krämer, Benedict-Tilmann Berger, Andreas Oder, Ryan Walker-Gray, Christin Kuschke, Kerstin Zühlke, Jenny Eichhorst, Martin Lehmann, Stefan Knapp, John Weston, Jens Peter von Kries, Roderich D Süssmuth, Enno Klussmann
Aurora Kinase A Is Involved in Controlling the Localization of Aquaporin-2 in Renal Principal Cells. International journal of molecular sciences 23 (2) (2022)
Martin Schröder, Matthias Leiendecker, Ulrich Grädler, Juliane Braun, Andreas Blum, Marek Wanior, Benedict-Tilmann Berger, Andreas Krämer, Susanne Müller, Christina Esdar, Stefan Knapp, Timo Heinrich
MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core. Journal of medicinal chemistry 66 (1) (2022)
Christian G Kurz, Franziska Preuss, Amelie Tjaden, Martin Cusack, Jennifer Alisa Amrhein, Deep Chatterjee, Sebastian Mathea, Lena Marie Berger, Benedict-Tilmann Berger, Andreas Krämer, Michael Weller, Tobias Weiss, Susanne Müller, Stefan Knapp, Thomas Hanke
Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5- a ]pyrimidine-Based Macrocycles. Journal of medicinal chemistry 65 (11) (2022)
Thomas Hanke, Sebastian Mathea, Julia Woortman, Eidarus Salah, Benedict-Tilmann Berger, Anthony Tumber, Risa Kashima, Akiko Hata, Bernhard Kuster, Susanne Müller, Stefan Knapp
Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. Journal of medicinal chemistry 65 (19) (2022)
Aziz M Rangwala, Benedict-Tilmann Berger, Matthew B Robers, Stefan Knapp, Markus A Seeliger
Resistance to kinase inhibition through shortened target engagement. Molecular & cellular oncology 9 (1) (2022)
Martin Schröder, Matthias Leiendecker, Ulrich Grädler, Juliane Braun, Andreas Blum, Marek Wanior, Benedict-Tilmann Berger, Andreas Krämer, Susanne Müller, Christina Esdar, Stefan Knapp, Timo Heinrich
MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core. Journal of medicinal chemistry 66 (1) (2022)
Milan Hluchý, Pavla Gajdušková, Ruiz De Los Mozos Igor, Michal Rájecký, Michael Kluge, Benedict-Tilmann Berger, Zuzana Slabá, David Potěšil, Elena Weiβ, Jernej Ule, Zbyněk Zdráhal, Stefan Knapp, Kamil Paruch, Caroline C Friedel, Dalibor Blazek
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1. Nature 609 (7928) (2022)
Martin Schröder, Matthias Leiendecker, Ulrich Grädler, Juliane Braun, Andreas Blum, Marek Wanior, Benedict-Tilmann Berger, Andreas Krämer, Susanne Müller, Christina Esdar, Stefan Knapp, Timo Heinrich
MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core. Journal of medicinal chemistry 66 (1) (2022)
Martin Schröder, Matthias Leiendecker, Ulrich Grädler, Juliane Braun, Andreas Blum, Marek Wanior, Benedict-Tilmann Berger, Andreas Krämer, Susanne Müller, Christina Esdar, Stefan Knapp, Timo Heinrich
MSC-1186, a Highly Selective Pan-SRPK Inhibitor Based on an Exceptionally Decorated Benzimidazole-Pyrimidine Core. Journal of medicinal chemistry (2022)
Ricardo A M Serafim, Fiona J Sorrell, Benedict-Tilmann Berger, Ross J Collins, Stanley N S Vasconcelos, Katlin B Massirer, Stefan Knapp, James Bennett, Oleg Fedorov, Hitesh Patel, William J Zuercher, Jonathan M Elkins
Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold. Journal of medicinal chemistry 64 (18) (2021)
Florian Wittlinger, David E Heppner, Ciric To, Marcel Günther, Bo Hee Shin, Jaimin K Rana, Anna M Schmoker, Tyler S Beyett, Lena Marie Berger, Benedict-Tilmann Berger, Nicolas Bauer, James D Vasta, Cesear R Corona, Matthew B Robers, Stefan Knapp, Pasi A Jänne, Michael J Eck, Stefan A Laufer
Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. Journal of medicinal chemistry (2021)
Roberta Tesch, Marcel Rak, Monika Raab, Lena Marie Berger, Thales Kronenberger, Andreas C Joerger, Benedict-Tilmann Berger, Ismahan Abdi, Thomas Hanke, Antti Poso, Klaus Strebhardt, Mourad Sanhaji, Stefan Knapp
Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors. Journal of medicinal chemistry 64 (12) (2021)
Martin Reynders, Apirat Chaikuad, Benedict-Tilmann Berger, Katharina Bauer, Pierre Koch, Stefan A Laufer, Stefan Knapp, Dirk H Trauner
Controlling the Covalent Reactivity of a Kinase Inhibitor with Light. Angewandte Chemie (International ed. in English) 60 (37) (2021)
Sandra Röhm, Benedict-Tilmann Berger, Martin Schröder, Deep Chatterjee, Sebastian Mathea, Andreas C Joerger, Daniel M Pinkas, Joshua C Bufton, Amelie Tjaden, Lohitesh Kovooru, Mark Kudolo, Christian Pohl, Alex N Bullock, Susanne Müller, Stefan A Laufer, Stefan Knapp
Development of a Selective Dual Discoidin Domain Receptor (DDR)/p38 Kinase Chemical Probe. Journal of medicinal chemistry 64 (18) (2021)
Thomas Hanke, Jong Fu Wong, Benedict-Tilmann Berger, Ismahan Abdi, Lena Marie Berger, Roberta Tesch, Claudia Tredup, Alex N Bullock, Susanne Müller, Stefan Knapp
A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5. ACS chemical biology 15 (4) (2020)
Júlia G B Pedreira, Philipp Nahidino, Mark Kudolo, Tatu Pantsar, Benedict-Tilmann Berger, Michael Forster, Stefan Knapp, Stefan A Laufer, Eliezer Jesus Barreiro
Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors. Journal of medicinal chemistry 63 (13) (2020)
Alix Tröster, Stephanie Heinzlmeir, Benedict-Tilmann Berger, Santosh L Gande, Krishna Saxena, Sridhar Sreeramulu, Verena Linhard, Amir H Nasiri, Michael Bolte, Susanne Müller, Bernhard Kuster, Guillaume Médard, Denis Kudlinzki, Harald Schwalbe
NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. ChemMedChem 13 (16) (2018)

Benedict-Tilmann Berger (Benedict-Tilman Berger)

Publication Activity (10 Years)

Top Topics

Top Venues