Timothy M Willson

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 58

Top Venues

bioRxiv : the preprint server for biology

Journal of medicinal chemistry

Pharmaceuticals (Basel, Switzerland)

Nature communications

University of North Carolina at Chapel Hill

University of Southampton (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of North Carolina at Chapel Hill

United States

Research Professor :: School of Pharmacy

GlaxoSmithKline

United States

Director :: Chemical Biology

Merck Sharpe & Dhome

United Kingdom

Research Scientist :: Chemistry

University of Illinois at Urbana-Champaign

United States

Post Doctoral Research Associate (Denmark group) :: Chemistry

Education History

University of Southampton

United Kingdom

PHD :: Chemistry

Publications

Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Holli-Joi Martin, Mohammad Anwar Hossain, James Wellnitz, Enes Kelestemur, Joshua E Hochuli, Sumera Parveen, Cheryl Arrowsmith, Timothy M Willson, Eugene N Muratov, Alexander Tropsha
Heli-SMACC: Helicase-targeting SMAll Molecule Compound Collection. bioRxiv : the preprint server for biology (2024)
Kesatebrhan Haile Asressu, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, James Wellnitz, Konstantin I Popov, Alison D Axtman, Timothy M Willson
Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity. Pharmaceuticals (Basel, Switzerland) 17 (3) (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Kesatebrhan Haile Asressu, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, James Wellnitz, Konstantin I Popov, Alison D Axtman, Timothy M Willson
Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity. Pharmaceuticals (Basel, Switzerland) 17 (3) (2024)
Kesatebrhan Haile Asressu, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, James Wellnitz, Konstantin I Popov, Alison D Axtman, Timothy M Willson
Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity. Pharmaceuticals (Basel, Switzerland) 17 (3) (2024)
James Wellnitz, Holli-Joi Sullivan, Mohammad Anwar Hossain, Marielle Rath, Colton Fox, Konstantin I Popov, Timothy M Willson, Eugene N Muratov, Alexander Trospsha
STOPLIGHT: A Hit Scoring Calculator. Journal of chemical information and modeling (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Sharon Taft-Benz, Stefanie Howell, Rebekah J Dickmander, Tammy M Havener, Marcia K Sanders, Jason W Brown, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2. Molecules (Basel, Switzerland) 29 (17) (2024)
Anirban Ghoshal, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Peter J Brown, Eric M Merten, John D Sears, Sumera Perveen, Kenneth H Pearce, Konstantin I Popov, Nathaniel J Moorman, Mark T Heise, Timothy M Willson
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Anti-alphavirus Activity. bioRxiv : the preprint server for biology (2024)
Kristina Edfeldt, Aled Morgan Edwards, Ola Engkvist, Judith Günther, Matthew Hartley, David G Hulcoop, Andrew R Leach, Brian D Marsden, Amelie Tjaden, Leonie Misquitta, Susanne Müller, Dafydd R Owen, Kristof T Schütt, Nicholas Skelton, Andreas Steffen, Alexander Trospsha, Erik Vernet, Yanli Wang, James Wellnitz, Timothy M Willson, Djork-Arné Clevert, Benjamin Haibe-Kains, Lovisa Holmberg Schiavone, Matthieu Schapira
A data science roadmap for open science organizations engaged in early-stage drug discovery. Nature communications 15 (1) (2024)
Anirban Ghoshal, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Peter J Brown, Eric M Merten, John D Sears, Sumera Perveen, Kenneth H Pearce, Konstantin I Popov, Nathaniel J Moorman, Mark T Heise, Timothy M Willson
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Anti-alphavirus Activity. bioRxiv : the preprint server for biology (2024)
Kristina Edfeldt, Aled Morgan Edwards, Ola Engkvist, Judith Günther, Matthew Hartley, David G Hulcoop, Andrew R Leach, Brian D Marsden, Amelie Tjaden, Leonie Misquitta, Susanne Müller, Dafydd R Owen, Kristof T Schütt, Nicholas Skelton, Andreas Steffen, Alexander Trospsha, Erik Vernet, Yanli Wang, James Wellnitz, Timothy M Willson, Djork-Arné Clevert, Benjamin Haibe-Kains, Lovisa Holmberg Schiavone, Matthieu Schapira
A data science roadmap for open science organizations engaged in early-stage drug discovery. Nature communications 15 (1) (2024)
Kristina Edfeldt, Aled Morgan Edwards, Ola Engkvist, Judith Günther, Matthew Hartley, David G Hulcoop, Andrew R Leach, Brian D Marsden, Amelie Tjaden, Leonie Misquitta, Susanne Müller, Dafydd R Owen, Kristof T Schütt, Nicholas Skelton, Andreas Steffen, Alexander Trospsha, Erik Vernet, Yanli Wang, James Wellnitz, Timothy M Willson, Djork-Arné Clevert, Benjamin Haibe-Kains, Lovisa Holmberg Schiavone, Matthieu Schapira
A data science roadmap for open science organizations engaged in early-stage drug discovery. Nature communications 15 (1) (2024)
Anirban Ghoshal, Álvaro F Magalhães, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Matthew H Todd, Timothy M Willson
Identification of Dihydropyrazolo[1,5- a ]pyrazin-4(5 H )-ones as Cyclic Products of β-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors. Pharmaceuticals (Basel, Switzerland) 17 (7) (2024)
Anirban Ghoshal, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Peter J Brown, Meganathan Nandakumar, Anand Vala, Eric M Merten, John D Sears, Isabella Law, Jane E Burdick, Noah L Morales, Sumera Perveen, Kenneth H Pearce, Konstantin I Popov, Nathaniel J Moorman, Mark T Heise, Timothy M Willson
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Antialphavirus Activity. Journal of medicinal chemistry (2024)
Anirban Ghoshal, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Peter J Brown, Eric M Merten, John D Sears, Sumera Perveen, Kenneth H Pearce, Konstantin I Popov, Nathaniel J Moorman, Mark T Heise, Timothy M Willson
Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Anti-alphavirus Activity. bioRxiv : the preprint server for biology (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Anirban Ghoshal, Álvaro F Magalhães, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Matthew H Todd, Timothy M Willson
Identification of Dihydropyrazolo[1,5- a ]pyrazin-4(5 H )-ones as Cyclic Products of β-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors. Pharmaceuticals (Basel, Switzerland) 17 (7) (2024)
Holli-Joi Martin, Mohammad Anwar Hossain, James Wellnitz, Enes Kelestemur, Joshua E Hochuli, Sumera Parveen, Cheryl Arrowsmith, Timothy M Willson, Eugene N Muratov, Alexander Tropsha
Heli-SMACC: Helicase-targeting SMAll Molecule Compound Collection. bioRxiv : the preprint server for biology (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry 67 (14) (2024)
Anirban Ghoshal, Álvaro F Magalhães, Kesatebrhan Haile Asressu, Mohammad Anwar Hossain, Matthew H Todd, Timothy M Willson
Identification of Dihydropyrazolo[1,5- a ]pyrazin-4(5 H )-ones as Cyclic Products of β-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors. Pharmaceuticals (Basel, Switzerland) 17 (7) (2024)
Han Wee Ong, Xuan Yang, Jeffery L Smith, Rebekah J Dickmander, Jason W Brown, Tammy M Havener, Sharon Taft-Benz, Stefanie Howell, Marcia K Sanders, Jacob L Capener, Rafael Miguez Couñago, Edcon Chang, Andreas Krämer, Nathaniel J Moorman, Mark Heise, Alison D Axtman, David Harold Drewry, Timothy M Willson
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication. Journal of medicinal chemistry (2024)
James Wellnitz, Holli-Joi Sullivan, Mohammad Anwar Hossain, Marielle Rath, Colton Fox, Konstantin I Popov, Timothy M Willson, Eugene N Muratov, Alexander Trospsha
STOPLIGHT: A Hit Scoring Calculator. Journal of chemical information and modeling 64 (11) (2024)
Eric M Merten, John D Sears, Tina M Leisner, Paul B Hardy, Anirban Ghoshal, Mohammad Anwar Hossain, Kesatebrhan Haile Asressu, Peter J Brown, Michael A Stashko, Laura Herring, Angie L Mordant, Thomas S Webb, Christine A Mills, Natalie K Barker, Zachary J Streblow, Sumera Perveen, Cheryl Arrowsmith, Jamie J Arnold, Craig E Cameron, Daniel N Streblow, Nathaniel J Moorman, Mark Heise, Timothy M Willson, Konstantin Popov, Kenneth H Pearce
Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach. bioRxiv : the preprint server for biology (2024)
Kesatebrhan Haile Asressu, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, James Wellnitz, Konstantin I Popov, Alison D Axtman, Timothy M Willson
Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity. Pharmaceuticals (Basel, Switzerland) 17 (3) (2024)
Xuan Yang, Jeffery L Smith, Michael T Beck, Jennifer M Wilkinson, Ani Michaud, James D Vasta, Matthew B Robers, Timothy M Willson
Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells. bioRxiv : the preprint server for biology (2023)
Kareem A Galal, Andreas Krämer, Benjamin G Strickland, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, Timothy M Willson
Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3. bioRxiv : the preprint server for biology (2023)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Kareem A Galal, Andreas Krämer, Benjamin G Strickland, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, Timothy M Willson
Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3. bioRxiv : the preprint server for biology (2023)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Suzanne Ackloo, Albert A Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex N Bullock, Ulrich A K Betz, Jark Böttcher, Peter J Brown, Menorca Chaturvedi, Alisa Crisp, Danette L Daniels, Jan Dreher, Kristina Edfeldt, Aled Morgan Edwards, Ursula Egner, Jon Elkins, Christian Fischer, Tine Glendorf, Steven Goldberg, Ingo V Hartung, Alexander Hillisch, Evert J Homan, Stefan Knapp, Markus Köster, Oliver Krämer, Josep Llaveria, Uta Lessel, Sven Lindemann, Lars Linderoth, Hisanori Matsui, Maurice Michel, Florian Montel, Anke Mueller-Fahrnow, Susanne Müller, Dafydd R Owen, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Wendy Sanderson, Cora Scholten, Matthieu Schapira, Sujata Sharma, Brock Shireman, Michael Sundström, Matthew H Todd, Claudia Tredup, Jennifer Venable, Timothy M Willson, Cheryl H Arrowsmith
Target 2035 - an update on private sector contributions. RSC medicinal chemistry 14 (6) (2023)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Suzanne Ackloo, Albert A Antolin, Jose Manuel Bartolome, Hartmut Beck, Alex N Bullock, Ulrich A K Betz, Jark Böttcher, Peter J Brown, Menorca Chaturvedi, Alisa Crisp, Danette L Daniels, Jan Dreher, Kristina Edfeldt, Aled Morgan Edwards, Ursula Egner, Jon Elkins, Christian Fischer, Tine Glendorf, Steven Goldberg, Ingo V Hartung, Alexander Hillisch, Evert J Homan, Stefan Knapp, Markus Köster, Oliver Krämer, Josep Llaveria, Uta Lessel, Sven Lindemann, Lars Linderoth, Hisanori Matsui, Maurice Michel, Florian Montel, Anke Mueller-Fahrnow, Susanne Müller, Dafydd R Owen, Kumar Singh Saikatendu, Vijayaratnam Santhakumar, Wendy Sanderson, Cora Scholten, Matthieu Schapira, Sujata Sharma, Brock Shireman, Michael Sundström, Matthew H Todd, Claudia Tredup, Jennifer Venable, Timothy M Willson, Cheryl H Arrowsmith
Target 2035 - an update on private sector contributions. RSC medicinal chemistry 14 (6) (2023)
Xuan Yang, Jeffery L Smith, Michael T Beck, Jennifer M Wilkinson, Ani Michaud, James D Vasta, Matthew B Robers, Timothy M Willson
Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells. bioRxiv : the preprint server for biology (2023)
Xuan Yang, Han Wee Ong, Rebekah J Dickmander, Jeffery L Smith, Jason W Brown, William Tao, Edcon Chang, Nathaniel J Moorman, Alison D Axtman, Timothy M Willson
Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5- a ]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2A. ACS omega 8 (42) (2023)
Frances M Bashore, Joel K Annor-Gyamfi, Yuhong Du, Vittorio Katis, Felix Nwogbo, Raymond G Flax, Stephen V Frye, Kenneth H Pearce, Haian Fu, Timothy M Willson, David Harold Drewry, Alison D Axtman
Fused Tetrahydroquinolines Are Interfering with Your Assay. Journal of medicinal chemistry (2023)
Christopher R M Asquith, Michael P East, Tuomo Laitinen, Carla Alamillo-Ferrer, Erkka Hartikainen, Carrow I Wells, Alison D Axtman, David Harold Drewry, Graham J Tizzard, Antti Poso, Timothy M Willson, Gary L Johnson
Discovery and Optimization of Narrow Spectrum Inhibitors of Tousled Like Kinase 2 (TLK2) Using Quantitative Structure Activity Relationships. bioRxiv : the preprint server for biology (2023)
Kareem A Galal, Andreas Krämer, Benjamin G Strickland, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, Timothy M Willson
Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3. bioRxiv : the preprint server for biology (2023)
Xuan Yang, Han Wee Ong, Rebekah J Dickmander, Jeffery L Smith, Jason W Brown, William Tao, Edcon Chang, Nathaniel J Moorman, Alison D Axtman, Timothy M Willson
Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines Toward the Development of an In Vivo Chemical Probe for CSNK2A. bioRxiv : the preprint server for biology (2023)
Kareem A Galal, Andreas Krämer, Benjamin G Strickland, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, Timothy M Willson
Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3. bioRxiv : the preprint server for biology (2023)
Xuan Yang, Jeffery L Smith, Michael T Beck, Jennifer M Wilkinson, Ani Michaud, James D Vasta, Matthew B Robers, Timothy M Willson
Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells. bioRxiv : the preprint server for biology (2023)
Kareem A Galal, Andreas Krämer, Benjamin G Strickland, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, Timothy M Willson
Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3. bioRxiv : the preprint server for biology (2023)
Ethan J Fritch, Angie L Mordant, Thomas S K Gilbert, Carrow I Wells, Xuan Yang, Natalie K Barker, Emily A Madden, Kenneth H Dinnon, Yixuan J Hou, Longping V Tse, Izabella N Castillo, Amy C Sims, Nathaniel J Moorman, Premkumar Lakshmanane, Timothy M Willson, Laura E Herring, Lee M Graves, Ralph S Baric
Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals. Journal of proteome research (2023)
Meganathan Nandakumar, Anja Ollodart, Neil Fleck, Nirav R Kapadia, Andrew Frando, Vishant Boradia, Jeffery L Smith, Junxi Chen, William J Zuercher, Timothy M Willson, Christoph Grundner
Dual Inhibition of Mycobacterium tuberculosis and the Host TGFBR1 by an Anilinoquinazoline. Journal of medicinal chemistry (2023)
Kareem A Galal, Andreas Krämer, Benjamin G Strickland, Jeffery L Smith, Rebekah J Dickmander, Nathaniel J Moorman, Timothy M Willson
Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3. bioRxiv : the preprint server for biology (2023)
Xuan Yang, Jeffery L Smith, Michael T Beck, Jennifer M Wilkinson, Ani Michaud, James D Vasta, Matthew B Robers, Timothy M Willson
Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells. Molecules (Basel, Switzerland) 28 (7) (2023)
Maria Korshunova, Niles Huang, Stephen Capuzzi, Dmytro S Radchenko, Olena Savych, Yuriy S Moroz, Carrow I Wells, Timothy M Willson, Alexander Trospsha, Oleksandr Isaev
Generative and reinforcement learning approaches for the automated de novo design of bioactive compounds. Communications chemistry 5 (1) (2022)
Maria Korshunova, Niles Huang, Stephen Capuzzi, Dmytro S Radchenko, Olena Savych, Yuriy S Moroz, Carrow I Wells, Timothy M Willson, Alexander Trospsha, Oleksandr Isaev
Generative and reinforcement learning approaches for the automated de novo design of bioactive compounds. Communications chemistry 5 (1) (2022)
Xuan Yang, Rebekah J Dickmander, Armin Bayati, Sharon A Taft-Benz, Jeffery L Smith, Carrow I Wells, Emily A Madden, Jason W Brown, Erik M Lenarcic, Boyd L Yount, Edcon Chang, Alison D Axtman, Ralph S Baric, Mark T Heise, Peter S McPherson, Nathaniel J Moorman, Timothy M Willson
Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses. ACS chemical biology 17 (7) (2022)
Vamshikrishna Reddy Sammeta, John D Norris, Sandeep Artham, Chad D Torrice, Jovita Byemerwa, Carstyn Joiner, Sean W Fanning, Donald P McDonnell, Timothy M Willson
A New Chemotype of Chemically Tractable Nonsteroidal Estrogens Based on a Thieno[2,3- d ]pyrimidine Core. ACS medicinal chemistry letters 13 (7) (2022)
Anna Cichońska, Balaguru Ravikumar, Robert J Allaway, Fangping Wan, Sungjoon Park, Oleksandr Isaev, Shuya Li, Michael Mason, Andrew Lamb, Ziaurrehman Tanoli, Minji Jeon, Sunkyu Kim, Mariya Popova, Stephen J Capuzzi, Jianyang Zeng, Kristen Dang, Gregory Koytiger, Jaewoo Kang, Carrow I Wells, Timothy M Willson, null null, Tudor I Oprea, Avner Schlessinger, David Harold Drewry, Gustavo Stolovitzky, Krister Wennerberg, Justin Guinney, Tero Aittokallio
Crowdsourced mapping of unexplored target space of kinase inhibitors. Nature communications 12 (1) (2021)
Benjamin J Eduful, Sean N O'Byrne, Louisa Temme, Christopher R M Asquith, Yi Liang, Alfredo Picado, Joseph R Pilotte, Mohammad Anwar Hossain, Carrow I Wells, William J Zuercher, Carolina M C Catta-Preta, Priscila Zonzini Ramos, André de S Santiago, Rafael M Couñago, Christopher G Langendorf, Kévin Nay, Jonathan S Oakhill, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Timothy M Willson, Daniel E Frigo, John W Scott, David Harold Drewry
Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes. Journal of medicinal chemistry 64 (15) (2021)
Carrow I Wells, James D Vasta, Cesear R Corona, Jennifer Wilkinson, Chad A Zimprich, Morgan R Ingold, Julie E Pickett, David Harold Drewry, Kathryn M Pugh, Marie K Schwinn, Byounghoon Brian Hwang, Hicham Zegzouti, Kilian V M Huber, Mei Cong, Poncho L Meisenheimer, Timothy M Willson, Matthew B Robers
Quantifying CDK inhibitor selectivity in live cells. Nature communications 11 (1) (2020)
Alfredo Picado, Apirat Chaikuad, Carrow I Wells, Safal Shrestha, William J Zuercher, Julie E Pickett, Frank E Kwarcinski, Parvathi Sinha, Chandi S de Silva, Reena Zutshi, Shubin Liu, Natarajan Kannan, Stefan Knapp, David Harold Drewry, Timothy M Willson
A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. Journal of medicinal chemistry 63 (23) (2020)
Cunyu Zhang, Katrina L Creech, William J Zuercher, Timothy M Willson
Gram-scale synthesis of FICZ, a photoreactive endogenous ligand of the aryl hydrocarbon receptor. Scientific reports 9 (1) (2019)
Christopher R M Asquith, Benedict-Tilman Berger, Jing Wan, James M Bennett, Stephen J Capuzzi, Daniel J Crona, David Harold Drewry, Michael P East, Jonathan M Elkins, Oleg Fedorov, Paulo H Godoi, Debra M Hunter, Stefan Knapp, Susanne Müller, Chad D Torrice, Carrow I Wells, H Shelton Earp, Timothy M Willson, William J Zuercher
SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK). Journal of medicinal chemistry 62 (5) (2019)
Christopher R M Asquith, Tuomo Laitinen, James M Bennett, Paulo H Godoi, Michael P East, Graham J Tizzard, Lee M Graves, Gary L Johnson, Ronna E Dornsife, Carrow I Wells, Jonathan M Elkins, Timothy M Willson, William J Zuercher
Identification and Optimization of 4-Anilinoquinolines as Inhibitors of Cyclin G Associated Kinase. ChemMedChem 13 (1) (2017)

Timothy M Willson.css-eqlu8i{font-size:small;padding-left:4px;}

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Timothy M Willson