David Benjamin Ascher (David B Ascher)

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 85

Top Topics

Convolutional Neural Network

Machine Learning

Top Venues

Protein science : a publication of the Protein Society

Nucleic acids research

Briefings in bioinformatics

Nature genetics

This page only lists publications with an associated author ORCID identifier.

Publications

Jayoung Ryu, Sam Barkal, Tian Yu, Martin Jankowiak, Yunzhuo Zhou, Matthew Francoeur, Quang Vinh Phan, Zhijian Li, Manuel Tognon, Lara Brown, Michael I Love, Vineel Bhat, Guillaume Lettre, David Benjamin Ascher, Christopher A Cassa, Richard I Sherwood, Luca Pinello
Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification. Nature genetics (2024)
Aaron S Kovacs, Stephanie Portelli, Michael Silk, Carlos H M Rodrigues, David Benjamin Ascher
MTR3D-AF2: Expanding the coverage of spatially derived missense tolerance scores across the human proteome using AlphaFold2. Protein science : a publication of the Protein Society 33 (8) (2024)
Yoochan Myung, Alex G C de Sá, David Benjamin Ascher
Deep-PK: deep learning for small molecule pharmacokinetic and toxicity prediction. Nucleic acids research 52 (W1) (2024)
Jayoung Ryu, Sam Barkal, Tian Yu, Martin Jankowiak, Yunzhuo Zhou, Matthew Francoeur, Quang Vinh Phan, Zhijian Li, Manuel Tognon, Lara Brown, Michael I Love, Vineel Bhat, Guillaume Lettre, David Benjamin Ascher, Christopher A Cassa, Richard I Sherwood, Luca Pinello
Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification. Nature genetics (2024)
João Paulo L Velloso, Alex G C de Sá, Douglas E V Pires, David Benjamin Ascher
Engineering G protein-coupled receptors for stabilization. Protein science : a publication of the Protein Society 33 (6) (2024)
Xiaotong Gu, Aaron S Kovacs, Yoochan Myung, David Benjamin Ascher
Mutations in Glycosyltransferases and Glycosidases: Implications for Associated Diseases. Biomolecules 14 (4) (2024)
Jayoung Ryu, Sam Barkal, Tian Yu, Martin Jankowiak, Yunzhuo Zhou, Matthew Francoeur, Quang Vinh Phan, Zhijian Li, Manuel Tognon, Lara Brown, Michael I Love, Vineel Bhat, Guillaume Lettre, David Benjamin Ascher, Christopher A Cassa, Richard I Sherwood, Luca Pinello
Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification. Nature genetics (2024)
Aaron S Kovacs, Stephanie Portelli, Michael Silk, Carlos H M Rodrigues, David Benjamin Ascher
MTR3D-AF2: Expanding the coverage of spatially derived missense tolerance scores across the human proteome using AlphaFold2. Protein science : a publication of the Protein Society 33 (8) (2024)
Aaron S Kovacs, Stephanie Portelli, Michael Silk, Carlos H M Rodrigues, David Benjamin Ascher
MTR3D-AF2: Expanding the coverage of spatially derived missense tolerance scores across the human proteome using AlphaFold2. Protein science : a publication of the Protein Society 33 (8) (2024)
Qisheng Pan, Georgina Becerra Parra, Yoochan Myung, Stephanie Portelli, Thanh Binh Nguyen, David Benjamin Ascher
AlzDiscovery: A computational tool to identify Alzheimer's disease-causing missense mutations using protein structure information. Protein science : a publication of the Protein Society 33 (10) (2024)
Olivia Craig, Samuel Lee, Courtney Pilcher, Rita Saoud, Suad Abdirahman, Carolina Salazar, Nathan Williams, David Benjamin Ascher, Robert Vary, Jennii Luu, Karla J Cowley, Susanne Ramm, Mark Xiang Li, Niko Thio, Jason Li, Tim Semple, Kaylene J Simpson, Kylie L Gorringe, Jessica K Holien
A new method for network bioinformatics identifies novel drug targets for mucinous ovarian carcinoma. NAR genomics and bioinformatics 6 (3) (2024)
Xiaotong Gu, Yoochan Myung, Carlos H M Rodrigues, David Benjamin Ascher
EFG-CS: Predicting chemical shifts from amino acid sequences with protein structure prediction using machine learning and deep learning models. Protein science : a publication of the Protein Society 33 (8) (2024)
Jayoung Ryu, Sam Barkal, Tian Yu, Martin Jankowiak, Yunzhuo Zhou, Matthew Francoeur, Quang Vinh Phan, Zhijian Li, Manuel Tognon, Lara Brown, Michael I Love, Vineel Bhat, Guillaume Lettre, David Benjamin Ascher, Christopher A Cassa, Richard I Sherwood, Luca Pinello
Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification. Nature genetics 56 (5) (2024)
Yunzhuo Zhou, YooChan Myung, Carlos H M Rodrigues, David Benjamin Ascher
DDMut-PPI: predicting effects of mutations on protein-protein interactions using graph-based deep learning. Nucleic acids research 52 (W1) (2024)
Yunzhuo Zhou, YooChan Myung, Carlos H M Rodrigues, David Benjamin Ascher
DDMut-PPI: predicting effects of mutations on protein-protein interactions using graph-based deep learning. Nucleic acids research 52 (W1) (2024)
João Paulo L Velloso, Alex G C de Sá, Douglas E V Pires, David Benjamin Ascher
Engineering G protein-coupled receptors for stabilization. Protein science : a publication of the Protein Society 33 (6) (2024)
Xiaotong Gu, Aaron S Kovacs, Yoochan Myung, David Benjamin Ascher
Mutations in Glycosyltransferases and Glycosidases: Implications for Associated Diseases. Biomolecules 14 (4) (2024)
Jayoung Ryu, Sam Barkal, Tian Yu, Martin Jankowiak, Yunzhuo Zhou, Matthew Francoeur, Quang Vinh Phan, Zhijian Li, Manuel Tognon, Lara Brown, Michael I Love, Vineel Bhat, Guillaume Lettre, David Benjamin Ascher, Christopher A Cassa, Richard I Sherwood, Luca Pinello
Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification. Nature genetics 56 (5) (2024)
Xiaotong Gu, Aaron S Kovacs, Yoochan Myung, David Benjamin Ascher
Mutations in Glycosyltransferases and Glycosidases: Implications for Associated Diseases. Biomolecules 14 (4) (2024)
Yoochan Myung, Alex G C de Sá, David Benjamin Ascher
Deep-PK: deep learning for small molecule pharmacokinetic and toxicity prediction. Nucleic acids research (2024)
Yunzhuo Zhou, YooChan Myung, Carlos H M Rodrigues, David Benjamin Ascher
DDMut-PPI: predicting effects of mutations on protein-protein interactions using graph-based deep learning. Nucleic acids research (2024)
Xiaotong Gu, Yoochan Myung, Carlos H M Rodrigues, David Benjamin Ascher
EFG-CS: Predicting chemical shifts from amino acid sequences with protein structure prediction using machine learning and deep learning models. Protein science : a publication of the Protein Society 33 (8) (2024)
Jayoung Ryu, Sam Barkal, Tian Yu, Martin Jankowiak, Yunzhuo Zhou, Matthew Francoeur, Quang Vinh Phan, Zhijian Li, Manuel Tognon, Lara Brown, Michael I Love, Vineel Bhat, Guillaume Lettre, David Benjamin Ascher, Christopher A Cassa, Richard I Sherwood, Luca Pinello
Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification. Nature genetics 56 (5) (2024)
Olivia Craig, Samuel Lee, Courtney Pilcher, Rita Saoud, Suad Abdirahman, Carolina Salazar, Nathan Williams, David Benjamin Ascher, Robert Vary, Jennii Luu, Karla J Cowley, Susanne Ramm, Mark Xiang Li, Niko Thio, Jason Li, Tim Semple, Kaylene J Simpson, Kylie L Gorringe, Jessica K Holien
A new method for network bioinformatics identifies novel drug targets for mucinous ovarian carcinoma. NAR genomics and bioinformatics 6 (3) (2024)
Yoochan Myung, Alex G C de Sá, David Benjamin Ascher
Deep-PK: deep learning for small molecule pharmacokinetic and toxicity prediction. Nucleic acids research 52 (W1) (2024)
Carlos H M Rodrigues, Stephanie Portelli, David Benjamin Ascher
Exploring the effects of missense mutations on protein thermodynamics through structure-based approaches: findings from the CAGI6 challenges. Human genetics (2024)
Xiaotong Gu, Yoochan Myung, Carlos H M Rodrigues, David Benjamin Ascher
EFG-CS: Predicting chemical shifts from amino acid sequences with protein structure prediction using machine learning and deep learning models. Protein science : a publication of the Protein Society 33 (8) (2024)
Vladimir Morozov, Carlos Henrique Miranda, David Benjamin Ascher
CSM-Toxin: A Web-Server for Predicting Protein Toxicity. Pharmaceutics 15 (2) (2023)
Raghad Aljarf, Simon Tang, Douglas Eduardo Valente Pires, David Benjamin Ascher
embryoTox: Using Graph-Based Signatures to Predict the Teratogenicity of Small Molecules. Journal of chemical information and modeling 63 (2) (2023)
Michael Silk, Alex de Sá, Moshe Olshansky, David Benjamin Ascher
Insights from Spatial Measures of Intolerance to Identifying Pathogenic Variants in Developmental and Epileptic Encephalopathies. International journal of molecular sciences 24 (6) (2023)
Raghad Aljarf, Simon Tang, Douglas Eduardo Valente Pires, David Benjamin Ascher
embryoTox: Using Graph-Based Signatures to Predict the Teratogenicity of Small Molecules. Journal of chemical information and modeling 63 (2) (2023)
Dana Jessen-Howard, Qisheng Pan, David Benjamin Ascher
Identifying the Molecular Drivers of Pathogenic Aldehyde Dehydrogenase Missense Mutations in Cancer and Non-Cancer Diseases. International journal of molecular sciences 24 (12) (2023)
Michael Silk, Alex de Sá, Moshe Olshansky, David Benjamin Ascher
Insights from Spatial Measures of Intolerance to Identifying Pathogenic Variants in Developmental and Epileptic Encephalopathies. International journal of molecular sciences 24 (6) (2023)
Michael Silk, Alex de Sá, Moshe Olshansky, David Benjamin Ascher
Insights from Spatial Measures of Intolerance to Identifying Pathogenic Variants in Developmental and Epileptic Encephalopathies. International journal of molecular sciences 24 (6) (2023)
Joicymara S Xavier, Monika Moir, Houriiyah Tegally, Nikita Sitharam, Wasim Abdool Karim, James Emmanuel San, Joana Linhares, Eduan Wilkinson, David Benjamin Ascher, Cheryl Baxter, Douglas Eduardo Valente Pires, Tulio de Oliveira
SARS-CoV-2 Africa dashboard for real-time COVID-19 information. Nature microbiology 8 (1) (2023)
Adam Serghini, Stephanie Portelli, Guillaume Troadec, Catherine Song, Qisheng Pan, Douglas Eduardo Valente Pires, David Benjamin Ascher
Characterizing and predicting ccRCC-causing missense mutations in Von Hippel-Lindau disease. Human molecular genetics (2023)
Vladimir Morozov, Carlos Henrique Miranda, David Benjamin Ascher
CSM-Toxin: A Web-Server for Predicting Protein Toxicity. Pharmaceutics 15 (2) (2023)
Carlos H M Rodrigues, David Benjamin Ascher
CSM-Potential2: A comprehensive deep learning platform for the analysis of protein interacting interfaces. Proteins (2023)
Raghad Aljarf, Simon Tang, Douglas Eduardo Valente Pires, David Benjamin Ascher
embryoTox: Using Graph-Based Signatures to Predict the Teratogenicity of Small Molecules. Journal of chemical information and modeling (2023)
Dana Jessen-Howard, Qisheng Pan, David Benjamin Ascher
Identifying the Molecular Drivers of Pathogenic Aldehyde Dehydrogenase Missense Mutations in Cancer and Non-Cancer Diseases. International journal of molecular sciences 24 (12) (2023)
Joicymara S Xavier, Monika Moir, Houriiyah Tegally, Nikita Sitharam, Wasim Abdool Karim, James Emmanuel San, Joana Linhares, Eduan Wilkinson, David Benjamin Ascher, Cheryl Baxter, Douglas Eduardo Valente Pires, Tulio de Oliveira
SARS-CoV-2 Africa dashboard for real-time COVID-19 information. Nature microbiology 8 (1) (2023)
Qisheng Pan, Stephanie Portelli, Thanh Binh Nguyen, David Benjamin Ascher
Characterization on the oncogenic effect of the missense mutations of p53 via machine learning. Briefings in bioinformatics 25 (1) (2023)
Yunzhuo Zhou, Qisheng Pan, Douglas Eduardo Valente Pires, Carlos H M Rodrigues, David Benjamin Ascher
DDMut: predicting effects of mutations on protein stability using deep learning. Nucleic acids research (2023)
Raghad Al-Jarf, Malancha Karmakar, Yoochan Myung, David Benjamin Ascher
Uncovering the Molecular Drivers of NHEJ DNA Repair-Implicated Missense Variants and Their Functional Consequences. Genes 14 (10) (2023)
Stephanie Portelli, Ruby Heaton, David Benjamin Ascher
Identifying Innate Resistance Hotspots for SARS-CoV-2 Antivirals Using In Silico Protein Techniques. Genes 14 (9) (2023)
Vladimir Morozov, Carlos Henrique Miranda, David Benjamin Ascher
CSM-Toxin: A Web-Server for Predicting Protein Toxicity. Pharmaceutics 15 (2) (2023)
Dana Jessen-Howard, Qisheng Pan, David Benjamin Ascher
Identifying the Molecular Drivers of Pathogenic Aldehyde Dehydrogenase Missense Mutations in Cancer and Non-Cancer Diseases. International journal of molecular sciences 24 (12) (2023)
Joicymara S Xavier, Monika Moir, Houriiyah Tegally, Nikita Sitharam, Wasim Abdool Karim, James Emmanuel San, Joana Linhares, Eduan Wilkinson, David Benjamin Ascher, Cheryl Baxter, Douglas Eduardo Valente Pires, Tulio de Oliveira
SARS-CoV-2 Africa dashboard for real-time COVID-19 information. Nature microbiology 8 (1) (2023)
Qisheng Pan, Thanh Binh Nguyen, David Benjamin Ascher, Douglas Eduardo Valente Pires
Systematic evaluation of computational tools to predict the effects of mutations on protein stability in the absence of experimental structures. Briefings in bioinformatics 23 (2) (2022)
Carlos H M Rodrigues, David Benjamin Ascher
CSM-Potential: mapping protein interactions and biological ligands in 3D space using geometric deep learning. Nucleic acids research (2022)
Yunzhuo Zhou, Raghad Al-Jarf, Azadeh Alavi, Thanh Binh Nguyen, Carlos H M Rodrigues, Douglas E V Pires, David Benjamin Ascher
kinCSM: Using graph-based signatures to predict small molecule CDK2 inhibitors. Protein science : a publication of the Protein Society 31 (11) (2022)
Vinícius A Paiva, Murillo V Mendonça, Sabrina A Silveira, David Benjamin Ascher, Douglas Eduardo Valente Pires, Sandro C Izidoro
GASS-Metal: identifying metal-binding sites on protein structures using genetic algorithms. Briefings in bioinformatics 23 (5) (2022)
Stephanie Portelli, Amanda Albanaz, Douglas Eduardo Valente Pires, David Benjamin Ascher
Identifying the molecular drivers of ALS-implicated missense mutations. Journal of medical genetics (2022)
Saba Iftkhar, Alex G C de Sá, João P L Velloso, Raghad Aljarf, Douglas Eduardo Valente Pires, David Benjamin Ascher
<i>cardioToxCSM</i>: A Web Server for Predicting Cardiotoxicity of Small Molecules. Journal of chemical information and modeling 62 (20) (2022)
Mehmet Akdel, Douglas E V Pires, Eduard Porta Pardo, Jürgen Jänes, Arthur O Zalevsky, Bálint Mészáros, Patrick Bryant, Lydia L Good, Roman A Laskowski, Gabriele Pozzati, Aditi Shenoy, Wensi Zhu, Petras Kundrotas, Victoria Ruiz Serra, Carlos Henrique Miranda, Alistair S Dunham, David Francis Burke, Neera Borkakoti, Sameer Velankar, Adam Frost, Jérôme Basquin, Kresten Lindorff-Larsen, Alex Bateman, Andrey V Kajava, Alfonso Valencia, Sergey Ovchinnikov, Janani Durairaj, David Benjamin Ascher, Janet M Thornton, Norman E Davey, Amelie Stein, Arne Elofsson, Tristan I Croll, Pedro Beltrao
A structural biology community assessment of AlphaFold2 applications. Nature structural & molecular biology 29 (11) (2022)
Swapnil Tichkule, Yoochan Myung, Myo T Naung, Brendan R E Ansell, Andrew J Guy, Namrata Srivastava, Somya Mehra, Simone M Cacciò, Ivo Mueller, Alyssa E Barry, Cock Van Oosterhout, Bernard J Pope, David Benjamin Ascher, Aaron R Jex
VIVID: A Web Application for Variant Interpretation and Visualization in Multi-dimensional Analyses. Molecular biology and evolution 39 (9) (2022)
Alex G C de Sá, Yangyang Long, Stephanie Portelli, Douglas Eduardo Valente Pires, David Benjamin Ascher
toxCSM: comprehensive prediction of small molecule toxicity profiles. Briefings in bioinformatics 23 (5) (2022)
Joicymara S Xavier, Monika Moir, Houriiyah Tegally, Nikita Sitharam, Wasim Abdool Karim, James Emmanuel San, Joana Linhares, Eduan Wilkinson, David Benjamin Ascher, Cheryl Baxter, Douglas Eduardo Valente Pires, Tulio de Oliveira
SARS-CoV-2 Africa dashboard for real-time COVID-19 information. Nature microbiology (2022)
Mahima Sharma, James P Lingford, Marija Petricevic, Alexander J D Snow, Yunyang Zhang, Michael A Järvå, Janice W-Y Mui, Nichollas E Scott, Eleanor C Saunders, Runyu Mao, Ruwan Epa, Bruna M da Silva, Douglas Eduardo Valente Pires, David Benjamin Ascher, Malcolm J McConville, Gideon J Davies, Spencer J Williams, Ethan D Goddard-Borger
Oxidative desulfurization pathway for complete catabolism of sulfoquinovose by bacteria. Proceedings of the National Academy of Sciences of the United States of America 119 (4) (2022)
Carlos H M Rodrigues, Douglas Eduardo Valente Pires, Tom L Blundell, David Benjamin Ascher
Structural landscapes of PPI interfaces. Briefings in bioinformatics 23 (4) (2022)
Pâmela M Rezende, Joicymara S Xavier, David Benjamin Ascher, Gabriel R Fernandes, Douglas Eduardo Valente Pires
Evaluating hierarchical machine learning approaches to classify biological databases. Briefings in bioinformatics 23 (4) (2022)
Carlos H M Rodrigues, Anjali Garg, David Keizer, Douglas E V Pires, David Benjamin Ascher
CSM-peptides: A computational approach to rapid identification of therapeutic peptides. Protein science : a publication of the Protein Society 31 (10) (2022)
György Abrusán, David Benjamin Ascher, Michael Inouye
Known allosteric proteins have central roles in genetic disease. PLoS computational biology 18 (2) (2022)
Douglas Eduardo Valente Pires, Keith A Stubbs, Joshua S Mylne, David Benjamin Ascher
cropCSM: designing safe and potent herbicides with graph-based signatures. Briefings in bioinformatics 23 (2) (2022)
Chien-Yi Lai, I-Jung Tsai, Pao-Chin Chiu, David Benjamin Ascher, Yin-Hsiu Chien, Yu-Hsuan Huang, Yi-Lin Lin, Wuh-Liang Hwu, Hung-Chang Lee
A novel deep intronic variant strongly associates with Alkaptonuria. NPJ genomic medicine 6 (1) (2021)
Carlos H M Rodrigues, Douglas Eduardo Valente Pires, David Benjamin Ascher
mmCSM-PPI: predicting the effects of multiple point mutations on protein-protein interactions. Nucleic acids research 49 (W1) (2021)
João Paulo L Velloso, David Benjamin Ascher, Douglas Eduardo Valente Pires
pdCSM-GPCR: predicting potent GPCR ligands with graph-based signatures. Bioinformatics advances 1 (1) (2021)
Carlos H M Rodrigues, Douglas Eduardo Valente Pires, David Benjamin Ascher
pdCSM-PPI: Using Graph-Based Signatures to Identify Protein-Protein Interaction Inhibitors. Journal of chemical information and modeling 61 (11) (2021)
Raghad Al-Jarf, Alex G C de Sá, Douglas Eduardo Valente Pires, David Benjamin Ascher
pdCSM-cancer: Using Graph-Based Signatures to Identify Small Molecules with Anticancer Properties. Journal of chemical information and modeling 61 (7) (2021)
Edward Airey, Stephanie Portelli, Joicymara S Xavier, Yoo Chan Myung, Michael Silk, Malancha Karmakar, João P L Velloso, Carlos H M Rodrigues, Hardik H Parate, Anjali Garg, Raghad Al-Jarf, Lucy Barr, Juliana A Geraldo, Pâmela M Rezende, Douglas Eduardo Valente Pires, David Benjamin Ascher
Identifying Genotype-Phenotype Correlations via Integrative Mutation Analysis. Methods in molecular biology (Clifton, N.J.) 2190 (2021)
Thanh Binh Nguyen, Douglas Eduardo Valente Pires, David Benjamin Ascher
CSM-carbohydrate: protein-carbohydrate binding affinity prediction and docking scoring function. Briefings in bioinformatics (2021)
Bruna Moreira da Silva, YooChan Myung, David Benjamin Ascher, Douglas Eduardo Valente Pires
epitope3D: a machine learning method for conformational B-cell epitope prediction. Briefings in bioinformatics (2021)
Thanh Binh Nguyen, Yoochan Myung, Alex G C de Sá, Douglas Eduardo Valente Pires, David Benjamin Ascher
mmCSM-NA: accurately predicting effects of single and multiple mutations on protein-nucleic acid binding affinity. NAR genomics and bioinformatics 3 (4) (2021)
Michael Silk, Douglas Eduardo Valente Pires, Carlos H M Rodrigues, Elston N D'Souza, Moshe Olshansky, Natalie Thorne, David Benjamin Ascher
MTR3D: identifying regions within protein tertiary structures under purifying selection. Nucleic acids research 49 (W1) (2021)
Jingyu Zhan, Angela R Harrison, Stephanie Portelli, Thanh Binh Nguyen, Isshu Kojima, Siqiong Zheng, Fei Yan, Tatsunori Masatani, Stephen M Rawlinson, Ashish Sethi, Naoto Ito, David Benjamin Ascher, Gregory W Moseley, Paul R Gooley
Definition of the immune evasion-replication interface of rabies virus P protein. PLoS pathogens 17 (7) (2021)
Joanne M Hildebrand, Maria Kauppi, Ian J Majewski, Zikou Liu, Allison J Cox, Sanae Miyake, Emma J Petrie, Michael A Silk, Zhixiu Li, Maria C Tanzer, Gabriela Brumatti, Samuel N Young, Cathrine Hall, Sarah E Garnish, Jason Corbin, Michael D Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C Josefsson, Kristin Rigbye, Holly Anderton, James A Rickard, Anne Tripaydonis, Julie M Sheridan, Thomas S Scerri, Victoria E Jackson, Peter E Czabotar, Jian-Guo Zhang, Leila Varghese, Cody C Allison, Marc Pellegrini, Gillian M Tannahill, Esme C Hatchell, Tracy A Willson, Dina Stockwell, Carolyn A de Graaf, Janelle Collinge, Adrienne Hilton, Natasha Silke, Sukhdeep K Spall, Diep Chau, Vicki Athanasopoulos, Donald Metcalf, Ronald M Laxer, Alexander G Bassuk, Benjamin W Darbro, Maria A Fiatarone Singh, Nicole Vlahovich, David Hughes, Maria Kozlovskaia, David Benjamin Ascher, Klaus Warnatz, Nils Venhoff, Jens Thiel, Christine Biben, Stefan Blum, John Reveille, Michael S Hildebrand, Carola G Vinuesa, Pamela A McCombe, Matthew A Brown, Benjamin T Kile, Catriona A Mclean, Melanie Bahlo, Seth L Masters, Hiroyasu Nakano, Polly J Ferguson, James G Murphy, Warren S Alexander, John Silke
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction. Nature communications 11 (1) (2020)
Malancha Karmakar, Carlos Henrique Miranda, Kristy Horan, Justin T Denholm, David Benjamin Ascher
Structure guided prediction of Pyrazinamide resistance mutations in pncA. Scientific reports 10 (1) (2020)
Stephanie Portelli, Moshe Olshansky, Carlos Henrique Miranda, Elston N D'Souza, Yoochan Myung, Michael Silk, Azadeh Alavi, Douglas E V Pires, David Benjamin Ascher
Exploring the structural distribution of genetic variation in SARS-CoV-2 with the COVID-3D online resource. Nature genetics 52 (10) (2020)
Stephanie Portelli, Yoochan Myung, Nicholas Furnham, Sundeep Chaitanya Vedithi, Douglas Eduardo Valente Pires, David Benjamin Ascher
Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches. Scientific reports 10 (1) (2020)
Douglas Eduardo Valente Pires, David Benjamin Ascher
mycoCSM: Using Graph-Based Signatures to Identify Safe Potent Hits against Mycobacteria. Journal of chemical information and modeling 60 (7) (2020)
Carlos H M Rodrigues, Douglas E V Pires, David Benjamin Ascher
DynaMut2: Assessing changes in stability and flexibility upon single and multiple point missense mutations. Protein science : a publication of the Protein Society 30 (1) (2020)
Lisa M Kaminskas, Douglas E V Pires, David Benjamin Ascher
dendPoint: a web resource for dendrimer pharmacokinetics investigation and prediction. Scientific reports 9 (1) (2019)
Malancha Karmakar, Maria Globan, Janet A M Fyfe, Timothy P Stinear, Paul D R Johnson, Natasha E Holmes, Justin T Denholm, David Benjamin Ascher
Analysis of a Novel pncA Mutation for Susceptibility to Pyrazinamide Therapy. American journal of respiratory and critical care medicine 198 (4) (2019)
Maryia Karpiyevich, Sophie Adjalley, Marco Mol, David Benjamin Ascher, Bethany Mason, Gerbrand J van der Heden van Noort, Heike Laman, Huib Ovaa, Marcus Chee San Lee, Katerina Artavanis-Tsakonas
Nedd8 hydrolysis by UCH proteases in Plasmodium parasites. PLoS pathogens 15 (10) (2019)
Nidhi Jatana, David Benjamin Ascher, Douglas Eduardo Valente Pires, Rajesh S Gokhale, Lipi Thukral
Human LC3 and GABARAP subfamily members achieve functional specificity via specific structural modulations. Autophagy 16 (2) (2019)