Husnu Ümit Kaniskan (H Ümit Kaniskan)

ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 29

Top Venues

Journal of medicinal chemistry

Journal of the American Chemical Society

Science advances

Science translational medicine

Icahn School of Medicine at Mount Sinai

Case Western Reserve University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Icahn School of Medicine at Mount Sinai Jan 01 2016

United States

Assistant Professor :: Department of Pharmacological Sciences

Education History

Case Western Reserve University Sep 01 2002 - Aug 01 2007

United States

PHD :: Department of Chemistry

Middle East Technical University Sep 01 1998 - Aug 01 2001

Turkey

MSC :: Department of Chemistry

Middle East Technical University Sep 01 1993 - Jun 01 1998

Turkey

BSC :: Deparment of Chemistry

Publications

Zhaoyu Xue, Lihuai Qin, Hongwen Xuan, Kaixiu Luo, Mengying Huang, Ling Xie, Yangzhou Su, Longxia Xu, Josiah Harsh, Brandon Dale, Xiaobing Shi, Xian Chen, Husnu Ümit Kaniskan, Jian Jin, Hong Wen
A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression. Science advances 10 (35) (2024)
Zhaoyu Xue, Lihuai Qin, Hongwen Xuan, Kaixiu Luo, Mengying Huang, Ling Xie, Yangzhou Su, Longxia Xu, Josiah Harsh, Brandon Dale, Xiaobing Shi, Xian Chen, Husnu Ümit Kaniskan, Jian Jin, Hong Wen
A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression. Science advances 10 (35) (2024)
Zhen Wang, Jing Liu, He Chen, Xing Qiu, Ling Xie, Husnu Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins. Journal of the American Chemical Society 145 (19) (2023)
Zhen Wang, Jing Liu, He Chen, Xing Qiu, Ling Xie, Husnu Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins. Journal of the American Chemical Society 145 (19) (2023)
Isha Singh, Fengling Li, Elissa A Fink, Irene Chau, Alice Shi Ming Li, Annía Rodriguez-Hernández, Isabella Glenn, Francisco J Zapatero-Belinchón, M Luis Rodriguez, Kanchan Devkota, Zhijie Deng, Kris White, Xiaobo Wan, Nataliya A Tolmachova, Yurii S Moroz, Husnu Ümit Kaniskan, Melanie Ott, Adolfo García-Sastre, Jian Jin, Danica Galonić Fujimori, John J Irwin, Masoud Vedadi, Brian K Shoichet
Structure-Based Discovery of Inhibitors of the SARS-CoV-2 Nsp14 N7-Methyltransferase. Journal of medicinal chemistry (2023)
Zhen Wang, Jing Liu, Xing Qiu, Dingpeng Zhang, Hiroyuki Inuzuka, Li Chen, He Chen, Ling Xie, Husnu Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Methylated Nucleotide-Based Proteolysis-Targeting Chimera Enables Targeted Degradation of Methyl-CpG-Binding Protein 2. Journal of the American Chemical Society (2023)
Zhen Wang, Jing Liu, He Chen, Xing Qiu, Ling Xie, Husnu Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins. Journal of the American Chemical Society 145 (19) (2023)
Fabin Dang, Lei Bai, Jiazhen Dong, Xiaoping Hu, Jingchao Wang, Joao A Paulo, Yan Xiong, Xiaowei Liang, Yishuang Sun, Yuncai Chen, Ming Guo, Xin Wang, Zhixiang Huang, Hiroyuki Inuzuka, Li Chen, Chen Chu, Jianping Liu, Tao Zhang, Abdol-Hossein Rezaeian, Jing Liu, Husnu Ümit Kaniskan, Bo Zhong, Jinfang Zhang, Michael Letko, Jian Jin, Ke Lan, Wenyi Wei
USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice. Science translational medicine 15 (725) (2023)
Zhen Wang, Jing Liu, He Chen, Xing Qiu, Ling Xie, Husnu Ümit Kaniskan, Xian Chen, Jian Jin, Wenyi Wei
Telomere Targeting Chimera Enables Targeted Destruction of Telomeric Repeat-Binding Factor Proteins. Journal of the American Chemical Society (2023)
Md Kabir, Ning Sun, Xiaoping Hu, Tiphaine C Martin, Jingjie Yi, Yue Zhong, Yan Xiong, Husnu Ümit Kaniskan, Wei Gu, Ramon Parsons, Jian Jin
Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53. Journal of the American Chemical Society (2023)
Leslie Salas-Estrada, Davide Provasi, Xing Qiu, Husnu Ümit Kaniskan, Xi-Ping Huang, Jeffrey F DiBerto, João Marcelo Lamim Ribeiro, Jian Jin, Bryan L Roth, Marta Filizola
De Novo Design of κ-Opioid Receptor Antagonists Using a Generative Deep-Learning Framework. Journal of chemical information and modeling (2023)
Md Kabir, Xufen Yu, Husnu Ümit Kaniskan, Jian Jin
Chemically induced degradation of epigenetic targets. Chemical Society reviews (2023)
Ning Sun, Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez, Xian Chen, Husnu Ümit Kaniskan, Jian Jin
Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of medicinal chemistry 66 (1) (2022)
Ning Sun, Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez, Xian Chen, Husnu Ümit Kaniskan, Jian Jin
Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of medicinal chemistry 66 (1) (2022)
Brandon Dale, Chris Anderson, Kwang-Su Park, Husnu Ümit Kaniskan, Anqi Ma, Yudao Shen, Chengwei Zhang, Ling Xie, Xian Chen, Xufen Yu, Jian Jin
Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2. ACS pharmacology & translational science 5 (7) (2022)
Fanye Meng, Chenxi Xu, Kwang-Su Park, Husnu Ümit Kaniskan, Gang Greg Wang, Jian Jin
Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos. Journal of medicinal chemistry 65 (15) (2022)
Ning Sun, Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez, Xian Chen, Husnu Ümit Kaniskan, Jian Jin
Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of medicinal chemistry 66 (1) (2022)
Ning Sun, Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez, Xian Chen, Husnu Ümit Kaniskan, Jian Jin
Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of medicinal chemistry 66 (1) (2022)
Ning Sun, Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez, Xian Chen, Husnu Ümit Kaniskan, Jian Jin
Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of medicinal chemistry (2022)
Ning Sun, Md Kabir, Youngeun Lee, Ling Xie, Xiaoping Hu, Julia Velez, Xian Chen, Husnu Ümit Kaniskan, Jian Jin
Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer. Journal of medicinal chemistry 66 (1) (2022)
Jing Liu, Xufen Yu, He Chen, Husnu Ümit Kaniskan, Ling Xie, Xian Chen, Jian Jin, Wenyi Wei
TF-DUBTACs Stabilize Tumor Suppressor Transcription Factors. Journal of the American Chemical Society 144 (28) (2022)
Jing Liu, He Chen, Husnu Ümit Kaniskan, Ling Xie, Xian Chen, Jian Jin, Wenyi Wei
TF-PROTACs Enable Targeted Degradation of Transcription Factors. Journal of the American Chemical Society 143 (23) (2021)
Xufen Yu, Dongxu Li, Jithesh Kottur, Yudao Shen, Huen Suk Kim, Kwang-Su Park, Yi-Hsuan Tsai, Weida Gong, Jun Wang, Kyogo Suzuki, Joel S Parker, Laura E Herring, Husnu Ümit Kaniskan, Ling Cai, Rinku Jain, Jing Liu, Aneel K Aggarwal, Gang Greg Wang, Jian Jin
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Science translational medicine 13 (613) (2021)
Jing Liu, He Chen, Yi Liu, Yudao Shen, Fanye Meng, Husnu Ümit Kaniskan, Jian Jin, Wenyi Wei
Cancer Selective Target Degradation by Folate-Caged PROTACs. Journal of the American Chemical Society 143 (19) (2021)
Yudao Shen, Fengling Li, Magdalena M Szewczyk, Levon Halabelian, Irene Chau, Mohammad S Eram, Carlo Dela Seña, Kwang-Su Park, Fanye Meng, He Chen, Hong Zeng, Aiping Dong, Hong Wu, Viacheslav V Trush, David McLeod, Carlos A Zepeda-Velázquez, Robert M Campbell, Mary M Mader, Brian M Watson, Matthieu Schapira, Cheryl H Arrowsmith, Rima Al-Awar, Dalia Barsyte-Lovejoy, Husnu Ümit Kaniskan, Peter J Brown, Masoud Vedadi, Jian Jin
A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6. Journal of medicinal chemistry 64 (7) (2021)
He Chen, Jing Liu, Husnu Ümit Kaniskan, Wenyi Wei, Jian Jin
Folate-Guided Protein Degradation by Immunomodulatory Imide Drug-Based Molecular Glues and Proteolysis Targeting Chimeras. Journal of medicinal chemistry 64 (16) (2021)
Brandon Dale, Meng Cheng, Kwang-Su Park, Husnu Ümit Kaniskan, Yue Xiong, Jian Jin
Advancing targeted protein degradation for cancer therapy. Nature reviews. Cancer 21 (10) (2021)
Jieli Wei, Fanye Meng, Kwang-Su Park, Hyerin Yim, Julia Velez, Prashasti Kumar, Li Wang, Ling Xie, He Chen, Yudao Shen, Emily Teichman, Dongxu Li, Gang Greg Wang, Xian Chen, Husnu Ümit Kaniskan, Jian Jin
Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation. Journal of the American Chemical Society 143 (37) (2021)
Sebastian Scheer, Suzanne Ackloo, Tiago S Medina, Matthieu Schapira, Fengling Li, Jennifer A Ward, Andrew M Lewis, Jeffrey P Northrop, Paul L Richardson, Husnu Ümit Kaniskan, Yudao Shen, Jing Liu, David Smil, David A McLeod, Carlos A Zepeda-Velazquez, Minkui Luo, Jian Jin, Dalia Barsyte-Lovejoy, Kilian V M Huber, Daniel D De Carvalho, Masoud Vedadi, Colby Zaph, Peter J Brown, Cheryl H Arrowsmith
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nature communications 10 (1) (2019)

Husnu Ümit Kaniskan.css-eqlu8i{font-size:small;padding-left:4px;} (H Ümit Kaniskan)

Publication Activity (10 Years)

Top Topics

Top Venues

Husnu Ümit Kaniskan (H Ümit Kaniskan)