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Lyn-Marié Birkholtz (Lyn-Marie Birkholtz)

ResearcherID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 18

Top Venues

Malaria journal

Scientific reports

ACS infectious diseases

ChemMedChem

University of Pretoria

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Pretoria Jan 1o 2004

South Africa

Professor & SARChI Chair :: Biochemistry, Genetics & Microbiology

Publications

Ashleigh van Heerden, Gemma Turon, Miquel Duran-Frigola, Nelishia Pillay, Lyn-Marié Birkholtz
Machine Learning Approaches Identify Chemical Features for Stage-Specific Antimalarial Compounds. ACS omega 8 (46) (2023)
Lauren B Arendse, James M Murithi, Tarrick Qahash, Charisse Flerida A Pasaje, Luiz C Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, Maria Jose Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte E van der Watt, Janette Reader, Ayesha S Aswat, Erica Erlank, Nelius Venter, Nimisha Mittal, Madeline R Luth, Sabine Ottilie, Elizabeth A Winzeler, Lizette Leonie Koekemoer, Lyn-Marié Birkholtz, Jacquin C Niles, Manuel Llinás, David A Fidock, Kelly Chibale
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages. Science translational medicine 14 (667) (2022)
Janette Reader, Daniel F L Opperman, Mariëtte E van der Watt, Anjo Theron, Meta Leshabane, Shanté da Rocha, Jonathan M Turner, Kathleen Garrabrant, Ivett Piña, Catherine M Mills, Patrick M Woster, Lyn-Marié Birkholtz
New Transmission-Selective Antimalarial Agents through Hit-to-Lead Optimization of 2-([1,1'-Biphenyl]-4-carboxamido)benzoic Acid Derivatives. Chembiochem : a European journal of chemical biology 23 (21) (2022)
Tania Olivier, Leigh Loots, Michélle Kok, Marianne de Villiers, Janette Reader, Lyn-Marié Birkholtz, Gareth E Arnott, Katherine Allison de Villiers
Adsorption to the Surface of Hemozoin Crystals: Structure-Based Design and Synthesis of Amino-Phenoxazine β-Hematin Inhibitors. ChemMedChem 17 (10) (2022)
Godwin Akpeko Dziwornu, Dina Coertzen, Meta Leshabane, Constance Mawunyo Korkor, Cleavon K Cloete, Mathew Njoroge, Liezl Gibhard, Nina Lawrence, Janette Reader, Mariëtte van der Watt, Sergio Wittlin, Lyn-Marié Birkholtz, Kelly Chibale
Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure-Activity Relationship and In Vivo Oral Efficacy Studies. Journal of medicinal chemistry 64 (8) (2021)
Meta Leshabane, Godwin Akpeko Dziwornu, Dina Coertzen, Janette Reader, Phanankosi Moyo, Mariëtte van der Watt, Kelly Chisanga, Consolata Nsanzubuhoro, Richard Ferger, Erica Erlank, Nelius Venter, Lizette Koekemoer, Kelly Chibale, Lyn-Marié Birkholtz
Benzimidazole Derivatives Are Potent against Multiple Life Cycle Stages of Plasmodium falciparum Malaria Parasites. ACS infectious diseases 7 (7) (2021)
Jessica Connacher, Gabrielle A Josling, Lindsey M Orchard, Janette Reader, Manuel Llinás, Lyn-Marié Birkholtz
H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum. Epigenetics & chromatin 14 (1) (2021)
Liezl Gibhard, Dina Coertzen, Janette Reader, Mariëtte E van der Watt, Lyn-Marié Birkholtz, Ho Ning Wong, Kevin T Batty, Richard K Haynes, Lubbe Wiesner
The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside. Pharmaceutics 13 (12) (2021)
Jandeli Niemand, Riëtte van Biljon, Mariëtte van der Watt, Ashleigh van Heerden, Janette Reader, Roelof van Wyk, Lindsey Orchard, Kelly Chibale, Manuel Llinás, Lyn-Marié Birkholtz
Chemogenomic Fingerprints Associated with Stage-Specific Gametocytocidal Compound Action against Human Malaria Parasites. ACS infectious diseases 7 (10) (2021)
Janette Reader, Mariëtte E van der Watt, Dale Taylor, Claire Le Manach, Nimisha Mittal, Sabine Ottilie, Anjo Theron, Phanankosi Moyo, Erica Erlank, Luisa Nardini, Nelius Venter, Sonja Lauterbach, Belinda Bezuidenhout, André Horatscheck, Ashleigh van Heerden, Natalie J Spillman, Anne N Cowell, Jessica Connacher, Daniel Opperman, Lindsey M Orchard, Manuel Llinás, Eva S Istvan, Daniel E Goldberg, Grant A Boyle, David Calvo, Dalu Mancama, Theresa L Coetzer, Elizabeth A Winzeler, James Duffy, Lizette Leonie Koekemoer, Gregory S Basarab, Kelly Chibale, Lyn-Marié Birkholtz
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box. Nature communications 12 (1) (2021)
Belinda J Morahan, Clarissa Abrie, Keith Al-Hasani, Mitchell B Batty, Victoria Corey, Anne N Cowell, Jandeli Niemand, Elizabeth A Winzeler, Lyn-Marié Birkholtz, Christian Doerig, Jose F Garcia-Bustos
Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases. Communications biology 3 (1) (2020)
Phanankosi Moyo, Grace Mugumbate, Jacobus Nicolaas Eloff, Abraham I Louw, Vinesh J Maharaj, Lyn-Marié Birkholtz
Natural Products: A Potential Source of Malaria Transmission Blocking Drugs? Pharmaceuticals (Basel, Switzerland) 13 (9) (2020)
Phanankosi Moyo, Phaladi Kunyane, Mamoalosi A Selepe, Jacobus N Eloff, Jandeli Niemand, Abraham I Louw, Vinesh J Maharaj, Lyn-Marié Birkholtz
Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae). Malaria journal 18 (1) (2019)
Riëtte van Biljon, Roelof van Wyk, Heather J Painter, Lindsey Orchard, Janette Reader, Jandeli Niemand, Manuel Llinás, Lyn-Marié Birkholtz
Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation. BMC genomics 20 (1) (2019)
Shehu S Awandu, Jaishree Raman, Takalani I Makhanthisa, Philip Kruger, John Frean, Teun Bousema, Jandeli Niemand, Lyn-Marié Birkholtz
Understanding human genetic factors influencing primaquine safety and efficacy to guide primaquine roll-out in a pre-elimination setting in southern Africa. Malaria journal 17 (1) (2018)
Riëtte van Biljon, Jandeli Niemand, Roelof van Wyk, Katherine Clark, Bianca Verlinden, Clarissa Abrie, Hilde von Grüning, Werner Smidt, Annél Smit, Janette Reader, Heather Painter, Manuel Llinás, Christian Doerig, Lyn-Marié Birkholtz
Inducing controlled cell cycle arrest and re-entry during asexual proliferation of Plasmodium falciparum malaria parasites. Scientific reports 8 (1) (2018)
Dina Coertzen, Janette Reader, Mariëtte van der Watt, Sindisiwe H Nondaba, Liezl Gibhard, Lubbe Wiesner, Peter Smith, Sarah D'Alessandro, Donatella Taramelli, Ho Ning Wong, Jan L du Preez, Ronald Wai Keung Wu, Lyn-Marié Birkholtz, Richard K Haynes
Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages. Antimicrobial agents and chemotherapy 62 (8) (2018)
Nanika Coetzee, Simone Sidoli, Riëtte van Biljon, Heather Painter, Manuel Llinás, Benjamin A Garcia, Lyn-Marié Birkholtz
Quantitative chromatin proteomics reveals a dynamic histone post-translational modification landscape that defines asexual and sexual Plasmodium falciparum parasites. Scientific reports 7 (1) (2017)

Lyn-Marié Birkholtz.css-eqlu8i{font-size:small;padding-left:4px;} (Lyn-Marie Birkholtz)

Publication Activity (10 Years)

Top Topics

Top Venues

Lyn-Marié Birkholtz (Lyn-Marie Birkholtz)