Sabine Ottilie

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 12

Top Topics

Structure Activity Relationship

Plasmodium Falciparum

Top Venues

Science translational medicine

ACS infectious diseases

Journal of medicinal chemistry

Proceedings of the National Academy of Sciences of the United States of America

This page only lists publications with an associated author ORCID identifier.

Publications

Jehad Almaliti, Pavla Fajtova, Jaeson Santos Calla-Choque, Gregory M LaMonte, Mudong Feng, Frances Rocamora, Sabine Ottilie, Evgenia Glukhov, Evzen Boura, Raymond T Suhandynata, Jeremiah D Momper, Michael K Gilson, Elizabeth A Winzeler, William H Gerwick, Anthony J O'Donoghue
Development of Potent and Highly Selective Epoxyketone-Based Plasmodium Proteasome Inhibitors. Chemistry (Weinheim an der Bergstrasse, Germany) (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Lauren B Arendse, James M Murithi, Tarrick Qahash, Charisse Flerida A Pasaje, Luiz C Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, Maria Jose Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte E van der Watt, Janette Reader, Ayesha S Aswat, Erica Erlank, Nelius Venter, Nimisha Mittal, Madeline R Luth, Sabine Ottilie, Elizabeth A Winzeler, Lizette Leonie Koekemoer, Lyn-Marié Birkholtz, Jacquin C Niles, Manuel Llinás, David A Fidock, Kelly Chibale
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages. Science translational medicine 14 (667) (2022)
Frances Rocamora, Purva Gupta, Eva S Istvan, Madeline R Luth, Emma F Carpenter, Krittikorn Kümpornsin, Erika Sasaki, Jaeson Calla, Nimisha Mittal, Krypton Carolino, Edward Owen, Manuel Llinás, Sabine Ottilie, Daniel E Goldberg, Marcus C S Lee, Elizabeth A Winzeler
PfMFR3: A Multidrug-Resistant Modulator in Plasmodium falciparum. ACS infectious diseases 7 (4) (2021)
Claire Le Manach, Jean Dam, John G Woodland, Gurminder Kaur, Lutete P Khonde, Christel Brunschwig, Mathew Njoroge, Kathryn J Wicht, André Horatscheck, Tanya Paquet, Grant A Boyle, Liezl Gibhard, Dale Taylor, Nina Lawrence, Tomas Yeo, Sachel Mok, Richard T Eastman, Dorjbal Dorjsuren, Daniel C Talley, Hui Guo, Anton Simeonov, Janette Reader, Mariëtte van der Watt, Erica Erlank, Nelius Venter, Jacek W Zawada, Ayesha Aswat, Luisa Nardini, Theresa L Coetzer, Sonja B Lauterbach, Belinda C Bezuidenhout, Anjo Theron, Dalu Mancama, Lizette L Koekemoer, Lyn-Marie Birkholtz, Sergio Wittlin, Michael Delves, Sabine Ottilie, Elizabeth A Winzeler, Thomas W von Geldern, Dennis Smith, David A Fidock, Leslie J Street, Gregory S Basarab, James Duffy, Kelly Chibale
Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts. Journal of medicinal chemistry 64 (4) (2021)
Stanley C Xie, Riley D Metcalfe, Hirotake Mizutani, Tanya Puhalovich, Eric Hanssen, Craig J Morton, Yawei Du, Con Dogovski, Shih-Chung Huang, Jeffrey Ciavarri, Paul Hales, Robert J Griffin, Lawrence H Cohen, Bei-Ching Chuang, Sergio Wittlin, Ioanna Deni, Tomas Yeo, Kurt E Ward, Daniel C Barry, Boyin Liu, David L Gillett, Benigno F Crespo-Fernandez, Sabine Ottilie, Nimisha Mittal, Alisje Churchyard, Daniel Ferguson, Anna Caroline Campos Aguiar, Rafael Victorio Carvalho Guido, Jake Baum, Kirsten K Hanson, Elizabeth A Winzeler, Francisco Javier Gamo, David A Fidock, Delphine Baud, Michael W Parker, Stephen Brand, Lawrence R Dick, Michael D W Griffin, Alexandra E Gould, Leann Tilley
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proceedings of the National Academy of Sciences of the United States of America 118 (39) (2021)
Barbara Forte, Sabine Ottilie, Andrew Plater, Brice Campo, Koen J Dechering, Francisco Javier Gamo, Daniel E Goldberg, Eva S Istvan, Marcus Lee, Amanda K Lukens, Case W MacNamara, Jacquin C Niles, John Okombo, Charisse Flerida A Pasaje, Miles G Siegel, Dyann Wirth, Susan Wyllie, David A Fidock, Beatriz Baragaña, Elizabeth A Winzeler, Ian H Gilbert
Prioritization of Molecular Targets for Antimalarial Drug Discovery. ACS infectious diseases 7 (10) (2021)
Rebecca E K Mandt, Maria Jose Lafuente-Monasterio, Tomoyo Sakata-Kato, Madeline R Luth, Delfina Segura-Carro, Alba Pablos-Tanarro, Sara Viera, Noemi Magan, Sabine Ottilie, Elizabeth A Winzeler, Amanda K Lukens, Francisco Javier Gamo, Dyann F Wirth
In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model. Science translational medicine 11 (521) (2020)
Madeline R Luth, Purva Gupta, Sabine Ottilie, Elizabeth A Winzeler
Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery. ACS infectious diseases 4 (3) (2018)
Gregory M LaMonte, Jehad Almaliti, Betsaida Bibo-Verdugo, Lena Keller, Bing Yu Zou, Jennifer Yang, Yevgeniya Antonova-Koch, Pamela Orjuela-Sanchez, Colleen A Boyle, Edgar Vigil, Lawrence Wang, Gregory M Goldgof, Lena Gerwick, Anthony J O'Donoghue, Elizabeth A Winzeler, William H Gerwick, Sabine Ottilie
Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. Journal of medicinal chemistry 60 (15) (2017)