Manuel Llinás (Manuel Llinas)

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 38

Top Venues

Journal of bacteriology

Science translational medicine

Nature communications

Nucleic acids research

Pennsylvania State University

University of California Berkeley (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Pennsylvania State University Jul 01 2013

United States

Professor :: Biochemistry & Molecular Biology, Chemistry

Princeton University Jul 01 2005 - Jun 30 2013

United States

Professor :: Molecular Biology & Lewis-Sigler Institute for Integrative Genomics

Education History

University of California Berkeley Sep 01 1993 - May 01 1999

United States

PHD :: Molecular and Cell Biology

Carnegie Mellon University

United States

BSC :: Chemistry

Publications

Victoria A Bonnell, Yuning Zhang, Alan S Brown, John Horton, Gabrielle A Josling, Tsu-Pei Chiu, Remo Rohs, Shaun Mahony, Raluca Gordân, Manuel Llinás
DNA sequence and chromatin differentiate sequence-specific transcription factor binding in the human malaria parasite Plasmodium falciparum. Nucleic acids research (2024)
Victoria A Bonnell, Yuning Zhang, Alan S Brown, John Horton, Gabrielle A Josling, Tsu-Pei Chiu, Remo Rohs, Shaun Mahony, Raluca Gordân, Manuel Llinás
DNA sequence and chromatin differentiate sequence-specific transcription factor binding in the human malaria parasite Plasmodium falciparum. Nucleic acids research (2024)
Victoria A Bonnell, Yuning Zhang, Alan S Brown, John Horton, Gabrielle A Josling, Tsu-Pei Chiu, Remo Rohs, Shaun Mahony, Raluca Gordân, Manuel Llinás
DNA sequence and chromatin differentiate sequence-specific transcription factor binding in the human malaria parasite Plasmodium falciparum. Nucleic acids research (2024)
Marine Le Berre, Thibault Tubiana, Philippa Reuterswärd, Noureddine Lazar, Inès Li De La Sierra-Gallay, Joana Mendonca Santos, Manuel Llinás, Sylvie Nessler
Structural characterization of the ACDC domain from ApiAP2 proteins of the malaria parasite. bioRxiv : the preprint server for biology (2024)
Gloria Komazin, Amena A Rizk, Krista M Armbruster, Victoria A Bonnell, Manuel Llinás, Timothy C Meredith
A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes. Journal of bacteriology (2023)
Gloria Komazin, Amena A Rizk, Krista M Armbruster, Victoria A Bonnell, Manuel Llinás, Timothy C Meredith
A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes. Journal of bacteriology (2023)
Laura M Hagenah, Satish K Dhingra, Jennifer L Small-Saunders, Tarrick Qahash, Andreas Willems, Kyra A Schindler, Gabriel W Rangel, Eva Gil-Iturbe, Jonathan Kim, Emiliya Akhundova, Tomas Yeo, John Okombo, Filippo Mancia, Matthias Quick, Paul D Roepe, Manuel Llinás, David A Fidock
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology. mBio (2023)
Gloria Komazin, Amena A Rizk, Krista M Armbruster, Victoria A Bonnell, Manuel Llinás, Timothy C Meredith
A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes. Journal of bacteriology 205 (1) (2023)
Gloria Komazin, Amena A Rizk, Krista M Armbruster, Victoria A Bonnell, Manuel Llinás, Timothy C Meredith
A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes. Journal of bacteriology 205 (1) (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Joshua H Butler, Heather J Painter, Emily K Bremers, Priscilla Krai, Manuel Llinás, Maria B Cassera
Cripowellins Pause Plasmodium falciparum Intraerythrocytic Development at the Ring Stage. Molecules (Basel, Switzerland) 28 (6) (2023)
Gloria Komazin, Amena A Rizk, Krista M Armbruster, Victoria A Bonnell, Manuel Llinás, Timothy C Meredith
A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes. Journal of bacteriology 205 (1) (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Joshua H Butler, Heather J Painter, Emily K Bremers, Priscilla Krai, Manuel Llinás, Maria B Cassera
Cripowellins Pause Plasmodium falciparum Intraerythrocytic Development at the Ring Stage. Molecules (Basel, Switzerland) 28 (6) (2023)
Gloria Komazin, Amena A Rizk, Krista M Armbruster, Victoria A Bonnell, Manuel Llinás, Timothy C Meredith
A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes. Journal of bacteriology 205 (1) (2023)
Sethu C Nair, Justin T Munro, Alexis Mann, Manuel Llinás, Sean T Prigge
The mitochondrion of Plasmodium falciparum is required for cellular acetyl-CoA metabolism and protein acetylation. Proceedings of the National Academy of Sciences of the United States of America 120 (17) (2023)
Joshua H Butler, Heather J Painter, Emily K Bremers, Priscilla Krai, Manuel Llinás, Maria B Cassera
Cripowellins Pause Plasmodium falciparum Intraerythrocytic Development at the Ring Stage. Molecules (Basel, Switzerland) 28 (6) (2023)
Eva S Istvan, Francisco M Guerra, Matthew Abraham, Kuo-Sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Madeline R Luth, Haissi Cui, Tuo Yang, Sara Palomo Diaz, Maria G Gomez-Lorenzo, Tarrick Qahash, Nimisha Mittal, Sabine Ottilie, Jacquin C Niles, Marcus Chee San Lee, Manuel Llinás, Nobutaka Kato, John Okombo, David A Fidock, Paul Schimmel, Francisco Javier Gamo, Daniel E Goldberg, Elizabeth A Winzeler
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science translational medicine 15 (686) (2023)
Gloria Komazin, Amena A Rizk, Krista M Armbruster, Victoria A Bonnell, Manuel Llinás, Timothy C Meredith
A Copper-Responsive Two-Component System Governs Lipoprotein Remodeling in Listeria monocytogenes. Journal of bacteriology 205 (1) (2023)
Lauren B Arendse, James M Murithi, Tarrick Qahash, Charisse Flerida A Pasaje, Luiz C Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, Maria Jose Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte E van der Watt, Janette Reader, Ayesha S Aswat, Erica Erlank, Nelius Venter, Nimisha Mittal, Madeline R Luth, Sabine Ottilie, Elizabeth A Winzeler, Lizette Leonie Koekemoer, Lyn-Marié Birkholtz, Jacquin C Niles, Manuel Llinás, David A Fidock, Kelly Chibale
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages. Science translational medicine 14 (667) (2022)
Riward A Campelo Morillo, Xinran Tong, Wei Xie, Steven Abel, Lindsey M Orchard, Wassim Daher, Dinshaw J Patel, Manuel Llinás, Karine G Le Roch, Björn F C Kafsack
The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites. Nature microbiology 7 (2) (2022)
Laura E de Vries, Patrick A M Jansen, Catalina Barcelo, Justin Munro, Julie M J Verhoef, Charisse Flerida A Pasaje, Kelly Rubiano, Josefine Striepen, Nada Abla, Luuk Berning, Judith M Bolscher, Claudia Demarta-Gatsi, Rob W M Henderson, Tonnie Huijs, Karin M J Koolen, Patrick K Tumwebaze, Tomas Yeo, Anna C C Aguiar, Inigo Angulo-Barturen, Alisje Churchyard, Jake Baum, Benigno Crespo Fernández, Aline Fuchs, Francisco-Javier Gamo, Rafael Victorio Carvalho Guido, María Belén Jiménez-Diaz, Dhelio Batista Pereira, Rosemary Rochford, Camille Roesch, Laura Maria Sanz, Graham Trevitt, Benoit Witkowski, Sergio Wittlin, Roland A Cooper, Philip J Rosenthal, Robert W Sauerwein, Joost Schalkwijk, Pedro H H Hermkens, Roger V Bonnert, Brice Campo, David A Fidock, Manuel Llinás, Jacquin C Niles, Taco W A Kooij, Koen J Dechering
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183. Nature communications 13 (1) (2022)
Timothy James Russell, Erandi K De Silva, Valerie M Crowley, Kathryn Shaw-Saliba, Namita Dube, Gabrielle Josling, Charisse Flerida A Pasaje, Irene Kouskoumvekaki, Gianni Panagiotou, Jacquin C Niles, Marcelo Jacobs-Lorena, C Denise Okafor, Francisco-Javier Gamo, Manuel Llinás
Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites. PLoS pathogens 18 (10) (2022)
Suprita Singh, Joana Mendonca Santos, Lindsey M Orchard, Naomi Yamada, Riëtte van Biljon, Heather J Painter, Shaun Mahony, Manuel Llinás
The PfAP2-G2 transcription factor is a critical regulator of gametocyte maturation. Molecular microbiology 115 (5) (2021)
Elisabet Tintó-Font, Lucas Michel-Todó, Timothy James Russell, Núria Casas-Vila, David J Conway, Zbynek Bozdech, Manuel Llinás, Alfred Cortes
A heat-shock response regulated by the PfAP2-HS transcription factor protects human malaria parasites from febrile temperatures. Nature microbiology 6 (9) (2021)
Manuel Llinás
The Kringle of Life. The protein journal 40 (4) (2021)
Sachel Mok, Barbara H Stokes, Nina F Gnädig, Leila S Ross, Tomas Yeo, Chanaki Amaratunga, Erik Allman, Lev Solyakov, Andrew R Bottrill, Jaishree Tripathi, Rick M Fairhurst, Manuel Llinás, Zbynek Bozdech, Andrew B Tobin, David A Fidock
Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival. Nature communications 12 (1) (2021)
Heather J Painter, Joanne M Morrisey, Michael W Mather, Lindsey M Orchard, Cuyler Luck, Martin J Smilkstein, Michael K Riscoe, Akhil B Vaidya, Manuel Llinás
Atypical Molecular Basis for Drug Resistance to Mitochondrial Function Inhibitors in Plasmodium falciparum. Antimicrobial agents and chemotherapy 65 (3) (2021)
Janette Reader, Mariëtte E van der Watt, Dale Taylor, Claire Le Manach, Nimisha Mittal, Sabine Ottilie, Anjo Theron, Phanankosi Moyo, Erica Erlank, Luisa Nardini, Nelius Venter, Sonja Lauterbach, Belinda Bezuidenhout, André Horatscheck, Ashleigh van Heerden, Natalie J Spillman, Anne N Cowell, Jessica Connacher, Daniel Opperman, Lindsey M Orchard, Manuel Llinás, Eva S Istvan, Daniel E Goldberg, Grant A Boyle, David Calvo, Dalu Mancama, Theresa L Coetzer, Elizabeth A Winzeler, James Duffy, Lizette Leonie Koekemoer, Gregory S Basarab, Kelly Chibale, Lyn-Marié Birkholtz
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box. Nature communications 12 (1) (2021)
Joost Schalkwijk, Erik L Allman, Patrick A M Jansen, Laura E de Vries, Julie M J Verhoef, Suzanne Jackowski, Peter N M Botman, Christien A Beuckens-Schortinghuis, Karin M J Koolen, Judith M Bolscher, Martijn W Vos, Karen Miller, Stacy A Reeves, Helmi Pett, Graham Trevitt, Sergio Wittlin, Christian Scheurer, Sibylle Sax, Christoph Fischli, Inigo Angulo-Barturen, Mariá Belén Jiménez-Diaz, Gabrielle Josling, Taco W A Kooij, Roger Bonnert, Brice Campo, Richard H Blaauw, Floris P J T Rutjes, Robert W Sauerwein, Manuel Llinás, Pedro H H Hermkens, Koen J Dechering
Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum. Science translational medicine 11 (510) (2020)
Sarah H Shafik, Simon A Cobbold, Kawthar Barkat, Sashika N Richards, Nicole S Lancaster, Manuel Llinás, Simon J Hogg, Robert L Summers, Malcolm J McConville, Rowena E Martin
The natural function of the malaria parasite's chloroquine resistance transporter. Nature communications 11 (1) (2020)
Munir Akkaya, Abhisheka Bansal, Patrick W Sheehan, Mirna Pena, Alvaro Molina-Cruz, Lindsey M Orchard, Clare K Cimperman, Chen-Feng Qi, Philipp Ross, Takele Yazew, Daniel Sturdevant, Sarah L Anzick, Girija Thiruvengadam, Thomas Dan Otto, Oliver Billker, Manuel Llinás, Louis H Miller, Susan K Pierce
A single-nucleotide polymorphism in a Plasmodium berghei ApiAP2 transcription factor alters the development of host immunity. Science advances 6 (6) (2020)
Carolina M Andrade, Hannah Fleckenstein, Richard Thomson-Luque, Safiatou Doumbo, Nathalia F Lima, Carrie Anderson, Julia Hibbert, Christine Sarah Hopp, Tuan M Tran, Shanping Li, Moussa Niangaly, Hamidou Cisse, Didier Doumtabe, Jeff Skinner, Dan Sturdevant, Stacy Ricklefs, Kimmo Virtaneva, Muhammad Asghar, Manijeh Vafa Homann, Louise Turner, Joana Martins, Erik L Allman, Marie-Esther N'Dri, Volker Winkler, Manuel Llinás, Catherine Lavazec, Craig Martens, Anna Färnert, Kassoum Kayentao, Aissata Ongoiba, Thomas Lavstsen, Nuno S Osório, Thomas Dan Otto, Mario Recker, Boubacar Traore, Peter D Crompton, Silvia Portugal
Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season. Nature medicine 26 (12) (2020)
Lia Chappell, Philipp Ross, Lindsey Orchard, Timothy J Russell, Thomas D Otto, Matthew Berriman, Julian C Rayner, Manuel Llinás
Refining the transcriptome of the human malaria parasite Plasmodium falciparum using amplification-free RNA-seq. BMC genomics 21 (1) (2020)
Eva S Istvan, Sudipta Das, Suyash Bhatnagar, Josh R Beck, Edward Owen, Manuel Llinás, Suresh M Ganesan, Jacquin C Niles, Elizabeth A Winzeler, Akhil B Vaidya, Daniel E Goldberg
Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis. eLife 8 (2019)
Yevgeniya Antonova-Koch, Stephan Meister, Matthew Abraham, Madeline R Luth, Sabine Ottilie, Amanda K Lukens, Tomoyo Sakata-Kato, Manu Vanaerschot, Edward Owen, Juan Carlos Jado, Steven P Maher, Jaeson Santos Calla-Choque, David Plouffe, Yang Zhong, Kaisheng Chen, Victor Chaumeau, Amy J Conway, Case W McNamara, Maureen Ibanez, Kerstin Gagaring, Fernando Neria Serrano, Korina Eribez, Cullin McLean Taggard, Andrea L Cheung, Christie Lincoln, Biniam Ambachew, Melanie Rouillier, Dionicio Siegel, Francois H Nosten, Dennis E Kyle, Francisco-Javier Gamo, Yingyao Zhou, Manuel Llinás, David A Fidock, Dyann F Wirth, Jeremy N Burrows, Brice Campo, Elizabeth A Winzeler
Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science (New York, N.Y.) 362 (6419) (2019)
Che Julius Ngwa, Meike Jutta Kiesow, Lindsey Marie Orchard, Afia Farrukh, Manuel Llinás, Gabriele Pradel
The G9a Histone Methyltransferase Inhibitor BIX-01294 Modulates Gene Expression during Plasmodium falciparum Gametocyte Development and Transmission. International journal of molecular sciences 20 (20) (2019)
Annie N Cowell, Eva S Istvan, Amanda K Lukens, Maria G Gomez-Lorenzo, Manu Vanaerschot, Tomoyo Sakata-Kato, Erika L Flannery, Pamela Magistrado, Edward Owen, Matthew Abraham, Gregory LaMonte, Heather J Painter, Roy M Williams, Virginia Franco, María Linares, Ignacio Arriaga, Selina Bopp, Victoria C Corey, Nina F Gnädig, Olivia Coburn-Flynn, Christin Reimer, Purva Gupta, James M Murithi, Pedro A Moura, Olivia Fuchs, Erika Sasaki, Sang W Kim, Christine H Teng, Lawrence T Wang, Aslı Akidil, Sophie Adjalley, Paul A Willis, Dionicio Siegel, Olga Tanaseichuk, Yang Zhong, Yingyao Zhou, Manuel Llinás, Sabine Ottilie, Francisco-Javier Gamo, Marcus Chee San Lee, Daniel E Goldberg, David A Fidock, Dyann F Wirth, Elizabeth A Winzeler
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Science (New York, N.Y.) 359 (6372) (2018)

Manuel Llinás.css-eqlu8i{font-size:small;padding-left:4px;} (Manuel Llinas)

Publication Activity (10 Years)

Top Topics

Top Venues

Manuel Llinás (Manuel Llinas)