Aviad Tsherniak

Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2015-2023
Publications (10 Years): 29

Top Venues

Nature communications

Nature genetics

Nature chemical biology

Nature biotechnology

Broad Institute

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Broad Institute

United States

Assoc. Director, Cancer Data Science :: Cancer Program

Publications

Ricardo de Matos Simoes, Ryosuke Shirasaki, Sondra L Downey-Kopyscinski, Geoffrey M Matthews, Benjamin G Barwick, Vilas A Gupta, Daphné Dupéré-Richer, Shizuka Yamano, Yiguo Hu, Michal Sheffer, Eugen Dhimolea, Olga Dashevsky, Sara Gandolfi, Kazuya Ishiguro, Robin M Meyers, Jordan G Bryan, Neekesh V Dharia, Paul J Hengeveld, Johanna B Brüggenthies, Huihui Tang, Andrew J Aguirre, Quinlan L Sievers, Benjamin L Ebert, Brian J Glassner, Christopher J Ott, James E Bradner, Nicholas P Kwiatkowski, Daniel Auclair, Joan Levy, Jonathan J Keats, Richard W J Groen, Nathanael S Gray, Aedin C Culhane, James M McFarland, Joshua M Dempster, Jonathan D Licht, Lawrence H Boise, William C Hahn, Francisca Vazquez, Aviad Tsherniak, Constantine S Mitsiades
Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias. Nature cancer 4 (5) (2023)
Hugh S Gannon, Tao Zou, Michael K Kiessling, Galen F Gao, Diana Cai, Peter S Choi, Alexandru P Ivan, Ilana Buchumenski, Ashton C Berger, Jonathan T Goldstein, Andrew D Cherniak, Francisca Vazquez, Aviad Tsherniak, Erez Y Levanon, William C Hahn, Matthew L Meyerson
Author Correction: Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells. Nature communications 13 (1) (2022)
Allison Warren, Yejia Chen, Andrew Jones, Tsukasa Shibue, William C Hahn, Jesse S Boehm, Francisca Vazquez, Aviad Tsherniak, James M McFarland
Global computational alignment of tumor and cell line transcriptional profiles. Nature communications 12 (1) (2021)
Michal Sheffer, Emily Lowry, Nicky Beelen, Minasri Borah, Suha Naffar-Abu Amara, Chris C Mader, Jennifer A Roth, Aviad Tsherniak, Samuel S Freeman, Olga Dashevsky, Sara Gandolfi, Samantha Bender, Jordan G Bryan, Cong Zhu, Li Wang, Ifrah Tariq, Govinda M Kamath, Ricardo De Matos Simoes, Eugen Dhimolea, Channing Yu, Yiguo Hu, Olli Dufva, Marios Giannakis, Vasilis Syrgkanis, Ernest Fraenkel, Todd R Golub, Rizwan Romee, Mohamed El Missiry, Aedin C Culhane, Lotte Wieten, Constantine S Mitsiades
Genome-scale screens identify factors regulating tumor cell responses to natural killer cells. Nature genetics 53 (8) (2021)
Clare Pacini, Joshua M Dempster, Isabella Boyle, Emanuel Gonçalves, Hanna Najgebauer, Emre Karakoc, Dieudonne van der Meer, Andrew Barthorpe, Howard Lightfoot, Patricia Jaaks, James M McFarland, Mathew J Garnett, Aviad Tsherniak, Francesco Iorio
Integrated cross-study datasets of genetic dependencies in cancer. Nature communications 12 (1) (2021)
Neekesh V Dharia, Guillaume Kugener, Lillian M Guenther, Clare F Malone, Adam D Durbin, Andrew L Hong, Thomas P Howard, Pratiti Bandopadhayay, Caroline S Wechsler, Iris Fung, Allison C Warren, Joshua M Dempster, John Michael Krill-Burger, Brenton R Paolella, Phoebe Moh, Nishant Jha, Andrew Tang, Phillip G Montgomery, Jesse S Boehm, William C Hahn, Charles W M Roberts, James M McFarland, Aviad Tsherniak, Todd R Golub, Francisca Vazquez, Kimberly Stegmaier
A first-generation pediatric cancer dependency map. Nature genetics 53 (4) (2021)
Gabriela S Kinker, Alissa C Greenwald, Rotem Tal, Zhanna Orlova, Michael S Cuoco, James M McFarland, Allison Warren, Christopher Rodman, Jennifer A Roth, Samantha A Bender, Bhavna Kumar, James W Rocco, Pedro A C M Fernandes, Christopher C Mader, Hadas Keren-Shaul, Alexander Plotnikov, Haim Barr, Aviad Tsherniak, Orit Rozenblatt-Rosen, Valery Krizhanovsky, Sidharth V Puram, Aviv Regev, Michael Mints
Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity. Nature genetics 52 (11) (2020)
James M McFarland, Brenton R Paolella, Allison Warren, Kathryn R Geiger-Schuller, Tsukasa Shibue, Michael Rothberg, Olena Kuksenko, William N Colgan, Andrew Jones, Emily Chambers, Danielle Dionne, Samantha Bender, Brian M Wolpin, Mahmoud Ghandi, Itay Tirosh, Orit Rozenblatt-Rosen, Jennifer A Roth, Todd R Golub, Aviv Regev, Andrew J Aguirre, Francisca Vazquez, Aviad Tsherniak
Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action. Nature communications 11 (1) (2020)
Haoxin Li, Shaoyang Ning, Mahmoud Ghandi, Gregory V Kryukov, Shuba Gopal, Amy Deik, Amanda Souza, Kerry Pierce, Paula Keskula, Desiree Hernandez, Julie Ann, Dojna Shkoza, Verena Apfel, Yilong Zou, Francisca Vazquez, Jordi Barretina, Raymond A Pagliarini, Giorgio G Galli, David E Root, William C Hahn, Aviad Tsherniak, Marios Giannakis, Stuart L Schreiber, Andrew T Chan, Levi A Garraway, William R Sellers
The landscape of cancer cell line metabolism. Nature medicine 25 (5) (2019)
Pratiti Bandopadhayay, Frederica Piccioni, Ryan O'Rourke, Patricia Ho, Elizabeth M Gonzalez, Graham Buchan, Kenin Qian, Gabrielle Gionet, Emily Girard, Margo Coxon, Matthew G Rees, Lisa Brenan, Frank Dubois, Ofer Shapira, Noah F Greenwald, Melanie Pages, Amanda Balboni Iniguez, Brenton R Paolella, Alice Meng, Claire Sinai, Giovanni Roti, Neekesh V Dharia, Amanda Creech, Benjamin Tanenbaum, Prasidda Khadka, Adam Tracy, Hong L Tiv, Andrew L Hong, Shannon Coy, Rumana Rashid, Jia-Ren Lin, Glenn S Cowley, Fred C Lam, Amy Goodale, Yenarae Lee, Kathleen Schoolcraft, Francisca Vazquez, William C Hahn, Aviad Tsherniak, James E Bradner, Michael B Yaffe, Till Milde, Stefan M Pfister, Jun Qi, Monica Schenone, Steven A Carr, Keith L Ligon, Mark W Kieran, Sandro Santagata, James M Olson, Prafulla C Gokhale, Jacob D Jaffe, David E Root, Kimberly Stegmaier, Cory M Johannessen, Rameen Beroukhim
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nature communications 10 (1) (2019)
Peter Tsvetkov, Alexandre Detappe, Kai Cai, Heather R Keys, Zarina Brune, Weiwen Ying, Prathapan Thiru, Mairead Reidy, Guillaume Kugener, Jordan Rossen, Mustafa Kocak, Nora Kory, Aviad Tsherniak, Sandro Santagata, Luke Whitesell, Irene M Ghobrial, John L Markley, Susan Lindquist, Todd R Golub
Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nature chemical biology 15 (7) (2019)
Joshua M Dempster, Clare Pacini, Sasha Pantel, Fiona M Behan, Thomas Green, John Michael Krill-Burger, Charlotte M Beaver, Scott T Younger, Victor Zhivich, Hanna Najgebauer, Felicity Allen, Emanuel Gonçalves, Rebecca Shepherd, John G Doench, Kosuke Yusa, Francisca Vazquez, Leopold Parts, Jesse S Boehm, Todd R Golub, William C Hahn, David E Root, Mathew J Garnett, Aviad Tsherniak, Francesco Iorio
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets. Nature communications 10 (1) (2019)
Colles Price, Stanley Gill, Zandra V Ho, Shawn M Davidson, Erin Merkel, James M McFarland, Lisa Leung, Andrew Tang, Maria Kost-Alimova, Aviad Tsherniak, Oliver Jonas, Francisca Vazquez, William C Hahn
Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers. Cancer research 79 (10) (2019)
Thomas P Howard, Taylor E Arnoff, Melinda R Song, Andrew O Giacomelli, Xiaofeng Wang, Andrew L Hong, Neekesh V Dharia, Su Wang, Francisca Vazquez, Minh-Tam Pham, Ann M Morgan, Franziska Wachter, Gregory H Bird, Guillaume Kugener, Elaine M Oberlick, Matthew G Rees, Hong L Tiv, Justin H Hwang, Katherine H Walsh, April Cook, John Michael Krill-Burger, Aviad Tsherniak, Prafulla C Gokhale, Peter J Park, Kimberly Stegmaier, Loren D Walensky, William C Hahn, Charles W M Roberts
MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors. Cancer research 79 (9) (2019)
Adam D Durbin, Mark W Zimmerman, Neekesh V Dharia, Brian J Abraham, Amanda Balboni Iniguez, Nina Weichert-Leahey, Shuning He, John M Krill-Burger, David E Root, Francisca Vazquez, Aviad Tsherniak, William C Hahn, Todd R Golub, Richard A Young, A Thomas Look, Kimberly Stegmaier
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nature genetics 50 (9) (2018)
James M McFarland, Zandra V Ho, Guillaume Kugener, Joshua M Dempster, Phillip G Montgomery, Jordan G Bryan, John Michael Krill-Burger, Thomas M Green, Francisca Vazquez, Jesse S Boehm, Todd R Golub, William C Hahn, David E Root, Aviad Tsherniak
Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration. Nature communications 9 (1) (2018)
Taibo Li, April Kim, Joseph Rosenbluh, Heiko Horn, Liraz Greenfeld, David An, Andrew Zimmer, Arthur Liberzon, Jon Bistline, Ted Natoli, Yang Li, Aviad Tsherniak, Rajiv Narayan, Aravind Subramanian, Ted Liefeld, Bang Wong, Dawn Thompson, Sarah Calvo, Steven A Carr, Jesse S Boehm, Jacob D Jaffe, Jill Mesirov, Nir Hacohen, Aviv Regev, Kasper Lage
GeNets: a unified web platform for network-based genomic analyses. Nature methods 15 (7) (2018)
Samuel Y Ng, Noriaki Yoshida, Amanda L Christie, Mahmoud Ghandi, Neekesh V Dharia, Joshua Dempster, Mark Murakami, Kay Shigemori, Sara N Morrow, Alexandria Van Scoyk, Nicolas A Cordero, Kristen E Stevenson, Maneka Puligandla, Brian Haas, Christopher Lo, Robin M Meyers, Galen F Gao, Andrew D Cherniak, Abner Louissaint, Valentina Nardi, Aaron R Thorner, Henry Long, Xintao Qiu, Elizabeth A Morgan, David M Dorfman, Danilo Fiore, Julie Jang, Alan L Epstein, Ahmet Dogan, Yanming Zhang, Steven M Horwitz, Eric D Jacobsen, Solimar Santiago, Jian-Guo Ren, Vincent Guerlavais, D Allen Annis, Manuel Aivado, Mansoor N Saleh, Amitkumar Mehta, Aviad Tsherniak, David Root, Francisca Vazquez, William C Hahn, Giorgio Inghirami, Jon C Aster, David M Weinstock, Raphael Koch
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Nature communications 9 (1) (2018)
Hugh S Gannon, Tao Zou, Michael K Kiessling, Galen F Gao, Diana Cai, Peter S Choi, Alexandru P Ivan, Ilana Buchumenski, Ashton C Berger, Jonathan T Goldstein, Andrew D Cherniak, Francisca Vazquez, Aviad Tsherniak, Erez Y Levanon, William C Hahn, Matthew L Meyerson
Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells. Nature communications 9 (1) (2018)
Andrew O Giacomelli, Xiaoping Yang, Robert E Lintner, James M McFarland, Marc Duby, Jaegil Kim, Thomas P Howard, David Y Takeda, Seav Huong Ly, Eejung Kim, Hugh S Gannon, Brian Hurhula, Ted Sharpe, Amy Goodale, Briana Fritchman, Scott Steelman, Francisca Vazquez, Aviad Tsherniak, Andrew J Aguirre, John G Doench, Frederica Piccioni, Charles W M Roberts, Matthew L Meyerson, Gad A Getz, Cory M Johannessen, David E Root, William C Hahn
Mutational processes shape the landscape of TP53 mutations in human cancer. Nature genetics 50 (10) (2018)
Björn Stolte, Amanda Balboni Iniguez, Neekesh V Dharia, Amanda L Robichaud, Amy Saur Conway, Ann M Morgan, Gabriela Alexe, Nathan J Schauer, Xiaoxi Liu, Gregory H Bird, Aviad Tsherniak, Francisca Vazquez, Sara J Buhrlage, Loren D Walensky, Kimberly Stegmaier
Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. The Journal of experimental medicine 215 (8) (2018)
Srinivas R Viswanathan, Marina F Nogueira, Colin G Buss, John M Krill-Burger, Mathias J Wawer, Edyta Malolepsza, Ashton C Berger, Peter S Choi, Juliann Shih, Alison M Taylor, Benjamin Tanenbaum, Chandra Sekhar Pedamallu, Andrew D Cherniak, Pablo Tamayo, Craig A Strathdee, Kasper Lage, Steven A Carr, Monica Schenone, Sangeeta N Bhatia, Francisca Vazquez, Aviad Tsherniak, William C Hahn, Matthew L Meyerson
Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. Nature genetics 50 (7) (2018)
Joseph Rosenbluh, Han Xu, William Harrington, Stanley Gill, Xiaoxing Wang, Francisca Vazquez, David E Root, Aviad Tsherniak, William C Hahn
Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression. Nature communications 8 (2017)
Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim
Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. eLife 6 (2017)
Robin M Meyers, Jordan G Bryan, James M McFarland, Barbara A Weir, Ann E Sizemore, Han Xu, Neekesh V Dharia, Phillip G Montgomery, Glenn S Cowley, Sasha Pantel, Amy Goodale, Yenarae Lee, Levi D Ali, Guozhi Jiang, Rakela Lubonja, William F Harrington, Matthew Strickland, Ting Wu, Derek C Hawes, Victor A Zhivich, Meghan R Wyatt, Zohra Kalani, Jaime J Chang, Michael Okamoto, Kimberly Stegmaier, Todd R Golub, Jesse S Boehm, Francisca Vazquez, David E Root, William C Hahn, Aviad Tsherniak
Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nature genetics 49 (12) (2017)
Nina Ilic, Kıvanç Birsoy, Andrew J Aguirre, Nora Kory, Michael E Pacold, Shambhavi Singh, Susan E Moody, Joseph D DeAngelo, Nicole A Spardy, Elizaveta Freinkman, Barbara A Weir, Aviad Tsherniak, Glenn S Cowley, David E Root, John M Asara, Francisca Vazquez, Hans R Widlund, David M Sabatini, William C Hahn
PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America 114 (17) (2017)
Jong Wook Kim, Olga B Botvinnik, Omar Abudayyeh, Chet Birger, Joseph Rosenbluh, Yashaswi Shrestha, Mohamed E Abazeed, Peter S Hammerman, Daniel DiCara, David J Konieczkowski, Cory M Johannessen, Arthur Liberzon, Amir Reza Alizad-Rahvar, Gabriela Alexe, Andrew Aguirre, Mahmoud Ghandi, Heidi Greulich, Francisca Vazquez, Barbara A Weir, Eliezer M Van Allen, Aviad Tsherniak, Diane D Shao, Travis I Zack, Michael Noble, Gad Getz, Rameen Beroukhim, Levi A Garraway, Masoud Ardakani, Chiara Romualdi, Gabriele Sales, David A Barbie, Jesse S Boehm, William C Hahn, Jill P Mesirov, Pablo Tamayo
Characterizing genomic alterations in cancer by complementary functional associations. Nature biotechnology 34 (5) (2016)
Channing Yu, Aristotle M Mannan, Griselda Metta Yvone, Kenneth N Ross, Yan-Ling Zhang, Melissa A Marton, Bradley R Taylor, Andrew Crenshaw, Joshua Z Gould, Pablo Tamayo, Barbara A Weir, Aviad Tsherniak, Bang Wong, Levi A Garraway, Alykhan F Shamji, Michelle A Palmer, Michael A Foley, Wendy Winckler, Stuart L Schreiber, Andrew L Kung, Todd R Golub
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines. Nature biotechnology 34 (4) (2016)
Andrew L Hong, Yuen-Yi Tseng, Glenn S Cowley, Oliver Jonas, Jaime H Cheah, Bryan D Kynnap, Mihir B Doshi, Coyin Oh, Stephanie C Meyer, Alanna J Church, Shubhroz Gill, Craig M Bielski, Paula Keskula, Alma Imamovic, Sara Howell, Gregory V Kryukov, Paul A Clemons, Aviad Tsherniak, Francisca Vazquez, Brian D Crompton, Alykhan F Shamji, Carlos Rodriguez-Galindo, Katherine A Janeway, Charles W M Roberts, Kimberly Stegmaier, Paul van Hummelen, Michael J Cima, Robert S Langer, Levi A Garraway, Stuart L Schreiber, David E Root, William C Hahn, Jesse S Boehm
Integrated genetic and pharmacologic interrogation of rare cancers. Nature communications 7 (2016)
Luc de Waal, Timothy A Lewis, Matthew G Rees, Aviad Tsherniak, Xiaoyun Wu, Peter S Choi, Lara Gechijian, Christina Hartigan, Patrick W Faloon, Mark J Hickey, Nicola Tolliday, Steven A Carr, Paul A Clemons, Benito Munoz, Bridget K Wagner, Alykhan F Shamji, Angela N Koehler, Monica Schenone, Alex B Burgin, Stuart L Schreiber, Heidi Greulich, Matthew Meyerson
Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nature chemical biology 12 (2) (2015)

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Publication Activity (10 Years)

Top Topics

Top Venues

Aviad Tsherniak